Aliases for LARP7 Gene
External Ids for LARP7 Gene
Previous GeneCards Identifiers for LARP7 Gene
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
GeneCards Summary for LARP7 Gene
LARP7 (La Ribonucleoprotein Domain Family Member 7) is a Protein Coding gene. Diseases associated with LARP7 include Alazami Syndrome and Bowen-Conradi Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is LARP6.
UniProtKB/Swiss-Prot for LARP7 Gene
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.