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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LARS Gene

protein-coding GIFtS: 65
GCID: GC05M145473

leucyl-tRNA synthetase

Explore 15 diseases affiliated with
LARS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucyl-TRNA Synthetase¹ ² ³		Cytosolic Leucyl-TRNA Synthetase²
HSPC192¹ ²		Hr025Cl¹
LARS1¹ ²		Leucine Translase²
LEUS¹ ²		Leucine TRNA Ligase 1, Cytoplasmic²
RNTLS¹ ²		Leucine--TRNA Ligase, Cytoplasmic²
EC 6.1.1.4³ ⁸		Leucine-TRNA Ligase²
FLJ10595¹		Leucyl-TRNA Synthetase, Cytoplasmic²
FLJ21788¹		Proliferation-Inducing Gene 44²
LEURS²		KIAA1352³
LRS²		LeuRS³
PIG44²		EC 6.1.1⁸
Cytoplasmic Leucyl-TRNA Synthetase²

External Ids:	HGNC: 6512¹	Entrez Gene: 51520²	Ensembl: ENSG00000133706⁷	OMIM: 151350⁵	UniProtKB: Q9P2J5³

Export aliases for LARS gene to outside databases

Previous GC identifers: GC05M145468 GC05M146077 GC05M145521 GC05M140639

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LARS:

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The

encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of

a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively

spliced transcript variants of this gene have been found; however, their full-length nature is not known. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5

Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid

(AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a

post-transfer editing activity to hydrolyze mischarged tRNAs

Gene Wiki entry for LARS (Leucyl-tRNA synthetase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LARS gene promoter:
c-Fos AP-1 JunB Pax-2 FosB Fra-1 Pax-2a Pax-2b JunD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LARS promoter sequence

Search SABiosciences Chromatin IP Primers for LARS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LARS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

LARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LARS gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M145473: view genomic region (about GC identifiers)

Start:	145,492,589 bp from pter	End:	145,562,294 bp from pter
Size:	69,706 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5 (See protein sequence)

Recommended Name: Leucine--tRNA ligase, cytoplasmic

Size: 1176 amino acids; 134466 Da

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=BAA92590.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for LARS:

2WFD (3D)

Secondary accessions: A7E266 Q9NSE1

Explore the universe of human proteins at neXtProt for LARS: NX_Q9P2J5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P2J5

4/13 DME Specific Peptides for LARS (Q9P2J5) (see all 13)

ATLRPET

EFEFWYP

ALKTGFFE

KMSKSTGN

LARS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_064502.9

ENSEMBL proteins:

ENSP00000377954 ENSP00000426005 ENSP00000437791 ENSP00000274562

Reactome Protein details: Q9P2J5
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for LARS
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LARS

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

LARS for ontologies About GeneDecksing

LARS Antibody Products:

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	Uscn Antibodies for LARS
	ThermoFisher Antibodies for LARS

Assay Products for LARS:

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	Uscn ELISAs and CLIAs for LARS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LARS for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR013155 V/L/I-tRNA-synth_anticodon-bd

IPR002300 aa-tRNA-synth_Ia

IPR004493 Leu-tRNA-synth_Ia_arc/euk

IPR001412 aa-tRNA-synth_I_CS

IPR009080 tRNAsynth_1a_anticodon-bd

Graphical View of Domain Structure for InterPro Entry Q9P2J5

ProtoNet protein and cluster: Q9P2J5

2 Blocks protein families:

IPB002300 Aminoacyl-tRNA synthetase

IPB002308 Cysteinyl-tRNA synthetase signature

UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYLC_HUMAN, Q9P2J5

Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid

(AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a

post-transfer editing activity to hydrolyze mischarged tRNAs

Catalytic activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

Enzyme regulation: (5-fluoro-1,3-dihydro-1-hydroxy-1,2-benzoxaborole) inhibits LARS by forming a covalent adduct with

the 3' adenosine of tRNA(Leu) at the editing site, thus locking the enzyme in an inactive conformation

