V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

LARP4 Gene

protein-coding   GIFtS: 49

GC12P049082
La ribonucleoprotein domain family, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp686E039 2
MGC74631 2
PP13296 1, 2
Descriptions
La ribonucleoprotein domain family member 4 3
La ribonucleoprotein domain family, member 4 2
c-Mpl binding protein 2
External Ids
HGNC: 243201
Entrez Gene: 1132512
UniProtKB: Q71RC23
Ensembl: ENSG000001618137
Search outside databases for aliases for LARP4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for LARP4
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LARP4 gene  

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.12

LARP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049082:     (about GC identifiers)

Start:
49,080,917 bp from pter
End:
49,160,055 bp from pter
Size:
79,139 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LARP4_HUMAN, Q71RC2 (See protein sequence)
Recommended Name: La-related protein 4  
Size: 724 amino acids; 80596 Da
Sequence caution: Sequence=BAC86052.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
PDB structures from and Proteopedia :
2CQK (3D)    
Secondary accessions: A8K6T1 Q5CZ97 Q6ZV14 Q96NF9
Alternative splicing: 4 isoforms:  Q71RC2-1   Q71RC2-2   Q71RC2-3   Q71RC2-4   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_443111.3  NP_954658.1  NP_954660.1  


    ENSEMBL proteins: 
    ENSP00000293618 ENSP00000381482 ENSP00000340901 ENSP00000344664 ENSP00000381490 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LARP4)
    Human Recombinant Proteins from Abnova (LARP4)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for LARP4: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LARP4
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LARP4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LARP4)
    Novus Biologicals Antibodies for LARP4

    Assays for LARP4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR006630 Lupus_La_RNA_bd
     IPR011991 Wing_hlx_DNA_bd
     IPR000504 RRM_RNP1


       GeneDecks  LARP4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q71RC2

    ProtoNet protein and cluster: Q71RC2

    UniProtKB/Swiss-Prot: LARP4_HUMAN, Q71RC2
    Similarity: Contains 1 HTH La-type RNA-binding domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LARP4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LARP4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_199190

                  Applied Biosystems Silencer® siRNAs for LARP4

                  Sigma-Aldrich siRNA for LARP4  
                         Sigma-Aldrich shRNA for LARP4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LARP4
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_052879
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_052879
                                     untagged cDNA clones in CMV expression vector (see all 4): AL832198 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_199188

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LARP4

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LARP4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LARP4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_199190

                  Sigma-Aldrich siRNA for LARP4  
                         Sigma-Aldrich shRNA for LARP4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_052879  NM_199188  NM_199190  

    REFSEQ mRNAs for LARP4 gene (3 alternative transcripts): 

    NM_052879.3   NM_199188.1   NM_199190.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_052879  NM_199188  NM_199190  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_052879
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_052879
                                     untagged cDNA clones in CMV expression vector (see all 4): AL832198 

    Additional cDNA sequence: 

    AF131755.1 AF370416.1 AK055521.1 AK125113.1 AK291746.1 AL050205.1 AL832198.1 AL833272.1 
    AY004310.1 BC017395.1 BC022377.1 BC032444.2 BC063479.1 BX647457.1 CR936626.1 

    12 DOTS entries:

    DT.446301  DT.97794300  DT.91762940  DT.101984628  DT.91979480  DT.91957330  DT.310491  DT.100739023 
    DT.100789960  DT.92414397  DT.92066168  DT.309208 

    24/277 AceView cDNA sequences (see all 277 ):

    AI635518 BM468853 BC022377 NM_199190 AI379558 BQ186310 AW614937 BM465910 
    R83608 BC032444 AI168148 NM_199188 BM454808 AA236079 AI360645 AI275480 
    BQ435023 AA954726 AW611857 BQ431746 BM977672 N29797 Z40209 AI239476 

    highest scoring ESTs for LARP4:

    AL043283 AL050205 AA194139 AA194141 AA210698 AA235371 AA236010 AA282284 AA329334 AA333290 

    Unigene Cluster for LARP4:

    La ribonucleoprotein domain family, member 4
    Hs.26613  [show with all ESTs]
    Unigene Representative Sequence: NM_199188


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LARP4 (see all 7 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                                                      -                 -                                             
    SP2:                          -                 -                                         -     -           -                                             
    SP3:                          -                 -                                         -     -                 -                                       
    SP4:                                            -                                         -                                                               
    SP5:                          -                 -                                         -                                                               

    About this scheme

    ECgene alternative splicing isoforms for LARP4

    5 Ensembl transcripts including schematic representations:
    ENST00000293618  ENST00000398464  ENST00000347328  ENST00000341915  ENST00000398473  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LARP4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LARP4

