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LARS Gene

protein-coding GIFtS: 62

GC05M145473

leucyl-tRNA synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.1.1.4 ^³
FLJ10595 ^¹, ²
FLJ21788 ^¹, ²
HSPC192 ^¹, ²
KIAA1352 ^², ³
LARS1 ^¹, ²
LEURS ^²
LEUS ^¹, ²
LRS ^²
LeuRS ^³
PIG44 ^²
RNTLS ^¹, ²
hr025Cl ^²

Descriptions
Leucine--tRNA ligase ^³
cytoplasmic leucyl-tRNA synthetase ^²
cytosolic leucyl-tRNA synthetase ^²
leucine tRNA ligase 1, cytoplasmic ^²
leucine translase ^²
leucine-tRNA ligase ^²
leucyl-tRNA synthetase ^²
proliferation-inducing gene 44 ^²

External Ids
HGNC: 6512¹
Entrez Gene: 51520²
UniProtKB: Q9P2J5³
Ensembl: ENSG00000133706⁷

Search outside databases for aliases for LARS gene

Previous GC identifers: GC05M145468 GC05M146077 GC05M145521

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LARS:

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA

synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to

tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with

the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript

variants of this gene have been found; however, their full-length nature is not known. [provided

by RefSeq]

Gene Wiki entry for LARS (Leucyl-tRNA_synthetase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LARS gene

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

LARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M145473: (about GC identifiers)

Start:	145,472,782 bp from pter
End:	145,549,064 bp from pter
Size:	76,283 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5 (See protein sequence)

Recommended Name: Leucyl-tRNA synthetase, cytoplasmic

Size: 1176 amino acids; 134466 Da

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: Q9NSE1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_064502.9

ENSEMBL proteins:

ENSP00000274562 ENSP00000354186 ENSP00000377954

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Leucyl tRNA synthetase)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for LARS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Leucyl tRNA synthetase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LARS)
	Search Novus for antibodies for LARS

Assays for LARS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9P2J5

ProtoNet protein and cluster: Q9P2J5

2 Blocks protein families:

IPB002300 Aminoacyl-tRNA synthetase

IPB002308 Cysteinyl-tRNA synthetase signature

UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LARS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020117

Applied Biosystems Silencer® siRNAs for LARS

Sigma-Aldrich siRNA for LARS

Sigma-Aldrich shRNA for LARS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020117
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020117
untagged cDNA clones in CMV expression vector (see all 4): AK095870

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020117

UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5

Catalytic activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

Enzyme Number (IUBMB): EC 6.1.1.4

Genatlas biochemistry entry for LARS:

leucyl-tRNA synthetase

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004823	leucine-tRNA ligase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for LARS (Your Favorite Gene powered by Ingenuity)

Valine, Leucine and Isoleucine Biosynthesis
Aminoacyl-tRNA Biosynthesis

GeneDecks LARS for the pathways selected above

About GeneDecksing

5/21 Interacting proteins for LARS (ENSP00000274562³ Q9P2J5²) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKG	Q9Y6K9²	MINT-48191
RELA	Q04206²	MINT-48940
TANK	Q92844²	MINT-48262
YWHAZ	P63104²	MINT-3318628
QARS	ENSP00000307567³	STRING (score=.957)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006429	leucyl-tRNA aminoacylation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LARS
5 Novoseek chemical compound relationships for LARS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
trna(leu)	88.70	2	16169847 (1), 19351898 (1)
leucine-trna	85.75	2	2076013 (1), 10723090 (1)
anticodon	79.17	3	15123417 (2), 15161932 (1)
trna	75.95	25	15161932 (4), 18550527 (3), 12071734 (2), 17378584 (1) (see all 8)
leucine	58.71	8	15123417 (1), 18550527 (1), 10547283 (1), 10723090 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LARS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020117

Sigma-Aldrich siRNA for LARS

Sigma-Aldrich shRNA for LARS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020117

REFSEQ mRNAs for LARS gene:

NM_020117.9

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020117

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020117
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020117
                                 untagged cDNA clones in CMV expression vector (see all 4): AK095870

Additional cDNA sequence:

