V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

LAT Gene

protein-coding   GIFtS: 60

GC16P028903
linker for activation of T cells
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for LAT

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
LAT1 1, 2
p36-38 3
pp36 2, 3
Descriptions
36 kDa phospho-tyrosine adapter protein 3
36 kDa phospho-tyrosine adaptor protein 2
linker for activation of T cells 2
External Ids
HGNC: 188741
Entrez Gene: 270402
UniProtKB: O435613
Ensembl: ENSG000002136587
Search outside databases for aliases for LAT gene

Previous GC identifers: GC16P079421 GC16P029319 GC16P028994 GC16P029033 GC16P029034

Summaries
for LAT

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for LAT:
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following
activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane
protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins.
Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling
molecules into multimolecular signaling complexes located near the site of TCR engagement.
Alternative splicing results in multiple transcript variants encoding different isoforms.
[provided by RefSeq]

UniProtKB/Swiss-Prot: LAT_HUMAN, O43561
Function: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in
mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma
Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity
immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these
receptors and their associated kinases with distal intracellular events such as mobilization of
intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization
through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules

Gene Wiki entry for LAT (Linker_of_activated_T_cells)

Genomic Location
for LAT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LAT gene  

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16q13

LAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028903:     (about GC identifiers)

Start:
 28,903,648 bp from pter
End:
 28,909,605 bp from pter
Size:
 5,958 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  

Proteins
for LAT

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LAT_HUMAN, O43561 (See protein sequence)
Recommended Name: Linker for activation of T-cells family member 1  
Size: 262 amino acids; 27930 Da
Subunit: When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide
3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL,
SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A
Subcellular location: Cell membrane; Single-pass type III membrane protein. Note=Present in lipid
rafts
Miscellaneous: Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1
with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation
of LAT
Secondary accessions: O43919
Alternative splicing: 2 isoforms:  O43561-1   O43561-2   

Post-translational modifications:

  • Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor
    activation; which leads to the recruitment of multiple signaling molecules. Is one of the most
    prominently tyrosine-phosphorylated proteins detected following TCR engagement1
  • Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_001014987.1  NP_001014988.1  NP_001014989.1  NP_055202.1  


    ENSEMBL proteins: 
    ENSP00000354119 ENSP00000378845 ENSP00000346441 ENSP00000378841 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant LAT Protein
    Sigma-Aldrich Proteins for LAT  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LAT)
    Human Recombinant Proteins from Abnova (LAT)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772 immunological synapse IDA12646565
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IDA12646565
    GO:0045121 membrane raft TAS14722116
    About this table

    Antibodies for LAT: 
    Invitrogen Antibodies for LAT
    Millipore Mono- and Polyclonal Antibodies for the study of LAT
    Sigma-Aldrich Antibodies for LAT
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LAT 
    Antibodies from Abcam (LAT), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LAT)
    Novus Biologicals Antibodies for LAT

    Assays for LAT: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of LAT
    Browse R&D Systems for biochemical assays
    Cell Signaling Technology (CST) Sandwich ELISA Kits for LAT
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for LAT

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR008359 LAT


       GeneDecks  LAT for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O43561

    ProtoNet protein and cluster: O43561

    1 Blocks protein family: IPB008359 Linker for activation of T cells (LAT) signature

    Gene Function
    for LAT

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LAT)
    Millipore RNAi Products for the Analysis of LAT Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (LAT)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_014387

                  Applied Biosystems Silencer® siRNAs for LAT

                  Sigma-Aldrich siRNA for LAT  
                         Sigma-Aldrich shRNA Panels and shRNA for LAT  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LAT
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001014987
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001014987
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001014987 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014387

    UniProtKB/Swiss-Prot: LAT_HUMAN, O43561
    Function: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in
    mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma
    Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity
    immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these
    receptors and their associated kinases with distal intracellular events such as mobilization of
    intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization
    through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules

    8 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Lat):

    hematopoietic systemhomeostasis/metabolismimmune systemlife span-post-weaning/agingliver/biliary system
    no phenotypic analysisrenal/urinary systemrespiratory system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070 SH3/SH2 adaptor activity IDA9489702
    GO:0005515 protein binding IPI16938345
    About this table

    Pathways & Interactions
    for LAT

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/9 Invitrogen iPath™ Online BioAtlas - Pathways for LAT (see all 9 ) (Maps provided by GeneGo):
     Role of CD28 signaling in cytoskeleton reorganization
     CD28 signaling
     TCR and CD28 co-stimulation in activation of NF-kB
     T cell receptor signaling pathway
     IP3 signaling