    1 / 2 / 3

    13 probe-sets matching LARP4 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    35180_at2, 3 U95-A 1 1.00 1.00 0.58 1.38 AL050205 1.00 1.00 1.00 1
    59320_at2, 3 U95-C 1 1.00 1.00 0.68 1.04 AL043283 1.00 1.00 1.00 1
    75858_at2, 3 U95-E 2 1.00 0.88 0.73 0.87 AA210698 0.80 1.00 0.91 1

    82254_at2, 3 U95-E 3 1.00 0.88 0.89 0.73 AI082828 0.80 1.00 0.91 1

    214155_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI743740 0.80 1.00 0.91 1

    212714_at2, 3 U133-A 1 1.00 1.00 -- -- AL050205 1.00 1.00 1.00 1

    238959_at2, 3 U133-B 2 1.00 0.95 -- -- AI082828 0.80 1.00 0.91 1

    238960_s_at2, 3 U133-B 2 1.00 0.86 -- -- AI082828 0.80 1.00 0.91 1

    214155_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    212714_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    238959_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --

    238960_s_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --

    1555384_a_at2 U133Plus2 2 1.00 0.82 -- -- -- -- -- -- --
    GeneDecks  LARP4 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CATAAAATGT

    SOURCE GeneReport for Unigene cluster: Hs.26613
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for LARP4 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LARP41   -- La ribonucleoprotein domain family, member 4 92.57(n)
    90.11(a)
    477609  XM_534803.2  XP_534803.2 
    chimpanzee
    (Pan troglodytes)
    LARP41   -- La ribonucleoprotein domain family, member 4 99.63(n)
    99.18(a)
    452428  XM_001153518.1  XP_001153518.1 
    cow
    (Bos taurus)
    LARP41   -- La ribonucleoprotein domain family, member 4 91.41(n)
    89.2(a)
    539286  XM_882245.2  XP_887338.2 
    mouse
    (Mus musculus)
    Larp41, 5 155
    La ribonucleoprotein domain family, member 41, 5 86.63(n)1
    84.68(a)1
    2072141  NM_001024526.21  NP_001019697.21 
     AA4128495  AA4163355  (see all 29)
    chicken
    (Gallus gallus)
    LARP41   -- La ribonucleoprotein domain family, member 4 73.19(n)
    71.97(a)
    426876  NM_001012700.1  NP_001012718.1 
    About this table        Species with no ortholog for LARP4

    ENSEMBL Gene Tree for LARP4
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LARP4 gene
    LARP52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/368 NCBI SNPs in LARP4 are shown (see all 368 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 77)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs42989821,2
    A,C,F,H49156696(-) TGACCG/TATGCA 3 -- ut31 ese39Minor allele frequency- T:0.44NA EU EA WA 736
    rs72962121,2
    A,C,F,H49079113(+) CACCTC/TGAGCC 3 -- ng518Minor allele frequency- T:0.45EU EA WA NA 782
    --
    rs47689361,2
    A,C,F,H49079534(+) ggctcA/Gctgca 3 -- ng514Minor allele frequency- G:0.00EU EA WA 412
    rs171247151,2
    C,F,H49147130(+) GGAGAA/CTAGGA 3 N/T mis17Minor allele frequency- C:0.01NA EU EA WA 548
    rs171247061,2
    C,F,H49134399(+) GGCTTT/AAATTC 3 L/F mis111Minor allele frequency- A:0.01NA EU EA WA 966
    rs73106861,2
    C,F,H49079220(+) GACCAG/CATTAG 3 -- ng514Minor allele frequency- C:0.02EU EA WA 408
    rs65807491,2
    C,F,H49080300(+) AGCGGA/TGACAT 3 -- ng517Minor allele frequency- T:0.03EU EA WA NA 560
    --
    rs44913311,2
    C,H49156412(-) TGATCT/CGCTTT 3 -- ut31 ese31Minor allele frequency- C:0.00EU 120
    rs116160541,2
    C,H49080857(+) TTTCCC/TTAGAC 3 -- ng514Minor allele frequency- T:0.00EU EA WA 416
    --
    rs122974921,2
    H49157390(+) GTTCTA/GTGTAA 3 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for LARP4 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for LARP4 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 113251 HGNC: 24320 AceView: LOC113251 Ensembl:ENSG00000161813 euGenes: HUgn113251
    ECgene: LARP4 H-InvDB: LARP4
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LARP4:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LARP4-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LARP4 Antibodies for LARP4
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LARP4 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (LARP4)
     Antibodies (LARP4)
     Chimera RNAi (LARP4)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (LARP4)
     Antibodies (LARP4)
     Search OriGene for LARP4
     Search Tocris compounds for LARP4




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LARP4

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    LARP4 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com