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LARP5 Gene

protein-coding GIFtS: 50

GC10M000850

La ribonucleoprotein domain family, member 5
(Previous name: KIAA0217 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: KIAA0217)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686M23113 ^²
KIAA0217 ^¹, ², ³
OTTHUMP00000018944 ^²
OTTHUMP00000044554 ^²

Descriptions
La ribonucleoprotein domain family member 5 ^³
La ribonucleoprotein domain family, member 5 ^²

External Ids
HGNC: 28987¹
Entrez Gene: 23185²
UniProtKB: Q92615³
Ensembl: ENSG00000107929⁷

Search outside databases for aliases for LARP5 gene

Previous GC identifer: GC10M000849

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LARP5 gene

Entrez Gene cytogenetic band: 10p15.3 Ensembl cytogenetic band: 10p15.3 HGNC cytogenetic band: 10p15.3

LARP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M000850: (about GC identifiers)

Start:	845,484 bp from pter
End:	967,440 bp from pter
Size:	121,957 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_077567.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LARP5_HUMAN, Q92615 (See protein sequence)

Recommended Name: La-related protein 5

Size: 738 amino acids; 80552 Da

Secondary accessions: Q5T3R3 Q5T3R4 Q5T3R5 Q68CY4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055970.1

ENSEMBL proteins:

ENSP00000385229 ENSP00000326128 ENSP00000263154

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for LARP5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LARP5

Assays for LARP5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92615

ProtoNet protein and cluster: Q92615

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: LARP5_HUMAN, Q92615

Similarity: Contains 1 HTH La-type RNA-binding domain

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LARP5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LARP5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_040265

Applied Biosystems Silencer® siRNAs for LARP5

Sigma-Aldrich siRNA for LARP5

Sigma-Aldrich shRNA for LARP5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LARP5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015155
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015155
untagged cDNA clones in CMV expression vector (see all 2): NM_015155

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015155

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for LARP5 (ENSP00000263154³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	ENSP00000374249³	STRING (score=.852)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LARP5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LARP5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LARP5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_040265

Sigma-Aldrich siRNA for LARP5

Sigma-Aldrich shRNA for LARP5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015155

REFSEQ mRNAs for LARP5 gene:

NM_015155.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015155

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015155
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015155
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015155

Additional cDNA sequence:

AK292946.1 BC003381.1 BC131630.1 BC152443.1 CR749653.1 D86971.2

15 DOTS entries:

DT.450001 DT.100793637 DT.75105539 DT.95292078 DT.92440885 DT.121294840 DT.91673242 DT.424824

DT.99946189 DT.100793635 DT.121294839 DT.92440883 DT.95123716 DT.97802714 DT.95094879

24/507 AceView cDNA sequences (see all 507 ):

CA945197 AI368725 AA491206 AI401153 CD364333 CA314397 BU189519 AI824551

BQ446962 BM699568 BQ001367 CN483402 AA130763 AI299649 BQ009242 AI859753

CR599351 AV656406 AI659259 CA449587 BC003381 BM997689 BX336908 AU117763

highest scoring ESTs for LARP5:

D86971 AA255606 AA258240 AA262432 AA262697 AA279974 AA280210 AA281097 AA426094 AA481411

Unigene Cluster for LARP5:

La ribonucleoprotein domain family, member 5

Hs.681734 [show with all ESTs]

Unigene Representative Sequence: CR749653

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LARP5 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13a	·	13b	·	13c
SP1:
SP2:
SP3:
SP4:
SP5:																																							-

About this scheme

ECgene alternative splicing isoforms for LARP5

3 Ensembl transcripts including schematic representations:

ENST00000406525 ENST00000316157 ENST00000263154

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LARP5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LARP5

¹ / ² / ³

9 probe-sets matching LARP5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32586_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D86971	1.00	1.00	1.00	1
214216_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW628686	0.80	1.00	0.91	1
208954_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003381	0.60	1.00	0.82	1
208952_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA811923	0.20	1.00	0.72	1
208953_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU154358	0.60	1.00	0.82	1
214216_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208954_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208952_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208953_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAACTATTG

SOURCE GeneReport for Unigene cluster: Hs.681734
Expression variation in blood from EXPOLDB for LARP5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LARP5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LARP5¹	--	La ribonucleoprotein domain family, member 5	99.5(n) 99.32(a)	450259 XM_001137242.1 XP_001137242.1
cow (Bos taurus)	LARP5¹	--	La ribonucleoprotein domain family, member 5	82.3(n) 83.22(a)	505723 XM_582060.3 XP_582060.3
rat (Rattus norvegicus)	Larp5¹	--	La ribonucleoprotein domain family, member 5	86.93(n) 89.15(a)	307070 XM_225526.4 XP_225526.4
mouse (Mus musculus)	Larp5^{1, 5}	13 (5.00 cM)⁵	La ribonucleoprotein domain family, member 5^{1, 5}	86.99(n)¹ 88.08(a)¹	217980¹ NM_172585.2¹ NP_766173.1¹ AA409804⁵ AI256361⁵ (see all 21)
chicken (Gallus gallus)	LARP5¹	--	La ribonucleoprotein domain family, member 5	75.48(n) 77.76(a)	420457 XM_418559.2 XP_418559.2

