LASP1 Gene
protein-coding GIFtS: 61
GCID: GC17P037026
|
|
LIM and SH3 protein 1
| |
Aliases
for LASP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LIM And SH3 Protein 11 2 | | LIM And SH3 Domain Protein 12 | | MLN501 2 3 5 | | LASP-13 | | Lasp-11 2 | | MLN 503 | | Metastatic Lymph Node Gene 50 Protein2 3 | | |
Export aliases for LASP1 gene to outside databasesPrevious GC identifers: GC17P036529 GC17P039024 GC17P036936 GC17P037401 GC17P034280 GC17P032821 |
Summaries
for LASP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LASP1:
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homologyregion 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMPdependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encodedprotein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectalcancer. (provided by RefSeq, Oct 2012)
UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependentchanges in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in theparietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)
Gene Wiki entry for LASP1
|
Genomic Views
for LASP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LASP1 gene promoter:
AREB6 CREB RFX1 MAZR deltaCREB STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for LASP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LASP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11-q21.3 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11-q21.3LASP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P037026: view genomic region
(about GC identifiers)
Start:
|
37,026,112 bp from pter |
End:
|
37,078,023 bp from pter |
Size:
|
51,912 bases |
Orientation:
|
plus strand |
|
Proteins
for LASP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847 (See
protein sequence)Recommended Name: LIM and SH3 domain protein 1 Size: 261 amino acids; 29717 Da
Subunit: Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10
Subcellular location: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associatedwith the F-actin rich cortical cytoskeleton (By similarity)
1 PDB 3D structure from  and Proteopedia  for LASP1:3I35 (3D)
Secondary accessions: Q96ED2 Q96IG0Alternative splicing: 2 isoforms: Q14847-1 Q14847-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LASP1: NX_Q14847
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14847
LASP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258537.1 NP_006139.1
ENSEMBL proteins: ENSP00000325240 ENSP00000468664 ENSP00000414803 ENSP00000391897 ENSP00000462564 ENSP00000392853 ENSP00000401048
Human Recombinant Protein Products for LASP1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
LASP1 for ontologies About GeneDecksing
LASP1 Antibody Products:
Assay Products for LASP1: |
Protein
Domains /
Families
for LASP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LASP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14847ProtoNet protein and cluster: Q14847 2 Blocks protein families: IPB001452 SH3 domain signature IPB001781 Zn-binding protein
UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847Similarity: Contains 1 LIM zinc-binding domainSimilarity: Contains 2 nebulin repeatsSimilarity: Contains 1 SH3 domain |
Function
for LASP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LASP1_HUMAN, Q14847Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependentchanges in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in theparietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity) Genatlas biochemistry entry for LASP1:LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymphnodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
LASP1 for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lasp1):
LASP1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Lasp1tm1Chew for LASP1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LASP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LASP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LASP1 (NM_006148) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LASP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LASP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LASP1 |
|
Pathways & Interactions
for LASP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Water Balance by Renal Aquaporins | | | 2 | Cytoskeletal Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for LASP1
1 
Cell Signaling Technology (CST) Pathway for LASP1
1  GeneGo (Thomson Reuters) Pathway for LASP1
LASP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LASP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/27 Interacting proteins for LASP1 (Q148471, 2, 3 ENSP000003252404) via UniProtKB, MINT, STRING, and/or I2D (see all 27)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TRIP13 | Q156451, 2, 3, ENSP000001663454 | EBI-742828,EBI-358993 MINT-66300 I2D:
score=6 STRING: ENSP00000166345 | | MDFI | Q997501, 2, 3, ENSP000002303214 | EBI-742828,EBI-724076 MINT-67947 I2D:
score=5 STRING: ENSP00000230321 | | FHL3 | Q136432, 3, ENSP000003621074 | MINT-67591 I2D:
score=5 STRING: ENSP00000362107 | | PLSCR1 | O151622, 3, ENSP000003454944 | MINT-66313 I2D:
score=5 STRING: ENSP00000345494 | | ZYX | Q159423, ENSP000003244224 | I2D:
score=3 STRING: ENSP00000324422 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
ISS | -- | | GO:0034220 | ion transmembrane transport |
-- | -- |
LASP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for LASP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LASP1
Search CenterWatch for drugs/clinical trials and news about LASP1
|
Transcripts
for LASP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LASP1 gene (2 alternative transcripts): NM_001271608.1 NM_006148.3 Unigene Cluster for LASP1: LIM and SH3 protein 1 Hs.741156 [show with all ESTs]Unigene Representative Sequence: NR_0733849 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000318008(uc002hra.3 uc010cvq.3 uc010wdz.2) ENST00000585841
ENST00000584106(uc010wdy.1) ENST00000443937 ENST00000419929 ENST00000581485
ENST00000579123 ENST00000435347 ENST00000433206
