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LASS2 Gene

protein-coding GIFtS: 56

GC01M149204

LAG1 homolog, ceramide synthase 2
(Previous names: longevity assurance (LAG1, S. cerevisiae) homolog 2, LAG1 longevity assurance homolog 2 (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CerS2 ^¹, ²
FLJ10243 ^¹, ²
L3 ^¹, ²
MGC987 ^²
OTTHUMP00000033028 ^²
SP260 ^¹, ², ³
TMSG1 ^², ³

Descriptions
LAG1 homolog, ceramide synthase 2 ^²
LAG1 longevity assurance 2 ^²
LAG1 longevity assurance homolog 2 (S. cerevisiae) ^¹
Tumor metastasis-suppressor gene 1 protein ^³
ceramide synthase 2 ^²
longevity assurance (LAG1, S. cerevisiae) homolog 2 ^¹, ²
tumor metastasis-suppressor ^²

External Ids
HGNC: 14076¹
Entrez Gene: 29956²
UniProtKB: Q96G23³
Ensembl: ENSG00000143418⁷

Search outside databases for aliases for LASS2 gene

Previous GC identifers: GC01M148779 GC01M146684 GC01M147708 GC01M148154 GC01M147750

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LASS2:

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1.

Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan.

The human protein may play a role in the regulation of cell growth. Alternatively spliced

transcript variants encoding the same protein have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: LASS2_HUMAN, Q96G23

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Wiki entry for LASS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LASS2 gene

Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1p36.13-q24.1

LASS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M149204: (about GC identifiers)

Start:	149,204,273 bp from pter
End:	149,214,064 bp from pter
Size:	9,792 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LASS2_HUMAN, Q96G23 (See protein sequence)

Recommended Name: LAG1 longevity assurance homolog 2

Size: 380 amino acids; 44876 Da

Subunit: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1

Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic

reticulum membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: Q9HD96 Q9NW79

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_071358.1 NP_859530.1

ENSEMBL proteins:

ENSP00000357945 ENSP00000271688 ENSP00000357950 ENSP00000355020 ENSP00000337842

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LASS2)
	Human Recombinant Proteins from Abnova (LASS2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for LASS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LASS2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LASS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LASS2)
	Novus Biologicals Antibodies for LASS2

Assays for LASS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96G23

ProtoNet protein and cluster: Q96G23

2 Blocks protein families:

IPB005547 Longevity-assurance protein (LAG1)

IPB006634 TRAM

UniProtKB/Swiss-Prot: LASS2_HUMAN, Q96G23

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LASS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LASS2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022075

Applied Biosystems Silencer® siRNAs for LASS2

Sigma-Aldrich siRNA for LASS2

Sigma-Aldrich shRNA for LASS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LASS2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_022075
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_022075
untagged cDNA clones in CMV expression vector (see all 5): NM_013384

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022075

UniProtKB/Swiss-Prot: LASS2_HUMAN, Q96G23

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	11543633 17353931
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for LASS2 (Your Favorite Gene powered by Ingenuity)

Sphingolipid Metabolism

GeneDecks LASS2 for the pathways selected above

About GeneDecksing

5/6 Interacting proteins for LASS2 (ENSP00000357945³ Q96G23¹) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASGR1	P07306¹	STRING (score=.844) EBI-1057080, EBI-1172335
ASGR2	P07307¹	STRING (score=.851) EBI-1057080, EBI-1172636
ATP6V0C	P27449¹	STRING (score=.879) EBI-1057080, EBI-721179
SLC22A1	O15245¹	STRING (score=.828) EBI-1057080, EBI-1172714
NDN	Q99608¹	EBI-1057080, EBI-718177

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008610	lipid biosynthetic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LASS2
1 Novoseek chemical compound relationship for LASS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
maleimide	80.78	2	15796876 (1), 15672611 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LASS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LASS2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022075

Sigma-Aldrich siRNA for LASS2

Sigma-Aldrich shRNA for LASS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022075 NM_181746

REFSEQ mRNAs for LASS2 gene (2 alternative transcripts):

