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Aliases for LASP1 Gene

Aliases for LASP1 Gene

  • LIM And SH3 Protein 1 2 3
  • MLN50 3 4 6
  • Metastatic Lymph Node Gene 50 Protein 3 4
  • Lasp-1 3 4
  • LIM And SH3 Domain Protein 1 3
  • MLN 50 4

External Ids for LASP1 Gene

Previous GeneCards Identifiers for LASP1 Gene

  • GC17P036529
  • GC17P039024
  • GC17P036936
  • GC17P037401
  • GC17P034280
  • GC17P037026
  • GC17P032821

Summaries for LASP1 Gene

Entrez Gene Summary for LASP1 Gene

  • This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

GeneCards Summary for LASP1 Gene

LASP1 (LIM And SH3 Protein 1) is a Protein Coding gene. Diseases associated with LASP1 include b-cell lymphomas and colorectal cancer. Among its related pathways are Cytoskeletal Signaling and Regulation of Water Balance by Renal Aquaporins. GO annotations related to this gene include actin filament binding and ion transmembrane transporter activity. An important paralog of this gene is NEBL.

UniProtKB/Swiss-Prot for LASP1 Gene

  • Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Gene Wiki entry for LASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LASP1 Gene

Genomics for LASP1 Gene

Regulatory Elements for LASP1 Gene

Genomic Location for LASP1 Gene

Start:
38,869,859 bp from pter
End:
38,921,770 bp from pter
Size:
51,912 bases
Orientation:
Plus strand

Genomic View for LASP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LASP1 Gene

Proteins for LASP1 Gene

  • Protein details for LASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14847-LASP1_HUMAN
    Recommended name:
    LIM and SH3 domain protein 1
    Protein Accession:
    Q14847
    Secondary Accessions:
    • B4DGQ0
    • Q96ED2
    • Q96IG0

    Protein attributes for LASP1 Gene

    Size:
    261 amino acids
    Molecular mass:
    29717 Da
    Quaternary structure:
    • Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10.

    Three dimensional structures from OCA and Proteopedia for LASP1 Gene

    Alternative splice isoforms for LASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LASP1 Gene

Proteomics data for LASP1 Gene at MOPED

Post-translational modifications for LASP1 Gene

  • Ubiquitination at Lys23, Lys75, Lys96, and Lys121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LASP1 Gene

Domains for LASP1 Gene

Protein Domains for LASP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14847

UniProtKB/Swiss-Prot:

LASP1_HUMAN :
  • Q14847
Domain:
  • Contains 1 LIM zinc-binding domain.
  • Contains 1 SH3 domain.
Similarity:
  • Contains 2 nebulin repeats.
genes like me logo Genes that share domains with LASP1: view

No data available for Gene Families for LASP1 Gene

Function for LASP1 Gene

Molecular function for LASP1 Gene

GENATLAS Biochemistry: LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Gene Ontology (GO) - Molecular Function for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 7589475
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0015075 ion transmembrane transporter activity ISS --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with LASP1: view
genes like me logo Genes that share phenotypes with LASP1: view

Animal Models for LASP1 Gene

MGI Knock Outs for LASP1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LASP1 Gene

Localization for LASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LASP1 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F-actin rich cortical cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LASP1 Gene COMPARTMENTS Subcellular localization image for LASP1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005925 focal adhesion IDA 21423176
GO:0030864 cortical actin cytoskeleton ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LASP1: view

Pathways for LASP1 Gene

genes like me logo Genes that share pathways with LASP1: view

Pathways by source for LASP1 Gene

1 Cell Signaling Technology pathway for LASP1 Gene
1 GeneGo (Thomson Reuters) pathway for LASP1 Gene

Gene Ontology (GO) - Biological Process for LASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport ISS --
GO:0009967 positive regulation of signal transduction TAS 7589475
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with LASP1: view

Transcripts for LASP1 Gene

Unigene Clusters for LASP1 Gene

LIM and SH3 protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - - - - - - - -
SP8:

Relevant External Links for LASP1 Gene

GeneLoc Exon Structure for
LASP1
ECgene alternative splicing isoforms for
LASP1

Expression for LASP1 Gene

mRNA expression in normal human tissues for LASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LASP1 Gene

This gene is overexpressed in Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LASP1 Gene

SOURCE GeneReport for Unigene cluster for LASP1 Gene Hs.741156

genes like me logo Genes that share expressions with LASP1: view

No data available for mRNA Expression by UniProt/SwissProt for LASP1 Gene

Orthologs for LASP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LASP1 35
  • 99.49 (n)
  • 100 (a)
LASP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LASP1 35
  • 92.95 (n)
  • 96.15 (a)
LASP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LASP1 35
  • 93.36 (n)
  • 97.32 (a)
LASP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lasp1 35
  • 91.06 (n)
  • 96.17 (a)
Lasp1 16
Lasp1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LASP1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LASP1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lasp1 35
  • 90.8 (n)
  • 96.93 (a)
chicken
(Gallus gallus)
Aves LASP1 35
  • 83.46 (n)
  • 86.43 (a)
LASP1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LASP1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lasp1 35
  • 76.65 (n)
  • 81.71 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.3684 35
lasp1 35
  • 71.65 (n)
  • 74.36 (a)
lasp1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006526 35
  • 58.79 (n)
  • 55.28 (a)
worm
(Caenorhabditis elegans)
Secernentea F42H10.3 35
  • 55.98 (n)
  • 56.52 (a)
F42H10.3 36
  • 37 (a)
OneToMany
F42H10.4 37
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for LASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LASP1 Gene

ENSEMBL:
Gene Tree for LASP1 (if available)
TreeFam:
Gene Tree for LASP1 (if available)

Paralogs for LASP1 Gene

Paralogs for LASP1 Gene

Selected SIMAP similar genes for LASP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LASP1: view

Variants for LASP1 Gene

Sequence variations from dbSNP and Humsavar for LASP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs28684 -- 38,873,760(-) ACCCT(C/G)GCCGG intron-variant
rs82974 -- 38,908,689(-) CTGGG(A/G)GGAGT intron-variant
rs82976 -- 38,908,420(-) AGTGA(C/T)CCCTG intron-variant
rs82977 -- 38,908,095(+) CCATC(A/G)CTAAT intron-variant
rs112901 -- 38,892,000(-) gtgat(A/C)ctccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LASP1 Gene

Variant ID Type Subtype PubMed ID
nsv833439 CNV Loss 17160897
nsv908199 CNV Loss 21882294
nsv2045 CNV Insertion 18451855

Relevant External Links for LASP1 Gene

HapMap Linkage Disequilibrium report
LASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LASP1 Gene

Disorders for LASP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for LASP1 Gene including...

Search for LASP1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for LASP1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 38.6 10

Relevant External Links for LASP1

Genetic Association Database (GAD)
LASP1
Human Genome Epidemiology (HuGE) Navigator
LASP1
genes like me logo Genes that share disorders with LASP1: view

No data available for UniProtKB/Swiss-Prot for LASP1 Gene

Publications for LASP1 Gene

  1. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PMID: 7589475) Tomasetto C. … Rio M.-C. (FEBS Lett. 1995) 3 4 23
  2. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PMID: 7490069) Tomasetto C.L. … Rio M.-C. (Genomics 1995) 2 3 4
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LASP1 Gene

Sources for LASP1 Gene

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