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LASS3 Gene

protein-coding   GIFtS: 46

GC15M098758
LAG1 homolog, ceramide synthase 3
(Previous name: LAG1 longevity assurance homolog 3 (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for LASS3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CerS3 1, 2
MGC27091 1, 2
OTTHUMP00000194816 2
Descriptions
LAG1 homolog, ceramide synthase 3 2
LAG1 longevity assurance homolog 3 2
LAG1 longevity assurance homolog 3 (S. cerevisiae) 1
External Ids
HGNC: 237521
Entrez Gene: 2042192
UniProtKB: Q8IU893
Ensembl: ENSG000001542277
Search outside databases for aliases for LASS3 gene

Previous GC identifers: GC15M098675 GC15M098674

Summaries
for LASS3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LASS3_HUMAN, Q8IU89
Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

Genomic Location
for LASS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LASS3 gene  

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

LASS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M098758:     (about GC identifiers)

Start:
 98,758,123 bp from pter
End:
 98,902,448 bp from pter
Size:
 144,326 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000015.8  NT_035325.6  

Proteins
for LASS3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LASS3_HUMAN, Q8IU89 (See protein sequence)
Recommended Name: LAG1 longevity assurance homolog 3  
Size: 383 amino acids; 46217 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8NE64 Q8NEN6

REFSEQ proteins: NP_849164.2  

ENSEMBL proteins: 
ENSP00000377672 ENSP00000284382 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (LASS3)
Human Recombinant Proteins from Abnova (LASS3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005737 cytoplasm IDA18029348
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
GO:0031965 nuclear membrane IEA--
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Antibodies for LASS3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for LASS3
Browse R&D Systems for Antibodies
Antibodies from Abcam (LASS3), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (LASS3)
Novus Biologicals Antibody for LASS3

Assays for LASS3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for LASS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR016439 Longevity_assurance_LAG1_LAC1
 IPR001356 Homeobox
 IPR017970 Homeobox_CS
 IPR006634 TLC


   GeneDecks  LASS3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q8IU89

ProtoNet protein and cluster: Q8IU89

2 Blocks protein families:
IPB005547 Longevity-assurance protein (LAG1)
IPB006634 TRAM


UniProtKB/Swiss-Prot: LASS3_HUMAN, Q8IU89
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

Gene Function
for LASS3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (LASS3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (LASS3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC028703

              Applied Biosystems Silencer® siRNAs for LASS3

              Sigma-Aldrich siRNA for LASS3  
                     Sigma-Aldrich shRNA for LASS3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178842
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178842
                                 untagged cDNA clones in CMV expression vector (see all 2): BC028703 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_178842

UniProtKB/Swiss-Prot: LASS3_HUMAN, Q8IU89
Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity IEA--
GO:0043565 sequence-specific DNA binding IEA--
GO:0050291 sphingosine N-acyltransferase activity IEA--
About this table

Pathways & Interactions
for LASS3

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  LASS3  (Your Favorite Gene powered by Ingenuity) 
 Sphingolipid Metabolism

   GeneDecks  LASS3 for the pathways selected above  
About GeneDecksing

  --

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0008610 lipid biosynthetic process IEA--
GO:0030148 sphingolipid biosynthetic process IEA--
About this table

Drugs & Compounds
for LASS3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LASS3

Transcripts
for LASS3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (LASS3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (LASS3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC028703

              Sigma-Aldrich siRNA for LASS3  
                     Sigma-Aldrich shRNA for LASS3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_178842  

REFSEQ mRNAs for LASS3 gene: 

NM_178842.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_178842  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178842
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178842
                                 untagged cDNA clones in CMV expression vector (see all 2): BC028703 

Additional cDNA sequence: 

AK307191.1 BC027616.2 BC028703.1 BC034500.1 BC034970.1 

6 DOTS entries:

DT.91818968  DT.100022188  DT.95265312  DT.40213181  DT.121075538  DT.92044510 

24/33 AceView cDNA sequences (see all 33 ):

BG739839 AI150300 BF980181 BG743450 NM_178842 BG772055 BM559623 BX109825 
BC034500 BC028703 BI459140 BG717442 BC027616 AA405035 BQ435498 AI818996 
CB857681 BG718327 BC034970 BX112012 AI091424 AA897501 BG772599 BF979454 

highest scoring ESTs for LASS3:

