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Aliases & Descriptions for LASS4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CerS4 1, 2 | | FLJ12089 1, 2 | | Trh1 1, 2 |
| | | Descriptions |
|---|
| LAG1 homolog, ceramide synthase 4 2 | | LAG1 longevity assurance homolog 4 2 | | LAG1 longevity assurance homolog 4 (S. cerevisiae) 1 |
|
| | Search outside databases for aliases for LASS4 gene |
Summaries for LASS4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: LASS4_HUMAN, Q9HA82Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) |
Genomic Location for LASS4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LASS4 gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3LASS4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P008180:
(about GC identifiers)
Start:
|
8,180,257 bp from pter |
End:
|
8,233,302 bp from pter |
Size:
|
53,046 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_077812.2
| Proteins for LASS4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LASS4_HUMAN, Q9HA82 (See
protein sequence)Recommended Name: LAG1 longevity assurance homolog 4 Size: 394 amino acids; 46399 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_078828.2
ENSEMBL proteins: ENSP00000251363
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for LASS4: Assays for LASS4: | Protein
Domains/ Families for LASS4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9HA82
ProtoNet protein and cluster: Q9HA82 2 Blocks protein families: IPB005547 Longevity-assurance protein (LAG1) IPB006634 TRAM
UniProtKB/Swiss-Prot: LASS4_HUMAN, Q9HA82Similarity: Contains 1 homeobox DNA-binding domainSimilarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain | Gene Function for LASS4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024552
Applied Biosystems Silencer® siRNAs for LASS4
Sigma-Aldrich siRNA for LASS4  Sigma-Aldrich shRNA for LASS4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024552                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024552                                  untagged cDNA clones in CMV expression vector (see all 2): NM_024552 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024552
UniProtKB/Swiss-Prot: LASS4_HUMAN, Q9HA82Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity)3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0050291 | sphingosine N-acyltransferase activity |
IEA | -- | About this table | Pathways & Interactions for LASS4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for LASS4 (Your Favorite Gene powered by Ingenuity) 
3 Interacting proteins for LASS4 (ENSP000002513633 Q9HA822) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008610 | lipid biosynthetic process |
IEA | -- | | GO:0030148 | sphingolipid biosynthetic process |
IEA | -- | | GO:0046513 | ceramide biosynthetic process |
IEA | -- | About this table
|
Drugs & Compounds for LASS4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LASS4
|
Transcripts for LASS4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024552
Sigma-Aldrich siRNA for LASS4  Sigma-Aldrich shRNA for LASS4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024552 REFSEQ mRNAs for LASS4 gene: NM_024552.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024552               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024552                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024552                                  untagged cDNA clones in CMV expression vector (see all 2): NM_024552  Additional cDNA sequence: AK022151.1 AK055414.1 AK222621.1 AK225394.1 BC009828.2 BC063621.1 CR598338.1 CR614629.1 CR623019.1 19 DOTS entries: DT.75103241 DT.91741576 DT.97773877 DT.95113227 DT.113394 DT.100019238 DT.97782292 DT.100829415 DT.95113232 DT.100811526 DT.95336878 DT.100749538 DT.86856887 DT.91741577 DT.91873859 DT.97803812 DT.121456286 DT.91659967 DT.99959718 24/184 AceView cDNA sequences (see all 184
):BQ214330 AW135503 BM697971 BE893168 BQ059431 BI490050 BM909942 CR614629 BU149864 BM045289 BU838297 BM927305 BQ684050 BU674824 BM667138 CR623019 BF724636 AW440633 BG695862 BI822463 CR598338 BI754920 AW135505 BM925905
highest scoring ESTs for LASS4:T68813 AA025778 AA025779 AA025920 AA282891 AA677312 AA700750 AA703705 AA988187 AI055945 Unigene Cluster for LASS4: LAG1 homolog, ceramide synthase 4 Hs.515111 [show with all ESTs]Unigene Representative Sequence: AK055414
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LASS4 (see all 7
)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LASS4
1 Ensembl transcript including schematic representation: ENST00000251363
|
Expression for LASS4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LASS4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LASS4
1 / 2 / 3 3 probe-sets matching LASS4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGAAGGGCC
SOURCE GeneReport for Unigene cluster: Hs.515111
|
Orthologs for LASS4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LASS4 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for LASS4
ENSEMBL Gene Tree for LASS4 | Paralogs for LASS4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LASS4 gene
- LASS32 LASS22
|
SNPs/Variants for LASS4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LASS4 (up to first 250kb)
|
Disorders & Mutations for LASS4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for LASS4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LASS4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for LASS4 gene: |
Search for LASS4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LASS4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LASS4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LASS4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LASS4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LASS4:

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| | | | Search Tocris compounds for LASS4 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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