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Aliases for LARP4 Gene

Aliases for LARP4 Gene

  • La Ribonucleoprotein Domain Family, Member 4 2 3
  • La Ribonucleoprotein Domain Family Member 4 4
  • C-Mpl Binding Protein 3
  • PP13296 3

External Ids for LARP4 Gene

Previous GeneCards Identifiers for LARP4 Gene

  • GC12P049082
  • GC12P050794
  • GC12P047827

Summaries for LARP4 Gene

GeneCards Summary for LARP4 Gene

LARP4 (La Ribonucleoprotein Domain Family, Member 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is LARP4B.

UniProtKB/Swiss-Prot for LARP4 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Wiki entry for LARP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP4 Gene

Genomics for LARP4 Gene

Regulatory Elements for LARP4 Gene

Genomic Location for LARP4 Gene

Chromosome:
12
Start:
50,392,383 bp from pter
End:
50,480,005 bp from pter
Size:
87,623 bases
Orientation:
Plus strand

Genomic View for LARP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LARP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP4 Gene

Proteins for LARP4 Gene

  • Protein details for LARP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RC2-LARP4_HUMAN
    Recommended name:
    La-related protein 4
    Protein Accession:
    Q71RC2
    Secondary Accessions:
    • A8K6T1
    • E9PDG5
    • G3XAA8
    • G5E976
    • Q5CZ97
    • Q6ZV14
    • Q96NF9

    Protein attributes for LARP4 Gene

    Size:
    724 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP4 Gene

    Alternative splice isoforms for LARP4 Gene

neXtProt entry for LARP4 Gene

Proteomics data for LARP4 Gene at MOPED

Post-translational modifications for LARP4 Gene

  • Ubiquitination at Lys 280 and Lys 372
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP4 Gene

Domains & Families for LARP4 Gene

Gene Families for LARP4 Gene

Protein Domains for LARP4 Gene

Suggested Antigen Peptide Sequences for LARP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q71RC2

UniProtKB/Swiss-Prot:

LARP4_HUMAN :
  • Contains 1 HTH La-type RNA-binding domain.
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with LARP4: view

Function for LARP4 Gene

Molecular function for LARP4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LARP4: view

Phenotypes for LARP4 Gene

GenomeRNAi human phenotypes for LARP4:
genes like me logo Genes that share phenotypes with LARP4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LARP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP4 Gene

Localization for LARP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LARP4 Gene COMPARTMENTS Subcellular localization image for LARP4 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LARP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LARP4 Gene

Pathways & Interactions for LARP4 Gene

SuperPathways for LARP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with LARP4: view

No data available for Pathways by source and SIGNOR curated interactions for LARP4 Gene

Drugs & Compounds for LARP4 Gene

No Compound Related Data Available

Transcripts for LARP4 Gene

Unigene Clusters for LARP4 Gene

La ribonucleoprotein domain family, member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LARP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for LARP4 Gene

GeneLoc Exon Structure for
LARP4
ECgene alternative splicing isoforms for
LARP4

Expression for LARP4 Gene

mRNA expression in normal human tissues for LARP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP4 Gene

This gene is overexpressed in Lung (30.0), Heart (22.3), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LARP4 Gene



SOURCE GeneReport for Unigene cluster for LARP4 Gene Hs.26613

genes like me logo Genes that share expression patterns with LARP4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LARP4 Gene

Orthologs for LARP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LARP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LARP4 35
  • 91.41 (n)
  • 89.2 (a)
LARP4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LARP4 35
  • 92.36 (n)
  • 89.86 (a)
LARP4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Larp4 35
  • 86.65 (n)
  • 84.7 (a)
Larp4 16
Larp4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LARP4 35
  • 99.63 (n)
  • 99.17 (a)
LARP4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910299 35
  • 84.75 (n)
  • 79.08 (a)
oppossum
(Monodelphis domestica)
Mammalia LARP4 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP4 35
  • 72.8 (n)
  • 71.53 (a)
LARP4 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP4 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp4 35
  • 66.43 (n)
  • 61.1 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.25940 35
LOC797570 35
  • 57.29 (n)
  • 53.94 (a)
larp4aa 36
  • 45 (a)
OneToMany
larp4ab 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11505 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-5 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10553 36
  • 18 (a)
OneToMany
Species with no ortholog for LARP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP4 Gene

ENSEMBL:
Gene Tree for LARP4 (if available)
TreeFam:
Gene Tree for LARP4 (if available)

Paralogs for LARP4 Gene

Paralogs for LARP4 Gene

Pseudogenes.org Pseudogenes for LARP4 Gene

genes like me logo Genes that share paralogs with LARP4: view

Variants for LARP4 Gene

Sequence variations from dbSNP and Humsavar for LARP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1063078 -- 50,473,491(+) ACTCA(A/G)TATGA reference, missense, intron-variant
rs1132935 -- 50,476,136(+) TTTTT(G/T)GTTTT utr-variant-3-prime
rs1132936 -- 50,476,137(+) TTTTG(G/T)TTTTA utr-variant-3-prime
rs1132937 -- 50,476,142(+) GTTTT(A/T)ATTTG utr-variant-3-prime
rs1139997 -- 50,473,516(+) TGTGC(A/T)GCTGA synonymous-codon, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LARP4 Gene

Variant ID Type Subtype PubMed ID
nsv899075 CNV Gain 21882294
nsv899076 CNV Loss 21882294
nsv469376 CNV Loss 19166990
nsv470291 CNV Gain 18288195
esv2745871 CNV Deletion 23290073

Variation tolerance for LARP4 Gene

Residual Variation Intolerance Score: 18.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LARP4 Gene

HapMap Linkage Disequilibrium report
LARP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP4 Gene

Disorders for LARP4 Gene

Relevant External Links for LARP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LARP4
genes like me logo Genes that share disorders with LARP4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP4 Gene

Publications for LARP4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for LARP4 Gene

Sources for LARP4 Gene

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