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LASP1 Gene

protein-coding   GIFtS: 61
GCID: GC17P037026

LIM And SH3 Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM And SH3 Protein 11 2     LIM And SH3 Domain Protein 12
MLN502 3 5     LASP-13
Metastatic Lymph Node Gene 50 Protein2 3     MLN 503
Lasp-12     

External Ids:    HGNC: 65131   Entrez Gene: 39272   Ensembl: ENSG000000028347   OMIM: 6029205   UniProtKB: Q148473   

Export aliases for LASP1 gene to outside databases

Previous GC identifers: GC17P036529 GC17P039024 GC17P036936 GC17P037401 GC17P034280 GC17P032821


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LASP1 Gene:
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src
homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a
cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane.
The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas,
and colorectal cancer. (provided by RefSeq, Oct 2012)

GeneCards Summary for LASP1 Gene:
LASP1 (LIM and SH3 protein 1) is a protein-coding gene. Diseases associated with LASP1 include b-cell lymphomas, and colorectal cancer. GO annotations related to this gene include actin filament binding and ion transmembrane transporter activity. An important paralog of this gene is NRAP.

UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847
Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities.
Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport
activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types
(By similarity)

Gene Wiki entry for LASP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LASP1 gene promoter:
         AREB6   CREB   RFX1   MAZR   deltaCREB   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLASP1 promoter sequence
   Search Chromatin IP Primers for LASP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LASP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q21.3   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11-q21.3

LASP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LASP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037026:  view genomic region     (about GC identifiers)

Start:
37,026,112 bp from pter      End:
37,078,023 bp from pter
Size:
51,912 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847 (See protein sequence)
Recommended Name: LIM and SH3 domain protein 1  
Size: 261 amino acids; 29717 Da
Subunit: Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10
1 PDB 3D structure from and Proteopedia for LASP1:
3I35 (3D)    
Secondary accessions: Q96ED2 Q96IG0
Alternative splicing: 2 isoforms:  Q14847-1   Q14847-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LASP1: NX_Q14847

Explore proteomics data for LASP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys75, Lys96, Lys121
  • Modification sites at PhosphoSitePlus

  • See LASP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258537.1  NP_006139.1  

    ENSEMBL proteins: 
     ENSP00000325240   ENSP00000468664   ENSP00000414803   ENSP00000391897   ENSP00000462564  
     ENSP00000392853   ENSP00000401048  

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    LASP1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000900 Nebulin_repeat
     IPR001781 Znf_LIM
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q14847

    ProtoNet protein and cluster: Q14847

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847
    Similarity: Contains 1 LIM zinc-binding domain
    Similarity: Contains 2 nebulin repeats
    Similarity: Contains 1 SH3 domain


    LASP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LASP1_HUMAN, Q14847
    Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities.
    Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport
    activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types
    (By similarity)

         Genatlas biochemistry entry for LASP1:
    LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph
    nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS7589475
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0015075ion transmembrane transporter activity ISS--
    GO:0051015actin filament binding IEA--
         
    LASP1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lasp1):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body  reproductive system 
     skeleton 

    LASP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lasp1tm1Chew for LASP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LASP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LASP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LASP1

    miRNA
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    miRTarBase miRNAs that target LASP1:
    hsa-mir-218-5p (MIRT003708), hsa-mir-505-5p (MIRT037933), hsa-mir-1 (MIRT002808), hsa-mir-193b-3p (MIRT016319), hsa-mir-23b-3p (MIRT046268), hsa-mir-133a-3p (MIRT005813)

    Block miRNA regulation of human, mouse, rat LASP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LASP1 (see all 73):
    hsa-miR-640 hsa-miR-1321 hsa-miR-4254 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-4267 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidLASP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LASP1
    Predesigned siRNA for gene silencing in human, mouse, rat LASP1

