Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LAPTM5 Gene

Aliases for LAPTM5 Gene

  • Lysosomal Protein Transmembrane 5 2 3
  • Lysosomal-Associated Multitransmembrane Protein 5 3 4
  • Lysosomal Multispanning Membrane Protein 5 2 3
  • Retinoic Acid-Inducible E3 Protein 3 4
  • Lysosomal Associated Multispanning Membrane Protein 5 3
  • Lysosomal-Associated Transmembrane Protein 5 3
  • CD40-Ligand-Activated Specific Transcripts 3
  • Human Retinoic Acid-Inducible E3 Protein 3
  • KIAA0085 4
  • CLAST6 3

External Ids for LAPTM5 Gene

Previous GeneCards Identifiers for LAPTM5 Gene

  • GC01M030999
  • GC01M030189
  • GC01M030631
  • GC01M030707
  • GC01M030874
  • GC01M031205
  • GC01M029311

Summaries for LAPTM5 Gene

Entrez Gene Summary for LAPTM5 Gene

  • This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

GeneCards Summary for LAPTM5 Gene

LAPTM5 (Lysosomal Protein Transmembrane 5) is a Protein Coding gene. Diseases associated with LAPTM5 include pigmented villonodular synovitis and villonodular synovitis. Among its related pathways are Lysosome.

UniProtKB/Swiss-Prot for LAPTM5 Gene

  • May have a special functional role during embryogenesis and in adult hematopoietic cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAPTM5 Gene

Genomics for LAPTM5 Gene

Regulatory Elements for LAPTM5 Gene

Genomic Location for LAPTM5 Gene

30,732,468 bp from pter
30,757,836 bp from pter
25,369 bases
Minus strand

Genomic View for LAPTM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAPTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAPTM5 Gene

Proteins for LAPTM5 Gene

  • Protein details for LAPTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosomal-associated transmembrane protein 5
    Protein Accession:
    Secondary Accessions:
    • Q13240
    • Q14698
    • Q3KP54

    Protein attributes for LAPTM5 Gene

    262 amino acids
    Molecular mass:
    29937 Da
    Quaternary structure:
    • Binds to ubiquitin
    • Sequence=BAA07643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LAPTM5 Gene

Proteomics data for LAPTM5 Gene at MOPED

Post-translational modifications for LAPTM5 Gene

  • Ubiquitination at Lys229, Lys233, and Lys248
  • Modification sites at PhosphoSitePlus

Other Protein References for LAPTM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LAPTM5 Gene

Domains for LAPTM5 Gene

Protein Domains for LAPTM5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q13571
  • Belongs to the LAPTM4/LAPTM5 transporter family.
genes like me logo Genes that share domains with LAPTM5: view

No data available for Gene Families for LAPTM5 Gene

Function for LAPTM5 Gene

Molecular function for LAPTM5 Gene

UniProtKB/Swiss-Prot Function: May have a special functional role during embryogenesis and in adult hematopoietic cells.
UniProtKB/Swiss-Prot Induction: By retinoic acid

Gene Ontology (GO) - Molecular Function for LAPTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LAPTM5: view

Phenotypes for LAPTM5 Gene

genes like me logo Genes that share phenotypes with LAPTM5: view

Animal Models for LAPTM5 Gene

MGI Knock Outs for LAPTM5:

Animal Model Products

CRISPR Products

miRNA for LAPTM5 Gene

miRTarBase miRNAs that target LAPTM5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LAPTM5 Gene

Localization for LAPTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAPTM5 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LAPTM5 Gene COMPARTMENTS Subcellular localization image for LAPTM5 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for LAPTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome TAS 8661146
GO:0005765 lysosomal membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LAPTM5: view

Pathways for LAPTM5 Gene

SuperPathways for LAPTM5 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAPTM5: view

Pathways by source for LAPTM5 Gene

1 KEGG pathway for LAPTM5 Gene

Gene Ontology (GO) - Biological Process for LAPTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LAPTM5: view

Transcripts for LAPTM5 Gene

mRNA/cDNA for LAPTM5 Gene

Unigene Clusters for LAPTM5 Gene

Lysosomal protein transmembrane 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAPTM5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -

Relevant External Links for LAPTM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAPTM5 Gene

mRNA expression in normal human tissues for LAPTM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAPTM5 Gene

This gene is overexpressed in Whole Blood (26.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LAPTM5 Gene

SOURCE GeneReport for Unigene cluster for LAPTM5 Gene Hs.371021

mRNA Expression by UniProt/SwissProt for LAPTM5 Gene

Tissue specificity: Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney.
genes like me logo Genes that share expressions with LAPTM5: view

In Situ Assay Products

Orthologs for LAPTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAPTM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LAPTM5 35
  • 99.24 (n)
  • 98.85 (a)
  • 84 (a)
(Bos Taurus)
Mammalia LAPTM5 35
  • 88.42 (n)
  • 87.4 (a)
  • 80 (a)
(Canis familiaris)
Mammalia LAPTM5 35
  • 88.68 (n)
  • 85.5 (a)
  • 85 (a)
(Mus musculus)
Mammalia Laptm5 35
  • 80.59 (n)
  • 78.54 (a)
Laptm5 16
Laptm5 36
  • 79 (a)
(Monodelphis domestica)
Mammalia LAPTM5 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia LAPTM5 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Laptm5 35
  • 80.2 (n)
  • 79.31 (a)
(Gallus gallus)
Aves LAPTM5 35
  • 64.63 (n)
  • 55.69 (a)
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia laptm5 35
  • 51.06 (n)
  • 34.09 (a)
Species with no ortholog for LAPTM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LAPTM5 Gene

Gene Tree for LAPTM5 (if available)
Gene Tree for LAPTM5 (if available)

Paralogs for LAPTM5 Gene

No data available for Paralogs for LAPTM5 Gene

Variants for LAPTM5 Gene

Sequence variations from dbSNP and Humsavar for LAPTM5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8048 -- 30,732,949(+) CACTG(C/T)TATGC utr-variant-3-prime
rs8056 -- 30,732,942(-) AGTGG(A/C)TTCCA utr-variant-3-prime
rs9146 -- 30,732,548(-) TGCAA(A/G)AGCTC utr-variant-3-prime
rs1050663 -- 30,742,517(-) CACTC(A/C/G)GTAGA reference, synonymous-codon
rs1050731 -- 30,732,616(-) ACCCA(A/G)AGGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LAPTM5 Gene

Variant ID Type Subtype PubMed ID
nsv460995 CNV Gain 19166990
nsv871304 CNV Loss 21882294
nsv509124 CNV Insertion 20534489
nsv512731 CNV Insertion 21212237

Relevant External Links for LAPTM5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAPTM5 Gene

Disorders for LAPTM5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for LAPTM5 Gene including...

Search for LAPTM5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LAPTM5 Gene

Relevant External Links for LAPTM5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LAPTM5: view

No data available for UniProtKB/Swiss-Prot for LAPTM5 Gene

Publications for LAPTM5 Gene

  1. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. (PMID: 8661146) Adra C.N. … Lim B. (Genomics 1996) 2 3 4
  2. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. (PMID: 12886255) Hayami Y. … Ueda R. (Leukemia 2003) 3 23
  3. Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas. (PMID: 19787053) Inoue J. … Inazawa J. (PLoS ONE 2009) 3 23
  4. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  5. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas. (PMID: 12527926) Seimiya M. … Tagawa M. (Int. J. Oncol. 2003) 2 3

Products for LAPTM5 Gene

Sources for LAPTM5 Gene

Back to Top