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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAPTM5 Gene

protein-coding   GIFtS: 58
GCID: GC01M031205

Lysosomal Protein Transmembrane 5

(Previous name: lysosomal multispanning membrane protein 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysosomal Protein Transmembrane 51 2     CD40-Ligand-Activated Specific Transcripts2
Lysosomal Multispanning Membrane Protein 51 2     Human Retinoic Acid-Inducible E3 Protein2
Lysosomal-Associated Multitransmembrane Protein 52 3     Lysosomal Associated Multispanning Membrane Protein 52
Retinoic Acid-Inducible E3 Protein2 3     Lysosomal-Associated Transmembrane Protein 52
CLAST62     KIAA00853

External Ids:    HGNC: 296121   Entrez Gene: 78052   Ensembl: ENSG000001625117   OMIM: 6014765   UniProtKB: Q135713   

Export aliases for LAPTM5 gene to outside databases

Previous GC identifers: GC01M030999 GC01M030189 GC01M030631 GC01M030707 GC01M030700 GC01M030874 GC01M029311


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAPTM5 Gene:
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as
E3 protein, may play a role in hematopoiesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for LAPTM5 Gene: 
LAPTM5 (lysosomal protein transmembrane 5) is a protein-coding gene. Diseases associated with LAPTM5 include villonodular synovitis, and synovitis.

UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
Function: May have a special functional role during embryogenesis and in adult hematopoietic cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAPTM5 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Lmo2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAPTM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAPTM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAPTM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p34

LAPTM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAPTM5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031205:  view genomic region     (about GC identifiers)

Start:
31,205,315 bp from pter      End:
31,230,683 bp from pter
Size:
25,369 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571 (See protein sequence)
Recommended Name: Lysosomal-associated transmembrane protein 5  
Size: 262 amino acids; 29937 Da
Subunit: Binds to ubiquitin
Subcellular location: Lysosome membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA07643.1; Type=Erroneous initiation;
Secondary accessions: Q13240 Q14698 Q3KP54

Explore the universe of human proteins at neXtProt for LAPTM5: NX_Q13571

Explore proteomics data for LAPTM5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13571

  • LAPTM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LAPTM5 Protein Expression
    REFSEQ proteins: NP_006753.1  
    ENSEMBL proteins: 
     ENSP00000294507  

    Human Recombinant Protein Products for LAPTM5: 
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    Novus Biologicals LAPTM5 Proteins
    Novus Biologicals LAPTM5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LAPTM5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS8661146
    GO:0005765lysosomal membrane IEA--
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane ----

    LAPTM5 for ontologies           About GeneDecksing



    LAPTM5 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR004687 LAPTM4/5
     IPR018396 LAPTM_4A/5
     IPR018397 Lysosomal-assoc_TM_prot5

    Graphical View of Domain Structure for InterPro Entry Q13571

    ProtoNet protein and cluster: Q13571

    1 Blocks protein domain: IPB004687 Golgi 4-transmembrane spanning transporter

    UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
    Similarity: Belongs to the LAPTM4/LAPTM5 transporter family


    LAPTM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAPM5_HUMAN, Q13571
    Function: May have a special functional role during embryogenesis and in adult hematopoietic cells
    Induction: By retinoic acid

    Phenotypes:
         2 GenomeRNAi human phenotypes for LAPTM5:

     Decreased p24 protein expressi  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Laptm5):
     cellular  hematopoietic system  immune system 

    LAPTM5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Laptm5tm1Jow for LAPTM5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LAPTM5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAPTM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAPTM5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAPTM5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAPTM5
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate LAPTM5:
    hsa-miR-579 hsa-miR-100* hsa-miR-3136-5p hsa-miR-2355-3p hsa-miR-330-3p hsa-miR-219-5p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidLAPTM5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of LAPTM5

    Clone
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    OriGene clones in human, mouse for LAPTM5 (see all 8)
    OriGene ORF clones in mouse, rat for LAPTM5
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    GenScript: all cDNA clones in your preferred vector: LAPTM5 (NM_006762)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of LAPTM5 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LAPTM5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for LAPTM5):
        Lysosome


