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Aliases & Descriptions for LARP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA0731 1 , 2 , 3 , 5 LARP 1 , 2 , 3 , 5 MGC19556 1 , 2
Descriptions La ribonucleoprotein domain family member 1 3 La ribonucleoprotein domain family, member 1 2 la related protein 2
Search outside databases for aliases for LARP1 gene
Summaries for LARP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for LARP1
Genomic Location for LARP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the LARP1 gene Entrez Gene cytogenetic band: 5q33.2 Ensembl cytogenetic band: 5q33.2 HGNC cytogenetic band: 5q33.2 LARP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05P154073:
(about GC identifiers )
Start:
154,072,655 bp from pter
End:
154,177,358 bp from pter
Size:
104,704 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000005.8 NT_029289.10 Proteins for LARP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: LARP1_HUMAN, Q6PKG0 (See
protein sequence )Recommended Name: La-related protein 1 Size : 1096 amino acids; 123510 Da
Secondary accessions : O94836 Q8N4M2 Q8NB73 Q9UFD7Alternative splicing : 3 isoforms : Q6PKG0-1 Q6PKG0-2 Q6PKG0-3
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_056130.2 NP_291029.2 ENSEMBL proteins: ENSP00000366871 ENSP00000285894 ENSP00000336721 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for LARP1: Assays for LARP1:
Protein
Domains/ Families for LARP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q6PKG0 ProtoNet protein and cluster: Q6PKG0
1 Blocks protein family : IPB001199 Cytochrome b5 UniProtKB/Swiss-Prot: LARP1_HUMAN, Q6PKG0 Similarity : Belongs to the LARP familySimilarity : Contains 1 HTH La-type RNA-binding domain
Gene Function for LARP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_015315 Applied Biosystems Silencer ® siRNAs for LARP1 Sigma-Aldrich siRNA for LARP1 Sigma-Aldrich shRNA for LARP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015315                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015315                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_015315  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033551 2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for LARP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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4 Interacting proteins for LARP1 (Q6PKG0 1 , 2 ) via UniProtKB, MINT, and/or STRING Interactant Interaction Details GeneCard External ID(s) YWHAZ P63104 1 , 2 EBI-1052114, EBI-347088 MINT-51028 MINT-3307331 EBI-1052114, EBI-347088 MINT-51028 MINT-3307331 YWHAB P31946 1 , 2 EBI-1052114, EBI-359815 MINT-50945 EBI-1052114, EBI-359815 MINT-50945 YWHAG P61981 1 , 2 EBI-1052114, EBI-359832 MINT-50802 EBI-1052114, EBI-359832 MINT-50802 YWHAQ P27348 1 , 2 EBI-1052114, EBI-359854 MINT-51000 EBI-1052114, EBI-359854 MINT-51000 YWHAZ P63104 1 , 2 EBI-1052114, EBI-347088 MINT-51028 MINT-3307331 EBI-1052114, EBI-347088 MINT-51028 MINT-3307331
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Drugs & Compounds for LARP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for LARP1
Transcripts for LARP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_015315 Sigma-Aldrich siRNA for LARP1 Sigma-Aldrich shRNA for LARP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015315 NM_033551
REFSEQ mRNAs for LARP1 gene (2 alternative transcripts): NM_015315.3 NM_033551.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015315 NM_033551
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015315                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015315                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_015315  
Additional cDNA sequence: AB018274.1 AK057839.1 AK091465.1 AK307554.1 AK312203.1 AL133034.1 BC001460.2 BC003063.2 BC010144.2 BC015573.1 BC033856.1 BC038220.2
24/33 DOTS entries (see all 33
): DT.100828903 DT.95146863 DT.95141146 DT.456155 DT.100828917 DT.92324864 DT.418478 DT.91764431 DT.100828919 DT.97860905 DT.120821119 DT.91851069 DT.92383726 DT.120820774 DT.120820957 DT.91678877 DT.91690201 DT.91701518 DT.97794635 DT.99997112 DT.100828916 DT.120821065 DT.91777126 DT.92409129
24/672 AceView cDNA sequences (see all 672
):AA887733 AK091465 AA985063 CA305884 AI679703 AA458929 CA424548 AW264453 CD673859 BU170403 AW510687 AW001844 AA026800 AX747001 BM477067 AW029160 AI375051 BQ014078 BG333217 AI762704 AI991955 AA385040 BU527498 AA282155
highest scoring ESTs for LARP1 :AA017136 AA019807 AA026800 AA091925 AA099610 AA099718 AA099719 AA101986 AA156172 AA156506
Unigene Cluster for LARP1: La ribonucleoprotein domain family, member 1 Hs.292078 [show with all ESTs ] Unigene Representative Sequence: NM_033551 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000377643
ENST00000285894
ENST00000336314
Expression for LARP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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LARP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for LARP1 1 / 2 / 3
12 probe-sets matching LARP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTGATGGCAGSOURCE GeneReport for Unigene cluster: Hs.292078
Orthologs for LARP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for LARP1 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for LARP1 ENSEMBL Gene Tree for LARP1 Paralogs for LARP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for LARP1 gene LARP2 2
SNPs/Variants for LARP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for LARP1 (up to first 250kb)
Disorders & Mutations for LARP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 612059
Medical News for LARP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for LARP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/22 PubMed articles for LARP1 gene (see all 22
): Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452) 2, 3, 4 Nagase T....Ohara O. (1998) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3, 4 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. (PubMed id 10878606) 2, 3 Chauvet S....Aragnol D. (2000) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) Phosphoproteome of resting human platelets. (PubMed id 18088087) 4 Zahedi R.P.... Sickmann A. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008)
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(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing LARP1
(According to HUGE )
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Specialized Databases showing LARP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for LARP1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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