Genatlas biochemistry entry for LARS:

leucyl-tRNA synthetase

Enzyme Numbers (IUBMB): EC 6.1.1.4¹ ² EC 6.1.1²

miRNA Products:		OriGene 3'-UTR Clone: LARS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LARS
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate LARS (see all 12):
		hsa-miR-186* hsa-miR-3614-3p hsa-miR-4282 hsa-miR-888* hsa-miR-519e* hsa-miR-515-5p hsa-miR-298 hsa-miR-637

		SwitchGear 3'UTR luciferase reporter plasmid: LARS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LARS (see all 7) Browse OriGene siRNA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LARS

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		GenScript: all cDNA clones in your preferred vector: LARS (NM_015340)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LARS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LARS
		Search LifeMap BioReagents cell lines for LARS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LARS

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002161	aminoacyl-tRNA editing activity	IEA	--
GO:0004812	aminoacyl-tRNA ligase activity	--	--
GO:0004823	leucine-tRNA ligase activity	TAS	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

LARS for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for LARS:

Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e	Decreased p24 protein expressi
Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

tRNA Aminoacylation

	tRNA Aminoacylation	1.00			Aminoacyl-tRNA biosynthesis	0.54
	Cytosolic tRNA aminoacylation	0.57

Valine, leucine and isoleucine biosynthesis

Valine, leucine and isoleucine biosynthesis

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for LARS

	Cytosolic tRNA aminoacylation
	tRNA Aminoacylation
	Gene Expression

2 Kegg Pathways (Kegg details for LARS):

	Valine, leucine and isoleucine biosynthesis
	Aminoacyl-tRNA biosynthesis

LARS for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LARS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for LARS (Q9P2J5^{1, 2, 3} ENSP00000377954⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TANK	Q92844²^,³, ENSP00000259075⁴	MINT-48262 I2D: score=2 STRING: ENSP00000259075
IKBKG	Q9Y6K9²^,³	MINT-48191 I2D: score=2
RARS	P54136¹^,³, ENSP00000231572⁴	EBI-356077,EBI-355482 I2D: score=1 STRING: ENSP00000231572
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3318628 I2D: score=1 STRING: ENSP00000309503
GBAS	O75323³, ENSP00000313050⁴	I2D: score=3 STRING: ENSP00000313050

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006418	tRNA aminoacylation for protein translation	TAS	--
GO:0006429	leucyl-tRNA aminoacylation	IEA	--
GO:0010467	gene expression	TAS	--

LARS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LARS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LARS

6 HMDB Compounds for LARS About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Ceramide (d18:1/16:0)	(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)	104404-17-3	--
L-Leucine	(2S)-2-Amino-4-methylpentanoate (see all 16)	61-90-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

1 DrugBank Compound for LARS About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Leucine	(2S)-2-Amino-4-methylpentanoic acid (see all 16)	61-90-5	target	--	17407263 16955236 16774921 17144674 16956879

5 Novoseek chemical compound relationships for LARS gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
trna(leu)	94.1	12	19540202 (4), 19426743 (2), 16169847 (1), 19351898 (1) (see all 5)
leucine-trna	88	3	19713640 (1), 2076013 (1), 10723090 (1)
anticodon	75.7	3	15123417 (2), 15161932 (1)
trna	74.3	28	15161932 (4), 18550527 (3), 12071734 (2), 17378584 (1) (see all 9)
leucine	59.7	10	15123417 (1), 18550527 (1), 19426743 (1), 10547283 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about LARS / SYLC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LARS gene:

NM_020117.9

Unigene Cluster for LARS:

Leucyl-tRNA synthetase

Hs.432674 [show with all ESTs]

Unigene Representative Sequence: NM_020117

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394434(uc003lnx.1 uc011dbq.1 uc011dbr.1 uc011dbs.1)

ENST00000506231(uc003lnw.1) ENST00000510191 ENST00000508709 ENST00000504611

ENST00000512412 ENST00000514104 ENST00000504323 ENST00000508667 ENST00000507095

ENST00000511505 ENST00000505223 ENST00000503654 ENST00000506436 ENST00000545646

ENST00000274562

miRNA Products:		OriGene 3'-UTR Clone: LARS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LARS
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate LARS (see all 12):
		hsa-miR-186* hsa-miR-3614-3p hsa-miR-4282 hsa-miR-888* hsa-miR-519e* hsa-miR-515-5p hsa-miR-298 hsa-miR-637

