Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAPTM5 Gene

protein-coding   GIFtS: 55
GCID: GC01M031205

lysosomal protein transmembrane 5

(Previous name: lysosomal multispanning membrane protein 5 )
 Explore 10 diseases affiliated with
LAPTM5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LAPTM5    

Aliases
for LAPTM5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lysosomal Protein Transmembrane 51 2     CD40-Ligand-Activated Specific Transcripts2
Lysosomal Multispanning Membrane Protein 51 2     Human Retinoic Acid-Inducible E3 Protein2
Lysosomal-Associated Multitransmembrane Protein 52 3     Lysosomal Associated Multispanning Membrane Protein 52
Retinoic Acid-Inducible E3 Protein2 3     Lysosomal-Associated Transmembrane Protein 52
CLAST62     KIAA00853

External Ids:    HGNC: 296121   Entrez Gene: 78052   Ensembl: ENSG000001625117   OMIM: 6014765   UniProtKB: Q135713   

Export aliases for LAPTM5 gene to outside databases

Previous GC identifers: GC01M030999 GC01M030189 GC01M030631 GC01M030707 GC01M030700 GC01M030874 GC01M029311


Summaries
for LAPTM5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LAPTM5:
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3
protein, may play a role in hematopoiesis. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
Function: May have a special functional role during embryogenesis and in adult hematopoietic cells




Genomic Views
for LAPTM5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAPTM5 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Lmo2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAPTM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAPTM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAPTM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p34

LAPTM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAPTM5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031205:  view genomic region     (about GC identifiers)

Start:
 31,205,315 bp from pter      End:
 31,230,683 bp from pter
Size:
 25,369 bases      Orientation:
 minus strand

Proteins
for LAPTM5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571 (See protein sequence)
Recommended Name: Lysosomal-associated transmembrane protein 5  
Size: 262 amino acids; 29937 Da
Subunit: Binds to ubiquitin
Subcellular location: Lysosome membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA07643.1; Type=Erroneous initiation;
Secondary accessions: Q13240 Q14698 Q3KP54

Explore the universe of human proteins at neXtProt for LAPTM5: NX_Q13571

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13571

    • LAPTM5 Protein expression data from MOPED and PaxDb:    About this image 
    LAPTM5 Protein Expression
    REFSEQ proteins: NP_006753.1  
    ENSEMBL proteins: 
     ENSP00000294507  

    Human Recombinant Protein Products for LAPTM5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: LAPTM5
    OriGene Protein Over-expression Lysate: LAPTM5
    OriGene Custom Protein Services for LAPTM5 
    GenScript Custom Purified and Recombinant Proteins Services for LAPTM5
    Novus Biologicals LAPTM5 Proteins
    Novus Biologicals LAPTM5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LAPTM5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS8661146
    GO:0005765lysosomal membrane IEA--
    GO:0005887integral to plasma membrane IEA--

    LAPTM5 for ontologies           About GeneDecksing



    LAPTM5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LAPTM5 
    GenScript Custom Superior Antibodies Services for LAPTM5
    Novus Biologicals LAPTM5 Antibodies
    Abcam antibodies for LAPTM5 
    Uscn Antibodies for LAPTM5
    ThermoFisher Antibody for LAPTM5

    Assay Products for LAPTM5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LAPTM5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LAPTM5

    Protein Domains /
    Families
    for LAPTM5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LAPTM5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018396 LAPTM_4A/5
     IPR018397 Lysosomal-assoc_TM_prot5
     IPR004687 LAPTM4/5

    Graphical View of Domain Structure for InterPro Entry Q13571

    ProtoNet protein and cluster: Q13571

    1 Blocks protein family: IPB004687 Golgi 4-transmembrane spanning transporter

    UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
    Similarity: Belongs to the LAPTM4/LAPTM5 transporter family


    Function
    for LAPTM5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAPM5_HUMAN, Q13571
    Function: May have a special functional role during embryogenesis and in adult hematopoietic cells
    Induction: By retinoic acid

    Phenotypes:
         2 GenomeRNAi human phenotypes for LAPTM5:

     Decreased p24 protein expressi  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Laptm5):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    LAPTM5 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Laptm5tm1Jow for LAPTM5
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LAPTM5 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: LAPTM5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAPTM5
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate LAPTM5:
    hsa-miR-579 hsa-miR-100* hsa-miR-3136-5p hsa-miR-2355-3p hsa-miR-330-3p hsa-miR-219-5p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: LAPTM5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAPTM5 (see all 7)
    OriGene shRNA RFP: LAPTM5
    OriGene siRNA: LAPTM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAPTM5
    Sirion Biotech Custom design and validation of potent shRNA sequences against LAPTM5 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LAPTM5
    Sirion Biotech Customized adenovirus for overexpression of LAPTM5 
    Sirion Biotech Customized adenovirus for potent knockdown of LAPTM5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM5 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LAPTM5 (NM_006762)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LAPTM5
    Search LifeMap BioReagents cell lines for LAPTM5
    Sirion Biotech Customized stable knockdown cell line services for LAPTM5 
    Sirion Biotech Customized inducible knockdown cell line services for LAPTM5
    Sirion Biotech Customized stable overexpressing cell line services for LAPTM5
    Sirion Biotech Customized inducible overexpressing cell line services for LAPTM5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5


