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LAPTM5 Gene

protein-coding   GIFtS: 59
GCID: GC01M031205

Lysosomal Protein Transmembrane 5

(Previous name: lysosomal multispanning membrane protein 5)
  See LAPTM5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysosomal Protein Transmembrane 51 2     CD40-Ligand-Activated Specific Transcripts2
Lysosomal Multispanning Membrane Protein 51 2     Human Retinoic Acid-Inducible E3 Protein2
Lysosomal-Associated Multitransmembrane Protein 52 3     Lysosomal Associated Multispanning Membrane Protein 52
Retinoic Acid-Inducible E3 Protein2 3     Lysosomal-Associated Transmembrane Protein 52
CLAST62     KIAA00853

External Ids:    HGNC: 296121   Entrez Gene: 78052   Ensembl: ENSG000001625117   OMIM: 6014765   UniProtKB: Q135713   

Export aliases for LAPTM5 gene to outside databases

Previous GC identifers: GC01M030999 GC01M030189 GC01M030631 GC01M030707 GC01M030700 GC01M030874 GC01M029311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LAPTM5 Gene:
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as
E3 protein, may play a role in hematopoiesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for LAPTM5 Gene:
LAPTM5 (lysosomal protein transmembrane 5) is a protein-coding gene. Diseases associated with LAPTM5 include villonodular synovitis, and pigmented villonodular synovitis.

UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
Function: May have a special functional role during embryogenesis and in adult hematopoietic cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAPTM5 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Lmo2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAPTM5 promoter sequence
   Search Chromatin IP Primers for LAPTM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAPTM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p34

LAPTM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAPTM5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031205:  view genomic region     (about GC identifiers)

Start:
31,205,315 bp from pter      End:
31,230,683 bp from pter
Size:
25,369 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571 (See protein sequence)
Recommended Name: Lysosomal-associated transmembrane protein 5  
Size: 262 amino acids; 29937 Da
Subunit: Binds to ubiquitin
Sequence caution: Sequence=BAA07643.1; Type=Erroneous initiation;
Secondary accessions: Q13240 Q14698 Q3KP54

Explore the universe of human proteins at neXtProt for LAPTM5: NX_Q13571

Explore proteomics data for LAPTM5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys229, Lys233, Lys248
  • Modification sites at PhosphoSitePlus

  • See LAPTM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006753.1  
    ENSEMBL proteins: 
     ENSP00000294507  

    LAPTM5 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LAPTM5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004687 LAPTM4/5
     IPR018396 LAPTM_4A/5
     IPR018397 Lysosomal-assoc_TM_prot5

    Graphical View of Domain Structure for InterPro Entry Q13571

    ProtoNet protein and cluster: Q13571

    1 Blocks protein domain: IPB004687 Golgi 4-transmembrane spanning transporter

    UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
    Similarity: Belongs to the LAPTM4/LAPTM5 transporter family


    Find genes that share domains with LAPTM5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAPM5_HUMAN, Q13571
    Function: May have a special functional role during embryogenesis and in adult hematopoietic cells
    Induction: By retinoic acid

    Phenotypes:
         2 GenomeRNAi human phenotypes for LAPTM5:

     Decreased p24 protein expressi  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Laptm5):
     hematopoietic system  immune system 

    Find genes that share phenotypes with LAPTM5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Laptm5tm1Jow for LAPTM5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAPTM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAPTM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAPTM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAPTM5

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAPTM5:
    hsa-mir-335-5p (MIRT018494)

    Block miRNA regulation of human, mouse, rat LAPTM5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate LAPTM5:
    hsa-miR-579 hsa-miR-100* hsa-miR-3136-5p hsa-miR-2355-3p hsa-miR-330-3p hsa-miR-219-5p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidLAPTM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAPTM5
    Predesigned siRNA for gene silencing in human, mouse, rat LAPTM5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: LAPTM5 (NM_006762)
    Sino Biological Human cDNA Clone for LAPTM5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LAPTM5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAPM5_HUMAN, Q13571: Lysosome membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS8661146
    GO:0005765lysosomal membrane IEA--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with LAPTM5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAPTM5 About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome


    Find genes that share SuperPaths with LAPTM5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for LAPTM5):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LAPTM5
    Interactions:

        Search GeneGlobe Interaction Network for LAPTM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for LAPTM5 (Q135712, 3 ENSP000002945074) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKRD13AQ8IZ072, 3MINT-62174 MINT-62173 I2D: score=4 
    UBA52P629872, 3, ENSP000003881074MINT-62176 I2D: score=3 STRING: ENSP00000388107
    DCUN1D1Q96GG92, 3MINT-62171 I2D: score=3 
    EPN1Q9Y6I32, 3MINT-62183 I2D: score=3 
    EPN3Q9H2012, 3MINT-62175 I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    Find genes that share ontologies with LAPTM5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAPTM5 (LAPM5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAPTM5 gene: 
    NM_006762.2  

    Unigene Cluster for LAPTM5:

    Lysosomal protein transmembrane 5
    Hs.371021  [show with all ESTs]
    Unigene Representative Sequence: NM_006762
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294507(uc001bsc.2) ENST00000464569 ENST00000476492
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LAPTM5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate LAPTM5:
    hsa-miR-579 hsa-miR-100* hsa-miR-3136-5p hsa-miR-2355-3p hsa-miR-330-3p hsa-miR-219-5p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidLAPTM5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LAPTM5
    Predesigned siRNA for gene silencing in human, mouse, rat LAPTM5
    Clone
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    OriGene ORF clones in mouse, rat for LAPTM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAPTM5 (NM_006762)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LAPTM5
    OriGene qSTAR qPCR primer pairs in human, mouse for LAPTM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAPTM5
      QuantiTect SYBR Green Assays in human, mouse, rat LAPTM5
      QuantiFast Probe-based Assays in human, mouse, rat LAPTM5