AB037773.1 AF151026.1 AK000277.1 AK001457.1 AK001682.1 AK021413.1 AK023777.1 AK025441.1

AK225372.1 AK293750.1 AK295874.1 AK304134.1 AK315178.1 AL390155.1 AY513284.1 AY926480.1

BC068041.1 BC105581.1 BC131798.1 BC150213.1 BC151214.1 BC152422.1 CR606937.1 D84223.1

U56252.1

24 DOTS entries:

DT.95149473 DT.65285043 DT.95146494 DT.120813264 DT.120813337 DT.95296014 DT.100037988 DT.99933314

DT.95146476 DT.75197325 DT.91757819 DT.95089730 DT.100655627 DT.120813281 DT.91827412 DT.120813283

DT.120813289 DT.120813334 DT.75127701 DT.91757813 DT.91936592 DT.92343920 DT.91747506 DT.91809897

24/494 AceView cDNA sequences (see all 494 ):

AA374317 AW673539 BX097653 CB160346 CD105853 AL698713 AU116792 BX408269

BG029817 BQ317074 AK025441 BU162064 AA243123 AA227141 CB130448 BQ685471

AA838417 AL390155 CR606937 AU140364 CB105557 BM793410 CB106163 BE888467

highest scoring ESTs for LARS:

AA216556 AA227350 AA355770 AA852565 AB037773 AF151026 AK025441 AL601728 AL698713 AL700021

Unigene Cluster for LARS:

Leucyl-tRNA synthetase

Hs.432674 [show with all ESTs]

Unigene Representative Sequence: NM_020117

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LARS (see all 8 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^
SP1:			-		-																																												-
SP2:
SP3:															-
SP4:
SP5:																																																	-

ExUns:	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33	^	34	^	35
SP1:	-						-
SP2:
SP3:
SP4:							-
SP5:

About this scheme

ECgene alternative splicing isoforms for LARS

3 Ensembl transcripts including schematic representations:

ENST00000274562 ENST00000360930 ENST00000394434

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LARS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LARS

¹ / ² / ³

10 probe-sets matching LARS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
61729_r_at²^{, 3}	U95-C	1	1.00	1.00	0.93	0.76	AA535938	0.60	1.00	0.82	1
54061_at²^{, 3}	U95-B	1	1.00	1.00	0.79	1.24	AA088424	0.60	1.00	0.82	1
222427_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK021413	0.60	1.00	0.82	1
222428_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	D84223	0.80	1.00	0.91	1
223888_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF151026	0.80	1.00	0.91	1
217810_x_at²^{, 3}	U133-A	9	1.00	0.86	--	--	NM_020117	0.60	1.00	0.82	1
222427_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222428_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223888_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217810_x_at²	U133Plus2	9	1.00	0.86	--	--	--	--	--	--	--

GeneDecks LARS for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATTCATAAT

SOURCE GeneReport for Unigene cluster: Hs.432674

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LARS gene from 5/26 species (see all 26 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LARS¹	--	leucyl-tRNA synthetase	92.38(n) 94.98(a)	478051 XM_535229.2 XP_535229.1
chimpanzee (Pan troglodytes)	LARS¹	--	leucyl-tRNA synthetase	99.35(n) 99.57(a)	462167 XM_001157096.1 XP_001157096.1
cow (Bos taurus)	LOC787149¹	--	hypothetical protein LOC787149	89.08(n) 87.93(a)	787149 XM_001253553.1 XP_001253554.1
rat (Rattus norvegicus)	Lars¹	--	leucyl-tRNA synthetase	86.9(n) 90.14(a)	291624 NM_001009637.1 NP_001009637.1
mouse (Mus musculus)	Lars^{1, 5}	18⁵	leucyl-tRNA synthetase^{1, 5}	85.97(n)¹ 90.22(a)¹	107045¹ NM_134137.2¹ NP_598898.2¹ AI844089⁵ AK009823⁵ (see all 19)

