Aliases for LARP1 Gene
External Ids for LARP1 Gene
Previous GeneCards Identifiers for LARP1 Gene
GeneCards Summary for LARP1 Gene
LARP1 (La Ribonucleoprotein Domain Family Member 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor binding. An important paralog of this gene is LARP1B.
UniProtKB/Swiss-Prot for LARP1 Gene
RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5cap in an MTOR-dependent manner and associates with mRNAs containing a 5 terminal oligopyrimidine (5TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).