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Aliases for LARP1B Gene

Aliases for LARP1B Gene

  • La Ribonucleoprotein Domain Family Member 1B 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 1B 2 3
  • La Ribonucleoprotein Domain Family, Member 2 2 3
  • La Ribonucleoprotein Domain Family Member 2 3 4
  • La-Related Protein 2 3 4
  • LARP2 3 4

External Ids for LARP1B Gene

Previous HGNC Symbols for LARP1B Gene

  • LARP2

Previous GeneCards Identifiers for LARP1B Gene

  • GC04P129202
  • GC04P128983
  • GC04P124714

Summaries for LARP1B Gene

Entrez Gene Summary for LARP1B Gene

  • This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]

GeneCards Summary for LARP1B Gene

LARP1B (La Ribonucleoprotein Domain Family Member 1B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is LARP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP1B Gene

Genomics for LARP1B Gene

Regulatory Elements for LARP1B Gene

Promoters for LARP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LARP1B on UCSC Golden Path with GeneCards custom track

Genomic Location for LARP1B Gene

Chromosome:
4
Start:
128,061,266 bp from pter
End:
128,222,931 bp from pter
Size:
161,666 bases
Orientation:
Plus strand

Genomic View for LARP1B Gene

Genes around LARP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP1B Gene

Proteins for LARP1B Gene

  • Protein details for LARP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q659C4-LAR1B_HUMAN
    Recommended name:
    La-related protein 1B
    Protein Accession:
    Q659C4
    Secondary Accessions:
    • Q2YDB6
    • Q4W599
    • Q4W5B2
    • Q659A0
    • Q6P5X2
    • Q7Z3F7
    • Q86VK7
    • Q8N6F4
    • Q8N7H4
    • Q8NAF2
    • Q9H5E7
    • Q9NW12

    Protein attributes for LARP1B Gene

    Size:
    914 amino acids
    Molecular mass:
    105322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH50654.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH50654.1; Type=Frameshift; Positions=753; Evidence={ECO:0000305}; Sequence=BAB15679.1; Type=Frameshift; Positions=721; Evidence={ECO:0000305}; Sequence=CAH56379.1; Type=Frameshift; Positions=113; Evidence={ECO:0000305};

    Alternative splice isoforms for LARP1B Gene

neXtProt entry for LARP1B Gene

Proteomics data for LARP1B Gene at MOPED

Post-translational modifications for LARP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LARP1B Gene

Domains & Families for LARP1B Gene

Gene Families for LARP1B Gene

Protein Domains for LARP1B Gene

Suggested Antigen Peptide Sequences for LARP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q659C4

UniProtKB/Swiss-Prot:

LAR1B_HUMAN :
  • Contains 1 HTH La-type RNA-binding domain.
  • Belongs to the LARP family.
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
Family:
  • Belongs to the LARP family.
genes like me logo Genes that share domains with LARP1B: view

Function for LARP1B Gene

Gene Ontology (GO) - Molecular Function for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with LARP1B: view
genes like me logo Genes that share phenotypes with LARP1B: view

Animal Model Products

CRISPR Products

miRNA for LARP1B Gene

miRTarBase miRNAs that target LARP1B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP1B Gene

Localization for LARP1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LARP1B Gene COMPARTMENTS Subcellular localization image for LARP1B gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with LARP1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LARP1B Gene

Pathways & Interactions for LARP1B Gene

SuperPathways for LARP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LARP1B Gene

Drugs & Compounds for LARP1B Gene

No Compound Related Data Available

Transcripts for LARP1B Gene

Unigene Clusters for LARP1B Gene

La ribonucleoprotein domain family, member 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LARP1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for LARP1B Gene

GeneLoc Exon Structure for
LARP1B
ECgene alternative splicing isoforms for
LARP1B

Expression for LARP1B Gene

mRNA expression in normal human tissues for LARP1B Gene

Protein differential expression in normal tissues from HIPED for LARP1B Gene

This gene is overexpressed in Testis (32.5), Plasma (12.2), Tlymphocyte (7.9), and Heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LARP1B Gene



SOURCE GeneReport for Unigene cluster for LARP1B Gene Hs.657067

genes like me logo Genes that share expression patterns with LARP1B: view

Protein tissue co-expression partners for LARP1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LARP1B Gene

Orthologs for LARP1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARP1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC515517 35
  • 91.89 (n)
  • 89.81 (a)
LARP1B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LARP1B 35
  • 92.78 (n)
  • 91.14 (a)
LARP1B 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LARP1B 35
  • 99.56 (n)
  • 99.23 (a)
LARP1B 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LARP1B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Larp1b 36
  • 87 (a)
OneToMany
Larp1b 36
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves LARP1B 35
  • 75.83 (n)
  • 71.82 (a)
LARP1B 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP1B 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp1b 35
  • 67.49 (n)
  • 63.88 (a)
Str.20349 35
zebrafish
(Danio rerio)
Actinopterygii larp1b 35
  • 62.92 (n)
  • 62.67 (a)
larp1b 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta larp 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-1 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRO9 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7357 35
barley
(Hordeum vulgare)
Liliopsida Hv.7702 35
wheat
(Triticum aestivum)
Liliopsida Ta.23156 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for LARP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LARP1B Gene

ENSEMBL:
Gene Tree for LARP1B (if available)
TreeFam:
Gene Tree for LARP1B (if available)

Paralogs for LARP1B Gene

Paralogs for LARP1B Gene

(4) SIMAP similar genes for LARP1B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LARP1B: view

Variants for LARP1B Gene

Sequence variations from dbSNP and Humsavar for LARP1B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12508837 - 128,122,049(+) ACATC(A/C/G)TGGAG intron-variant, nc-transcript-variant, reference, missense
rs12645577 - 128,179,488(+) AGACC(A/G)TGGGC intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs290000 -- 128,215,708(+) agacc(A/G)tcgag intron-variant
rs429566 -- 128,062,307(-) CCTGG(G/T)GCCCG intron-variant
rs364550 -- 128,059,922(+) agact(C/G)tgtct upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LARP1B Gene

Variant ID Type Subtype PubMed ID
nsv879915 CNV Gain 21882294
nsv879923 CNV Loss 21882294
esv24873 CNV Loss 19812545
nsv879929 CNV Loss 21882294
esv2728292 CNV Deletion 23290073

Variation tolerance for LARP1B Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LARP1B Gene

HapMap Linkage Disequilibrium report
LARP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP1B Gene

Disorders for LARP1B Gene

Relevant External Links for LARP1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LARP1B

No disorders were found for LARP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP1B Gene

Publications for LARP1B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The La protein. (PMID: 12045101) Wolin S.L. … Cedervall T. (Annu. Rev. Biochem. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for LARP1B Gene

Sources for LARP1B Gene

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