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Aliases for LARP4 Gene

Aliases for LARP4 Gene

  • La Ribonucleoprotein Domain Family Member 4 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 4 2
  • C-Mpl Binding Protein 3
  • La-Related Protein 4 3
  • PP13296 3

External Ids for LARP4 Gene

Previous GeneCards Identifiers for LARP4 Gene

  • GC12P049082
  • GC12P050794
  • GC12P047827

Summaries for LARP4 Gene

GeneCards Summary for LARP4 Gene

LARP4 (La Ribonucleoprotein Domain Family Member 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is LARP4B.

UniProtKB/Swiss-Prot for LARP4 Gene

  • RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

Gene Wiki entry for LARP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP4 Gene

Genomics for LARP4 Gene

Regulatory Elements for LARP4 Gene

Enhancers for LARP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G050571 1.4 Ensembl ENCODE dbSUPER 24.9 +181.6 181561 5.2 ELF3 MLX ARID4B RAD21 RFX5 YY1 MIXL1 DEK THAP11 CEBPB LARP4 DIP2B CERS5 SLC11A2 GC12P050634
GH12G050389 1 Ensembl ENCODE 27.9 -1.9 -1866 1.6 PKNOX1 TAF1 JUN RFX5 CTBP1 GATA3 GATA2 EED FOSL2 FOS LARP4 LIMA1 COX14 GC12P050366
GH12G050185 1.5 Ensembl ENCODE dbSUPER 14.5 -205.0 -204958 4.7 HDGF PKNOX1 FOXA2 GATA2 FOS ZHX2 JUNB TBX21 KAT8 RCOR2 CERS5 LARP4 ENSG00000257298 GC12M050176 GC12M050177
GH12G050612 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +225.4 225419 10.4 PKNOX1 ATF1 ZNF133 SIN3A GLI4 FEZF1 ZNF121 FOS ZNF263 YY2 LIMA1 ATF1 ENSG00000257298 TFCP2 DIP2B FAM186A LARP4 GC12P050634
GH12G050074 1.2 Ensembl ENCODE 13.5 -316.9 -316859 1.2 HDGF FOXA2 ZFP64 ARID4B ZNF2 ZNF48 YY1 SLC30A9 GLIS2 ZNF143 LARP4 SMARCD1 GC12P050064
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LARP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LARP4 Gene

Chromosome:
12
Start:
50,392,383 bp from pter
End:
50,480,005 bp from pter
Size:
87,623 bases
Orientation:
Plus strand

Genomic View for LARP4 Gene

Genes around LARP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP4 Gene

Proteins for LARP4 Gene

  • Protein details for LARP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RC2-LARP4_HUMAN
    Recommended name:
    La-related protein 4
    Protein Accession:
    Q71RC2
    Secondary Accessions:
    • A8K6T1
    • E9PDG5
    • G3XAA8
    • G5E976
    • Q5CZ97
    • Q6ZV14
    • Q96NF9

    Protein attributes for LARP4 Gene

    Size:
    724 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    • Interacts (via N-terminal region) with PABPC1 (PubMed:27615744, PubMed:21098120). Interacts with RACK1 (PubMed:21098120).
    SequenceCaution:
    • Sequence=BAC86052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP4 Gene

    Alternative splice isoforms for LARP4 Gene

neXtProt entry for LARP4 Gene

Post-translational modifications for LARP4 Gene

  • Ubiquitination at isoforms=2, 3, 4, 6, 7280 and posLast=372372
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP4 Gene

Domains & Families for LARP4 Gene

Gene Families for LARP4 Gene

Protein Domains for LARP4 Gene

Suggested Antigen Peptide Sequences for LARP4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LARP4: view

No data available for UniProtKB/Swiss-Prot for LARP4 Gene

Function for LARP4 Gene

Molecular function for LARP4 Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

Gene Ontology (GO) - Molecular Function for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 21098120
GO:0008143 poly(A) binding IDA 21098120
genes like me logo Genes that share ontologies with LARP4: view

Phenotypes for LARP4 Gene

genes like me logo Genes that share phenotypes with LARP4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP4 Gene

