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Aliases for LARP1B Gene

Aliases for LARP1B Gene

  • La Ribonucleoprotein Domain Family Member 1B 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 2 2 3
  • La-Related Protein 2 3 4
  • LARP2 3 4
  • La Ribonucleoprotein Domain Family, Member 1B 2
  • La Ribonucleoprotein Domain Family Member 2 4
  • La-Related Protein 1B 3

External Ids for LARP1B Gene

Previous HGNC Symbols for LARP1B Gene

  • LARP2

Previous GeneCards Identifiers for LARP1B Gene

  • GC04P129202
  • GC04P128983
  • GC04P124714

Summaries for LARP1B Gene

Entrez Gene Summary for LARP1B Gene

  • This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]

GeneCards Summary for LARP1B Gene

LARP1B (La Ribonucleoprotein Domain Family Member 1B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is LARP1.

Additional gene information for LARP1B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP1B Gene

Genomics for LARP1B Gene

Regulatory Elements for LARP1B Gene

Enhancers for LARP1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LARP1B on UCSC Golden Path with GeneCards custom track

Promoters for LARP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for LARP1B Gene

Genomic Locations for LARP1B Gene
161,666 bases
Plus strand

Genomic View for LARP1B Gene

Genes around LARP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP1B Gene

Proteins for LARP1B Gene

  • Protein details for LARP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    La-related protein 1B
    Protein Accession:
    Secondary Accessions:
    • Q2YDB6
    • Q4W599
    • Q4W5B2
    • Q659A0
    • Q6P5X2
    • Q7Z3F7
    • Q86VK7
    • Q8N6F4
    • Q8N7H4
    • Q8NAF2
    • Q9H5E7
    • Q9NW12

    Protein attributes for LARP1B Gene

    914 amino acids
    Molecular mass:
    105322 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH50654.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH50654.1; Type=Frameshift; Positions=753; Evidence={ECO:0000305}; Sequence=BAB15679.1; Type=Frameshift; Positions=721; Evidence={ECO:0000305}; Sequence=CAH56379.1; Type=Frameshift; Positions=113; Evidence={ECO:0000305};

    Alternative splice isoforms for LARP1B Gene

neXtProt entry for LARP1B Gene

Post-translational modifications for LARP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LARP1B Gene

Domains & Families for LARP1B Gene

Gene Families for LARP1B Gene

Protein Domains for LARP1B Gene

Suggested Antigen Peptide Sequences for LARP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LARP family.
  • Belongs to the LARP family.
genes like me logo Genes that share domains with LARP1B: view

Function for LARP1B Gene

Gene Ontology (GO) - Molecular Function for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LARP1B: view
genes like me logo Genes that share phenotypes with LARP1B: view

Animal Model Products

miRNA for LARP1B Gene

miRTarBase miRNAs that target LARP1B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP1B Gene

Localization for LARP1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP1B gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with LARP1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LARP1B Gene

Pathways & Interactions for LARP1B Gene

SuperPathways for LARP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP1B Gene


No data available for Pathways by source and SIGNOR curated interactions for LARP1B Gene

Drugs & Compounds for LARP1B Gene

No Compound Related Data Available

Transcripts for LARP1B Gene

Unigene Clusters for LARP1B Gene

La ribonucleoprotein domain family, member 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP4: -
SP5: -
SP6: -

Relevant External Links for LARP1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LARP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LARP1B Gene

Protein differential expression in normal tissues from HIPED for LARP1B Gene

This gene is overexpressed in Testis (32.5), Plasma (12.2), Tlymphocyte (7.9), and Heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LARP1B Gene

Protein tissue co-expression partners for LARP1B Gene

NURSA nuclear receptor signaling pathways regulating expression of LARP1B Gene:


SOURCE GeneReport for Unigene cluster for LARP1B Gene:


Evidence on tissue expression from TISSUES for LARP1B Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Intestine(4.2)
  • Lung(4.2)
  • Thyroid gland(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with LARP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP1B Gene

Orthologs for LARP1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LARP1B 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia LARP1B 33 34
  • 92.78 (n)
(Bos Taurus)
Mammalia LOC515517 33
  • 91.89 (n)
  • 85 (a)
(Mus musculus)
Mammalia Larp1b 34 34
  • 87 (a)
(Monodelphis domestica)
Mammalia LARP1B 34
  • 69 (a)
(Gallus gallus)
Aves LARP1B 33 34
  • 75.83 (n)
(Anolis carolinensis)
Reptilia LARP1B 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia larp1b 33
  • 67.49 (n)
Str.20349 33
(Danio rerio)
Actinopterygii larp1b 33 34
  • 62.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta larp 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea larp-1 34
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRO9 36
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7357 33
(Hordeum vulgare)
Liliopsida Hv.7702 33
(Triticum aestivum)
Liliopsida Ta.23156 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
-- 34
  • 24 (a)
Species where no ortholog for LARP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LARP1B Gene

Gene Tree for LARP1B (if available)
Gene Tree for LARP1B (if available)

Paralogs for LARP1B Gene

Paralogs for LARP1B Gene

(4) SIMAP similar genes for LARP1B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LARP1B: view

Variants for LARP1B Gene

Sequence variations from dbSNP and Humsavar for LARP1B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs193920764 Uncertain significance 128,121,988(+) TTGAT(G/T)ACCAA nc-transcript-variant, reference, missense
rs1000011941 -- 128,095,754(+) GGCAT(C/G)TTTAG intron-variant
rs1000022508 -- 128,082,029(+) CCGTG(C/T)CTGGC intron-variant
rs1000048762 -- 128,124,152(+) GCACA(A/G)AGTGA intron-variant, downstream-variant-500B
rs1000068431 -- 128,136,603(+) ACAAT(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LARP1B Gene

Variant ID Type Subtype PubMed ID
nsv967794 CNV duplication 23825009
nsv966318 CNV duplication 23825009
nsv966317 CNV duplication 23825009
nsv955820 CNV deletion 24416366
nsv595396 CNV loss 21841781
nsv595391 CNV gain 21841781
nsv595388 CNV gain 21841781
nsv473285 CNV novel sequence insertion 20440878
nsv1078542 CNV duplication 25765185
esv3602159 CNV loss 21293372
esv2728292 CNV deletion 23290073
esv24873 CNV loss 19812545
dgv9260n54 CNV loss 21841781
dgv9259n54 CNV gain 21841781
dgv9258n54 CNV loss 21841781
dgv5385n100 CNV gain 25217958

Variation tolerance for LARP1B Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LARP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP1B Gene

Disorders for LARP1B Gene

Relevant External Links for LARP1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LARP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP1B Gene

Publications for LARP1B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The La protein. (PMID: 12045101) Wolin SL … Cedervall T (Annual review of biochemistry 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for LARP1B Gene

Sources for LARP1B Gene

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