       GeneDecks  LAT for the pathways selected above  
    About GeneDecksing

    5/10 Millipore Pathways for LAT (see all 10 )
     Immune response CD16 signaling in NK cells
     Immune response Role of DAP12 receptors in NK cells
     Signal transduction IP3 signaling
     Immune response NFAT in immune response
     Immune response Fc epsilon RI pathway

       GeneDecks  LAT for the pathways selected above  
    About GeneDecksing

    5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for  LAT  (Your Favorite Gene powered by Ingenuity) (see all 7 ) 
     Natural Killer Cell Signaling
     CTLA4 Signaling in Cytotoxic T Lymphocytes
     Role of NFAT in Regulation of the Immune Response
     Fc Epsilon RI Signaling
     iCOS-iCOSL Signaling in T Helper Cells

       GeneDecks  LAT for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for LAT: 
     T Cell Receptor Signaling

       GeneDecks  LAT for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for LAT):
     hsa04650 Natural killer cell mediated cytotoxicity
     hsa04660 T cell receptor signaling pathway
     hsa04664 Fc epsilon RI signaling pathway

       GeneDecks  LAT for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  LAT 


    5/11 Interacting proteins for LAT (O435611, 2) via UniProtKB, MINT, and/or STRING (see all 11 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2EBI-1222766, EBI-401755 MINT-3382320 MINT-3382392 MINT-3382363 MINT-3382412 MINT-3382436 EBI-1222766, EBI-401755 MINT-3382320 MINT-3382392 MINT-3382363 MINT-3382412 MINT-3382436
    FYNP062411EBI-1222766, EBI-515315
    LCKP062391EBI-1222766, EBI-1348
    PLCG1P191741EBI-1222766, EBI-79387
    GRB2P629931, 2EBI-1222766, EBI-401755 MINT-3382320 MINT-3382392 MINT-3382363 MINT-3382412 MINT-3382436 EBI-1222766, EBI-401755 MINT-3382320 MINT-3382392 MINT-3382363 MINT-3382412 MINT-3382436
    About this table

    5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response IDA15100278
    GO:0007229 integrin-mediated signaling pathway IDA15100278
    GO:0007242 intracellular signaling cascade IDA12646565
    GO:0007265 Ras protein signal transduction IMP12646565
    GO:0019722 calcium-mediated signaling IMP12646565
    About this table

    Drugs & Compounds
    for LAT

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LAT
    6 Novoseek chemical compound relationships for LAT gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    pp36 92.74 4 9541596 (2), 8063801 (1), 7561087 (1)
    tyrosine 62.12 30 11368773 (4), 12186560 (4), 9541596 (1), 11752630 (1) (see all 14)
    phosphatidylinositol 41.86 1 12359715 (1)
    lipid 26.16 5 12356870 (1), 17148460 (1), 12186560 (1), 12359715 (1) (see all 5)
    phenylalanine 21.08 3 11368773 (1), 12186560 (1)
    calcium 8.65 2 12356870 (1), 10934198 (1)
    About this table


    Transcripts
    for LAT

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LAT)
    Millipore RNAi Products for the Analysis of LAT Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (LAT)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_014387

                  Sigma-Aldrich siRNA for LAT  
                         Sigma-Aldrich shRNA Panels and shRNA for LAT  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001014987  NM_001014988  NM_001014989  NM_014387  

    REFSEQ mRNAs for LAT gene (4 alternative transcripts): 

    NM_001014987.1   NM_001014988.1   NM_001014989.1   NM_014387.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001014987  NM_001014988  NM_001014989  NM_014387  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001014987
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001014987
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001014987 

    Additional cDNA sequence: 

    AF036905.1 AF036906.1 AJ223280.1 AK093815.1 AK307342.1 BC011563.1 CR592470.1 CR597721.1 
    CR602091.1 CR624409.1 

    14 DOTS entries:

    DT.212803  DT.97821383  DT.91813625  DT.120697691  DT.86846602  DT.95279632  DT.120697773  DT.212804 
    DT.92422795  DT.100646119  DT.100837133  DT.86847375  DT.92422794  DT.120696242 

    24/100 AceView cDNA sequences (see all 100 ):

    AI093373 CR597721 AW296085 AJ223280 CA433887 AW137801 CR592470 BQ549485 
    BX107839 BX437371 CR624409 BQ072651 BQ581351 BM682360 CA426247 BC011563 
    AW474918 AI224538 CK902086 CR602091 BE463927 BM715456 BM717829 CB160324 

    highest scoring ESTs for LAT:

    AJ223280 AA311132 AA535611 AA628009 AA655020 AA773038 AA987807 AI093373 AI224538 AI288988 

    Unigene Cluster for LAT:

    Linker for activation of T cells
    Hs.632179  [show with all ESTs]
    Unigene Representative Sequence: AK093815


