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Aliases for LARP1 Gene

Aliases for LARP1 Gene

  • La Ribonucleoprotein Domain Family Member 1 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 1 2 3
  • LARP 3 4
  • KIAA0731 4

External Ids for LARP1 Gene

Previous GeneCards Identifiers for LARP1 Gene

  • GC05P154073
  • GC05P154092
  • GC05P149234

Summaries for LARP1 Gene

GeneCards Summary for LARP1 Gene

LARP1 (La Ribonucleoprotein Domain Family Member 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor binding. An important paralog of this gene is LARP1B.

UniProtKB/Swiss-Prot for LARP1 Gene

  • RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5cap in an MTOR-dependent manner and associates with mRNAs containing a 5 terminal oligopyrimidine (5TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).

Gene Wiki entry for LARP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP1 Gene

Genomics for LARP1 Gene

Regulatory Elements for LARP1 Gene

Genomic Location for LARP1 Gene

Chromosome:
5
Start:
154,682,663 bp from pter
End:
154,817,607 bp from pter
Size:
134,945 bases
Orientation:
Plus strand

Genomic View for LARP1 Gene

Genes around LARP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP1 Gene

Proteins for LARP1 Gene

  • Protein details for LARP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PKG0-LARP1_HUMAN
    Recommended name:
    La-related protein 1
    Protein Accession:
    Q6PKG0
    Secondary Accessions:
    • O94836
    • Q8N4M2
    • Q8NB73
    • Q9UFD7

    Protein attributes for LARP1 Gene

    Size:
    1096 amino acids
    Molecular mass:
    123510 Da
    Quaternary structure:
    • Interacts with PABPC1/PABP. Associates with the mTORC1 complex. Interacts with EIF4E. Found in a complex with PABPC1 and RYDEN (PubMed:26735137).
    SequenceCaution:
    • Sequence=AAH33856.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA34451.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP1 Gene

    Alternative splice isoforms for LARP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LARP1 Gene

Proteomics data for LARP1 Gene at MOPED

Post-translational modifications for LARP1 Gene

  • Ubiquitination at Lys 539, Lys 753, Lys 792, Lys 805, Lys 881, Lys 944, Lys 972, and Lys 1017
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LARP1 (LARP)

No data available for DME Specific Peptides for LARP1 Gene

Domains & Families for LARP1 Gene

Gene Families for LARP1 Gene

Protein Domains for LARP1 Gene

Suggested Antigen Peptide Sequences for LARP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PKG0

UniProtKB/Swiss-Prot:

LARP1_HUMAN :
  • Contains 1 HTH La-type RNA-binding domain.
  • Belongs to the LARP family.
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
Family:
  • Belongs to the LARP family.
genes like me logo Genes that share domains with LARP1: view

Function for LARP1 Gene

Molecular function for LARP1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5cap in an MTOR-dependent manner and associates with mRNAs containing a 5 terminal oligopyrimidine (5TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).
UniProtKB/Swiss-Prot Induction:
Up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate (at protein level).

Gene Ontology (GO) - Molecular Function for LARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20430826
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LARP1: view
genes like me logo Genes that share phenotypes with LARP1: view

Animal Model Products

miRNA for LARP1 Gene

miRTarBase miRNAs that target LARP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP1 Gene

Localization for LARP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LARP1 Gene COMPARTMENTS Subcellular localization image for LARP1 gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for LARP1 Gene

Pathways & Interactions for LARP1 Gene

SuperPathways for LARP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IMP 20430826
genes like me logo Genes that share ontologies with LARP1: view

No data available for Pathways by source and SIGNOR curated interactions for LARP1 Gene

Drugs & Compounds for LARP1 Gene

No Compound Related Data Available

Transcripts for LARP1 Gene

Unigene Clusters for LARP1 Gene

La ribonucleoprotein domain family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LARP1 Gene

No ASD Table

Relevant External Links for LARP1 Gene

GeneLoc Exon Structure for
LARP1
ECgene alternative splicing isoforms for
LARP1

Expression for LARP1 Gene

mRNA expression in normal human tissues for LARP1 Gene

Protein differential expression in normal tissues from HIPED for LARP1 Gene

This gene is overexpressed in Lung (31.0) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LARP1 Gene



SOURCE GeneReport for Unigene cluster for LARP1 Gene Hs.292078

genes like me logo Genes that share expression patterns with LARP1: view

Protein tissue co-expression partners for LARP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LARP1 Gene

Orthologs for LARP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP1 36
  • 100 (a)
OneToOne
LARP1 35
  • 99.61 (n)
  • 99.51 (a)
cow
(Bos Taurus)
Mammalia LARP1 36
  • 96 (a)
OneToOne
LARP1 35
  • 91.15 (n)
  • 94.3 (a)
dog
(Canis familiaris)
Mammalia LARP1 35
  • 93.73 (n)
  • 97.58 (a)
LARP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Larp1 36
  • 85 (a)
OneToOne
Larp1 16
Larp1 35
  • 90.19 (n)
  • 95.37 (a)
oppossum
(Monodelphis domestica)
Mammalia LARP1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Larp1 35
  • 89.68 (n)
  • 95.34 (a)
chicken
(Gallus gallus)
Aves LARP1 35
  • 78.15 (n)
  • 84.84 (a)
LARP1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp1 35
  • 72.91 (n)
  • 79.3 (a)
zebrafish
(Danio rerio)
Actinopterygii larp1 36
  • 63 (a)
OneToOne
larp1 35
  • 69.46 (n)
  • 70.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta larp 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-1 36
  • 20 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.4402 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
Species with no ortholog for LARP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP1 Gene

ENSEMBL:
Gene Tree for LARP1 (if available)
TreeFam:
Gene Tree for LARP1 (if available)

Paralogs for LARP1 Gene

Paralogs for LARP1 Gene

Pseudogenes.org Pseudogenes for LARP1 Gene

genes like me logo Genes that share paralogs with LARP1: view

Variants for LARP1 Gene

Sequence variations from dbSNP and Humsavar for LARP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs39615 -- 154,790,030(-) GTTCC(A/G)TAACA intron-variant
rs39953 -- 154,793,349(-) ATCCC(A/C/T)TTCTG intron-variant
rs255531 -- 154,795,809(-) atggc(A/G)ccaat intron-variant
rs1063410 -- 154,816,452(+) AGGAA(A/G)CCCCT utr-variant-3-prime
rs816718 -- 154,804,588(+) TTTCT(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LARP1 Gene

Variant ID Type Subtype PubMed ID
esv2730937 CNV Deletion 23290073
nsv830521 CNV Gain 17160897

Variation tolerance for LARP1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LARP1 Gene

HapMap Linkage Disequilibrium report
LARP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP1 Gene

Disorders for LARP1 Gene

Relevant External Links for LARP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LARP1

No disorders were found for LARP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP1 Gene

Publications for LARP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. (PMID: 10878606) Chauvet S. … Aragnol D. (Dev. Dyn. 2000) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for LARP1 Gene

Sources for LARP1 Gene

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