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Aliases & Descriptions for LASP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LASP-1 3 | | Lasp-1 1, 2 | | MLN50 1, 2, 3, 5 |
| | | Descriptions |
|---|
| LIM and SH3 protein 1 2 | | MLN 50 3 |
|
| | Search outside databases for aliases for LASP1 genePrevious GC identifers: GC17P036529 GC17P039024 GC17P036936 GC17P037401 |
Summaries for LASP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LASP1: This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization. [provided by RefSeq] UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)Gene Wiki entry for LASP1 |
Genomic Location for LASP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LASP1 gene 
Entrez Gene cytogenetic band: 17q11-q21.3 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11-q21.3LASP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P034280:
(about GC identifiers)
Start:
|
34,279,894 bp from pter |
End:
|
34,331,541 bp from pter |
Size:
|
51,648 bases |
Orientation:
|
plus strand |
| Proteins for LASP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847 (See
protein sequence)Recommended Name: LIM and SH3 domain protein 1 Size: 261 amino acids; 29717 Da
Subunit: Interacts with F-actin (By similarity)
Subcellular location: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the F-actin rich cortical cytoskeleton (By similarity)
Secondary accessions: Q96ED2 Q96IG0Alternative splicing: 2 isoforms: Q14847-1 Q14847-2 Post-translational modifications:
Phosphorylated (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006139.1
ENSEMBL proteins: ENSP00000325240
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: LASP1 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LASP1: Assays for LASP1: | Protein
Domains/ Families for LASP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14847
ProtoNet protein and cluster: Q14847 2 Blocks protein families: IPB001452 SH3 domain signature IPB001781 Zn-binding protein
UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847Similarity: Contains 1 LIM zinc-binding domainSimilarity: Contains 2 nebulin repeatsSimilarity: Contains 1 SH3 domain | Gene Function for LASP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006148
Applied Biosystems Silencer® siRNAs for LASP1
Sigma-Aldrich siRNA for LASP1  Sigma-Aldrich shRNA Panels and shRNA for LASP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006148                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006148                                  untagged cDNA clone in CMV expression vector: NM_006148 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006148
UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)Genatlas biochemistry entry for LASP1:LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lasp1):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for LASP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for LASP1 
4 Interacting proteins for LASP1 (Q148472) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
ISS | -- | | GO:0030865 | cortical cytoskeleton organization |
IEA | -- | About this table
|
Drugs & Compounds for LASP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LASP1
|
Transcripts for LASP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006148
Sigma-Aldrich siRNA for LASP1  Sigma-Aldrich shRNA Panels and shRNA for LASP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006148 REFSEQ mRNAs for LASP1 gene: NM_006148.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006148               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006148                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006148                                  untagged cDNA clone in CMV expression vector: NM_006148  24/984 AceView cDNA sequences (see all 984
):BM694929 CB125284 AI869239 BQ023027 AA834479 AI769037 BM830011 AI291491 CB120048 BP362580 BM783295 T61881 BM766838 BM746502 AI568122 AA043214 CR621995 AI435882 BM849660 BM786583 AW860349 BM795228 BM996225 AI754080
highest scoring ESTs for LASP1:X82456 AA022732 AA022824 AA035778 AA043214 AA043215 AA056356 AA074317 AA102155 AA121101
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 (see all 8
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LASP1
1 Ensembl transcript including schematic representation: ENST00000318008
|
Expression for LASP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LASP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LASP1
1 / 2 / 3 3 probe-sets matching LASP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CACTTTTGGG
Expression variation in blood from EXPOLDB for LASP1 |
Orthologs for LASP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LASP1 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for LASP1
ENSEMBL Gene Tree for LASP1 | Paralogs for LASP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LASP1 gene
- NRAP2 NEB2 NEBL2
|
SNPs/Variants for LASP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LASP1 (up to first 250kb)
|
Disorders & Mutations for LASP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602920
1 Novoseek disease relationship for LASP1 gene
About this table
1 PharmGKB disease relationship for LASP1 geneAbout this table
Human Genome Epidemiology Navigator: LASP1 (1 document)
|
Medical News for LASP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LASP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for LASP1 gene (see all 26
):- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)2, 3, 4 Tomasetto C....Rio M.C. (1995)
- Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PubMed id 7589475)1, 3, 4 Tomasetto C....Rio M.-C. (1995)
- Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)3, 4 Tao W.A.... Aebersold R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)3, 4 Gevaert K.... Vandekerckhove J. (2003)
- Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. (PubMed id 15465019)1, 3 Keicher C....Butt E. (2004)
- Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. (PubMed id 16430883)1, 3 Grunewald T.G....Butt E. (2006)
- Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. (PubMed id 15004028)1, 3 Li B.... Trueb B. (2004)
- Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. (PubMed id 9848085)1, 3 Schreiber V....Rio M.C. (1998)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)4 Zahedi R.P.... Sickmann A. (2008)
|
Search for LASP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LASP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LASP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LASP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LASP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LASP1:

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Incremental update: 13 Oct 2009
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