    Additional mRNA sequence: 

    AK292009.1 AK297014.1 BC106896.1 BC106897.1 D42042.1 U30498.1 U51240.1 

    12 DOTS entries:

    DT.447574  DT.92438025  DT.100809473  DT.121407327  DT.100840534  DT.121407323  DT.121407335  DT.95209605 
    DT.100715378  DT.121407347  DT.87016466  DT.91794966 

    Selected AceView cDNA sequences (see all 366):

    AW402135 BU616667 CA748549 F12601 CD368456 CD369704 BG393652 AA583177 
    AA404598 BQ181916 AL548614 AA973666 D42042 CR607333 AI453635 BX483822 
    CD369983 BM543413 AA022995 BF001471 AI695031 AA320479 AI361789 AA022463 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d
    SP1:              -           -                             -                                 
    SP2:                          -                             -                                 
    SP3:              -     -     -                             -                                 
    SP4:                                                        -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for LAPTM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAPTM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGTTGTGG
    LAPTM5 Expression
    About this image


    LAPTM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    LAPTM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAPTM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371021

    UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
    Tissue specificity: Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid
    tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver
    and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LAPTM5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Laptm51 , 5 lysosomal-associated protein transmembrane 51, 5 80.59(n)1
    78.54(a)1
      4 (64.00 cM)5
    167921  NM_010686.31  NP_034816.11 
     1309131255 
    chicken
    (Gallus gallus)
    Aves LAPTM51 lysosomal protein transmembrane 5 64.63(n)
    55.69(a)
      419552  XM_417701.4  XP_417701.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia laptm51 lysosomal protein transmembrane 5 51.06(n)
    34.09(a)
      548401  NM_001195709.1  NP_001182638.1 


    ENSEMBL Gene Tree for LAPTM5 (if available)
    TreeFam Gene Tree for LAPTM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAPTM5 (see all 600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456126061,2
    C--31204869(+) GTGCAC/TGCCTG 1 -- ds50010--------
    rs1454127601,2
    --31204883(+) AGGGAA/GACATC 1 -- ds50010--------
    rs1860171501,2
    --31204957(+) TCAGCA/CTGGCC 1 -- ds50010--------
    rs74168741,2
    A--31205031(+) gtgggC/Ggtgtg 1 -- ds50010--------
    rs1113472921,2
    C--31205125(+) TGTGGA/GGAGGG 1 -- ds50010--------
    rs1116728541,2
    C--31205126(+) GTGGGA/GAGGGT 1 -- ds50010--------
    rs74152921,2
    A--31205162(+) gtgtgG/Tgtgtt 1 -- ds50010--------
    rs1116823741,2
    C--31205196(+) GGGTGA/GGTGTG 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs3777137161,2
    C--31205207(+) AGTGT-/GTGGAGGG 1 -- ds50010--------
    rs751023601,2
    C,F--31205279(+) ACCCTC/TCCTAC 1 -- ds50011Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for LAPTM5 (31205315 - 31230683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LAPTM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv512731CNV Insertion21212237
    nsv509124CNV Insertion20534489
    nsv871304CNV Loss21882294
    nsv460995CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAPTM5
    DNA2.0 Custom Variant and Variant Library Synthesis for LAPTM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601476    OMIM disorders: --

    2 diseases for LAPTM5:    
    About MalaCards
    villonodular synovitis    pigmented villonodular synovitis

    1 disease from the University of Copenhagen DISEASES database for LAPTM5:
    Pigmented villonodular synovitis

    Find genes that share disorders with LAPTM5           About GenesLikeMe

    Genetic Association Database (GAD): LAPTM5
    Human Genome Epidemiology (HuGE) Navigator: LAPTM5 (1 document)

    Export disorders for LAPTM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAPTM5 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with LAPTM5)
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    1. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. (PubMed id 8661146)1, 2, 3 Adra C.N.... Lim B. (Genomics 1996)
    2. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas. (PubMed id 12527926)1, 3 Seimiya M....Tagawa M. (Int. J. Oncol. 2003)
    3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    4. Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas. (PubMed id 19787053)1, 9 Inoue J....Inazawa J. (PLoS ONE 2009)
    5. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. (PubMed id 12886255)1, 9 Hayami Y....Ueda R. (Leukemia 2003)
    6. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    7. Lysosomal-associated transmembrane protein 5 (LAPTM5) is a molecular partner of CD1e. (PubMed id 22880058)1 AngAcnieux C....de la Salle H. (PLoS ONE 2012)
    8. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. (PubMed id 22733818)1 Glowacka W.K....Rotin D. (J. Biol. Chem. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7805 HGNC: 29612 AceView: LAPTM5 Ensembl:ENSG00000162511 euGenes: HUgn7805
    ECgene: LAPTM5 Kegg: 7805 H-InvDB: LAPTM5

    (According to HUGE)
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    HUGE: KIAA0085

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAPTM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LAPTM5 gene:
    Search GeneIP for patents involving LAPTM5

    GeneCards and IP:
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