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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LARP7 Gene

protein-coding   GIFtS: 48
GCID: GC04P113559

La ribonucleoprotein domain family, member 7

 Explore 4 diseases affiliated with
LARP7 via our new
 Human Malady Compendium 
Biological research products
for LARP7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
La Ribonucleoprotein Domain Family, Member 71 2     HDCMA18P1
PIP7S1 2 3 5     ALAZS2
P-TEFb-Interaction Protein For 7SK Stability2 3     La-Related Protein 72
DKFZP564K1121     La Ribonucleoprotein Domain Family Member 73

External Ids:    HGNC: 249121   Entrez Gene: 515742   Ensembl: ENSG000001747207   OMIM: 6120265   UniProtKB: Q4G0J33   

Export aliases for LARP7 gene to outside databases

Previous GC identifers: GC04P113777 GC04P109286


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LARP7:
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex
inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA
polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3
Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the
7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form,
preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LARP7 gene promoter:
         E2F-4   E2F-3a   E2F   E2F-1   FOXO4   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LARP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for LARP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LARP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

LARP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LARP7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P113559:  view genomic region     (about GC identifiers)

Start:
113,558,120 bp from pter      End:
113,578,748 bp from pter
Size:
20,629 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3 (See protein sequence)
Recommended Name: La-related protein 7  
Size: 582 amino acids; 66899 Da
Subunit: Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of
7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex
Subcellular location: Nucleus, nucleoplasm
Sequence caution: Sequence=ACD13786.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=EAX06284.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2ZHN6 Q3B7A9 Q9P1S7 Q9Y3Z8
Alternative splicing: 2 isoforms:  Q4G0J3-1   Q4G0J3-2   

Explore the universe of human proteins at neXtProt for LARP7: NX_Q4G0J3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q4G0J3

  • LARP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001253968.1  NP_056269.1  NP_057732.2  

    ENSEMBL proteins: 
     ENSP00000344950   ENSP00000426709   ENSP00000422626   ENSP00000422451   ENSP00000426646  
     ENSP00000422013   ENSP00000421541   ENSP00000424116   ENSP00000421963   ENSP00000426376  
     ENSP00000314311  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LARP7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IDA--
    GO:0030529ribonucleoprotein complex IEA--


    LARP7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LARP7 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR002344 Lupus_La
     IPR014886 RRM_3
     IPR012677 Nucleotide-bd_a/b_plait
     IPR006630 Lupus_La_RNA-bd
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q4G0J3

    ProtoNet protein and cluster: Q4G0J3

    1 Blocks protein family: IPB002344 Lupus La protein signature

    UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3
    Similarity: Contains 1 HTH La-type RNA-binding domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3
    Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the
    7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form,
    preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation

    miRNA
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    hsa-miR-3065-5p
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LARP7

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--


    LARP7 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Larp7tm1Ymat for LARP7
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Larp7):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 
     reproductive system 

    LARP7 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LARP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for LARP7 (Q4G0J32, 3 ENSP000003143114) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-8267468 I2D: score=2 
    CDK9P507502, 3, ENSP000003623614MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629599 MINT-6629464 MINT-6629479 MINT-6629534 I2D: score=2 STRING: ENSP00000362361
    HEXIM1O949922, 3, ENSP000003287734MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629464 MINT-6629479 MINT-6629588 MINT-6629534 I2D: score=1 STRING: ENSP00000328773
    CCNT1O605632, ENSP000002619004MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629464 MINT-6629479 MINT-6629534 STRING: ENSP00000261900
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--


    LARP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LARP7
    Search CenterWatch for drugs/clinical trials and news about LARP7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LARP7 gene (3 alternative transcripts): 
    NM_001267039.1  NM_015454.2  NM_016648.3  

    Unigene Cluster for LARP7:

    La ribonucleoprotein domain family, member 7
    Hs.713663  [show with all ESTs]
    Unigene Representative Sequence: NM_001267039
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344442(uc003iay.3 uc003iba.3) ENST00000512589 ENST00000509061(uc003iaz.3)
    ENST00000509622 ENST00000508577 ENST00000513553 ENST00000504079 ENST00000505034
    ENST00000505216 ENST00000507443 ENST00000503316 ENST00000511529 ENST00000512361
    ENST00000503898 ENST00000324052(uc003ibb.3)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate LARP7:
    hsa-miR-3065-5p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF068284.1 AK000089.1 AK000274.1 AK225900.1 AL049996.1 BC006981.1 BC066945.1 BC107709.1 
    BX647100.1 EU667388.1 NR_049768.1 

    24/27 DOTS entries (see all 27):