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000360872  ENST00000395461  ENST00000354453  ENST00000395456  

    Expression
    for LAT

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LAT expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LAT

    1 / 2 / 3

    5 probe-sets matching LAT gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40688_at2, 3 U95-A 2 1.00 0.50 1.00 1.00 AJ223280 1.00 0.80 0.91 1

    		209881_s_at2, 3 U133-A 2 1.00 0.50 -- -- AF036905 0.60 1.00 0.82 1

    		211005_at2, 3 U133-A 2 1.00 0.50 -- -- AF036906 0.60 1.00 0.82 1

    		209881_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --

    		211005_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    GeneDecks  LAT for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGGGCTCAGC

    SOURCE GeneReport for Unigene cluster: Hs.632179

    Expression variation in blood from EXPOLDB for LAT

    UniProtKB/Swiss-Prot: LAT_HUMAN, O43561
    Tissue specificity: Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in
    spleen. Present in T-cells but not B-cells (at protein level)

    Orthologs
    for LAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for LAT gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LAT1   -- linker for activation of T cells 75.93(n)
    72.65(a)    		 607947  XM_844817.1  XP_849910.1 
    chimpanzee
    (Pan troglodytes)    		 LAT1   -- linker for activation of T cells 99.43(n)
    99.14(a)    		 743295  XM_001147360.1  XP_001147360.1 
    cow
    (Bos taurus)    		 LAT1   -- linker for activation of T cells 79.15(n)
    73.93(a)    		 514735  XM_878670.2  XP_883763.1 
    rat
    (Rattus norvegicus)    		 Lat1   -- linker for activation of T cells 76.91(n)
    67.97(a)    		 81511  NM_030853.1  NP_110480.1 
    mouse
    (Mus musculus)    		 Lat1, 5 75
    		 linker for activation of T cells1, 5 78.55(n)1
    70.87(a)1    		 167971  NM_010689.21  NP_034819.11 
     AF0369075  AJ4384355  (see all 9)
    About this table        Species with no ortholog for LAT

    ENSEMBL Gene Tree for LAT

    Paralogs
    for LAT

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for LAT

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/26 NCBI SNPs in LAT are shown (see all 26 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs18021411,2
    		C,F28909510(+) GTTTCA/GCCATC 4 -- ut313Minor allele frequency- G:0.27NA 122
    --
    rs80623741,2
    		A28910089(+) agctgA/Ggatta 4 -- ng310--------
    rs11315431,2
    		C,F,H28905498(+) GATGCG/AGATGA 4 A/A syn110Minor allele frequency- A:0.27EA NA MN EU WA 846
    rs47881151,2
    		C,F,H28905612(+) TCACTT/ACCTTT 4 -- int17Minor allele frequency- A:0.14NA EU EA WA 554
    rs72020931,2
    		F,H28906450(+) TATACC/TCTGGC 4 -- int14Minor allele frequency- T:0.19EU EA WA 410
    rs99290881,2
    		C28908961(+) GCTGAA/CCCCCG 4 -- int10--------
    --
    rs560581401,2
    		--28905622(+) TCAGGA/GTGGTG 4 V/M mis10--------
    --
    rs412808521,2
    		--28909356(+) CTGTGA/GGTCTC 4 -- ut310--------
    --
    rs559450241,2
    		--28904543(+) CCTACA/GACAGC 4 D/N mis10--------
    rs342824881,2
    		--28903925(+) GGCGCC/TGAGGA 4 -- ut51 int10--------
    About this table

    HapMap Linkage Disequilibrium images for LAT (up to first 250kb)

    Disorders & Mutations
    for LAT

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 602354

    1 Novoseek disease relationship for LAT gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 4.81 1 17178387 (1)
    About this table

    1 PharmGKB disease relationship for LAT gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Human Gene Mutation Database: LAT
    Human Genome Epidemiology Navigator: LAT (4 documents)

    Medical News
    for LAT

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for LAT

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/101 PubMed articles for LAT gene (see all 101 ):

    Search for LAT

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LAT

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 27040 HGNC: 18874 AceView: LAT Ensembl:ENSG00000213658 euGenes: HUgn27040
    ECgene: LAT H-InvDB: LAT

    Other Databases showing LAT

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing LAT

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for LAT

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for LAT

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LAT:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LAT-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LAT Antibodies for LAT
     Explore super-pooled esiRNAs Proteins for LAT
     Lentivirus-delivered shRNAs for LAT Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (LAT)
     Antibodies (LAT)
     Chimera RNAi (LAT)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for LAT 

     Recombinant Proteins
    (LAT)
     Antibodies (LAT)
     Search OriGene for LAT
     Search Tocris compounds for LAT




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LAT

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    LAT Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com