Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LAS1L Gene

protein-coding   GIFtS: 51
GCID: GC0XM064649

LAS1-Like (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
LAS1-Like (S. Cerevisiae)1 2
Protein LAS1 Homolog2 3
Las1-like2
dJ475B7.22
Ribosomal Biogenesis Protein LAS1L2

External Ids:    HGNC: 257261   Entrez Gene: 818872   Ensembl: ENSG000000014977   UniProtKB: Q9Y4W23   

Export aliases for LAS1L gene to outside databases

Previous GC identifers: GC0XM064516 GC0XM058560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for LAS1L Gene:
LAS1L (LAS1-like (S. cerevisiae)) is a protein-coding gene. Diseases associated with LAS1L include brain cancer, and breast and colorectal cancer.

UniProtKB/Swiss-Prot: LAS1L_HUMAN, Q9Y4W2
Function: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA.
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to
ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target
genes

Gene Wiki entry for LAS1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAS1L gene promoter:
         TBP   HOXA9   HOXA9B   AML1a   Pax-5   Evi-1   Meis-1b   FAC1   c-Myb   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAS1L promoter sequence
   Search Chromatin IP Primers for LAS1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAS1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq12   Ensembl cytogenetic band:  Xq12   HGNC cytogenetic band: Xq12

LAS1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAS1L gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM064649:  view genomic region     (about GC identifiers)

Start:
64,732,462 bp from pter      End:
64,754,686 bp from pter
Size:
22,225 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LAS1L_HUMAN, Q9Y4W2 (See protein sequence)
Recommended Name: Ribosomal biogenesis protein LAS1L  
Size: 734 amino acids; 83065 Da
Subunit: Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L,
HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4,
TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and
SENP3; the complex interacts with methylated CHTOP and ZNF148
Sequence caution: Sequence=BAB84913.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A9X410 Q5JXQ0 Q8TEN5 Q9H9V5
Alternative splicing: 4 isoforms:  Q9Y4W2-1   Q9Y4W2-2   Q9Y4W2-3   Q9Y4W2-4   (Gene prediction based on EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LAS1L: NX_Q9Y4W2

Explore proteomics data for LAS1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys31, Lys64, Lys98, Lys139, Lys263, Lys286, Lys295, Lys312, Lys365, Lys376,
                                 Lys486, Lys499, Lys540, Lys691
  • Modification sites at PhosphoSitePlus

  • See LAS1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164120.1  NP_001164121.1  NP_112483.1  

    ENSEMBL proteins: 
     ENSP00000363940   ENSP00000363944   ENSP00000363937   ENSP00000473471   ENSP00000473630  
     ENSP00000308649  

    LAS1L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LAS1L
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LAS1L
    GenScript Custom Purified and Recombinant Proteins Services for LAS1L
    Novus Biologicals LAS1L Protein
    Novus Biologicals LAS1L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LAS1L

    LAS1L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LAS1L
    OriGene Custom Antibody Services for LAS1L
    Novus Biologicals LAS1L Antibodies
    Abcam antibodies for LAS1L
    Cloud-Clone Corp. Antibodies for LAS1L
    Search ThermoFisher Antibodies for LAS1L
    LSBio Antibodies in human, mouse, rat for LAS1L

    LAS1L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LAS1L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LAS1L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LAS1L
    Cloud-Clone Corp. CLIAs for LAS1L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007174 Las1

    Graphical View of Domain Structure for InterPro Entry Q9Y4W2

    ProtoNet protein and cluster: Q9Y4W2

    UniProtKB/Swiss-Prot: LAS1L_HUMAN, Q9Y4W2
    Similarity: Belongs to the LAS1 family


    LAS1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAS1L_HUMAN, Q9Y4W2
    Function: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA.
    Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to
    ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target
    genes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
         
    LAS1L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LAS1L:
     Decreased TP53 protein express  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAS1L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAS1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAS1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAS1L

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAS1L:
    hsa-mir-124-3p (MIRT022244), hsa-mir-17-5p (MIRT051007)

    Block miRNA regulation of human, mouse, rat LAS1L using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LAS1L:
    hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidLAS1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAS1L
    Predesigned siRNA for gene silencing in human, mouse, rat LAS1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LAS1L

    Clone
    Products:
         
    OriGene clones in human, mouse for LAS1L (see all 15)
    OriGene ORF clones in mouse, rat for LAS1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LAS1L (NM_031206)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAS1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAS1L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LAS1L
    Browse ESI BIO Cell Lines and PureStem Progenitors for LAS1L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAS1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LAS1L_HUMAN, Q9Y4W2: Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity).
    Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By
    similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA
    processing and subunit assembly and export
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IDA--
    GO:0071339MLL1 complex IDA15960975