    Pathways & Interactions
    for LAPTM5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for LAPTM5):
        Lysosome


    LAPTM5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LAPTM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/31 Interacting proteins for LAPTM5 (Q135712, 3 ENSP000002945074) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKRD13AQ8IZ072, 3MINT-62174 MINT-62173 I2D: score=4 
    SMURF2Q9HAU42, 3MINT-61804 MINT-62170 I2D: score=3 
    UBA52P629872, 3, ENSP000003881074MINT-62176 I2D: score=3 STRING: ENSP00000388107
    DCUN1D1Q96GG92, 3MINT-62171 I2D: score=3 
    EPN1Q9Y6I32, 3MINT-62183 I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    LAPTM5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LAPTM5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAPTM5
    Search CenterWatch for drugs/clinical trials and news about LAPTM5 / LAPM5 

    Transcripts
    for LAPTM5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LAPTM5 gene: 
    NM_006762.2  

    Unigene Cluster for LAPTM5:

    Lysosomal protein transmembrane 5
    Hs.371021  [show with all ESTs]
    Unigene Representative Sequence: NM_006762
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294507(uc001bsc.2) ENST00000464569 ENST00000476492

    miRNA
    Products:             		 OriGene 3'-UTR Clone: LAPTM5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAPTM5
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate LAPTM5:
    hsa-miR-579 hsa-miR-100* hsa-miR-3136-5p hsa-miR-2355-3p hsa-miR-330-3p hsa-miR-219-5p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: LAPTM5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAPTM5 (see all 7)
    OriGene shRNA RFP: LAPTM5
    OriGene siRNA: LAPTM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAPTM5
    Sirion Biotech Custom design and validation of potent shRNA sequences against LAPTM5 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM5 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LAPTM5 (NM_006762)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAPTM5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LAPTM5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAPTM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAPTM5

    Additional cDNA sequence: 

    AK292009.1 AK297014.1 BC106896.1 BC106897.1 D42042.1 U30498.1 U51240.1 

    12 DOTS entries:

    DT.447574  DT.92438025  DT.100809473  DT.121407327  DT.100840534  DT.121407323  DT.121407335  DT.95209605 
    DT.100715378  DT.121407347  DT.87016466  DT.91794966 

    24/366 AceView cDNA sequences (see all 366):

    BU616667 CF242935 CD368845 BX483822 AA382107 AW574642 AI695031 F12601 
    AA586871 AW513037 CR607333 AW575972 AW402266 AW402135 BM055391 AA687715 
    BG393652 BF432318 D42042 AA583177 AL548614 AI352642 CR626282 AW082541 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d
    SP1:              -           -                             -                                 
    SP2:                          -                             -                                 
    SP3:              -     -     -                             -                                 
    SP4:                                                        -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for LAPTM5

    Expression
    for LAPTM5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAPTM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGGTTGTGG
    LAPTM5 Expression
    About this image

    LAPTM5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium

    See LAPTM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAPTM5

    SOURCE GeneReport for Unigene cluster: Hs.371021

    UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
    Tissue specificity: Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid
    tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and
    kidney

        SABiosciences Custom PCR Arrays for LAPTM5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAPTM5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LAPTM5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAPTM5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAPTM5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5

    Orthologs
    for LAPTM5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LAPTM5 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Laptm51 , 5 lysosomal-associated protein transmembrane 51, 5 81.1(n)1
    79.31(a)1    		   4 (64.00 cM)5
    167921  NM_010686.31  NP_034816.11 
     1309131255 
    chicken
    (Gallus gallus)    		 Aves LAPTM51 lysosomal protein transmembrane 5 64.36(n)
    56.1(a)    		   419552  XM_417701.3  XP_417701.1 


    ENSEMBL Gene Tree for LAPTM5 (if available)
    TreeFam Gene Tree for LAPTM5 (if available) 

