Aliases for LAS1L Gene
External Ids for LAS1L Gene
Previous GeneCards Identifiers for LAS1L Gene
GeneCards Summary for LAS1L Gene
LAS1L (LAS1 Like, Ribosome Biogenesis Factor) is a Protein Coding gene. Diseases associated with LAS1L include Wilson-Turner Syndrome and Spinal Muscular Atrophy With Respiratory Distress Type 2. Among its related pathways are rRNA processing and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.
UniProtKB/Swiss-Prot for LAS1L Gene
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.