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Aliases for LARP4 Gene

Aliases for LARP4 Gene

  • La Ribonucleoprotein Domain Family Member 4 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 4 2
  • C-Mpl Binding Protein 3
  • La-Related Protein 4 3
  • PP13296 3

External Ids for LARP4 Gene

Previous GeneCards Identifiers for LARP4 Gene

  • GC12P049082
  • GC12P050794
  • GC12P047827

Summaries for LARP4 Gene

GeneCards Summary for LARP4 Gene

LARP4 (La Ribonucleoprotein Domain Family Member 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is LARP4B.

UniProtKB/Swiss-Prot for LARP4 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Wiki entry for LARP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP4 Gene

Genomics for LARP4 Gene

Regulatory Elements for LARP4 Gene

Enhancers for LARP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LARP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LARP4 Gene

Chromosome:
12
Start:
50,392,383 bp from pter
End:
50,480,005 bp from pter
Size:
87,623 bases
Orientation:
Plus strand

Genomic View for LARP4 Gene

Genes around LARP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP4 Gene

Proteins for LARP4 Gene

  • Protein details for LARP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RC2-LARP4_HUMAN
    Recommended name:
    La-related protein 4
    Protein Accession:
    Q71RC2
    Secondary Accessions:
    • A8K6T1
    • E9PDG5
    • G3XAA8
    • G5E976
    • Q5CZ97
    • Q6ZV14
    • Q96NF9

    Protein attributes for LARP4 Gene

    Size:
    724 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP4 Gene

    Alternative splice isoforms for LARP4 Gene

neXtProt entry for LARP4 Gene

Post-translational modifications for LARP4 Gene

  • Ubiquitination at Lys 280 and Lys 372
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP4 Gene

Domains & Families for LARP4 Gene

Gene Families for LARP4 Gene

Protein Domains for LARP4 Gene

Suggested Antigen Peptide Sequences for LARP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q71RC2

UniProtKB/Swiss-Prot:

LARP4_HUMAN :
  • Contains 1 HTH La-type RNA-binding domain.
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with LARP4: view

Function for LARP4 Gene

Molecular function for LARP4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LARP4: view

Phenotypes for LARP4 Gene

genes like me logo Genes that share phenotypes with LARP4: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP4 Gene

Localization for LARP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LARP4 Gene COMPARTMENTS Subcellular localization image for LARP4 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LARP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LARP4 Gene

Pathways & Interactions for LARP4 Gene

SuperPathways for LARP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with LARP4: view

No data available for Pathways by source and SIGNOR curated interactions for LARP4 Gene

Drugs & Compounds for LARP4 Gene

No Compound Related Data Available

Transcripts for LARP4 Gene

Unigene Clusters for LARP4 Gene

La ribonucleoprotein domain family, member 4:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for LARP4 Gene

GeneLoc Exon Structure for
LARP4
ECgene alternative splicing isoforms for
LARP4

Expression for LARP4 Gene

mRNA expression in normal human tissues for LARP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP4 Gene

This gene is overexpressed in Lung (30.0), Heart (22.3), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LARP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of LARP4 Gene:

LARP4

SOURCE GeneReport for Unigene cluster for LARP4 Gene:

Hs.26613
genes like me logo Genes that share expression patterns with LARP4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LARP4 Gene

Orthologs for LARP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LARP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LARP4 34
  • 91.41 (n)
  • 89.2 (a)
LARP4 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LARP4 34
  • 92.36 (n)
  • 89.86 (a)
LARP4 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Larp4 34
  • 86.65 (n)
  • 84.7 (a)
Larp4 16
Larp4 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LARP4 34
  • 99.63 (n)
  • 99.17 (a)
LARP4 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910299 34
  • 84.75 (n)
  • 79.08 (a)
oppossum
(Monodelphis domestica)
Mammalia LARP4 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP4 34
  • 72.8 (n)
  • 71.53 (a)
LARP4 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP4 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp4 34
  • 66.43 (n)
  • 61.1 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.25940 34
LOC797570 34
  • 57.29 (n)
  • 53.94 (a)
larp4aa 35
  • 45 (a)
OneToMany
larp4ab 35
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11505 35
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-5 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10553 35
  • 18 (a)
OneToMany
Species where no ortholog for LARP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP4 Gene

ENSEMBL:
Gene Tree for LARP4 (if available)
TreeFam:
Gene Tree for LARP4 (if available)

Paralogs for LARP4 Gene

Paralogs for LARP4 Gene

Pseudogenes.org Pseudogenes for LARP4 Gene

genes like me logo Genes that share paralogs with LARP4: view

Variants for LARP4 Gene

Sequence variations from dbSNP and Humsavar for LARP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17124706 - 50,454,349(+) GGCTT(A/T)AATTC nc-transcript-variant, reference, missense
rs17124715 - 50,467,080(+) GGAGA(A/C)TAGGA intron-variant, reference, missense
rs7301142 -- 50,409,808(+) ttatt(A/T)ttttt intron-variant
rs7302222 -- 50,427,357(+) AGCAG(C/T)ATTTC intron-variant
rs7304017 -- 50,468,072(+) cctcc(C/T)gggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LARP4 Gene

Variant ID Type Subtype PubMed ID
dgv1498n100 CNV gain 25217958
dgv1499n100 CNV gain 25217958
esv2745871 CNV deletion 23290073
esv2761738 CNV gain 21179565
esv3629481 CNV loss 21293372
nsv1122732 CNV deletion 24896259
nsv1134229 CNV deletion 24896259
nsv1144624 CNV deletion 24896259
nsv469376 CNV loss 19166990
nsv470291 CNV gain 18288195
nsv558841 CNV loss 21841781
nsv973063 CNV duplication 23825009
nsv973064 CNV duplication 23825009

Variation tolerance for LARP4 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LARP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP4 Gene

Disorders for LARP4 Gene

Relevant External Links for LARP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LARP4

No disorders were found for LARP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP4 Gene

Publications for LARP4 Gene

  1. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner. (PMID: 26644407) Mattijssen S. … Maraia R.J. (Mol. Cell. Biol. 2016) 3 65

Products for LARP4 Gene

Sources for LARP4 Gene

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