NM_022075.3 NM_181746.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022075 NM_181746

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_022075
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_022075
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_013384

Additional cDNA sequence:

AF177338.2 AF189062.4 AK001105.1 AK290989.1 AY091458.1 BC001357.2 BC010032.2

23 DOTS entries:

DT.95266941 DT.91758853 DT.100835331 DT.97860965 DT.100835330 DT.95125678 DT.121452948 DT.121453027

DT.95266953 DT.121453035 DT.121452946 DT.91758855 DT.100708569 DT.100835334 DT.100835339 DT.121452942

DT.121453018 DT.95257627 DT.100792734 DT.100792739 DT.313478 DT.95093003 DT.97859023

24/480 AceView cDNA sequences (see all 480 ):

BM744561 BQ233443 CA449459 W39754 BI757217 BI028067 W76578 BM907435

AL711029 AL554049 CB156094 BE272613 AL537627 AU120413 BE162717 BX360205

CA392778 CD106460 BU164844 BM472770 BM451302 CD675166 AA345236 BQ673270

highest scoring ESTs for LASS2:

AF177338 AK001105 AL046139 AL554049 AL562208 AL711029 AU120413 AW674778 AW675095 AY091458

Unigene Cluster for LASS2:

LAG1 homolog, ceramide synthase 2

Hs.713103 [show with all ESTs]

Unigene Representative Sequence: NM_181746

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LASS2 (see all 12 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·
SP1:							-		-		-		-		-																		-						-						-
SP2:							-		-		-		-		-		-																-						-						-
SP3:													-		-																		-						-						-
SP4:							-		-		-		-																				-						-
SP5:											-		-		-																		-

ExUns:	12b	^	13a	·	13b	·	13c	^	14	^	15
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LASS2

5 Ensembl transcripts including schematic representations:

ENST00000368949 ENST00000271688 ENST00000368954 ENST00000361419 ENST00000345896

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LASS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LASS2

¹ / ² / ³

3 probe-sets matching LASS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56446_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AL046139	0.80	1.00	0.91	1
222212_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK001105	0.80	1.00	0.91	1
222212_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAATAAGTG

SOURCE GeneReport for Unigene cluster: Hs.713103
UniProtKB/Swiss-Prot: LASS2_HUMAN, Q96G23
Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LASS2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LASS2¹	--	LAG1 homolog, ceramide synthase 2	92.54(n) 97.63(a)	483187 XM_540305.2 XP_540305.1
chimpanzee (Pan troglodytes)	LASS2¹	--	LAG1 homolog, ceramide synthase 2	99.82(n) 100(a)	469482 XM_524865.2 XP_524865.2
cow (Bos taurus)	LASS2¹	--	LAG1 homolog, ceramide synthase 2	93.33(n) 96.05(a)	539223 NM_001034667.1 NP_001029839.1
rat (Rattus norvegicus)	Lass2¹	--	LAG1 homolog, ceramide synthase 2	87.67(n) 89.6(a)	310667 NM_001033700.1 NP_001028872.1
mouse (Mus musculus)	Lass2^{1, 5}	3⁵	LAG1 homolog, ceramide synthase 2^{1, 5}	90.88(n)¹ 92.37(a)¹	76893¹ NM_029789.1¹ NP_084065.1¹ AI225939⁵ AK002626⁵ (see all 16)

About this table Species with no ortholog for LASS2

ENSEMBL Gene Tree for LASS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LASS2 gene

