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Aliases for LASP1 Gene

Aliases for LASP1 Gene

  • LIM And SH3 Protein 1 2 3 5
  • Metastatic Lymph Node Gene 50 Protein 3 4
  • Lasp-1 3 4
  • MLN50 3 4
  • MLN 50 4

External Ids for LASP1 Gene

Previous GeneCards Identifiers for LASP1 Gene

  • GC17P036529
  • GC17P039024
  • GC17P036936
  • GC17P037401
  • GC17P034280
  • GC17P037026
  • GC17P032821

Summaries for LASP1 Gene

Entrez Gene Summary for LASP1 Gene

  • This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

GeneCards Summary for LASP1 Gene

LASP1 (LIM And SH3 Protein 1) is a Protein Coding gene. Diseases associated with LASP1 include Breast Cancer. Among its related pathways are Aquaporin-mediated transport and Cytoskeletal Signaling. GO annotations related to this gene include actin filament binding and ion transmembrane transporter activity. An important paralog of this gene is NEBL.

UniProtKB/Swiss-Prot for LASP1 Gene

  • Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Gene Wiki entry for LASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LASP1 Gene

Genomics for LASP1 Gene

Regulatory Elements for LASP1 Gene

Enhancers for LASP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LASP1 on UCSC Golden Path with GeneCards custom track

Promoters for LASP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LASP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LASP1 Gene

Chromosome:
17
Start:
38,869,859 bp from pter
End:
38,921,770 bp from pter
Size:
51,912 bases
Orientation:
Plus strand

Genomic View for LASP1 Gene

Genes around LASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LASP1 Gene

Proteins for LASP1 Gene

  • Protein details for LASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14847-LASP1_HUMAN
    Recommended name:
    LIM and SH3 domain protein 1
    Protein Accession:
    Q14847
    Secondary Accessions:
    • B4DGQ0
    • Q96ED2
    • Q96IG0

    Protein attributes for LASP1 Gene

    Size:
    261 amino acids
    Molecular mass:
    29717 Da
    Quaternary structure:
    • Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10.

    Three dimensional structures from OCA and Proteopedia for LASP1 Gene

    Alternative splice isoforms for LASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LASP1 Gene

Proteomics data for LASP1 Gene at MOPED

Post-translational modifications for LASP1 Gene

  • Ubiquitination at Lys 23
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LASP1 (Lasp-1)

No data available for DME Specific Peptides for LASP1 Gene

Domains & Families for LASP1 Gene

Gene Families for LASP1 Gene

Protein Domains for LASP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14847

UniProtKB/Swiss-Prot:

LASP1_HUMAN :
  • Contains 1 LIM zinc-binding domain.
  • Contains 2 nebulin repeats.
Domain:
  • Contains 1 LIM zinc-binding domain.
  • Contains 1 SH3 domain.
Similarity:
  • Contains 2 nebulin repeats.
genes like me logo Genes that share domains with LASP1: view

Function for LASP1 Gene

Molecular function for LASP1 Gene

GENATLAS Biochemistry:
LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Gene Ontology (GO) - Molecular Function for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16189514
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with LASP1: view
genes like me logo Genes that share phenotypes with LASP1: view

Animal Models for LASP1 Gene

MGI Knock Outs for LASP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LASP1 Gene

Localization for LASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LASP1 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F-actin rich cortical cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LASP1 Gene COMPARTMENTS Subcellular localization image for LASP1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LASP1: view

Pathways & Interactions for LASP1 Gene

genes like me logo Genes that share pathways with LASP1: view

Pathways by source for LASP1 Gene

1 Cell Signaling Technology pathway for LASP1 Gene
1 GeneGo (Thomson Reuters) pathway for LASP1 Gene

SIGNOR curated interactions for LASP1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LASP1 Gene

None

Drugs & Compounds for LASP1 Gene

No Compound Related Data Available

Transcripts for LASP1 Gene

Unigene Clusters for LASP1 Gene

LIM and SH3 protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - - - - - - - -
SP8:

Relevant External Links for LASP1 Gene

GeneLoc Exon Structure for
LASP1
ECgene alternative splicing isoforms for
LASP1

Expression for LASP1 Gene

mRNA expression in normal human tissues for LASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LASP1 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for LASP1 Gene

This gene is overexpressed in Bone marrow stromal cell (9.3) and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LASP1 Gene



SOURCE GeneReport for Unigene cluster for LASP1 Gene Hs.741156

genes like me logo Genes that share expression patterns with LASP1: view

Protein tissue co-expression partners for LASP1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LASP1 Gene

Orthologs for LASP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LASP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LASP1 35
  • 92.95 (n)
  • 96.15 (a)
LASP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LASP1 35
  • 93.36 (n)
  • 97.32 (a)
LASP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lasp1 35
  • 91.06 (n)
  • 96.17 (a)
Lasp1 16
Lasp1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LASP1 35
  • 99.49 (n)
  • 100 (a)
LASP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lasp1 35
  • 90.8 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia LASP1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LASP1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LASP1 35
  • 83.46 (n)
  • 86.43 (a)
LASP1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LASP1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lasp1 35
  • 76.65 (n)
  • 81.71 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.3684 35
lasp1 35
  • 71.65 (n)
  • 74.36 (a)
lasp1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006526 35
  • 58.79 (n)
  • 55.28 (a)
worm
(Caenorhabditis elegans)
Secernentea F42H10.4 37
  • 52 (a)
F42H10.3 35
  • 55.98 (n)
  • 56.52 (a)
F42H10.3 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for LASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LASP1 Gene

ENSEMBL:
Gene Tree for LASP1 (if available)
TreeFam:
Gene Tree for LASP1 (if available)

Paralogs for LASP1 Gene

Paralogs for LASP1 Gene

(10) SIMAP similar genes for LASP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LASP1: view

Variants for LASP1 Gene

Sequence variations from dbSNP and Humsavar for LASP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs28684 -- 38,873,760(-) ACCCT(C/G)GCCGG intron-variant
rs82974 -- 38,908,689(-) CTGGG(A/G)GGAGT intron-variant
rs82976 -- 38,908,420(-) AGTGA(C/T)CCCTG intron-variant
rs82977 -- 38,908,095(+) CCATC(A/G)CTAAT intron-variant
rs112901 -- 38,892,000(-) gtgat(A/C)ctccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LASP1 Gene

Variant ID Type Subtype PubMed ID
nsv833439 CNV Loss 17160897
nsv908199 CNV Loss 21882294
nsv2045 CNV Insertion 18451855

Variation tolerance for LASP1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LASP1 Gene

Disorders for LASP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LASP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search LASP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LASP1

Genetic Association Database (GAD)
LASP1
Human Genome Epidemiology (HuGE) Navigator
LASP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LASP1
genes like me logo Genes that share disorders with LASP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LASP1 Gene

Publications for LASP1 Gene

  1. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PMID: 7490069) Tomasetto C.L. … Rio M.-C. (Genomics 1995) 2 3 4 67
  2. An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. (PMID: 25622104) Orth M.F. … Grunewald T.G. (Oncotarget 2015) 2 3
  3. LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. (PMID: 20419088) Raman D. … Richmond A. (PLoS ONE 2010) 3 23
  4. Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. (PMID: 20461080) Frietsch J.J. … Butt E. (Br. J. Cancer 2010) 3 23
  5. Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. (PMID: 17211471) Grunewald T.G. … Butt E. (Br. J. Cancer 2007) 3 23

Products for LASP1 Gene

Sources for LASP1 Gene

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