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Aliases & Descriptions for LARP7
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZP564K112 1 DKFZp564K112 2 HDCMA18P 1 , 2 MGC104360 2 PIP7S 1 , 2 , 3 , 5
Descriptions La ribonucleoprotein domain family member 7 3 La ribonucleoprotein domain family, member 7 2 La-related protein 7 2 P-TEFb-interaction protein for 7SK stability 2 , 3
Search outside databases for aliases for LARP7 gene
Summaries for LARP7 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3 Function : Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNPsystem. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) issequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequenttranscriptional elongation
Genomic Location for LARP7
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the LARP7 gene Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25 LARP7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P113777:
(about GC identifiers )
Start:
113,777,569 bp from pter
End:
113,798,191 bp from pter
Size:
20,623 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for LARP7
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3 (See
protein sequence )Recommended Name: La-related protein 7 Size : 582 amino acids; 66899 Da
Subunit : Integral part of the 7SK RNP complex. Specifically binds to the highly conserved3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereasP-TEFb is released from the complex
Subcellular location : Nucleus, nucleoplasm
Sequence caution : Sequence=ACD13786.1; Type=Erroneous initiation; Note=Translation N-terminallyshortened; Sequence=EAX06284.1; Type=Erroneous initiation; Note=Translation N-terminallyshortened;
Secondary accessions : B2ZHN6 Q3B7A9 Q9P1S7 Q9Y3Z8Alternative splicing : 2 isoforms : Q4G0J3-1 Q4G0J3-2
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity)1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_056269.1 NP_057732.2 ENSEMBL proteins: ENSP00000311306 ENSP00000378069 ENSP00000344950 ENSP00000314311 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA -- GO:0030529 ribonucleoprotein complex
IEA --
About this table Antibodies for LARP7: Assays for LARP7:
Protein
Domains/ Families for LARP7(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q4G0J3 ProtoNet protein and cluster: Q4G0J3
1 Blocks protein family : IPB002344 Lupus La protein signature UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3 Similarity : Contains 1 HTH La-type RNA-binding domainSimilarity : Contains 1 RRM (RNA recognition motif) domain
Gene Function for LARP7
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_016648 Applied Biosystems Silencer ® siRNAs for LARP7 Sigma-Aldrich siRNA for LARP7 Sigma-Aldrich shRNA for LARP7 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015454                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015454                                  untagged cDNA clones in CMV expression vector (see all 5 ): AK000274  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016648 UniProtKB/Swiss-Prot: LARP7_HUMAN, Q4G0J3 Function : Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNPsystem. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) issequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequenttranscriptional elongation
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
IEA -- GO:0003723 RNA binding
IEA --
About this table
Pathways & Interactions for LARP7
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for LARP7 4 Interacting proteins for LARP7 (ENSP00000344950 3 Q4G0J3 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006396 RNA processing
IEA --
About this table
Drugs & Compounds for LARP7 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for LARP7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_016648 Sigma-Aldrich siRNA for LARP7 Sigma-Aldrich shRNA for LARP7 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015454 NM_016648
REFSEQ mRNAs for LARP7 gene (2 alternative transcripts): NM_015454.1 NM_016648.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015454 NM_016648
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015454                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015454                                  untagged cDNA clones in CMV expression vector (see all 5 ): AK000274  
Additional cDNA sequence: AF068284.1 AK000089.1 AK000274.1 AK225900.1 AL049996.1 BC006981.1 BC066945.1 BC107709.1 BX647100.1 EU667388.1
24/27 DOTS entries (see all 27
): DT.455967 DT.100826219 DT.95070005 DT.102833758 DT.102833759 DT.100826216 DT.95074509 DT.100826217 DT.121220526 DT.121220517 DT.40287376 DT.99998927 DT.101959098 DT.121220527 DT.91755773 DT.99976930 DT.100826221 DT.121220446 DT.424894 DT.121220493 DT.121220512 DT.86855559 DT.92001063 DT.97771568
24/246 AceView cDNA sequences (see all 246
):AI635804 BX107395 AI811605 AW339069 BU676360 AW614164 AI478927 AI655849 AV692449 CA419668 CA420422 CB122680 AV690220 AA741383 BM311174 BF593364 AI276533 AW172889 BU784632 AA046636 AI670112 AI004357 AW514049 BQ048930
highest scoring ESTs for LARP7 :AL049996 AI933958 AK000274 BC066945 BE748634 BX405367 BX647100 CA314598 CA416523 CA420422
Unigene Cluster for LARP7: La ribonucleoprotein domain family, member 7 Hs.713663 [show with all ESTs ] Unigene Representative Sequence: BC066945 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LARP7 (see all 6
) ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 SP1 :                         -                 SP2 :         -                                 SP3 :                                         SP4 :                                         SP5 :                                        
About this scheme ECgene alternative splicing isoforms for LARP7 4 Ensembl transcripts including schematic representations : ENST00000308878
ENST00000394568
ENST00000344442
ENST00000324052
Expression for LARP7
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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LARP7 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for LARP7 1 / 2 / 3
6 probe-sets matching LARP7 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GACACAAGCASOURCE GeneReport for Unigene cluster: Hs.713663
Orthologs for LARP7
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for LARP7 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for LARP7 ENSEMBL Gene Tree for LARP7 Paralogs for LARP7 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for LARP7 gene SSB 2
SNPs/Variants for LARP7 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for LARP7 (up to first 250kb)
Disorders & Mutations for LARP7
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 612026
Medical News for LARP7 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for LARP7 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for LARP7 gene (see all 15
): A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. (PubMed id 18249148) 2, 3, 4 He N....Zhou Q. (2008) LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. (PubMed id 18281698) 2, 3 Krueger B.J....Price D.H. (2008) The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. (PubMed id 18483487) 3, 4 Markert A.... Fischer U. (2008) Gene expression in early stage cervical cancer. (PubMed id 18191186) 2, 3 Biewenga P....Baas F. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008) 4 Han G.... Gu J. (2008) The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005) 4 Bechtel S....Schupp I. (2007) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 4 Olsen J.V....Mann M. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 4 Gerhard D.S....Malek J. (2004)
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Genome Databases showing LARP7
(According to
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ECgene ,
and/or
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(According to HUGE )
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Specialized Databases showing LARP7 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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