Aliases for LARP1 Gene
External Ids for LARP1 Gene
Previous GeneCards Identifiers for LARP1 Gene
GeneCards Summary for LARP1 Gene
LARP1 (La Ribonucleoprotein Domain Family Member 1) is a Protein Coding gene. Diseases associated with LARP1 include Hepatocellular Carcinoma. Among its related pathways are Translational Control. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor binding. An important paralog of this gene is LARP1B.
UniProtKB/Swiss-Prot for LARP1 Gene
RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5cap in an MTOR-dependent manner and associates with mRNAs containing a 5 terminal oligopyrimidine (5TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669). Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).