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LAT Gene

protein-coding   GIFtS: 62
GCID: GC16P028998

Linker For Activation Of T Cells

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Linker For Activation Of T Cells1 2     36 KDa Phospho-Tyrosine Adaptor Protein2
36 KDa Phospho-Tyrosine Adapter Protein2 3     LAT12
p36-382 3     Linker For Activation Of T Cells, Transmembrane Adaptor2
pp362 3     Linker For Activation Of T-Cells Family Member 12
Transmembrane Adaptor1     

External Ids:    HGNC: 188741   Entrez Gene: 270402   Ensembl: ENSG000002136587   OMIM: 6023545   UniProtKB: O435613   

Export aliases for LAT gene to outside databases

Previous GC identifers: GC16P079421 GC16P029319 GC16P028994 GC16P029033 GC16P029034 GC16P028903 GC16P026864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LAT Gene:
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of
the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid
rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits
multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near
the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for LAT Gene:
LAT (linker for activation of T cells) is a protein-coding gene. GO annotations related to this gene include SH3/SH2 adaptor activity and protein kinase binding.

UniProtKB/Swiss-Prot: LAT_HUMAN, O43561
Function: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and
during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated
signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in
mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events
such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal
reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules

Gene Wiki entry for LAT (Linker of activated T cells) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAT gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAT promoter sequence
   Search Chromatin IP Primers for LAT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16q13

LAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAT gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028998:  view genomic region     (about GC identifiers)

Start:
28,996,147 bp from pter      End:
29,002,104 bp from pter
Size:
5,958 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LAT_HUMAN, O43561 (See protein sequence)
Recommended Name: Linker for activation of T-cells family member 1  
Size: 262 amino acids; 27930 Da
Subunit: When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2
domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with
SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR
activation in thymocytes (By similarity)
Miscellaneous: Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and
blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT
Secondary accessions: O43919
Alternative splicing: 2 isoforms:  O43561-1   O43561-2   

Explore the universe of human proteins at neXtProt for LAT: NX_O43561

Explore proteomics data for LAT at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which
    leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated
    proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to
    the recruitment of VAV1 to LAT-containing complexes1
  • Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation1
  • Ubiquitination2 at Lys52
  • Modification sites at PhosphoSitePlus

  • See LAT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001014987.1  NP_001014988.1  NP_001014989.2  NP_055202.1  

    ENSEMBL proteins: 
     ENSP00000378845   ENSP00000457036   ENSP00000378841   ENSP00000398793   ENSP00000354119  
     ENSP00000456761   ENSP00000454793   ENSP00000455728   ENSP00000346441  
    Reactome Protein details: O43561

    LAT Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LAT
    OriGene Custom MassSpec
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    Novus Biologicals LAT Proteins
    Novus Biologicals LAT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LAT
    Cloud-Clone Corp. Proteins for LAT

     
    Search eBioscience for Proteins for LAT 

    LAT Antibody Products:

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    LAT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LAT
    Cell Signaling Technology (CST) Sandwich ELISA Kits for LAT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LAT
    Cloud-Clone Corp. CLIAs for LAT
    Search eBioscience for ELISAs for LAT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008359 Linker_for_activat_Tcells_prot

    Graphical View of Domain Structure for InterPro Entry O43561

    ProtoNet protein and cluster: O43561

    1 Blocks protein domain: IPB008359 Linker for activation of T cells (LAT) signature


    Find genes that share domains with LAT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAT_HUMAN, O43561
    Function: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and
    during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated
    signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in
    mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events
    such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal
    reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IDA9489702
    GO:0005515protein binding IPI10811803
    GO:0019901protein kinase binding IPI12186560
         
    Find genes that share ontologies with LAT           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 15 alleles(MGI details for Lat):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     no phenotypic analysis  renal/urinary system  respiratory system 

    Find genes that share phenotypes with LAT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LAT: Lattm1Bpay Lattm4Mal Lattm5Mal Lattm1Les

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAT

    miRNA
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    Block miRNA regulation of human, mouse, rat LAT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LAT (see all 11):
    hsa-miR-3678-3p hsa-miR-22 hsa-miR-18a hsa-miR-1266 hsa-miR-186* hsa-miR-3155 hsa-miR-484 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidLAT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LAT

