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LARP1 Gene

protein-coding   GIFtS: 54

GC05P154073
La ribonucleoprotein domain family, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA0731 1, 2, 3, 5
LARP 1, 2, 3, 5
MGC19556 1, 2
Descriptions
La ribonucleoprotein domain family member 1 3
La ribonucleoprotein domain family, member 1 2
la related protein 2
External Ids
HGNC: 295311
Entrez Gene: 233672
UniProtKB: Q6PKG03
Ensembl: ENSG000001555067
Search outside databases for aliases for LARP1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for LARP1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LARP1 gene  

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33.2

LARP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P154073:     (about GC identifiers)

Start:
154,072,655 bp from pter
End:
154,177,358 bp from pter
Size:
104,704 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.8  NT_029289.10  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LARP1_HUMAN, Q6PKG0 (See protein sequence)
Recommended Name: La-related protein 1  
Size: 1096 amino acids; 123510 Da
Secondary accessions: O94836 Q8N4M2 Q8NB73 Q9UFD7
Alternative splicing: 3 isoforms:  Q6PKG0-1   Q6PKG0-2   Q6PKG0-3   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_056130.2  NP_291029.2  


    ENSEMBL proteins: 
    ENSP00000366871 ENSP00000285894 ENSP00000336721 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (LARP1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for LARP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LARP1
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (LARP1)
    Novus Biologicals Antibodies for LARP1

    Assays for LARP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR006630 Lupus_La_RNA_bd
     IPR011991 Wing_hlx_DNA_bd
     IPR006607 DM15


       GeneDecks  LARP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6PKG0

    ProtoNet protein and cluster: Q6PKG0

    1 Blocks protein family: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: LARP1_HUMAN, Q6PKG0
    Similarity: Belongs to the LARP family
    Similarity: Contains 1 HTH La-type RNA-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LARP1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015315

                  Applied Biosystems Silencer® siRNAs for LARP1

                  Sigma-Aldrich siRNA for LARP1  
                         Sigma-Aldrich shRNA for LARP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LARP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015315
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015315
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_015315 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_033551

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    GO:0005515 protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for LARP1 (Q6PKG01, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2EBI-1052114, EBI-347088 MINT-51028 MINT-3307331 EBI-1052114, EBI-347088 MINT-51028 MINT-3307331
    YWHABP319461, 2EBI-1052114, EBI-359815 MINT-50945 EBI-1052114, EBI-359815 MINT-50945
    YWHAGP619811, 2EBI-1052114, EBI-359832 MINT-50802 EBI-1052114, EBI-359832 MINT-50802
    YWHAQP273481, 2EBI-1052114, EBI-359854 MINT-51000 EBI-1052114, EBI-359854 MINT-51000
    YWHAZP631041, 2EBI-1052114, EBI-347088 MINT-51028 MINT-3307331 EBI-1052114, EBI-347088 MINT-51028 MINT-3307331
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LARP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LARP1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015315

                  Sigma-Aldrich siRNA for LARP1  
                         Sigma-Aldrich shRNA for LARP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015315  NM_033551  

    REFSEQ mRNAs for LARP1 gene (2 alternative transcripts): 

    NM_015315.3   NM_033551.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015315  NM_033551  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015315
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015315
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_015315 

    Additional cDNA sequence: 

    AB018274.1 AK057839.1 AK091465.1 AK307554.1 AK312203.1 AL133034.1 BC001460.2 BC003063.2 
    BC010144.2 BC015573.1 BC033856.1 BC038220.2 

    24/33 DOTS entries (see all 33 ):

    DT.100828903  DT.95146863  DT.95141146  DT.456155  DT.100828917  DT.92324864  DT.418478  DT.91764431 
    DT.100828919  DT.97860905  DT.120821119  DT.91851069  DT.92383726  DT.120820774  DT.120820957  DT.91678877 
    DT.91690201  DT.91701518  DT.97794635  DT.99997112  DT.100828916  DT.120821065  DT.91777126  DT.92409129 

    24/672 AceView cDNA sequences (see all 672 ):

    AA887733 AK091465 AA985063 CA305884 AI679703 AA458929 CA424548 AW264453 
    CD673859 BU170403 AW510687 AW001844 AA026800 AX747001 BM477067 AW029160 
    AI375051 BQ014078 BG333217 AI762704 AI991955 AA385040 BU527498 AA282155 

    highest scoring ESTs for LARP1:

    AA017136 AA019807 AA026800 AA091925 AA099610 AA099718 AA099719 AA101986 AA156172 AA156506 

    Unigene Cluster for LARP1:

    La ribonucleoprotein domain family, member 1
    Hs.292078  [show with all ESTs]
    Unigene Representative Sequence: NM_033551