    Gene Editing
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    OriGene clones in human, mouse for LASP1 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: LASP1 (NM_006148)
    Sino Biological Human cDNA Clone for LASP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LASP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LASP1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LASP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LASP1_HUMAN, Q14847: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity).
    Note=Associated with the F-actin rich cortical cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005925focal adhesion IEA--
    GO:0030864cortical actin cytoskeleton ISS--

    LASP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LASP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    2Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for LASP1
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for LASP1
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation




    LASP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LASP1
    Interactions:

        GeneGlobe Interaction Network for LASP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for LASP1 (Q148471, 2, 3 ENSP000003252404) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZYXQ159421, 3, ENSP000003244224EBI-742828,EBI-444225 I2D: score=3 STRING: ENSP00000324422
    TRIP13Q156451, 2, 3, ENSP000001663454EBI-742828,EBI-358993 MINT-66300 I2D: score=6 STRING: ENSP00000166345
    MDFIQ997501, 2, 3, ENSP000002303214EBI-742828,EBI-724076 MINT-67947 I2D: score=5 STRING: ENSP00000230321
    FHL3Q136432, 3, ENSP000003621074MINT-67591 I2D: score=5 STRING: ENSP00000362107
    PLSCR1O151622, 3, ENSP000003454944MINT-66313 I2D: score=5 STRING: ENSP00000345494
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ISS--
    GO:0009967positive regulation of signal transduction TAS7589475
    GO:0034220ion transmembrane transport ----

    LASP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LASP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LASP1 gene (2 alternative transcripts): 
    NM_001271608.1  NM_006148.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318008(uc002hra.3 uc010cvq.3 uc010wdz.2) ENST00000585841
    ENST00000584106(uc010wdy.1) ENST00000443937 ENST00000419929 ENST00000581485
    ENST00000579123 ENST00000435347 ENST00000433206
    miRNA
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    Block miRNA regulation of human, mouse, rat LASP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LASP1 (see all 73):
    hsa-miR-640 hsa-miR-1321 hsa-miR-4254 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-4267 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidLASP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LASP1
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    Primer
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    OriGene qPCR primer pairs and template standards for LASP1
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      QuantiTect SYBR Green Assays in human, mouse, rat LASP1
      QuantiFast Probe-based Assays in human, mouse, rat LASP1

    Selected AceView cDNA sequences (see all 984):

    AA829908 BF924683 BM795312 AI865332 BT007076 AW510845 BQ016512 AI423322 
    BM746502 AW439319 BF870291 AI275233 AW074350 CB159518 AW009642 BU541964 
    AW276519 AW672702 AA458833 BM824053 AY070271 AA506059 AU117156 BM766443 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                    -           -           -                                                                     
    SP2:                                -           -                                                                     
    SP3:                    -           -     -     -                                                                     
    SP4:                                -           -           -     -     -                                             
    SP5:                                            -                                                                     


    ECgene alternative splicing isoforms for LASP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LASP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTTTGGG
    LASP1 Expression
    About this image


    LASP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Lung (Respiratory System)
    LASP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LASP1 Protein Expression
        Custom PCR Arrays for LASP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LASP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LASP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lasp11 , 5 LIM and SH3 protein 11, 5 91.06(n)1
    96.17(a)1
      11 (61.10 cM)5
    167961  NM_010688.41  NP_034818.11 
     977990005 
    chicken
    (Gallus gallus)
    Aves LASP11 LIM and SH3 protein 1 83.46(n)
    86.43(a)
      420002  NM_001177329.1  NP_001170800.1 
    lizard
    (Anolis carolinensis)
    Reptilia LASP16
    LIM and SH3 protein 1
    87(a)
    1 ↔ 1
    6(80647701-80702643)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044681.12   -- 81.97(n)    BC044681.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.36842 Danio rerio cDNA clone IMAGE3816398, partial cds 83.13(n)    BC054945.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0065261 AgaP_AGAP006526 58.79(n)
    55.28(a)
      5667268  XM_001688840.1  XP_001688892.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F42H10.43
    F42H10.31
    F42H10.31 52(a)3
    55.98(n)1
    56.52(a)1
      III(8555233-8557506)3
    1856851  NM_066473.41  NP_498874.21 