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for LAT (see all 20)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAT (NM_001931)
    Sino Biological Human cDNA Clone for LAT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAT

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAT_HUMAN, O43561: Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    extracellular3
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA12646565
    GO:0005886plasma membrane TAS--
    GO:0008180COP9 signalosome ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA12646565

    Find genes that share ontologies with LAT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAT About   (see all 30)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    Fc epsilon RI signaling pathway0.41
    2Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.33
    3B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36
    4CD28 co-stimulation
    GPVI-mediated activation cascade0.31
    CTLA4 Signaling0.30
    5TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    ITK and TCR Signaling0.54
    TCR Signaling0.68
    Fc-EpsilonRI Pathway0.49


    Find genes that share SuperPaths with LAT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAT (see all 14)
        ICos-ICosL Pathway in T-Helper Cell
    Rap1 Pathway
    CD28 Signaling in T-Helper Cell
    Tec Kinases Signaling
    CTLA4 Signaling

    1 Cell Signaling Technology (CST) Pathway for LAT
        Lymphocyte Signaling

    Selected GeneGo (Thomson Reuters) Pathways for LAT (see all 10)
        Immune response CD28 signaling
    Immune response CD16 signaling in NK cells
    G-protein signaling N-RAS regulation pathway
    Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway

    4 BioSystems Pathways for LAT
        TCR Signaling Pathway
    TCR signaling in naive CD8+ T cells
    Signaling events mediated by PTP1B
    Fc-epsilon receptor I signaling in mast cells


    2 Reactome Pathways for LAT
        GPVI-mediated activation cascade
    Generation of second messenger molecules


    Selected Kegg Pathways  (Kegg details for LAT) (see all 7):
        Ras signaling pathway
    Rap1 signaling pathway
    NF-kappa B signaling pathway
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAT: 
              Th1/Th2 Response in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAT (O435611, 2, 3 ENSP000003541194) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-1222766,EBI-401755 MINT-8034048 MINT-8032337 MINT-8033992 MINT-3382320 MINT-3382392 MINT-3382363 MINT-8032277 MINT-3382412 MINT-8034033 MINT-3382436 MINT-8032322 I2D: score=7 STRING: ENSP00000339007
    PLCG1P191741, 2, 3, ENSP000002440074EBI-1222766,EBI-79387 MINT-8032266 MINT-8033981 MINT-8027843 MINT-8027828 I2D: score=6 STRING: ENSP00000244007
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-1222766,EBI-79464 MINT-8034007 MINT-8032307 MINT-8032292 MINT-8034022 I2D: score=2 STRING: ENSP00000274335
    ZAP70P434032, 3, ENSP000002649724MINT-3382488 I2D: score=4 STRING: ENSP00000264972
    LCKP062391, 3, ENSP000003378254EBI-1222766,EBI-1348 I2D: score=3 STRING: ENSP00000337825
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    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response ----
    GO:0006955immune response IDA15100278
    GO:0007165signal transduction ----
    GO:0007229integrin-mediated signaling pathway IDA15100278
    GO:0007265Ras protein signal transduction IMP12646565

    Find genes that share ontologies with LAT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAT

    1 HMDB Compound for LAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for LAT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pp36 92.2 4 9541596 (2), 8063801 (1), 7561087 (1)
    tyrosine 62.4 34 11368773 (4), 12186560 (4), 9541596 (1), 11752630 (1) (see all 16)
    phosphatidylinositol 40.1 1 12359715 (1)
    lipid 23.8 5 12356870 (1), 17148460 (1), 12186560 (1), 12359715 (1) (see all 5)
    phenylalanine 19.3 3 11368773 (1), 12186560 (1)
    calcium 12.1 2 12356870 (1), 10934198 (1)



    Find genes that share compounds with LAT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAT gene (4 alternative transcripts): 
    NM_001014987.1  NM_001014988.1  NM_001014989.1  NM_014387.3  

    Unigene Cluster for LAT:

