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LARP2 Gene

protein-coding   GIFtS: 47

GC04P129201
La ribonucleoprotein domain family, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp434K245 1
DKFZp686E0316 1
DKFZp686L13217 2
FLJ10378 1
MGC117277 2
MGC75174 2
Descriptions
La ribonucleoprotein domain family member 2 2, 3
La ribonucleoprotein domain family, member 2 2
External Ids
HGNC: 247041
Entrez Gene: 551322
UniProtKB: Q659C43
Ensembl: ENSG000001387097
Search outside databases for aliases for LARP2 gene

Previous GC identifer: GC04P129341

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LARP2:
This gene encodes a protein containing domains found in the La related protein of Drosophila
melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La
motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in
proteins unrelated to the La protein. Alternative splicing has been observed at this locus and
three variants, encoding distinct isoforms, are described. Additional splice variation has been
identified but the full-length nature of these transcripts has not been determined. [provided by
RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LARP2 gene  

Entrez Gene cytogenetic band: 4q28.2   Ensembl cytogenetic band:  4q28.2   HGNC cytogenetic band: 4q28.2

LARP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P129201:     (about GC identifiers)

Start:
129,201,953 bp from pter
End:
129,362,995 bp from pter
Size:
161,043 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LARP2_HUMAN, Q659C4 (See protein sequence)
Recommended Name: La-related protein 2  
Size: 914 amino acids; 105322 Da
Sequence caution: Sequence=AAH50654.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=AAH50654.1; Type=Frameshift; Positions=753; Sequence=BAB15679.1;
Type=Frameshift; Positions=721; Sequence=CAH56379.1; Type=Frameshift; Positions=113;
Secondary accessions: Q2YDB6 Q4W599 Q4W5B2 Q659A0 Q6P5X2 Q7Z3F7 Q86VK7 Q8N6F4 Q8N7H4 Q8NAF2 Q9H5E7
Q9NW12
Alternative splicing: 9 isoforms:  Q659C4-1   Q659C4-2   Q659C4-3   Q659C4-4   Q659C4-5   Q659C4-6   Q659C4-7   Q659C4-8   
Q659C4-9   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_060548.2  NP_115615.2  NP_835144.1  


    ENSEMBL proteins: 
    ENSP00000346444 ENSP00000264584 ENSP00000377829 ENSP00000321997 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LARP2)
    Human Recombinant Proteins from Abnova (LARP2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for LARP2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LARP2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LARP2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LARP2)
    Novus Biologicals Antibody for LARP2

    Assays for LARP2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR006630 Lupus_La_RNA_bd
     IPR011991 Wing_hlx_DNA_bd
     IPR006607 DM15


       GeneDecks  LARP2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q659C4

    ProtoNet protein and cluster: Q659C4

    UniProtKB/Swiss-Prot: LARP2_HUMAN, Q659C4
    Similarity: Belongs to the LARP family
    Similarity: Contains 1 HTH La-type RNA-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LARP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018078

                  Applied Biosystems Silencer® siRNAs for LARP2

                  Sigma-Aldrich siRNA for LARP2  
                         Sigma-Aldrich shRNA for LARP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LARP2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_018078
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_018078
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_018078 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018078

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LARP2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LARP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018078

                  Sigma-Aldrich siRNA for LARP2  
                         Sigma-Aldrich shRNA for LARP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018078  NM_032239  NM_178043  

    REFSEQ mRNAs for LARP2 gene (3 alternative transcripts): 

    NM_018078.2   NM_032239.2   NM_178043.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018078  NM_032239  NM_178043  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_018078
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_018078
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_018078 

    Additional cDNA sequence: 

    AK001240.1 AK027164.1 AK092764.1 AK098437.1 AK310421.1 AL137759.1 AL832170.1 BC002840.1 
    BC018794.1 BC030516.1 BC050654.1 BC062606.1 BC110300.1 BX537937.1 

    23 DOTS entries:

    DT.92437998  DT.40244678  DT.312719  DT.75102991  DT.100677870  DT.100815009  DT.101980003  DT.92437999 
    DT.121229770  DT.70100606  DT.100815013  DT.100815015  DT.434459  DT.121229787  DT.121229797  DT.121229803 
    DT.121229810  DT.86821135  DT.91649312  DT.91774935  DT.92438002  DT.95366387  DT.99980326 

    24/194 AceView cDNA sequences (see all 194 ):

    BM995827 BG565906 BU189933 AA927790 AI270097 AW264125 W74420 AA278959 
    AI767732 BG184686 BC030516 BG213124 CF528630 AI095346 BG191369 BM129812 
    AI222996 AW675315 BM698505 BX956784 BM904233 BU676813 AA781270 AA382919 

    highest scoring ESTs for LARP2:

    AI207757 AI806546 AA278485 AA382919 AA604704 AI738989 AI767732 AI873450 AK027164 AK098437 

    Unigene Cluster for LARP2:

    La ribonucleoprotein domain family, member 2
    Hs.657067  [show with all ESTs]
    Unigene Representative Sequence: NM_018078


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LARP2 (see all 6 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                                                        -               
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                            -                           
    SP5:                                                        -                                                               

    About this scheme

    ECgene alternative splicing isoforms for LARP2

    4 Ensembl transcripts including schematic representations:
    ENST00000354456  ENST00000264584  ENST00000394288  ENST00000326639  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LARP2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LARP2

    1 / 2 / 3

    13 probe-sets matching LARP2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    91175_at2, 3 U95-E 1 1.00 1.00 0.85 1.34 AI767732 0.80 1.00 0.91 1

    72798_at2, 3 U95-D 1 1.00 1.00 0.71 0.37 AI806546 1.00 1.00 1.00 1

    62028_at2, 3 U95-C 1 1.00 1.00 0.63 0.79 AW009514 0.80 1.00 0.91 1
    74899_at2, 3 U95-E 1 1.00 1.00 0.78 1.17 AI207757 1.00 1.00 1.00 1

    82952_at2, 3 U95-E 2 1.00 0.97 0.94 1.29 AI738989 0.80 1.00 0.91 1
    88161_at2, 3 U95-E 3 0.81 0.92 0.68 1.09 N29152 0.40 1.00 0.76 1

    231824_at2, 3 U133-B 1 1.00 1.00 -- -- AK027164 0.80 1.00 0.91 1

    226750_at2, 3 U133-B 1 1.00 1.00 -- -- AI767732 0.80 1.00 0.91 1

    233764_s_at2, 3 U133-B 2 1.00 0.95 -- -- BE463539 0.60 1.00 0.82 1

    231824_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    226750_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554038_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    233764_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  LARP2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.657067
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for LARP2 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LARP21   -- La ribonucleoprotein domain family, member 2 93.49(n)
    92.01(a)
    476085  XM_533293.2  XP_533293.2 
    chimpanzee
    (Pan troglodytes)
    LARP21   -- La ribonucleoprotein domain family, member 2 99.56(n)
    99.23(a)
    461482  XM_517433.2  XP_517433.2 
    mouse
    (Mus musculus)
    Larp25 3 La ribonucleoprotein domain family, member 2   -- BG070579 
    chicken
    (Gallus gallus)
    LARP21   -- La ribonucleoprotein domain family, member 2 75.77(n)
    71.54(a)
    422500  XM_420465.2  XP_420465.2 
    zebrafish
    (Danio rerio)
    larp11   -- La ribonucleoprotein domain family, member 1 60.02(n)
    61.29(a)
    327175  XM_001920867.1  XP_001920902.1 
    About this table        Species with no ortholog for LARP2

    ENSEMBL Gene Tree for LARP2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LARP2 gene
    LARP12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/706 NCBI SNPs in LARP2 are shown (see all 706 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 100)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs110989501,2
    A,C,F,H129248129(+) TCTTAT/CGTTTC 3 -- int1 ut317Minor allele frequency- C:0.46NA EU EA WA 538
    --
    rs125088371,2
    A,C,F,H129262654(+) ACATCC/GTGGAG 2 P/R mis112Minor allele frequency- G:0.46EA NA WA EU 984
    rs126455771,2
    A,C,F,H129320093(+) AGACCG/ATGGGC 1 H/R mis1 ese311Minor allele frequency- A:0.49EU EA WA NA 1082
    rs125090921,2
    A,C,F,H129263259(+) ATGGTG/ACATGA 2 -- int1 ng317Minor allele frequency- A:0.49NA EU EA WA 556
    rs48342241,2
    A,C,F,H129200786(+) AATACA/GGCTTT 3 -- ng51 tfbs34Minor allele frequency- G:0.40EU EA WA 416
    rs22041171,2
    A,C,F,H129351860(+) TACATC/TCACTT 1 -- ng317Minor allele frequency- T:0.44EU EA WA NA 546
    rs76961301,2
    A,C,F129215090(+) ATAAAA/GGCAGG 3 -- ut51 ese31Minor allele frequency- G:0.35MN 184
    --
    rs126505561,2
    A,C129200351(+) ccaacA/Ctgatg 3 -- ng510--------
    --
    rs37333211,2
    A,C129263064(+) GTTTTG/TTTTTT 2 -- int1 ng310--------
    rs100495641,2
    F,H129249103(+) CATCAG/ATATGA 3 -- int1 ut314Minor allele frequency- A:0.01EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for LARP2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for LARP2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55132 HGNC: 24704 AceView: FLJ10378 Ensembl:ENSG00000138709 euGenes: HUgn55132
    ECgene: LARP2 H-InvDB: LARP2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LARP2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LARP2-related products

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     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for LARP2 Antibodies for LARP2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LARP2 Browse small molecules at Sigma-Aldrich
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     Antibodies for LARP2

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