    DT.455967  DT.100826219  DT.95070005  DT.102833758  DT.102833759  DT.100826216  DT.95074509  DT.100826217 
    DT.121220526  DT.121220517  DT.40287376  DT.99998927  DT.121220527  DT.91755773  DT.100826221  DT.101959098 
    DT.121220446  DT.424894  DT.99976930  DT.121220493  DT.121220512  DT.86855559  DT.92001063  DT.97771568 

    24/246 AceView cDNA sequences (see all 246):

    AI670112 AI635804 CB157479 AA741383 N64387 AW589864 BE348878 AA047503 
    BU784632 AW589419 BG113704 AA503848 AI767841 BQ774592 AA946892 AV689069 
    AW172825 AA370734 AI655849 BM263404 BE048409 BF593364 AV690220 BE221466 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LARP7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                          -                                             
    SP2:                          -                                                                                             
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for LARP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LARP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACACAAGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See LARP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LARP7

    SOURCE GeneReport for Unigene cluster: Hs.713663
        SABiosciences Expression via Pathway-Focused PCR Array including LARP7: 
              Polycomb & Trithorax Complexes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LARP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LARP7 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Larp71 , 5 La ribonucleoprotein domain family, member 71, 5 81.54(n)1
    82.89(a)1
      3 (56.54 cM)5
    280361  NM_138593.21  NP_613059.21 
     1275369545 
    chicken
    (Gallus gallus)
    Aves LARP71 La ribonucleoprotein domain family, member 7 74.35(n)
    75.04(a)
      422690  XM_420643.3  XP_420643.3 
    lizard
    (Anolis carolinensis)
    Reptilia LARP76
    --
    70(a)
    1 ↔ 1
    5(142951357-142975652)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.130442 Xenopus laevis transcribed sequence with weak similarity to protein pirT08692 (H.sapiens) T08692 hypothetical protein DKFZp564K112.1 - human (fragment) less 78.33(n)    BJ093043.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10g042 wufa10g04 71.02(n)   334956  BC049455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425691 CG42569 44.02(n)
    33.86(a)
      44900  NM_080056.5  NP_524795.2 


    ENSEMBL Gene Tree for LARP7 (if available)
    TreeFam Gene Tree for LARP7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LARP7 gene
    SSB2  
    4 SIMAP similar genes for LARP7 using alignment to 9 protein entries:     LARP7_HUMAN (see all proteins):
    LARP1B    LARP1    LARP4    SSB

    LARP7 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for LARP7 (see all 6)
    PGOHUM00000248749 PGOHUM00000235095 PGOHUM00000244394 PGOHUM00000250309 PGOHUM00000243832


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): LARP7
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LARP7
    DNA2.0 Custom Variant and Variant Library Synthesis for LARP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LARP7 for disorders           About GeneDecksing

    OMIM gene information: 612026    OMIM disorders: --

    UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3
  • Note=Defects in LARP7 are a cause of primordial dwarfism (PD). PD is a pathological condition characterized by
  • severe growth restriction that has its onset in utero. All growth parameters are several standards of deviation below
    the age adjusted mean and frank skeletal dysplasia is excluded

    4 diseases for LARP7:    About MalaCards
    alcohol dependence    alcoholism    cervical cancer    cervicitis

    Human Genome Epidemiology (HuGE) Navigator: LARP7 (1 document)

    Export disorders for LARP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LARP7 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with LARP7)
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    1. Loss of function mutation in LARP7, chaperone of 7SK n cRNA, causes a syndrome of facial dysmorphism, intellectual disability, and prim ordial dwarfism. (PubMed id 22865833)1, 2, 3 Alazami A.M....Alkuraya F.S. (2012)
    2. A La-related protein modulates 7SK snRNP integrity to suppress P- TEFb-dependent transcriptional elongation and tumorigenesis. (PubMed id 18249148)1, 2, 3 He N.... Zhou Q. (2008)
    3. LARP7 is a potential tumor suppressor gene in gastric cancer. (PubMed id 22488152)1, 3 Cheng Y....Mori Y. (2012)
    4. LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. (PubMed id 18281698)1, 3 Krueger B.J....Price D.H. (2008)
    5. Gene expression in early stage cervical cancer. (PubMed id 18191186)1, 3 Biewenga P....Baas F. (2008)
    6. The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. (PubMed id 18483487)1, 2 Markert A.... Fischer U. (2008)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. (PubMed id 21853533)1 Peterlin B.M....Price D.H. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51574 HGNC: 24912 AceView: HDCMA18P Ensembl:ENSG00000174720 euGenes: HUgn51574
    ECgene: LARP7 H-InvDB: LARP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LARP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LARP7 gene:
    Search GeneIP for patents involving LARP7

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