    LAS1L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LAS1L
    Interactions:

        Search GeneGlobe Interaction Network for LAS1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAS1L (Q9Y4W21, 2, 3 ENSP000003639444) via UniProtKB, MINT, STRING, and/or I2D (see all 727)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PELP1Q8IZL82, 3, ENSP000003013964MINT-8150101 MINT-8151622 MINT-6488791 I2D: score=2 STRING: ENSP00000301396
    WDR18Q9BV382, ENSP000002512894MINT-7947479 MINT-8151622 MINT-6488791 STRING: ENSP00000251289
    UBCP0CG482, 3, ENSP000003448184MINT-6488791 I2D: score=1 STRING: ENSP00000344818
    PNKPQ96T601, 3, ENSP000003235114EBI-1051591,EBI-1045072 I2D: score=2 STRING: ENSP00000323511
    COPAP536212, ENSP000003570484MINT-7947479 MINT-6488791 STRING: ENSP00000357048
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    LAS1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAS1L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LAS1L gene (3 alternative transcripts): 
    NM_001170649.1  NM_001170650.1  NM_031206.4  

    Unigene Cluster for LAS1L:

    LAS1-like (S. cerevisiae)
    Hs.522675  [show with all ESTs]
    Unigene Representative Sequence: BC014545
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374807(uc004dvz.2) ENST00000374811(uc004dwa.2 uc004dwc.2 uc004dwd.2)
    ENST00000374804(uc004dvy.1) ENST00000484069 ENST00000469091 ENST00000312391

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LAS1L using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LAS1L:
    hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidLAS1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LAS1L
    Predesigned siRNA for gene silencing in human, mouse, rat LAS1L
    Clone
    Products:
         
    OriGene clones in human, mouse for LAS1L (see all 15)
    OriGene ORF clones in mouse, rat for LAS1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LAS1L (NM_031206)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAS1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAS1L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LAS1L
    OriGene qSTAR qPCR primer pairs in human, mouse for LAS1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAS1L
      QuantiTect SYBR Green Assays in human, mouse, rat LAS1L
      QuantiFast Probe-based Assays in human, mouse, rat LAS1L

    Additional mRNA sequence: 

    AF116730.1 AK022587.1 AK054817.1 AK097383.1 AK225059.1 AK295591.1 BC014545.1 BC018610.1 
    BC019302.1 DQ323624.1 

    Selected DOTS entries (see all 29):

    DT.91683998  DT.86855154  DT.314513  DT.100789754  DT.121295646  DT.95287927  DT.95319722  DT.40251891 
    DT.100696063  DT.97815386  DT.121295618  DT.121295641  DT.206759  DT.87015359  DT.99951817  DT.121295656 
    DT.40129698  DT.121295654  DT.121295670  DT.91921710  DT.100789752  DT.101984626  DT.121295655  DT.121295660 

    Selected AceView cDNA sequences (see all 404):

    CB164815 BX096385 BE276406 AL041746 BE391411 BQ021338 AA279770 BU186410 
    BE502155 BM768239 BC019302 BP365669 AI829588 BQ057378 BM787780 BQ005113 
    AW946071 AU280508 CF265033 AU124456 BM797687 AK074087 BM129839 BU188685 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LAS1L (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ·
    SP1:                                                                                            -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for LAS1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LAS1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCAAAAC
    LAS1L Expression
    About this image

    LAS1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAS1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522675
        Custom PCR Arrays for LAS1L
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LAS1L
    OriGene qSTAR qPCR primer pairs in human, mouse for LAS1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAS1L
    QuantiTect SYBR Green Assays in human, mouse, rat LAS1L
    QuantiFast Probe-based Assays in human, mouse, rat LAS1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAS1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LAS1L gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Las1l1 , 5 LAS1-like (S. cerevisiae)1, 5 78.94(n)1
    73.33(a)1
      X (42.58 cM)5
    761301  NM_152822.21  NP_690035.21 
     959353355 
    chicken
    (Gallus gallus)
    Aves LAS1L1 LAS1-like (S. cerevisiae) 54.08(n)
    42.07(a)
      422174  XM_001231273.2  XP_001231274.2 
    lizard
    (Anolis carolinensis)
    Reptilia LAS1L6
    LAS1-like (S. cerevisiae)
    42(a)
    1 ↔ 1
    GL343376.1(732803-753281)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.289682 Xenopus laevis transcribed sequence with weak similarity more 71.29(n)    CA971479.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5613211 novel protein similar to vertebrate LAS1-like (S. cerevisiae) more 51.73(n)
    41.8(a)
      561321  NM_001126400.1  NP_001119872.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y6B3B.96
    Protein Y6B3B.9, isoform a
    21(a)
    1 ↔ 1
    I(13734670-13751124) WBGene00012393


