 |
 | Services
| |
 |
Aliases & Descriptions for LARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.4 3 | | KIAA0028 1, 2, 3 | | LEURS 1, 2 | | LeuRS 3 | | MGC26121 1, 2 |
| | | Descriptions |
|---|
| Leucine--tRNA ligase 3 | | leucine tRNA ligase 2, mitocondrial 2 | | leucine translase 2 | | leucine-tRNA ligase 2 | | leucyl-tRNA synthetase 2, mitochondrial 2 |
|
| | Search outside databases for aliases for LARS2 genePrevious GC identifers: GC03P044670 GC03P045249 GC03P045390 |
Summaries for LARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LARS2: This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq] Gene Wiki entry for LARS2 |
Genomic Location for LARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LARS2 gene 
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3LARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P045405:
(about GC identifiers)
Start:
|
45,405,072 bp from pter |
End:
|
45,565,332 bp from pter |
Size:
|
160,261 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for LARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYLM_HUMAN, Q15031 (See
protein sequence)Recommended Name: Probable leucyl-tRNA synthetase, mitochondrial precursor Size: 903 amino acids; 101976 Da
Subcellular location: Mitochondrion matrix (By similarity)REFSEQ proteins: NP_056155.1
ENSEMBL proteins: ENSP00000265537
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LARS2: Assays for LARS2: | Protein
Domains/ Families for LARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15031
ProtoNet protein and cluster: Q15031 2 Blocks protein families: IPB002300 Aminoacyl-tRNA synthetase IPB002302 Leucyl-tRNA synthetase signature
UniProtKB/Swiss-Prot: SYLM_HUMAN, Q15031Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family | Gene Function for LARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015340
Applied Biosystems Silencer® siRNAs for LARS2
Sigma-Aldrich siRNA and siRNA Panels for LARS2  Sigma-Aldrich shRNA for LARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015340                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015340                                  untagged cDNA clone in CMV expression vector: NM_015340 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015340
UniProtKB/Swiss-Prot: SYLM_HUMAN, Q15031Catalytic activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)Enzyme Number (IUBMB): EC 6.1.1.4 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for LARS2 (Your Favorite Gene powered by Ingenuity) 
5 Interacting proteins for LARS2 (ENSP000002655373) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006429 | leucyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for LARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LARS2 1 Novoseek chemical compound relationship for LARS2 gene
About this table
|
Transcripts for LARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015340
Sigma-Aldrich siRNA and siRNA Panels for LARS2  Sigma-Aldrich shRNA for LARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015340 REFSEQ mRNAs for LARS2 gene: NM_015340.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015340               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015340                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015340                                  untagged cDNA clone in CMV expression vector: NM_015340  Additional cDNA sequence: AK025465.1 AK026113.1 AK308146.1 BC025989.2 CR620253.1 D21851.1 5 DOTS entries: DT.452983 DT.97788299 DT.120879587 DT.120879610 DT.91738877 24/135 AceView cDNA sequences (see all 135
):BE464286 BU730560 AK026113 BM982045 BM471576 CA439386 BU609039 BM564210 NM_015340 CR620253 CA431425 AI361703 BQ226824 AI658894 AW087297 AL599220 BU184816 BM927807 AW075872 BG286778 D21851 AA489504 AI352357 BQ649567
highest scoring ESTs for LARS2:D21851 AA080981 AA312721 AA482999 AA489504 AA564414 AA688001 AA877570 AA884360 AA969386 Unigene Cluster for LARS2: Leucyl-tRNA synthetase 2, mitochondrial Hs.526975 [show with all ESTs]Unigene Representative Sequence: BC025989
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for LARS2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LARS2
1 Ensembl transcript including schematic representation: ENST00000265537
|
Expression for LARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LARS2
1 / 2 / 3 5 probe-sets matching LARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGTCCCCCT
SOURCE GeneReport for Unigene cluster: Hs.526975
Expression variation in blood from EXPOLDB for LARS2 |
Orthologs for LARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LARS2 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for LARS2
ENSEMBL Gene Tree for LARS2 | Paralogs for LARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for LARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LARS2 (up to first 250kb)
|
Disorders & Mutations for LARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604544
Human Gene Mutation Database: LARS2 Genetic Association Database: LARS2 Human Genome Epidemiology Navigator: LARS2 (1 document)
|
Medical News for LARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for LARS2 gene (see all 22
):- Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. (PubMed id 15919814)1, 3, 6 't Hart L.M....Maassen J.A. (2005)
- Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase. (PubMed id 15123417)1, 2, 3 Sohm B....Florentz C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)3, 4 Nomura N....Tabata S. (1994)
- Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. (PubMed id 15737668)1, 3 Munakata K....Kato T. (2005)
- Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli. (PubMed id 12821328)1, 3 Yao Y.N....Wang E.D. (2003)
- Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene. (PubMed id 18796578)1, 3 Park H....King M.P. (2008)
- The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells. (PubMed id 12527375)1, 3 Yao Y.N....Wang E.D. (2003)
- The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation. (PubMed id 12549915)1, 3 Park H....King M.P. (2003)
- A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 10647888)1, 3 Kiss H.... Dumanski J.P. (1999)
|
Search for LARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LARS2
(According to HUGE)
About This Section
| |
Specialized Databases showing LARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LARS2:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for LARS2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|