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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAS1L Gene

protein-coding   GIFtS: 50
GCID: GC0XM064649

LAS1-Like (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LAS1-Like (S. Cerevisiae)1 2
Protein LAS1 Homolog2 3
Las1-like2
dJ475B7.22
Ribosomal Biogenesis Protein LAS1L2

External Ids:    HGNC: 257261   Entrez Gene: 818872   Ensembl: ENSG000000014977   UniProtKB: Q9Y4W23   

Export aliases for LAS1L gene to outside databases

Previous GC identifers: GC0XM064516 GC0XM058560


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LAS1L Gene: 
LAS1L (LAS1-like (S. cerevisiae)) is a protein-coding gene. Diseases associated with LAS1L include pancreatic cancer, and pancreatitis.

UniProtKB/Swiss-Prot: LAS1L_HUMAN, Q9Y4W2
Function: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA.
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to
ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target
genes

Gene Wiki entry for LAS1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAS1L gene promoter:
         TBP   HOXA9   HOXA9B   AML1a   Pax-5   Evi-1   Meis-1b   FAC1   c-Myb   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAS1L promoter sequence
   Search SABiosciences Chromatin IP Primers for LAS1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAS1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq12   Ensembl cytogenetic band:  Xq12   HGNC cytogenetic band: Xq12

LAS1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAS1L gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM064649:  view genomic region     (about GC identifiers)

Start:
64,732,462 bp from pter      End:
64,754,686 bp from pter
Size:
22,225 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAS1L_HUMAN, Q9Y4W2 (See protein sequence)
Recommended Name: Ribosomal biogenesis protein LAS1L  
Size: 734 amino acids; 83065 Da
Subunit: Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L,
HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4,
TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and
SENP3; the complex interacts with methylated CHTOP and ZNF148
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity).
Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By
similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA
processing and subunit assembly and export
Sequence caution: Sequence=BAB84913.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A9X410 Q5JXQ0 Q8TEN5 Q9H9V5
Alternative splicing: 4 isoforms:  Q9Y4W2-1   Q9Y4W2-2   Q9Y4W2-3   Q9Y4W2-4   (Gene prediction based on EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LAS1L: NX_Q9Y4W2

Explore proteomics data for LAS1L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4W2

  • LAS1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LAS1L Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001164120.1  NP_001164121.1  NP_112483.1  

    ENSEMBL proteins: 
     ENSP00000363940   ENSP00000363944   ENSP00000363937   ENSP00000473471   ENSP00000473630  
     ENSP00000308649  

    Human Recombinant Protein Products for LAS1L: 
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    Novus Biologicals LAS1L Protein
    Novus Biologicals LAS1L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LAS1L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0071339MLL1 complex IDA15960975

    LAS1L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007174 Las1

    Graphical View of Domain Structure for InterPro Entry Q9Y4W2

    ProtoNet protein and cluster: Q9Y4W2

    UniProtKB/Swiss-Prot: LAS1L_HUMAN, Q9Y4W2
    Similarity: Belongs to the LAS1 family


    LAS1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAS1L_HUMAN, Q9Y4W2
    Function: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA.
    Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to
    ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target
    genes

    Phenotypes:
         2 GenomeRNAi human phenotypes for LAS1L:

     Decreased TP53 protein express  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LAS1L 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAS1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAS1L 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAS1L 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAS1L
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LAS1L:
    hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidLAS1L 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): LAS1L (NM_031206)
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                         Customized lentivirus expression plasmids for stable overexpression of LAS1L 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAS1L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LAS1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/670 Interacting proteins for LAS1L (Q9Y4W21, 2, 3 ENSP000003639444) via UniProtKB, MINT, STRING, and/or I2D (see all 670)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PELP1Q8IZL82, 3, ENSP000003013964MINT-8150101 MINT-8151622 MINT-6488791 I2D: score=2 STRING: ENSP00000301396
    UBCP0CG482, 3, ENSP000003448184MINT-6488791 I2D: score=1 STRING: ENSP00000344818
    PNKPQ96T601, 3, ENSP000003235114EBI-1051591,EBI-1045072 I2D: score=2 STRING: ENSP00000323511
    NPM1P067482MINT-7947479 MINT-8151622 MINT-6488791
    SENP3Q9H4L42, ENSP000003140294MINT-7947479 MINT-8151622 STRING: ENSP00000314029
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    LAS1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAS1L

    Search CenterWatch for drugs/clinical trials and news about LAS1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAS1L gene (3 alternative transcripts): 
    NM_001170649.1  NM_001170650.1  NM_031206.4  

    Unigene Cluster for LAS1L:

    LAS1-like (S. cerevisiae)
    Hs.522675  [show with all ESTs]
    Unigene Representative Sequence: BC014545
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374807(uc004dvz.2) ENST00000374811(uc004dwa.2 uc004dwc.2 uc004dwd.2)
    ENST00000374804(uc004dvy.1) ENST00000484069 ENST00000469091 ENST00000312391