    Linker for activation of T cells
    Hs.632179  [show with all ESTs]
    Unigene Representative Sequence: AK093815
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395461(uc010vdk.1 uc010vdj.2) ENST00000566270 ENST00000564277
    ENST00000562472 ENST00000563964 ENST00000395456 ENST00000454369 ENST00000360872(uc010vdl.1)
    ENST00000566177 ENST00000562701 ENST00000568899 ENST00000568440 ENST00000570232
    ENST00000564447 ENST00000566415 ENST00000354453
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LAT (see all 11):
    hsa-miR-3678-3p hsa-miR-22 hsa-miR-18a hsa-miR-1266 hsa-miR-186* hsa-miR-3155 hsa-miR-484 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidLAT 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: LAT (NM_001931)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAT
      QuantiTect SYBR Green Assays in human, mouse, rat LAT
      QuantiFast Probe-based Assays in human, mouse, rat LAT

    Additional mRNA sequence: 

    AF036905.1 AF036906.1 AJ223280.1 AK093815.1 AK307342.1 BC011563.1 FN432831.1 FN432832.1 
    FN432833.1 FN432834.1 

    14 DOTS entries:

    DT.212803  DT.97821383  DT.91813625  DT.120697691  DT.86846602  DT.95279632  DT.120697773  DT.212804 
    DT.92422795  DT.100646119  DT.100837133  DT.86847375  DT.92422794  DT.120696242 

    Selected AceView cDNA sequences (see all 100):

    BM673935 BM717829 AW137801 BQ549485 BX107839 BE463927 CA426247 CR597721 
    AI093373 CB160324 CA433887 CR624409 BQ581351 BC011563 CR592470 AW296085 
    AJ223280 AA311132 AW474918 BX437371 CR602091 AI224538 BM715456 BQ072651 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCTCAGC
    LAT Expression
    About this image


    LAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             Umbilical cord blood-derived hematopoietic stem cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Liver (Hepatobiliary System)
    LAT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632179

    UniProtKB/Swiss-Prot: LAT_HUMAN, O43561
    Tissue specificity: Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in
    T-cells but not B-cells (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAT: 
              Th1/Th2 Response in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LAT
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAT
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    QuantiFast Probe-based Assays in human, mouse, rat LAT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for LAT gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lat1 , 5 linker for activation of T cells1, 5 78.15(n)1
    68.42(a)1
      7 (69.01 cM)5
    167971  NM_010689.21  NP_034819.11 
     1263638275 


    ENSEMBL Gene Tree for LAT (if available)
    TreeFam Gene Tree for LAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LAT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518648CNV Loss19592680
    esv2750677CNV Loss17666407
    nsv519100CNV Gain19592680
    nsv457480CNV Gain19166990
    nsv905702CNV Gain+Loss21882294
    dgv842e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): LAT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAT
    DNA2.0 Custom Variant and Variant Library Synthesis for LAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602354    OMIM disorders: --


    Find genes that share disorders with LAT           About GenesLikeMe

    1 Novoseek inferred disease relationship for LAT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 2.19 1 17178387 (1)

    Genetic Association Database (GAD): LAT
    Human Genome Epidemiology (HuGE) Navigator: LAT (8 documents)

    Export disorders for LAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAT gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with LAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PubMed id 9489702)1, 2, 3 Zhang W.... Samelson L.E. (Cell 1998)
    2. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. (PubMed id 12186560)1, 2, 9 Perez-Villar J.J.... Kanner S.B. (Biochemistry 2002)
    3. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. (PubMed id 11368773)1, 2, 9 Paz P.E.... Abo A. (Biochem. J. 2001)
    4. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. (PubMed id 11259588)1, 2, 9 Baker J.E.... Weiss A. (Mol. Cell. Biol. 2001)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. Transmembrane adaptor molecules: a new category of lymphoid-cell markers. (PubMed id 16160011)1, 2 Tedoldi S....Horejsi V. (Blood 2006)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. (PubMed id 14696041)1, 2 Sommers C.L.... Love P.E. (Bioessays 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells. (PubMed id 10781611)1, 2 Tridandapani S....Anderson C.L. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27040 HGNC: 18874 AceView: LAT Ensembl:ENSG00000213658 euGenes: HUgn27040
    ECgene: LAT Kegg: 27040 H-InvDB: LAT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LAT gene:
    Search GeneIP for patents involving LAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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