LASS3² LASS4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/70 NCBI SNPs in LASS2 are shown (see all 70 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8444^1,2	A,C,F,H,O	149205195(-)	`TACCCC/TGCTCC`	2	--	ut3¹ ese³		9		MN NA EU EA WA	932
	rs267738^1,2	C,F,H	149207249(-)	`GGTAGA/CGCGTT`	2	E/A	mis¹		12		EU EA WA	1258
	rs7550809^1,2	C,F,H	149205005(+)	`TTGGCG/AGGTAG`	2	--	ut3¹ ese³		5		MN EU EA WA	592
--	rs8544^1,2	A,C,F	149204395(-)	`tttttT/Aaaaat`	2	--	ut3¹		4		MN NA	314
	rs267739^1,2	C,F,H	149205240(-)	`CATTAT/CTCCAG`	2	--	ut3¹ ese³		11		NA EU EA WA	974
	rs9436017^1,2	H	149204442(+)	`CCTCTG/ACTGAA`	2	--	ut3¹ ese³		4		EU EA WA	420
	rs3768010^1,2	H	149204974(-)	`TGAGGC/GCCTCC`	2	--	ut3¹ ese³		5		EA EU WA	1730
--	rs267735^1,2	A	149215120(-)	`tttttA/Taattt`	2	--	ng3¹		0	--	--	--	--
	rs9435954^1,2	F,H	149205942(+)	`CCCGCG/ATAGTT`	2	Y/Y	syn¹ ese³		4		EU EA WA	420
	rs752376^1,2	A,C,F,H	149208005(+)	`GTAGGC/TTGGCA`	2	--	int¹		4		EU EA WA	412

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HapMap Linkage Disequilibrium images for LASS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606920

3 Novoseek disease relationships for LASS2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	27.76	10	18759044 (3), 15672611 (3), 15796876 (1)
cancer	12.84	5	15672611 (2), 15796876 (1)
tumors	5.82	14	15796876 (3), 18759044 (3), 15672611 (3)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/19 PubMed articles for LASS2 gene (see all 19 ):

Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)^{1, 2, 3, 4} Pan H....Gu J.-R. (2001)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. (PubMed id 18165233)³ Laviad E.L....Futerman A.H. (2008)
Phosphoproteome of resting human platelets. (PubMed id 18088087)⁴ Zahedi R.P.... Sickmann A. (2008)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 29956	HGNC: 14076	AceView: LASS2	Ensembl:ENSG00000143418	euGenes: HUgn29956
ECgene: LASS2	H-InvDB: LASS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for LASS2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LASS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LASS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LASS2		Antibodies for LASS2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LASS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LASS2)
	Antibodies (LASS2)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for LASS2

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Antibodies for LASS2

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LASS2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for LASS2

Summaries
for LASS2

Genomic Location
for LASS2

Proteins
for LASS2

Protein Domains/
Families
for LASS2

Gene Function
for LASS2

Pathways & Interactions
for LASS2

Drugs & Compounds
for LASS2

Transcripts
for LASS2

Expression
for LASS2

Orthologs
for LASS2

Paralogs
for LASS2

SNPs/Variants
for LASS2

Disorders & Mutations
for LASS2

Medical News
for LASS2

Publications
for LASS2

Search for LASS2

Genome Databases showing LASS2

Other Databases showing LASS2

Specialized Databases showing LASS2

Licensable Technologies
for LASS2

Services
for LASS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LASS2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor LASS2

Summariesfor LASS2

Genomic Locationfor LASS2

Proteinsfor LASS2

Protein Domains/Familiesfor LASS2

Gene Functionfor LASS2

Pathways & Interactionsfor LASS2

Drugs & Compoundsfor LASS2

Transcriptsfor LASS2

Expression for LASS2

Orthologsfor LASS2

Paralogsfor LASS2

SNPs/Variantsfor LASS2

Disorders & Mutationsfor LASS2

Medical Newsfor LASS2

Publicationsfor LASS2

Search for LASS2

Genome Databases showing LASS2

Other Databases showing LASS2

Specialized Databases showing LASS2

Licensable Technologiesfor LASS2

Servicesfor LASS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LASS2

Summaries
for LASS2

Genomic Location
for LASS2

Proteins
for LASS2

Protein Domains/
Families
for LASS2

Gene Function
for LASS2

Pathways & Interactions
for LASS2

Drugs & Compounds
for LASS2

Transcripts
for LASS2

Expression
for LASS2

Orthologs
for LASS2

Paralogs
for LASS2

SNPs/Variants
for LASS2

Disorders & Mutations
for LASS2

Medical News
for LASS2

Publications
for LASS2

Licensable Technologies
for LASS2

Services
for LASS2