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Aliases for LASP1 Gene

Aliases for LASP1 Gene

  • LIM And SH3 Protein 1 2 3 5
  • Metastatic Lymph Node Gene 50 Protein 3 4
  • Lasp-1 3 4
  • MLN50 3 4
  • LIM And SH3 Domain Protein 1 3
  • MLN 50 4

External Ids for LASP1 Gene

Previous GeneCards Identifiers for LASP1 Gene

  • GC17P036529
  • GC17P039024
  • GC17P036936
  • GC17P037401
  • GC17P034280
  • GC17P037026
  • GC17P032821

Summaries for LASP1 Gene

Entrez Gene Summary for LASP1 Gene

  • This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

GeneCards Summary for LASP1 Gene

LASP1 (LIM And SH3 Protein 1) is a Protein Coding gene. Diseases associated with LASP1 include Breast Cancer and Colorectal Cancer. Among its related pathways are Aquaporin-mediated transport and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include actin filament binding and ion transmembrane transporter activity. An important paralog of this gene is NEBL.

UniProtKB/Swiss-Prot for LASP1 Gene

  • Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Gene Wiki entry for LASP1 Gene

Additional gene information for LASP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LASP1 Gene

Genomics for LASP1 Gene

GeneHancer (GH) Regulatory Elements for LASP1 Gene

Promoters and enhancers for LASP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I038867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.3 +1.8 1844 9.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 LASP1 MED1 CDK12 SNORA21 LOC105371762 RPL23 CWC25 PSMB3 SNORA21B C17orf98
GH17I038895 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.1 +29.6 29558 7.7 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF766 FOS JUNB SNORA21 MED1 LASP1 RPS20P35 SNORA21B RPL23 LOC105371762 CWC25 LINC00672 ENSG00000266588
GH17I038889 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.3 +22.4 22438 5 HDAC1 ZFP64 ZSCAN4 RAD21 TCF12 GATA2 EGR1 SCRT2 EGR2 RXRA LASP1 RPL23 RPS20P35 SNORA21 SNORA21B CWC25 PIP4K2B PSMB3 GC17M038893
GH17I038876 Enhancer 1.4 Ensembl ENCODE dbSUPER 10 +12.3 12290 11.1 SMAD1 ARNT ZFP64 ARID4B FEZF1 GLI4 YY1 ETS1 GLIS2 RUNX3 SNORA21 MED1 RPL23 RPS20P35 SNORA21B C17orf98 CWC25 PSMB3 LASP1 PCGF2
GH17I038850 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 5.6 -16.4 -16361 5.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A SNORA21 RPL23 RPS20P35 GC17M038850 GC17M038858 GC17M038862 GC17M038872 GC17M038875 GC17P038858 PIR38457
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LASP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LASP1 gene promoter:

Genomic Locations for LASP1 Gene

Genomic Locations for LASP1 Gene
chr17:38,869,859-38,921,770
(GRCh38/hg38)
Size:
51,912 bases
Orientation:
Plus strand
chr17:37,026,112-37,078,023
(GRCh37/hg19)

Genomic View for LASP1 Gene

Genes around LASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LASP1 Gene

Proteins for LASP1 Gene

  • Protein details for LASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14847-LASP1_HUMAN
    Recommended name:
    LIM and SH3 domain protein 1
    Protein Accession:
    Q14847
    Secondary Accessions:
    • B4DGQ0
    • Q96ED2
    • Q96IG0

    Protein attributes for LASP1 Gene

    Size:
    261 amino acids
    Molecular mass:
    29717 Da
    Quaternary structure:
    • Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10.

    Three dimensional structures from OCA and Proteopedia for LASP1 Gene

    Alternative splice isoforms for LASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LASP1 Gene

Post-translational modifications for LASP1 Gene

No data available for DME Specific Peptides for LASP1 Gene

Domains & Families for LASP1 Gene

Gene Families for LASP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LASP1: view

No data available for UniProtKB/Swiss-Prot for LASP1 Gene

Function for LASP1 Gene

Molecular function for LASP1 Gene

GENATLAS Biochemistry:
LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Phenotypes From GWAS Catalog for LASP1 Gene

Gene Ontology (GO) - Molecular Function for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 7589475
GO:0005515 protein binding IPI 16189514
GO:0015075 ion transmembrane transporter activity ISS --
GO:0045296 cadherin binding IDA 25468996
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LASP1: view
genes like me logo Genes that share phenotypes with LASP1: view

