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LARP6 Gene

protein-coding GIFtS: 49

GC15M068911

La ribonucleoprotein domain family, member 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ACHN ^²
Acheron ^³
Achn ^³
FLJ11196 ^¹, ²
acheron ^¹, ²

Descriptions
La ribonucleoprotein domain family member 6 ^³
La ribonucleoprotein domain family, member 6 ^²
death-associated LA motif protein ^²

External Ids
HGNC: 24012¹
Entrez Gene: 55323²
UniProtKB: Q9BRS8³
Ensembl: ENSG00000166173⁷

Search outside databases for aliases for LARP6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LARP6 gene

Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q23

LARP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M068911: (about GC identifiers)

Start:	68,910,943 bp from pter
End:	68,933,552 bp from pter
Size:	22,610 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LARP6_HUMAN, Q9BRS8 (See protein sequence)

Recommended Name: La-related protein 6

Size: 491 amino acids; 54737 Da

Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm

Secondary accessions: Q8N3N2 Q9NUR0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_060827.2 NP_932062.1

ENSEMBL proteins:

ENSP00000299213 ENSP00000343869

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LARP6 )
	Human Recombinant Proteins from Abnova (LARP6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0030529	ribonucleoprotein complex	IEA	--

About this table

Antibodies for LARP6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LARP6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LARP6 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LARP6)
	Novus Biologicals Antibodies for LARP6

Assays for LARP6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BRS8

ProtoNet protein and cluster: Q9BRS8

1 Blocks protein family: IPB002344 Lupus La protein signature

UniProtKB/Swiss-Prot: LARP6_HUMAN, Q9BRS8

Similarity: Contains 1 HTH La-type RNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LARP6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LARP6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_197958

Applied Biosystems Silencer® siRNAs for LARP6

Sigma-Aldrich siRNA for LARP6

Sigma-Aldrich shRNA for LARP6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LARP6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_018357
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_018357
untagged cDNA clones in CMV expression vector (see all 2): NM_018357

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018357

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for LARP6

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006396	RNA processing	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LARP6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LARP6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LARP6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_197958

Sigma-Aldrich siRNA for LARP6

Sigma-Aldrich shRNA for LARP6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018357 NM_197958

REFSEQ mRNAs for LARP6 gene (2 alternative transcripts):

NM_018357.2 NM_197958.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018357 NM_197958

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_018357
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_018357
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018357

Additional cDNA sequence:

AF443828.1 AF443829.1 AK002058.1 AK130092.1 AL833876.1 BC006082.1 BC009446.1 BC014018.2

BC039153.1 CR592697.1

12 DOTS entries:

DT.114978 DT.121037236 DT.65285913 DT.121037219 DT.100760375 DT.95153114 DT.100760371 DT.100760376

DT.121037212 DT.91750832 DT.100668393 DT.95083472

24/155 AceView cDNA sequences (see all 155 ):

AI344651 BC014018 AI951514 AW270834 BX105798 CR592697 AI817444 BU727388

AA906881 AK130092 T32975 BC009446 CA449315 AI805067 NM_197958 AI560444

AI968173 CA314151 NM_018357 BQ688985 BM547272 AI022341 BP373249 BU145475

highest scoring ESTs for LARP6:

AF443828 AF443829 AI244015 AI376944 AI968173 AK002058 AL833876 AU138018 AW270834 AW410501

Unigene Cluster for LARP6:

La ribonucleoprotein domain family, member 6

Hs.416755 [show with all ESTs]

Unigene Representative Sequence: NM_018357

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for LARP6

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c
SP1:									-		-		-		-
SP2:									-		-		-		-
SP3:											-		-		-
SP4:									-		-
SP5:									-

About this scheme

ECgene alternative splicing isoforms for LARP6

2 Ensembl transcripts including schematic representations:

ENST00000299213 ENST00000344870

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LARP6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LARP6

¹ / ² / ³

6 probe-sets matching LARP6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53962_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.28	AI376944	0.80	1.00	0.91	1
81476_at²^{, 3}	U95-E	1	0.69	1.00	0.96	0.75	AI247437	0.60	1.00	0.82	1
218651_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018357	0.60	1.00	0.82	1
236565_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF792126	0.80	1.00	0.91	1
218651_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236565_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LARP6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGTCTTGTA

SOURCE GeneReport for Unigene cluster: Hs.416755
UniProtKB/Swiss-Prot: LARP6_HUMAN, Q9BRS8
Tissue specificity: Expressed in numerous tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LARP6 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LARP6¹	--	La ribonucleoprotein domain family, member 6	87.49(n) 93.71(a)	487625 XM_544750.2 XP_544750.2
chimpanzee (Pan troglodytes)	LARP6¹	--	La ribonucleoprotein domain family, member 6	99.59(n) 100(a)	453549 XM_510512.2 XP_510512.2
cow (Bos taurus)	LARP6¹	--	La ribonucleoprotein domain family, member 6	86.92(n) 91.16(a)	787569 XM_001254925.1 XP_001254926.1
rat (Rattus norvegicus)	Larp6¹	--	La ribonucleoprotein domain family, member 6	85.88(n) 89.82(a)	315731 XM_236338.4 XP_236338.4
mouse (Mus musculus)	Larp6^{1, 5}	9⁵	La ribonucleoprotein domain family, member 6^{1, 5}	86.76(n)¹ 91.24(a)¹	67557¹ NM_026235.3¹ NP_080511.2¹ AI552438⁵ AI854845⁵ (see all 12)