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000377643  ENST00000285894  ENST00000336314  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LARP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LARP1

    1 / 2 / 3

    12 probe-sets matching LARP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    41829_at2, 3 U95-A 1 1.00 1.00 0.58 0.96 AB018274 0.80 1.00 0.91 1

    89317_i_at2, 3 U95-D 1 1.00 1.00 0.58 0.75 AI768454 0.60 1.00 0.82 1
    89319_r_at2, 3 U95-D 1 1.00 1.00 0.82 1.07 AI768454 0.60 1.00 0.82 1
    71985_f_at2, 3 U95-E 1 0.50 1.00 0.38 1.24 AA416611 0.60 1.00 0.82 1

    212193_s_at2, 3 U133-A 1 1.00 1.00 -- -- BE881529 0.80 1.00 0.91 1

    212137_at2, 3 U133-A 1 1.00 1.00 -- -- AV746402 0.80 1.00 0.91 1

    239663_x_at2, 3 U133-B 1 1.00 1.00 -- -- AI768454 0.60 1.00 0.82 1

    210966_x_at2, 3 U133-A 1 1.00 1.00 -- -- BC001460 0.80 1.00 0.91 1

    212193_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    212137_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    239663_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210966_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  LARP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTGATGGCAG

    SOURCE GeneReport for Unigene cluster: Hs.292078
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for LARP1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LARP11   -- La ribonucleoprotein domain family, member 1 93.64(n)
    97.64(a)
    612929  XM_848301.1  XP_853394.1 
    chimpanzee
    (Pan troglodytes)
    LARP11   -- La ribonucleoprotein domain family, member 1 99.6(n)
    99.54(a)
    462356  XM_518174.2  XP_518174.2 
    cow
    (Bos taurus)
    LARP11   -- La ribonucleoprotein domain family, member 1 91.88(n)
    95.35(a)
    505690  XM_582017.3  XP_582017.3 
    rat
    (Rattus norvegicus)
    Larp11   -- La ribonucleoprotein domain family, member 1 88.85(n)
    94.08(a)
    303158  XM_220446.4  XP_220446.4 
    mouse
    (Mus musculus)
    Larp11, 5 115
    La ribonucleoprotein domain family, member 11, 5 88.95(n)1
    93.16(a)1
    731581  XM_126172.81  XP_126172.61 
     AI1818365  AK0075975  (see all 13)
    About this table        Species with no ortholog for LARP1

    ENSEMBL Gene Tree for LARP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LARP1 gene
    LARP22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/360 NCBI SNPs in LARP1 are shown (see all 360 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 104)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs324271,2
    A,C,F,H,O154176786(-) AAGGGA/GAAAAA 2 -- ut31 trp35Minor allele frequency- G:0.50MN EU EA WA 602
    rs49587651,2
    A,C,F,H154071950(+) ATAATG/CTCCAA 1 -- ng5112Minor allele frequency- C:0.23EU EA WA 1258
    rs38674291,2
    C,F,H154072395(+) AGGACC/TAGGGC 1 -- ng518Minor allele frequency- T:0.22EU EA WA 816
    rs120550151,2
    C,F,H154072097(+) GGTGTG/AGTCCA 1 -- ng514Minor allele frequency- A:0.15EU EA WA 416
    rs117504751,2
    C,F,H154113887(+) GTAGCC/TCATCT 2 -- ng51 int18Minor allele frequency- T:0.06EU EA WA 840
    rs100397091,2
    C,F,H154070704(+) ACAATA/GTGAGA 1 -- ng514Minor allele frequency- G:0.25EU EA WA 418
    rs171164551,2
    F,H154177731(+) CAACCC/GCTCTA 2 -- ng317Minor allele frequency- G:0.06NA EU EA WA 556
    rs8636491,2
    C,H154173928(+) CAGGAG/AAGGGG 2 -- ut31 trp35Minor allele frequency- A:0.00MN EU EA WA 602
    --
    rs65801161,2
    C154114968(+) gcgccC/Gtcccg 2 -- ng51 int10--------
    --
    rs131859501,2
    H154174584(+) TTTTCT/CCTGAC 2 -- ut31 ese34Minor allele frequency- C:0.00EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for LARP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612059

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/22 PubMed articles for LARP1 gene (see all 22 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23367 HGNC: 29531 AceView: LARP Ensembl:ENSG00000155506 euGenes: HUgn23367
    ECgene: LARP1 H-InvDB: LARP1
    (According to HUGE)
    About This Section

    HUGE: KIAA0731
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LARP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LARP1-related products

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     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LARP1 Antibodies for LARP1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LARP1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for LARP1

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