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LASS1 Gene

protein-coding   GIFtS: 49

GC19M018845
LAG1 homolog, ceramide synthase 1
(Previous names: longevity assurance (LAG1, S. cerevisiae) homolog 1, LAG1 longevity assurance homolog 1 (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for LASS1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CerS1 1, 2
LAG1 1, 2, 3
MGC90349 2
UOG1 1, 2, 3, 5
Descriptions
LAG1 homolog, ceramide synthase 1 2
LAG1 longevity assurance homolog 1 2
LAG1 longevity assurance homolog 1 (S. cerevisiae) 1
Longevity assurance gene 1 protein homolog 1 3
Protein UOG-1 3
longevity assurance (LAG1, S. cerevisiae) homolog 1 1, 2
longevity assurance gene 1 2
upstream of GDF1 2
External Ids
HGNC: 142531
Entrez Gene: 107152
UniProtKB: P275443
Search outside databases for aliases for LASS1 gene

Previous GC identifers: GC19M019473 GC19M019372 GC19M018825 GC19M018840

Summaries
for LASS1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for LASS1:
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta
superfamily. This group of proteins is characterized by a polybasic proteolytic processing site
that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members
of this family are regulators of cell growth and differentiation in both embryonic and adult
tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is
transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth
differentiation factor 1. [provided by RefSeq]

UniProtKB/Swiss-Prot: LASS1_HUMAN, P27544
Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When
overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty
acid donnor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By
similarity)

Gene Wiki entry for LASS1

Genomic Location
for LASS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LASS1 gene  

Entrez Gene cytogenetic band: 19p12   HGNC cytogenetic band: 19p12

LASS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018845:     (about GC identifiers)

Start:
 18,842,117 bp from pter
End:
 18,867,953 bp from pter
Size:
 25,837 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011295.10  

Proteins
for LASS1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LASS1_HUMAN, P27544 (See protein sequence)
Recommended Name: LAG1 longevity assurance homolog 1  
Size: 350 amino acids; 39536 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Subcellular location: Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein (By
similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Isoform 1
may recycle from the Golgi to the endoplasmic reticulum
Miscellaneous: This protein is produced by a bicistronic gene which also produces the GDF1 protein
from a non-overlapping reading frame
Alternative splicing: 2 isoforms:  P27544-1   P27544-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_067090.1  NP_937850.1  

    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LASS1)
    Human Recombinant Proteins from Abnova (LASS1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139 Golgi membrane IEA--
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005792 microsome ISS--
    GO:0005794 Golgi apparatus IEA--
    About this table

    Antibodies for LASS1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LASS1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LASS1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LASS1)
    Novus Biologicals Antibodies for LASS1

    Assays for LASS1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for LASS1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR006634 TLC


       GeneDecks  LASS1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P27544

    ProtoNet protein and cluster: P27544

    2 Blocks protein families:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: LASS1_HUMAN, P27544
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

    Gene Function
    for LASS1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LASS1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021267

                  Applied Biosystems Silencer® siRNAs for LASS1

                  Sigma-Aldrich siRNA for LASS1  
                         Sigma-Aldrich shRNA for LASS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LASS1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_021267
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_021267
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_021267 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021267

    UniProtKB/Swiss-Prot: LASS1_HUMAN, P27544
    Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When
    overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty
    acid donnor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By
    similarity)

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    GO:0050291 sphingosine N-acyltransferase activity ISS--
    About this table

    Pathways & Interactions
    for LASS1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  LASS1  (Your Favorite Gene powered by Ingenuity) 
     Sphingolipid Metabolism

       GeneDecks  LASS1 for the pathways selected above  
    About GeneDecksing

      --

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008610 lipid biosynthetic process IEA--
    GO:0046513 ceramide biosynthetic process ISS--
    About this table

    Drugs & Compounds
    for LASS1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for LASS1 available from Tocris Bioscience
    CompoundAction CAS number
    Fumonisin B1Inhibitor of sphingosine N-acyltransferase[116355-83-0]
    About this table


    2 Novoseek chemical compound relationships for LASS1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydroceramide 93.23 5 12912983 (1), 16951403 (1), 17308067 (1)
    ceramide 77.56 11 12105227 (3), 12869556 (1), 16765836 (1), 16303764 (1) (see all 5)
    About this table