About this table Species with no ortholog for LARP6

ENSEMBL Gene Tree for LARP6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/90 NCBI SNPs in LARP6 are shown (see all 90 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3809562^1,2	A,C,F,H	68935462(-)	`TGAGAT/CGAATG`	2	--	ng3¹		4	EU EA WA	420
	rs3809563^1,2	H	68935330(-)	`AGGCAT/CGGTGG`	2	--	ng3¹		4	EU EA WA	418
	rs1549317^1,2	A,C,F,H,O	68912258(+)	`GTCCCA/GAAAAG`	1	F/F	syn¹		21	NA EA MN EU WA	3316
	rs3825970^1,2	A,C,F,H	68912147(+)	`ATGGCA/GCACTC`	1	C/C	syn¹ ese³		9	EA NA EU WA	2092
	rs28676469^1,2	C,F	68912393(+)	`TTGGGG/AAACAG`	1	F/F	syn¹ ese³		1	NA	70
	rs7180700^1,2	A,C,F,H	68923992(+)	`tgtctC/Taaagt`	1	--	int¹		7	EU EA WA NA	534
	rs7176104^1,2	A,C,F,H	68917746(+)	`ccagaA/Ggagtg`	1	--	int¹		12	EU EA WA NA	1054
	rs4776529^1,2	A,C,F,H	68916835(+)	`GCGCTC/TTGCCA`	1	--	int¹		3	EA WA	294
	rs11635165^1,2	A,C,F,H	68926760(+)	`CAGTGC/TTGAAt`	1	--	int¹		4	EU EA WA	418
	rs7175862^1,2	A,C,F,H	68932042(+)	`TACTTG/AGCACA`	2	--	int¹		8	EU EA WA NA	774

About this table

HapMap Linkage Disequilibrium images for LARP6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611300

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for LARP6 gene:

Acheron, a novel member of the Lupus antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. (PubMed id 17383118)^{3, 4} Valavanis C.... Schwartz L.M. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55323	HGNC: 24012	AceView: FLJ11196	Ensembl:ENSG00000166173	euGenes: HUgn55323
ECgene: LARP6	H-InvDB: LARP6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LARP6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LARP6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LARP6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LARP6		Antibodies for LARP6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LARP6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LARP6)
	Antibodies (LARP6)
	Chimera RNAi (LARP6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for LARP6

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Antibodies for LARP6

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LARP6 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for LARP6

Summaries
for LARP6

Genomic Location
for LARP6

Proteins
for LARP6

Protein Domains/
Families
for LARP6

Gene Function
for LARP6

Pathways & Interactions
for LARP6

Drugs & Compounds
for LARP6

Transcripts
for LARP6

Expression
for LARP6

Orthologs
for LARP6

Paralogs
for LARP6

SNPs/Variants
for LARP6

Disorders & Mutations
for LARP6

Medical News
for LARP6

Publications
for LARP6

Search for LARP6

Genome Databases showing LARP6

Other Databases showing LARP6

Specialized Databases showing LARP6

Licensable Technologies
for LARP6

Services
for LARP6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LARP6 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor LARP6

Summariesfor LARP6

Genomic Locationfor LARP6

Proteinsfor LARP6

Protein Domains/Familiesfor LARP6

Gene Functionfor LARP6

Pathways & Interactionsfor LARP6

Drugs & Compoundsfor LARP6

Transcriptsfor LARP6

Expression for LARP6

Orthologsfor LARP6

Paralogsfor LARP6

SNPs/Variantsfor LARP6

Disorders & Mutationsfor LARP6

Medical Newsfor LARP6

Publicationsfor LARP6

Search for LARP6

Genome Databases showing LARP6

Other Databases showing LARP6

Specialized Databases showing LARP6

Licensable Technologiesfor LARP6

Servicesfor LARP6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LARP6

Summaries
for LARP6

Genomic Location
for LARP6

Proteins
for LARP6

Protein Domains/
Families
for LARP6

Gene Function
for LARP6

Pathways & Interactions
for LARP6

Drugs & Compounds
for LARP6

Transcripts
for LARP6

Expression
for LARP6

Orthologs
for LARP6

Paralogs
for LARP6

SNPs/Variants
for LARP6

Disorders & Mutations
for LARP6

Medical News
for LARP6

Publications
for LARP6

Licensable Technologies
for LARP6

Services
for LARP6