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LASP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LASP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LASP1 (NM_006148) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LASP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LASP1 |
Additional cDNA sequence: AK095958.1 AK289847.1 AK294704.1 AK295522.1 AK296092.1 AK307868.1 AK309933.1 AY358253.1 BC007367.2 BC007560.1 BC012460.1 NR_073384.1 X82456.1 24/39 DOTS entries (see all 39): DT.219536 DT.98083914 DT.100061169 DT.92071080 DT.100675532 DT.97818959 DT.120896350 DT.92407416 DT.95377448 DT.100059716 DT.100649842 DT.120896359 DT.100675538 DT.100764548 DT.91895016 DT.75119038 DT.120896203 DT.120896352 DT.100644005 DT.100675529 DT.100675534 DT.100675535 DT.100675542 DT.100893925 24/984 AceView cDNA sequences (see all 984): BG338462 AF233349 BM795565 CK819273 BM839764 AI275233 BQ928310 BM833806 AA834479 AW069179 BU174365 CD245068 BE395506 BQ891748 CB125284 AI804985 AL532968 T33826 AA626863 AA595258 AW850113 H27598 CA397492 AA716725
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LASP1
|
Expression
for LASP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LASP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTTTTGGG
About this image
See LASP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LASP1
SOURCE GeneReport for Unigene cluster: Hs.741156
SABiosciences Custom PCR Arrays for LASP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LASP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LASP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LASP1 |
Orthologs
for LASP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LASP1 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LASP11 |
LIM and SH3 protein 1 |
84.5(n)
87.98(a) |
|
420002 NM_001177329.1 NP_001170800.1 |
lizard
(Anolis carolinensis) |
Reptilia |
LASP16 |
-- |
86(a) |
1 ↔ 1 |
6(80647715-80698751) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC044681.12 |
-- |
81.97(n) |
|
BC044681.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.36842 |
Danio rerio cDNA clone IMAGE3816398, partial cds |
83.13(n) |
|
BC054945.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Lasp1 |
CG3849-PA |
53.8(n)
48.91(a) |
|
39864 NM_168681.3 NP_730192.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F42H10.43
F42H10.31 |
Protein F42H10.31 |
52(a)3
48.06(n)1
43.02(a)1 |
|
III(8555233-8557506)3
1856851 NM_066473.31 NP_498874.21 |
ENSEMBL Gene Tree for LASP1 (if available)
TreeFam Gene Tree for LASP1 (if available) |
Paralogs
for LASP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LASP1 gene
- NRAP2 NEB2 NEBL2
9 SIMAP similar genes for LASP1 using alignment to 6 protein entries: LASP1_HUMAN (see all proteins):ARHGEF7 SH3GL2 CRIP1 NEBL SH3GL1 CRIP2
LIMD2 LHx4 LHX8
LASP1 for paralogs About GeneDecksing
|
Genomic Variants
for LASP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LASP1 (37026112 - 37078023 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LASP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LASP1 |
|
Disorders
/ Diseases
for LASP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LASP1 for disorders About GeneDecksing
OMIM gene information: 602920
OMIM disorders: --
8  diseases for LASP1: About MalaCardsfemale breast cancer breast cancer medulloblastoma hepatocellular carcinoma
ovarian cancer breast carcinoma colorectal cancer carcinoma
1 Novoseek disease relationship for LASP1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: LASP1 (2 documents)
Export disorders for LASP1 gene to outside databases
|
Publications
for LASP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LASP1 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with LASP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2, 3 Tomasetto C.L.... Rio M.-C. (1995)
- Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PubMed id 7589475)1, 2, 9 Tomasetto C....Rio M.-C. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- LIM and SH3 protein-1 modulates CXCR2-mediated cell m igration. (PubMed id 20419088)1, 9 Raman D....Richmond A. (2010)
- Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. (PubMed id 15465019)1, 9 Keicher C....Butt E. (2004)
- Nuclear localisation of LASP-1 correlates with poor l ong-term survival in female breast cancer. (PubMed id 20461080)1, 9 Frietsch J.J....Butt E. (2010)
- Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. (PubMed id 17211471)1, 9 Grunewald T.G....Butt E. (2007)
- Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. (PubMed id 16430883)1, 9 Grunewald T.G....Butt E. (2006)
- Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. (PubMed id 15004028)1, 9 Li B.... Trueb B. (2004)
|
External Searches for LASP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LASP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LASP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LASP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LASP1 gene:
Search GeneIP for patents involving LASP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LASP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for LASP1 | | OriGene shRNA RFP for LASP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LASP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LASP1 | | | OriGene Protein Over-expression Lysate for LASP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LASP1 | | OriGene 3'-UTR Clone for LASP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LASP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LASP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LASP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LASP1 | | OriGene Custom Protein Services for LASP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LASP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LASP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LASP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LASP1 |
| |
 |  |  |  | |
| | Antibodies & Assays for LASP1 (Lasp-1) |
| | | | Search Tocris compounds for LASP1 |
| |  |  |  |  | | | | | | Recombinant Protein for LASP1 |
|
 |
 |
 |
 | | | LASP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LASP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for LASP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LASP1 |
| |  | |
|
|
|
