Aliases for LARP7 Gene
External Ids for LARP7 Gene
Previous GeneCards Identifiers for LARP7 Gene
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
GeneCards Summary for LARP7 Gene
LARP7 (La Ribonucleoprotein Domain Family Member 7) is a Protein Coding gene. Diseases associated with LARP7 include Alazami Syndrome and Microcephalic Primordial Dwarfism, Alazami Type. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is LARP6.
UniProtKB/Swiss-Prot for LARP7 Gene
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.