		SwitchGear 3'UTR luciferase reporter plasmid: LARS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LARS (see all 7) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LARS

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		GenScript: all cDNA clones in your preferred vector: LARS (NM_015340)
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LARS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LARS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LARS

Additional cDNA sequence:

AB037773.1 AF151026.1 AK000277.1 AK001457.1 AK001682.1 AK021413.1 AK023777.1 AK025441.1

AK225372.1 AK293750.1 AK295874.1 AK304134.1 AK315178.1 AL390155.1 AY513284.1 AY926480.1

BC068041.1 BC105581.1 BC131798.1 BC150213.1 BC151214.1 BC152422.1 D84223.1 U56252.1

24/25 DOTS entries (see all 25):

DT.95149473 DT.65285043 DT.95146494 DT.120813264 DT.120813337 DT.95296014 DT.100037988 DT.95146476

DT.75197325 DT.91757819 DT.95089730 DT.100655627 DT.120813281 DT.91827412 DT.99933314 DT.120813283

DT.120813289 DT.120813334 DT.75127701 DT.91757813 DT.91936592 DT.92343920 DT.91747506 DT.91809897

24/494 AceView cDNA sequences (see all 494):

AW673539 BU194919 BX097653 F06989 BM744625 CB160346 AB037773 BM801177

BM789694 BE888467 CB106163 AL703923 AI143462 AK021413 BQ670751 BQ956142

AU132992 BF034739 BU631292 BF725138 AA148756 AA064920 BQ317074 CB105993

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LARS (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^
SP1:			-		-																																												-
SP2:
SP3:															-
SP4:
SP5:																																																	-

ExUns:	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33	^	34	^	35
SP1:	-						-
SP2:
SP3:
SP4:							-
SP5:

ECgene alternative splicing isoforms for LARS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LARS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCATAAT

About this image

LARS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Long Bone

Bone

Caudal Endochondral Bones

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LARS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LARS

SOURCE GeneReport for Unigene cluster: Hs.432674

SABiosciences Expression via Pathway-Focused PCR Array including LARS:

Amino Acid Metabolism I in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LARS Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LARS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LARS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for LARS gene from 11/45 species (see all 45) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lars^{1 , 5}	leucyl-tRNA synthetase^{1, 5}	85.97(n)¹ 90.22(a)¹		18 (22.37 cM)⁵ 107045¹ NM_134137.2¹ NP_598898.2¹ 42202349⁵
chicken (Gallus gallus)	Aves	LARS¹	leucyl-tRNA synthetase	79.11(n) 87.07(a)		416347 XM_414663.3 XP_414663.2
lizard (Anolis carolinensis)	Reptilia	LARS⁶ LARS2⁶	--	85(a) 12(a)	1 ↔ 1 possible ortholog	GL343234.1(648939-709338) GL343324.1(3117-82449)
African clawed frog (Xenopus laevis)	Amphibia	BM191686.1²	--	78.97(n)		BM191686.1
zebrafish (Danio rerio)	Actinopterygii	wufb36b12²	Transcribed sequence with weak similarity to protein more	74.62(n)		57057586
fruit fly (Drosophila melanogaster)	Insecta	CG33123¹	CG33123	60.04(n) 59.81(a)		326262 NM_175954.1 NP_787968.1
worm (Caenorhabditis elegans)	Secernentea	lars-1¹	Protein LARS-1	59.57(n) 57.59(a)		175538 NM_065436.4 NP_497837.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC60(YPL160W)⁴ CDC60¹	Cytosolic leucyl tRNA synthetase, ligates leucine to more⁴ Cdc60p¹	54.29(n)¹ 48.19(a)¹		16(246990-250262)⁴ 855943^{1, 4} NP_015165.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G09620¹	leucyl-tRNA synthetase	56.44(n) 50.24(a)		837489 NM_100834.5 NP_172433.2
rice (Oryza sativa)	Liliopsida	Os.24539²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.73(n)		AK068860.1