    ENSEMBL Gene Tree for LASP1 (if available)
    TreeFam Gene Tree for LASP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LASP1 gene
    NRAP2  NEB2  NEBL2  
    10 SIMAP similar genes for LASP1 using alignment to 6 protein entries:     LASP1_HUMAN (see all proteins):
    ARHGEF7    SH3GL2    CRIP1    NEBL    SH3GL1    CRIP2
    LIMD2    ABLIM1    LHx4    LHX8

    LASP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LASP1 (see all 1131)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563197291,2
    C,F--37024141(+) TTAGGT/AGGATC 3 -- us2k12Minor allele frequency- A:0.04WA NA 238
    rs1905772831,2
    --37024147(+) GGATCG/TGAGCC 3 -- us2k10--------
    rs9796071,2
    C,F,O,H--37024319(+) AAAACT/CAGGAG 3 -- us2k133Minor allele frequency- C:0.39EA NA NS WA CSA 2891
    rs1496683711,2
    --37024324(+) TAGGAA/GAAGTA 3 -- us2k10--------
    rs1444228791,2
    --37024398(+) GTAGAC/GAGCGA 3 -- us2k10--------
    rs116555411,2
    C,H--37024410(+) CAATTG/TTCCCC 3 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs1830917071,2
    --37024548(+) TCTGTA/GATCTC 3 -- us2k10--------
    rs732971271,2
    C--37024702(+) CCTTTC/ATCCTT 3 -- us2k12Minor allele frequency- A:0.07WA 120
    rs37601521,2
    C,F--37024840(+) TTTAGG/ATTATG 3 -- us2k11Minor allele frequency- A:0.10EA 120
    rs1877787551,2
    --37024982(+) CAGTGG/TTTTAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for LASP1 (37026112 - 37078023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LASP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2045CNV Insertion18451855
    nsv908199CNV Loss21882294
    nsv833439CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602920    OMIM disorders: --

    15 diseases for LASP1:    
    About MalaCards
    b-cell lymphomas    colorectal cancer    breast cancer    medulloblastoma
    esophageal squamous cell carcinoma    hepatitis b    hepatocellular carcinoma    tonsillitis
    ovarian cancer    esophagitis    schizophrenia    hepatitis
    squamous cell carcinoma    malaria    cerebritis


    LASP1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for LASP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 38.6 13 20461080 (4), 16430883 (2), 12883659 (1), 17211471 (1) (see all 6)

    Genetic Association Database (GAD): LASP1
    Human Genome Epidemiology (HuGE) Navigator: LASP1 (2 documents)

    Export disorders for LASP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LASP1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with LASP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2, 3 Tomasetto C.L.... Rio M.-C. (Genomics 1995)
    2. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PubMed id 7589475)1, 2, 9 Tomasetto C....Rio M.-C. (FEBS Lett. 1995)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. High density SNP association study of a major autism linkage region on chromosome 17. (PubMed id 17376794)1, 4 Stone J.L....Nelson S.F. (Hum. Mol. Genet. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. (PubMed id 20419088)1, 9 Raman D....Richmond A. (PLoS ONE 2010)
    8. Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. (PubMed id 15465019)1, 9 Keicher C....Butt E. (Biochem. Biophys. Res. Commun. 2004)
    9. Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. (PubMed id 20461080)1, 9 Frietsch J.J....Butt E. (Br. J. Cancer 2010)
    10. Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. (PubMed id 17211471)1, 9 Grunewald T.G....Butt E. (Br. J. Cancer 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3927 HGNC: 6513 AceView: LASP1andPPP1R1B Ensembl:ENSG00000002834 euGenes: HUgn3927
    ECgene: LASP1 H-InvDB: LASP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LASP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LASP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LASP1 gene:
    Search GeneIP for patents involving LASP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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