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAS1L
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LAS1L:
    hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidLAS1L 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAS1L
    Sirion Biotech Customized lentivirus for stable overexpression of LAS1L 
                         Customized lentivirus expression plasmids for stable overexpression of LAS1L 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAS1L
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    Additional mRNA sequence: 

    AF116730.1 AK022587.1 AK054817.1 AK097383.1 AK225059.1 AK295591.1 BC014545.1 BC018610.1 
    BC019302.1 DQ323624.1 

    24/29 DOTS entries (see all 29):

    DT.91683998  DT.86855154  DT.314513  DT.100789754  DT.121295646  DT.95287927  DT.95319722  DT.40251891 
    DT.100696063  DT.97815386  DT.121295618  DT.121295641  DT.206759  DT.87015359  DT.99951817  DT.121295656 
    DT.40129698  DT.121295654  DT.121295670  DT.91921710  DT.100789752  DT.101984626  DT.121295655  DT.121295660 

    24/404 AceView cDNA sequences (see all 404):

    BU856533 BQ052607 BM999345 AI537784 BQ942511 AI703136 BU188685 BE781771 
    BE276618 AK054817 BQ232904 BM552148 AF116730 AU280508 AI343416 BG286347 
    AI204400 AA494543 BU509562 BM693012 AW016897 BU186410 BU859154 BM787780 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for LAS1L (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ·
    SP1:                                                                                            -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for LAS1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAS1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCAAAAC
    LAS1L Expression
    About this image


    See LAS1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAS1L

    SOURCE GeneReport for Unigene cluster: Hs.522675
        SABiosciences Custom PCR Arrays for LAS1L
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAS1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAS1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for LAS1L gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Las1l1 , 5 LAS1-like (S. cerevisiae)1, 5 79.49(n)1
    72.68(a)1
      X (42.58 cM)5
    761301  NM_152822.21  NP_690035.21 
     959353355 
    chicken
    (Gallus gallus)
    Aves LAS1L6
    LAS1-like (S. cerevisiae)
    37(a)
    1 ↔ 1
    4(80824-106303)
    lizard
    (Anolis carolinensis)
    Reptilia LAS1L6
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343376.1(732803-753281)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.289682 Xenopus laevis transcribed sequence with weak similarity more 71.29(n)    CA971479.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5613211 novel protein similar to vertebrate LAS1-like (S. cerevisiae) more 51.7(n)
    40.85(a)
      561321  NM_001126400.1  NP_001119872.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG320756
    --
    16(a)
    1 ↔ 1
    3L(11055826-11058041)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAS1(YKR063C)4 Essential nuclear protein possibly involved in bud more   --   11(562297-560789) 853937  NP_012989.1 


    ENSEMBL Gene Tree for LAS1L (if available)
    TreeFam Gene Tree for LAS1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/314 SNPs in LAS1L are shown (see all 314)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365874
    A colorectal cancer sample4--see VAR_0365872 R C mis40--------
    rs1409192591,2
    --64732211(+) TGTAGC/TCAGCA 3 -- int10--------
    rs1851005561,2
    --64732321(+) GGTTAC/TAGGAG 3 -- int10--------
    rs1891789181,2
    --64732436(+) CCCACC/GCTCTT 3 -- int10--------
    rs31921871,2
    C--64732526(-) CCACCA/CCAGGG 3 -- ut312Minor allele frequency- C:0.02MN NA 186
    rs1997320161,2
    --64732664(+) AAGAGC/GTGCAG 6 H Q mis10--------
    rs1400561701,2
    F--64732712(+) AGAAGG/CCCCTC 6 /G syn11Minor allele frequency- C:0.00NA 2606
    rs59649821,2
    C,H--64732944(+) CCCCAG/AGGTTG 3 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1818555091,2
    --64733046(+) TTAAAA/GCAGAG 3 -- int10--------
    rs1501869161,2
    C--64733477(+) GTTAAC/TTGAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for LAS1L (64732462 - 64754686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LAS1L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1584074OTHER Inversion17803354


    Locus Specific Mutation Databases (LSDB): LAS1L
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for LAS1L:    About MalaCards
    pancreatic cancer    pancreatitis


    LAS1L for disorders           About GeneDecksing


    Export disorders for LAS1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAS1L gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with LAS1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Las1L is a nucleolar protein required for cell prolif eration and ribosome biogenesis. (PubMed id 20647540)1, 2 Castle C.D....Denicourt C. (2010)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81887 HGNC: 25726 AceView: FLJ12525 Ensembl:ENSG00000001497 euGenes: HUgn81887
    ECgene: LAS1L H-InvDB: LAS1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAS1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LAS1L gene:
    Search GeneIP for patents involving LAS1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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