Localization for LARP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP4 Gene

Cytoplasmic granule. Cytoplasm, cytosol. Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment. {ECO:0000269 PubMed:21098120}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP4 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 21098120
GO:0005844 colocalizes_with polysome IDA 21098120
GO:0010494 colocalizes_with cytoplasmic stress granule IDA 21098120
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LARP4: view

Pathways & Interactions for LARP4 Gene

SuperPathways for LARP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0045727 positive regulation of translation IMP 21098120
genes like me logo Genes that share ontologies with LARP4: view

No data available for Pathways by source and SIGNOR curated interactions for LARP4 Gene

Drugs & Compounds for LARP4 Gene

No Compound Related Data Available

Transcripts for LARP4 Gene

Unigene Clusters for LARP4 Gene

La ribonucleoprotein domain family, member 4:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for LARP4 Gene

GeneLoc Exon Structure for
LARP4
ECgene alternative splicing isoforms for
LARP4

Expression for LARP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LARP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP4 Gene

This gene is overexpressed in Lung (30.0), Heart (22.3), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LARP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of LARP4 Gene:

LARP4

SOURCE GeneReport for Unigene cluster for LARP4 Gene:

Hs.26613

Evidence on tissue expression from TISSUES for LARP4 Gene

  • Bone marrow(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with LARP4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP4 Gene

Orthologs for LARP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LARP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP4 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia LARP4 34 35
  • 92.36 (n)
cow
(Bos Taurus)
Mammalia LARP4 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Larp4 34 16 35
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910299 34
  • 84.75 (n)
oppossum
(Monodelphis domestica)
Mammalia LARP4 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP4 34 35
  • 72.8 (n)
lizard
(Anolis carolinensis)
Reptilia LARP4 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp4 34
  • 66.43 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797570 34
  • 57.29 (n)
larp4ab 35
  • 47 (a)
OneToMany
larp4aa 35
  • 45 (a)
OneToMany
Dr.25940 34
fruit fly
(Drosophila melanogaster)
Insecta CG11505 35
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-5 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10553 35
  • 18 (a)
OneToMany
Species where no ortholog for LARP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP4 Gene

ENSEMBL:
Gene Tree for LARP4 (if available)
TreeFam:
Gene Tree for LARP4 (if available)

Paralogs for LARP4 Gene

Paralogs for LARP4 Gene

Pseudogenes.org Pseudogenes for LARP4 Gene

genes like me logo Genes that share paralogs with LARP4: view

Variants for LARP4 Gene

Sequence variations from dbSNP and Humsavar for LARP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000003071 -- 50,416,217(+) TAAAG(G/T)TTATA intron-variant
rs1000018827 -- 50,469,459(+) ATTAG(C/T)CAGGC intron-variant
rs1000048544 -- 50,469,754(+) AAATA(G/T)AAAAA intron-variant
rs1000051031 -- 50,439,508(+) AGCAG(C/T)CCTCC intron-variant
rs1000074919 -- 50,423,332(+) ATTTA(A/C)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LARP4 Gene

Variant ID Type Subtype PubMed ID
dgv1498n100 CNV gain 25217958
dgv1499n100 CNV gain 25217958
esv2745871 CNV deletion 23290073
esv2761738 CNV gain 21179565
esv3629481 CNV loss 21293372
nsv1122732 CNV deletion 24896259
nsv1134229 CNV deletion 24896259
nsv1144624 CNV deletion 24896259
nsv469376 CNV loss 19166990
nsv470291 CNV gain 18288195
nsv558841 CNV loss 21841781
nsv973063 CNV duplication 23825009
nsv973064 CNV duplication 23825009

Variation tolerance for LARP4 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LARP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP4 Gene

Disorders for LARP4 Gene

Relevant External Links for LARP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LARP4

No disorders were found for LARP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP4 Gene

Publications for LARP4 Gene

  1. La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. (PMID: 21098120) Yang R. … Maraia R.J. (Mol. Cell. Biol. 2011) 3 4 64
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for LARP4 Gene

Sources for LARP4 Gene

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