About this table Species with no ortholog for LARP5

ENSEMBL Gene Tree for LARP5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LARP5 gene

LARP4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/373 NCBI SNPs in LARP5 are shown (see all 373 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 158)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4229^1,2	A,C,F,H,O	846918(+)	`GATTTA/TAATTA`	1	--	ut3¹ ese³		17	MN EU EA WA NA	1712
	rs2892159^1,2	A,C,F,H	845061(+)	`GCCCCG/ACCTCC`	1	--	ng5¹		4	EU EA WA	406
	rs9124^1,2	A,C,F,H	848022(-)	`TGTCCG/ATGTTC`	1	--	ut3¹ ese³		10	MN EA NA EU WA	1004
	rs7703^1,2	A,C,F,H	848394(-)	`GCCTCG/ATAGAG`	1	--	ut3¹ ese³		6	MN EU EA WA	788
	rs11816921^1,2	C,F,H	847151(+)	`AAAATA/GATATT`	1	--	ut3¹		4	EU EA WA	420
	rs11253452^1,2	C,F,H	848033(+)	`GAAATG/ATGCAC`	1	--	ut3¹ ese³		4	EU EA WA	410
	rs17293531^1,2	C,F,H	848207(+)	`AGCTGG/ATTACT`	1	--	ut3¹		7	NA EU EA WA	560
	rs10795298^1,2	C,F,H	846325(+)	`AGCAAG/CGTTTC`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs17159943^1,2	F,H	848541(+)	`AGCTTG/CCATTC`	1	--	ut3¹ ese³		7	NA EU EA WA	554
	rs12261693^1,2	H	923061(+)	`gtgacT/Caccag`	1	--	ng3¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for LARP5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/14 PubMed articles for LARP5 gene (see all 14 ):

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{2, 3, 4} Nagase T....Nomura N. (1996)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)⁴ Imami K.... Ishihama Y. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23185	HGNC: 28987	AceView: KIAA0217	Ensembl:ENSG00000107929	euGenes: HUgn23185
ECgene: LARP5	H-InvDB: LARP5

(According to HUGE)
About This Section

HUGE: KIAA0217

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LARP5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LARP5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LARP5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LARP5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LARP5		Browse small molecules at Sigma-Aldrich
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LARP5 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for LARP5

Summaries
for LARP5

Genomic Location
for LARP5

Proteins
for LARP5

Protein Domains/
Families
for LARP5

Gene Function
for LARP5

Pathways & Interactions
for LARP5

Drugs & Compounds
for LARP5

Transcripts
for LARP5

Expression
for LARP5

Orthologs
for LARP5

Paralogs
for LARP5

SNPs/Variants
for LARP5

Disorders & Mutations
for LARP5

Medical News
for LARP5

Publications
for LARP5

Search for LARP5

Genome Databases showing LARP5

Other Databases showing LARP5

Specialized Databases showing LARP5

Licensable Technologies
for LARP5

Services
for LARP5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LARP5 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor LARP5

Summariesfor LARP5

Genomic Locationfor LARP5

Proteinsfor LARP5

Protein Domains/Familiesfor LARP5

Gene Functionfor LARP5

Pathways & Interactionsfor LARP5

Drugs & Compoundsfor LARP5

Transcriptsfor LARP5

Expression for LARP5

Orthologsfor LARP5

Paralogsfor LARP5

SNPs/Variantsfor LARP5

Disorders & Mutationsfor LARP5

Medical Newsfor LARP5

Publicationsfor LARP5

Search for LARP5

Genome Databases showing LARP5

Other Databases showing LARP5

Specialized Databases showing LARP5

Licensable Technologiesfor LARP5

Servicesfor LARP5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LARP5

Summaries
for LARP5

Genomic Location
for LARP5

Proteins
for LARP5

Protein Domains/
Families
for LARP5

Gene Function
for LARP5

Pathways & Interactions
for LARP5

Drugs & Compounds
for LARP5

Transcripts
for LARP5

Expression
for LARP5

Orthologs
for LARP5

Paralogs
for LARP5

SNPs/Variants
for LARP5

Disorders & Mutations
for LARP5

Medical News
for LARP5

Publications
for LARP5

Licensable Technologies
for LARP5

Services
for LARP5