    Paralogs
    for LAPTM5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for LAPTM5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/537 NCBI SNPs in LAPTM5 are shown (see all 537)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1456126061,2
    		--31204869(+) GTGCAC/TGCCTG 1 -- ds50010--------
    rs1454127601,2
    		--31204883(+) AGGGAA/GACATC 1 -- ds50010--------
    rs1860171501,2
    		--31204957(+) TCAGCA/CTGGCC 1 -- ds50010--------
    rs74168741,2
    		A--31205031(+) gtgggC/Ggtgtg 1 -- ds50010--------
    rs1113472921,2
    		C--31205125(+) TGTGGA/GGAGGG 1 -- ds50010--------
    rs1116728541,2
    		C--31205126(+) GTGGGA/GAGGGT 1 -- ds50010--------
    rs74152921,2
    		A--31205162(+) gtgtgG/Tgtgtt 1 -- ds50010--------
    rs1116823741,2
    		C--31205196(+) GGGTGA/GGTGTG 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1415611241,2
    		C--31205215(+) AGGGG-/TGTGTA
                TGTGG     		1 -- ds50010--------
    rs751023601,2
    		C,F--31205279(+) NNNNTC/TCCTAC 1 -- ds50011Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for LAPTM5 (31205315 - 31230683 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LAPTM5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAPTM5
    DNA2.0 Custom Variant and Variant Library Synthesis for LAPTM5

    Disorders / Diseases
    for LAPTM5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LAPTM5 for disorders           About GeneDecksing

    OMIM gene information: 601476    OMIM disorders: --

    10 diseases for LAPTM5:    About MalaCards
    pigmented villonodular synovitis    villonodular synovitis    hematopoiesis    multiple myeloma
    hepatocellular carcinoma    synovitis    myeloma    lung cancer
    carcinoma    neuroblastoma

    Human Genome Epidemiology (HuGE) Navigator: LAPTM5 (1 document)

    Export disorders for LAPTM5 gene to outside databases

    Publications
    for LAPTM5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAPTM5 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with LAPTM5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. (PubMed id 8661146)1, 2, 3 Adra C.N.... Lim B. (1996)
    2. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas. (PubMed id 12527926)1, 3 Seimiya M....Tagawa M. (2003)
    3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
    4. Lysosomal-associated protein multispanning transmembr ane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas . (PubMed id 19787053)1, 9 Inoue J....Inazawa J. (2009)
    5. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. (PubMed id 12886255)1, 9 Hayami Y....Ueda R. (2003)
    6. Lysosomal-associated transmembrane protein 5 (LAPTM5) is a molecular partner of CD1e. (PubMed id 22880058)1 Angenieux C....de la Salle H. (2012)
    7. LAPTM5 protein is a positive regulator of proinflammat ory signaling pathways in macrophages. (PubMed id 22733818)1 Glowacka W.K....Rotin D. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for LAPTM5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LAPTM5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7805 HGNC: 29612 AceView: LAPTM5 Ensembl:ENSG00000162511 euGenes: HUgn7805
    ECgene: LAPTM5 Kegg: 7805 H-InvDB: LAPTM5

    Other Databases showing LAPTM5 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0085

    Specialized Databases showing LAPTM5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAPTM5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LAPTM5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LAPTM5 gene:
    Search GeneIP for patents involving LAPTM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for LAPTM5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for LAPTM5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAPTM5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAPTM5  
     OriGene Protein Over-expression Lysate for LAPTM5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for LAPTM5   OriGene 3'-UTR Clone for LAPTM5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for LAPTM5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LAPTM5   OriGene Custom Protein Services for LAPTM5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LAPTM5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAPTM5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAPTM5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAPTM5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAPTM5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAPTM5
     GenScript Custom Purified and Recombinant Proteins Services for LAPTM5 GenScript cDNA clones with any tag delivered in your preferred vector for LAPTM5
     GenScript Custom Assay Services for LAPTM5 GenScript Custom Superior Antibodies Services for LAPTM5
     GenScript Custom overexpressing Cell Line Services for LAPTM5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LAPTM5 promoter
     Search Chromatin IP Primers for LAPTM5
     RT2 qPCR Primer Assay in human, mouse, rat LAPTM5
     Search GNC Networks for LAPTM5
     SABiosciences Custom PCR Arrays for LAPTM5
     Search Tocris compounds for LAPTM5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LAPTM5 antibodies
     LAPTM5 proteins
     LAPTM5 lysates
     Antibodies for LAPTM5
     See all of Abcam's Antibodies, Kits and Proteins for LAPTM5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     LAPTM5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for LAPTM5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5
     SwitchGear 3'UTR luciferase reporter plasmids for LAPTM5
     SwitchGear Promoter luciferase reporter plasmids for LAPTM5
     ThermoFisher Antibody for LAPTM5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM5
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LAPTM5
    Sirion Biotech Customized:
     stable knockdown cell line services for LAPTM5
     inducible knockdown cell line services for LAPTM5
     design and validation of potent shRNA sequences against LAPTM5
     adenovirus for potent knockdown of LAPTM5
     adenovirus for overexpression of LAPTM5
     stable overexpressing cell line services for LAPTM5
     inducible overexpressing cell line services for LAPTM5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      LAPTM5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4