AA897501 BC034500 BC034970 BG717442 AA405035 AA406205 AI091424 AW043654 BC027616 BC028703 

Unigene Cluster for LASS3:

LAG1 homolog, ceramide synthase 3
Hs.662371  [show with all ESTs]
Unigene Representative Sequence: BC034970


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000394113  ENST00000284382  

Expression
for LASS3

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LASS3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LASS3

1 / 2 / 3

3 probe-sets matching LASS3 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

75414_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AA897501 0.80 1.00 0.91 1

1554252_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1554253_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GATTTTTACT

SOURCE GeneReport for Unigene cluster: Hs.662371

Orthologs
for LASS3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for LASS3 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LASS31   -- LAG1 homolog, ceramide synthase 3 89.56(n)
89.03(a)		 607925  XM_844788.1  XP_849881.1 
chimpanzee
(Pan troglodytes)		 LASS31   -- LAG1 homolog, ceramide synthase 3 99.65(n)
99.22(a)		 453683  XM_001141298.1  XP_001141298.1 
rat
(Rattus norvegicus)		 Lass31   -- LAG1 homolog, ceramide synthase 3 82.29(n)
77.75(a)		 499174  XM_574469.2  XP_574469.2 
mouse
(Mus musculus)		 Lass31, 5 75
 LAG1 homolog, ceramide synthase 31, 5 83.07(n)1
78.53(a)1		 5459751  XM_620510.31  XP_620510.21 
 BY7764885  DQ3580875  (see all 6)
African clawed frog
(Xenopus laevis)		 BG363905.12   --   -- 74.58(n)  BG363905.1 
About this table        Species with no ortholog for LASS3

ENSEMBL Gene Tree for LASS3

Paralogs
for LASS3

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for LASS3 gene
LASS42  LASS22  

SNPs/Variants
for LASS3

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/1269 NCBI SNPs in LASS3 are shown (see all 1269 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 337)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 15 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs10237821,2
A,C,F,H98760366(+) GGGTCG/TGTGTG 1 -- ut31 ese311Minor allele frequency- T:0.44MN EU EA WA NA 2378
--
rs129142351,2
A,C,F,H98759896(+) TGCTGC/TAACCC 1 -- ut31 ese34Minor allele frequency- T:0.48EU EA WA 412
rs18671611,2
A,C,F,H98757948(+) ACACCA/GCAAAC 1 -- ng5111Minor allele frequency- G:0.17EU EA WA NA 964
rs80259541,2
A,C,F98759164(+) CTTCCT/GGAGGG 1 -- ut31 ese33Minor allele frequency- G:0.45NA 142
rs10237831,2
C,F,H98760568(+) CCTCGT/CCATCA 1 G/D mis1 ese312Minor allele frequency- C:0.01MN EU EA WA NA 1162
rs25877341,2
C,F,H98758480(-) GTATGT/CTTTCT 1 -- ut31 trp37Minor allele frequency- C:0.02EU EA WA NA 538
rs24399281,2
C,F,H98760485(-) GCCTCG/AGGGCT 1 G/R mis111Minor allele frequency- A:0.02EU EA WA NA 980
--
rs116375751,2
A,C98904412(+) GAGTAA/GAGACT 1 -- ng31 tfbs30--------
--
rs178568161,2
H98813673(+) AGTAAA/CGGTGA 1 L/R mis1 ese34Minor allele frequency- C:0.00EU EA WA 420
--
rs71714611,2
C98903417(+) ctcaaC/Tatctt 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for LASS3 (up to first 250kb)

Disorders & Mutations
for LASS3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for LASS3

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for LASS3

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for LASS3 gene:

Search for LASS3

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing LASS3

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 204219 HGNC: 23752 AceView: LASS3 Ensembl:ENSG00000154227 euGenes: HUgn204219
ECgene: LASS3 H-InvDB: LASS3

Other Databases showing LASS3

(According to HUGE)
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   --

Specialized Databases showing LASS3

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for LASS3

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for LASS3

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LASS3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LASS3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for LASS3 Antibodies for LASS3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for LASS3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
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 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (LASS3)
 Antibodies (LASS3)
 Chimera RNAi (LASS3)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(LASS3)
 Antibodies (LASS3)
 Search OriGene for LASS3
 Search Tocris compounds for LASS3




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for LASS3

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