ENSEMBL Gene Tree for LARS (if available)
TreeFam Gene Tree for LARS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4913066^1,2	C,F,A,	--	145492092(+)	`TAAACG/ATCTCA`	1	--	ds500¹		7		NA WA CSA EA	366
rs138897683^1,2		--	145492212(+)	`AACCTA/GGCTAG`	1	--	ds500¹		0	--	--	--	--
rs4913067^1,2	C,F,H,	--	145492230(+)	`TCAGAG/ACATGC`	1	--	ds500¹		16		NS EA NA	1934
rs181309167^1,2		--	145492366(+)	`CCTAGG/TGGTCC`	1	--	ds500¹		0	--	--	--	--
rs141996501^1,2		--	145492424(+)	`TAACCA/GCAGTT`	1	--	ds500¹		0	--	--	--	--
rs185520886^1,2		--	145492636(+)	`TTGATA/GGATTG`	1	--	ut3¹		0	--	--	--	--
rs3836839^1,2	C,	--	145492660(-)	`CAGCT-/TAGGC AACAAGAGTGAA`	1	--	ut3¹		1		NA	2
rs58569901^1,2	C,	--	145492709(+)	`TGCAAA/CCTCGG`	1	--	ut3¹		2		WA CSA	3
rs138184888^1,2		--	145492712(+)	`AACCTC/TGGTCT`	1	--	ut3¹		0	--	--	--	--
rs189158554^1,2		--	145492834(+)	`TGTTGA/GTCAGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LARS (145492589 - 145562294 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LARS: --
Human Gene Mutation Database (HGMD): LARS

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LARS

DNA2.0 Custom Variant and Variant Library Synthesis for LARS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LARS for disorders           About GeneDecksing

OMIM gene information: 151350    OMIM disorders: --

15 diseases for LARS:    About MalaCards

conjugate gaze palsy bovine spongiform encephalopathy patellofemoral pain syndrome gastroesophageal reflux disease

alagille syndrome scrapie paine syndrome appendicitis

familial breast cancer breast cancer myopathy lung cancer

atherosclerosis hepatitis malaria

4 diseases from the University of Copenhagen DISEASES database for LARS:

Gastroesophageal reflux disease Scrapie Patellofemoral pain syndrome Conjugate gaze palsy

Human Genome Epidemiology (HuGE) Navigator: LARS (1 document)

Export disorders for LARS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LARS gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with LARS)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles. (PubMed id 19426743)^{1, 2, 9} Seiradake E.... Cusack S. (2009)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells. (PubMed id 6933703)^{1, 3} Giles R.E....Ruddle F.H. (1980)
Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. (PubMed id 18446061)^{1, 9} Shin S.H....Chung Y.J. (2008)
A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase. (PubMed id 19702327)^{1, 9} Pang Y.L. and Martinis S.A. (2009)
A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation. (PubMed id 17378584)^{1, 9} Lue S.W. and Kelley S.O. (2007)
Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypes. (PubMed id 16955236)^{7, 9} Dohm J.C....Staub E. (2006)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51520	HGNC: 6512	AceView: LARS	Ensembl:ENSG00000133706	euGenes: HUgn51520
ECgene: LARS	Kegg: 51520	H-InvDB: LARS

(According to HUGE)
About This Section

HUGE: KIAA1352

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LARS	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LARS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LARS gene:
Search GeneIP for patents involving LARS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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LARS (Gene Symbol)
Leucyl-TRNA Synthetase
HSPC192
LARS1
LEUS
RNTLS
EC 6.1.1.4
FLJ10595
FLJ21788
LEURS
LRS
PIG44
Cytoplasmic Leucyl-TRNA Synthetase
Cytosolic Leucyl-TRNA Synthetase
Hr025Cl
Leucine Translase
Leucine TRNA Ligase 1, Cytoplasmic
Leucine--TRNA Ligase, Cytoplasmic
Leucine-TRNA Ligase
Leucyl-TRNA Synthetase, Cytoplasmic
Proliferation-Inducing Gene 44
KIAA1352
LeuRS
EC 6.1.1

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LARS Gene

leucyl-tRNA synthetase

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