    ENSEMBL Gene Tree for LAS1L (if available)
    TreeFam Gene Tree for LAS1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LAS1L (see all 314)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365874
    A colorectal cancer sample4--see VAR_0365872 R C mis40--------
    rs1409192591,2
    --64732211(+) TGTAGC/TCAGCA 3 -- int10--------
    rs1851005561,2
    --64732321(+) GGTTAC/TAGGAG 3 -- int10--------
    rs1891789181,2
    --64732436(+) CCCACC/GCTCTT 3 -- int10--------
    rs31921871,2
    C--64732526(-) CCACCA/CCAGGG 3 -- ut312Minor allele frequency- C:0.02MN NA 186
    rs1997320161,2
    --64732664(+) AAGAGC/GTGCAG 6 H Q mis10--------
    rs1400561701,2
    F--64732712(+) AGAAGG/CCCCTC 6 /G syn11Minor allele frequency- C:0.00NA 2606
    rs59649821,2
    C,H--64732944(+) CCCCAG/AGGTTG 3 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1818555091,2
    --64733046(+) TTAAAA/GCAGAG 3 -- int10--------
    rs1501869161,2
    C--64733477(+) GTTAAC/TTGAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for LAS1L (64732462 - 64754686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LAS1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): LAS1L

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAS1L
    DNA2.0 Custom Variant and Variant Library Synthesis for LAS1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    5 diseases for LAS1L:    About MalaCards
    brain cancer    breast and colorectal cancer    pancreatic cancer    pancreatitis
    colorectal cancer


    LAS1L for disorders           About GeneDecksing


    Export disorders for LAS1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LAS1L gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with LAS1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. (PubMed id 20647540)1, 2 Castle C.D.... Denicourt C. (Mol. Cell. Biol. 2010)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 81887 HGNC: 25726 AceView: FLJ12525 Ensembl:ENSG00000001497 euGenes: HUgn81887
    ECgene: LAS1L H-InvDB: LAS1L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LAS1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LAS1L gene:
    Search GeneIP for patents involving LAS1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LAS1L   OriGene RNAi products in human, mouse, rat for LAS1L  
     OriGene qPCR primer pairs and template standards for LAS1L   OriGene Protein Over-expression Lysate for LAS1L  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LAS1L  
     OriGene qSTAR qPCR primer pairs in human, mouse for LAS1L   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LAS1L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LAS1L   OriGene Custom Protein Services for LAS1L  

     
     
     Block miRNA regulation of human, mouse, rat LAS1L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LAS1L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAS1L Predesigned siRNA for gene silencing in human, mouse, rat LAS1L
     QuantiFast Probe-based Assays in human, mouse, rat LAS1L QuantiTect SYBR Green Assays in human, mouse, rat LAS1L
     Custom PCR Arrays for LAS1L Search Chromatin IP Primers for LAS1L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAS1L  Search GeneGlobe Interaction Network for LAS1L
     Regulatory tfbs in LAS1L promoter
     GenScript Custom Purified and Recombinant Proteins Services for LAS1L GenScript cDNA clones with any tag delivered in your preferred vector for LAS1L
     GenScript Custom Assay Services for LAS1L GenScript Custom overexpressing Cell Line Services for LAS1L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LAS1L
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LAS1L antibodies
     LAS1L proteins
     LAS1L lysates
     Antibodies for LAS1L
     See all of Abcam's Antibodies, Kits and Proteins for LAS1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LAS1L
     Antibodies for LAS1L
     ELISAs for LAS1L
     CLIAs for LAS1L



     Browse ESI BIO Cell Lines and PureStem Progenitors for LAS1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAS1L
     SwitchGear 3'UTR luciferase reporter plasmids for LAS1L
     SwitchGear Promoter luciferase reporter plasmids for LAS1L
     Search ThermoFisher Antibodies for LAS1L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAS1L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAS1L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAS1L
     LSBio Antibodies in human, mouse, rat for LAS1L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LAS1L gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4