About this table Species with no ortholog for LARS

ENSEMBL Gene Tree for LARS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/535 NCBI SNPs in LARS are shown (see all 535 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 154)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs17428724^1,2	C,F,H	145542758(+)	`ACTATG/ACACAG`	1	--	ng3¹		9		NA MN EA EU WA	1802
	rs10988^1,2	C,F,H	145480189(+)	`CTTGCC/TTGATT`	1	R/K	mis¹		23		NA EA MN EU WA	3206
	rs4913067^1,2	C,F,H	145472423(+)	`TCAGAG/ACATGC`	1	--	ng5¹		4		EU EA WA	408
--	rs2963938^1,2	A,C	145544434(-)	`caggcA/Gtgagc`	1	--	ng3¹		0	--	--	--	--
	rs17428647^1,2	C,F	145542544(+)	`CACTCA/GGAGGG`	1	--	ng3¹		5		NA MN EA	1392
--	rs16742^1,2	C,F	145473093(+)	`ggattAA/-atagg`	1	--	ut3¹		4		EU NA EA	342
	rs13186701^1,2	C,F	145542475(+)	`ACCCAG/TCAGGC`	1	--	ut5¹		5		NA MN EA	1392
	rs11540215^1,2	F	145542336(-)	`GCATCC/TCCGAG`	1	--	ut5¹		2		MN EA	1252
--	rs4913066^1,2	A	145472285(+)	`TAAACA/GTCTCA`	1	--	ng5¹		0	--	--	--	--
	rs4549582^1,2	H	145488744(+)	`CTTTAG/ACTGGC`	1	V/A	mis¹ ese³		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for LARS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 151350

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/41 PubMed articles for LARS gene (see all 41 ):

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{3, 4} Nagase T....Ohara O. (2000)
Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells. (PubMed id 6933703)^{2, 3} Giles R.E....Ruddle F.H. (1980)
Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. (PubMed id 18446061)^{1, 3} Shin S.H....Chung Y.J. (2008)
A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation. (PubMed id 17378584)^{1, 3} Lue S.W. and Kelley S.O. (2007)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
A novel mutation in the mitochondrial DNA tRNA Leu (UUR) gene associated with late-onset ocular myopathy. (PubMed id 17363246)³ Maeso E....Campos Y. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex. (PubMed id 16055448)³ Ling C....Wang E.D. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51520	HGNC: 6512	AceView: LARS	Ensembl:ENSG00000133706	euGenes: HUgn51520
ECgene: LARS	H-InvDB: LARS

(According to HUGE)
About This Section

HUGE: KIAA1352

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LARS
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LARS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LARS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LARS		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LARS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (LARS)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Leucyl tRNA synthetase)
	Antibodies (Leucyl tRNA synthetase)

Search OriGene for LARS

Search Tocris compounds for LARS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LARS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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LARS Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for LARS

Summaries
for LARS

Genomic Location
for LARS

Proteins
for LARS

Protein Domains/
Families
for LARS

Gene Function
for LARS

Pathways & Interactions
for LARS

Drugs & Compounds
for LARS

Transcripts
for LARS

Expression
for LARS

Orthologs
for LARS

Paralogs
for LARS

SNPs/Variants
for LARS

Disorders & Mutations
for LARS

Medical News
for LARS

Publications
for LARS

Search for LARS

Genome Databases showing LARS

Other Databases showing LARS

Specialized Databases showing LARS

Licensable Technologies
for LARS

Services
for LARS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LARS (Gene Symbol)
EC 6.1.1.4
FLJ10595
FLJ21788
HSPC192
KIAA1352
LARS1
LEURS
LEUS
LRS
LeuRS
PIG44
RNTLS
hr025Cl
Leucine--tRNA ligase
cytoplasmic leucyl-tRNA synthetase
cytosolic leucyl-tRNA synthetase
leucine tRNA ligase 1, cytoplasmic
leucine translase
leucine-tRNA ligase
leucyl-tRNA synthetase
proliferation-inducing gene 44

LARS Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor LARS

Summariesfor LARS

Genomic Locationfor LARS

Proteinsfor LARS

Protein Domains/Familiesfor LARS

Gene Functionfor LARS

Pathways & Interactionsfor LARS

Drugs & Compoundsfor LARS

Transcriptsfor LARS

Expression for LARS

Orthologsfor LARS

Paralogsfor LARS

SNPs/Variantsfor LARS

Disorders & Mutationsfor LARS

Medical Newsfor LARS

Publicationsfor LARS

Search for LARS

Genome Databases showing LARS

Other Databases showing LARS

Specialized Databases showing LARS

Licensable Technologiesfor LARS

Servicesfor LARS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LARS

Summaries
for LARS

Genomic Location
for LARS

Proteins
for LARS

Protein Domains/
Families
for LARS

Gene Function
for LARS

Pathways & Interactions
for LARS

Drugs & Compounds
for LARS

Transcripts
for LARS

Expression
for LARS

Orthologs
for LARS

Paralogs
for LARS

SNPs/Variants
for LARS

Disorders & Mutations
for LARS

Medical News
for LARS

Publications
for LARS

Licensable Technologies
for LARS

Services
for LARS