    Transcripts
    for LASS1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LASS1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021267

                  Sigma-Aldrich siRNA for LASS1  
                         Sigma-Aldrich shRNA for LASS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021267  NM_198207  

    REFSEQ mRNAs for LASS1 gene (2 alternative transcripts): 

    NM_021267.3   NM_198207.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021267  NM_198207  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_021267
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_021267
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_021267 

    Additional cDNA sequence: 

    AB209169.1 AK293463.1 BC022450.1 BC032615.1 BC084582.1 CR594445.1 CR614536.1 CR623677.1 
    M62302.1 

    7 DOTS entries:

    DT.405921  DT.97842228  DT.108612  DT.100774492  DT.75101756  DT.97828722  DT.95211314 

    24/96 AceView cDNA sequences (see all 96 ):

    NM_198207 BM727671 CR623677 CR594445 AI671814 AI936592 BX339170 BG060020 
    AL134361 BQ876590 NM_021267 CF541171 AI017572 AI671986 BM503409 BQ636104 
    AA457570 BM503247 CR614536 BM129680 AA912332 BF516540 M62302 BC022450 

    highest scoring ESTs for LASS1:

    AW003099 M62302 BC084582 BQ876590 BX419800 BX422837 BX444664 BX461198 CR594445 CR623677 

    Unigene Cluster for LASS1:

    LAG1 homolog, ceramide synthase 1
    Hs.412355  [show with all ESTs]
    Unigene Representative Sequence: NM_001492


    GeneLoc Exon Structure

    Expression
    for LASS1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LASS1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LASS1

    1 / 2 / 3

    7 probe-sets matching LASS1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    50096_at2, 3 U95-B 1 1.00 1.00 0.99 0.69 AW002982 0.60 0.62 0.61 1
    888_s_at2, 3 U95-A 2 1.00 0.50 0.91 1.07 M62302 0.80 0.47 0.65 1
    887_at2, 3 U95-A 2 1.00 0.50 0.97 1.33 M62302 0.80 0.47 0.65 1

    		229448_at2, 3 U133-B 2 1.00 0.95 -- -- BF305369 0.40 0.38 0.39 1

    		206397_x_at2, 3 U133-A 2 1.00 0.50 -- -- NM_001492 0.40 0.50 0.45 1

    		229448_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --

    		206397_x_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    GeneDecks  LASS1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.412355

    Orthologs
    for LASS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for LASS1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LASS11   -- LAG1 homolog, ceramide synthase 1 77.29(n)
    78.99(a)    		 609789  XM_847126.1  XP_852219.1 
    chimpanzee
    (Pan troglodytes)    		 LASS11   -- LAG1 homolog, ceramide synthase 1 97.97(n)
    96.51(a)    		 468773  XM_524160.2  XP_524160.2 
    cow
    (Bos taurus)    		 LASS11   -- LAG1 homolog, ceramide synthase 1 89.15(n)
    91.57(a)    		 615296  XM_866827.2  XP_871920.1 
    rat
    (Rattus norvegicus)    		 Gdf11   -- growth differentiation factor 1 80(n)
    80.57(a)    		 306351  XM_224733.4  XP_224733.4 
    mouse
    (Mus musculus)    		 Lass11, 5 85
    		 LAG1 homolog, ceramide synthase 11, 5 79.81(n)1
    80.86(a)1    		 938981  NM_138647.11  NP_619588.11 
     AC0737805  AK0538855  (see all 7)
    About this table        Species with no ortholog for LASS1

    Paralogs
    for LASS1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for LASS1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for LASS1

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 606919

    Medical News
    for LASS1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for LASS1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/16 PubMed articles for LASS1 gene (see all 16 ):

    Search for LASS1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LASS1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 10715 HGNC: 14253 AceView: GDF1 euGenes: HUgn10715 ECgene: LASS1
    H-InvDB: LASS1

    Other Databases showing LASS1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing LASS1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for LASS1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for LASS1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LASS1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LASS1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LASS1 Antibodies for LASS1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LASS1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (LASS1)
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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (LASS1)
     Antibodies (LASS1)
     Search OriGene for LASS1
     Tocris compounds for LASS1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LASS1

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