Aliases for LASP1 Gene
External Ids for LASP1 Gene
Previous GeneCards Identifiers for LASP1 Gene
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
GeneCards Summary for LASP1 Gene
LASP1 (LIM And SH3 Protein 1) is a Protein Coding gene. Diseases associated with LASP1 include b-cell lymphomas and colorectal cancer. Among its related pathways are Cytoskeletal Signaling and Regulation of Water Balance by Renal Aquaporins. GO annotations related to this gene include actin filament binding and ion transmembrane transporter activity. An important paralog of this gene is NEBL.
UniProtKB/Swiss-Prot for LASP1 Gene
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).