Animal Models for LASP1 Gene

MGI Knock Outs for LASP1:

miRNA for LASP1 Gene

miRTarBase miRNAs that target LASP1

Clone Products

  • Addgene plasmids for LASP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LASP1 Gene

Localization for LASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LASP1 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F-actin rich cortical cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LASP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 4
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25468996
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IDA,HDA 21423176
GO:0005938 cell cortex IEA --
GO:0030864 cortical actin cytoskeleton ISS --
genes like me logo Genes that share ontologies with LASP1: view

Pathways & Interactions for LASP1 Gene

genes like me logo Genes that share pathways with LASP1: view

Pathways by source for LASP1 Gene

1 Cell Signaling Technology pathway for LASP1 Gene
1 GeneGo (Thomson Reuters) pathway for LASP1 Gene

SIGNOR curated interactions for LASP1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport ISS --
GO:0009967 positive regulation of signal transduction IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with LASP1: view

Drugs & Compounds for LASP1 Gene

No Compound Related Data Available

Transcripts for LASP1 Gene

Unigene Clusters for LASP1 Gene

LIM and SH3 protein 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for LASP1

Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - - - - - - - -
SP8:

Relevant External Links for LASP1 Gene

GeneLoc Exon Structure for
LASP1
ECgene alternative splicing isoforms for
LASP1

Expression for LASP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LASP1 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for LASP1 Gene

This gene is overexpressed in Bone marrow stromal cell (9.3) and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LASP1 Gene



Protein tissue co-expression partners for LASP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LASP1 Gene:

LASP1

SOURCE GeneReport for Unigene cluster for LASP1 Gene:

Hs.741156

Evidence on tissue expression from TISSUES for LASP1 Gene

  • Nervous system(5)
  • Skin(4.7)
  • Liver(4.6)
  • Blood(4.4)
  • Intestine(4)
  • Lung(3.8)
  • Pancreas(3.4)
  • Kidney(3.1)
  • Stomach(2.9)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with LASP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LASP1 Gene

Orthologs for LASP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LASP1 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia LASP1 33 34
  • 93.36 (n)
cow
(Bos Taurus)
Mammalia LASP1 33 34
  • 92.95 (n)
oppossum
(Monodelphis domestica)
Mammalia LASP1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lasp1 33 16 34
  • 91.06 (n)
rat
(Rattus norvegicus)
Mammalia Lasp1 33
  • 90.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LASP1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LASP1 33 34
  • 83.46 (n)
lizard
(Anolis carolinensis)
Reptilia LASP1 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lasp1 33
  • 76.65 (n)
zebrafish
(Danio rerio)
Actinopterygii lasp1 33 34
  • 71.65 (n)
Dr.3684 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006526 33
  • 58.79 (n)
worm
(Caenorhabditis elegans)
Secernentea F42H10.3 33 34
  • 55.98 (n)
F42H10.4 35
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
Species where no ortholog for LASP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LASP1 Gene

ENSEMBL:
Gene Tree for LASP1 (if available)
TreeFam:
Gene Tree for LASP1 (if available)

Paralogs for LASP1 Gene

Paralogs for LASP1 Gene

(10) SIMAP similar genes for LASP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LASP1: view

Variants for LASP1 Gene

Sequence variations from dbSNP and Humsavar for LASP1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000017435 -- 38,873,935(+) C/A intron_variant
rs1000063619 -- 38,919,844(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000069829 -- 38,873,756(+) C/T intron_variant
rs1000093742 -- 38,892,205(+) G/A/T intron_variant
rs1000126412 -- 38,892,483(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LASP1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv2045 CNV insertion 18451855
nsv833439 CNV loss 17160897
nsv960484 CNV duplication 23825009

Variation tolerance for LASP1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LASP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LASP1 Gene

Disorders for LASP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LASP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search LASP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LASP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LASP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LASP1 Gene

Publications for LASP1 Gene

  1. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PMID: 7490069) Tomasetto C … Rio MC (Genomics 1995) 2 3 4 58
  2. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PMID: 7589475) Tomasetto C … Rio MC (FEBS letters 1995) 3 4 22 58
  3. An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. (PMID: 25622104) Orth MF … Grunewald TG (Oncotarget 2015) 2 3 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. (PMID: 20461080) Frietsch JJ … Butt E (British journal of cancer 2010) 3 22 58

Products for LASP1 Gene

Sources for LASP1 Gene

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