    LAPTM5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LAPTM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/31 Interacting proteins for LAPTM5 (Q135712, 3 ENSP000002945074) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKRD13AQ8IZ072, 3MINT-62174 MINT-62173 I2D: score=4 
    SMURF2Q9HAU42, 3MINT-61804 MINT-62170 I2D: score=3 
    UBA52P629872, 3, ENSP000003881074MINT-62176 I2D: score=3 STRING: ENSP00000388107
    DCUN1D1Q96GG92, 3MINT-62171 I2D: score=3 
    EPN1Q9Y6I32, 3MINT-62183 I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    LAPTM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAPTM5 (LAPM5)

    Search CenterWatch for drugs/clinical trials and news about LAPTM5 / LAPM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAPTM5 gene: 
    NM_006762.2  

    Unigene Cluster for LAPTM5:

    Lysosomal protein transmembrane 5
    Hs.371021  [show with all ESTs]
    Unigene Representative Sequence: NM_006762
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294507(uc001bsc.2) ENST00000464569 ENST00000476492
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate LAPTM5:
    hsa-miR-579 hsa-miR-100* hsa-miR-3136-5p hsa-miR-2355-3p hsa-miR-330-3p hsa-miR-219-5p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidLAPTM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAPTM5
    Clone
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    GenScript: all cDNA clones in your preferred vector: LAPTM5 (NM_006762)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM5
    Sirion Biotech Customized lentivirus for stable overexpression of LAPTM5 
                         Customized lentivirus expression plasmids for stable overexpression of LAPTM5 
    Primer
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    OriGene qPCR primer pairs and template standards for LAPTM5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAPTM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAPTM5

    Additional mRNA sequence: 

    AK292009.1 AK297014.1 BC106896.1 BC106897.1 D42042.1 U30498.1 U51240.1 

    12 DOTS entries:

    DT.447574  DT.92438025  DT.100809473  DT.121407327  DT.100840534  DT.121407323  DT.121407335  DT.95209605 
    DT.100715378  DT.121407347  DT.87016466  DT.91794966 

    24/366 AceView cDNA sequences (see all 366):

    AA380698 CR607333 BM055391 BQ707246 BF432318 AA479762 AW402266 CA427529 
    CR626282 BQ695184 CA748549 AL548614 AA022463 AA364564 BM992365 AW082541 
    BQ181916 AA382107 CK822044 AA583177 AI695031 AA973666 AW575972 AA687715 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d
    SP1:              -           -                             -                                 
    SP2:                          -                             -                                 
    SP3:              -     -     -                             -                                 
    SP4:                                                        -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for LAPTM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAPTM5 expression in normal human tissues (normalized intensities)      LAPTM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGTTGTGG
    LAPTM5 Expression
    About this image


    LAPTM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 15 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood Pan-T Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Cord Blood Pan-T Cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Human umbilical vein endothelial cells (HUVEC)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
             Human Lymphatic Endothelial Cells (HLEC)   
     
     Lymph (Cardiovascular System)    fully expand to see all 2 entries
             Human Lymphatic Endothelial Cells (HLEC)   
             Lymphnode   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor RP1-MV2-16

    See LAPTM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAPTM5

    SOURCE GeneReport for Unigene cluster: Hs.371021

    UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571
    Tissue specificity: Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid
    tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver
    and kidney

        SABiosciences Custom PCR Arrays for LAPTM5
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAPTM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LAPTM5 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Laptm51 , 5 lysosomal-associated protein transmembrane 51, 5 81.1(n)1
    79.31(a)1
      4 (64.00 cM)5
    167921  NM_010686.31  NP_034816.11 
     1309131255 
    chicken
    (Gallus gallus)
    Aves LAPTM51 lysosomal protein transmembrane 5 64.36(n)
    56.1(a)
      419552  XM_417701.3  XP_417701.1 


    ENSEMBL Gene Tree for LAPTM5 (if available)
    TreeFam Gene Tree for LAPTM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/600 SNPs in LAPTM5 are shown (see all 600)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456126061,2
    C--31204869(+) GTGCAC/TGCCTG 1 -- ds50010--------
    rs1454127601,2
    --31204883(+) AGGGAA/GACATC 1 -- ds50010--------
    rs1860171501,2
    --31204957(+) TCAGCA/CTGGCC 1 -- ds50010--------
    rs74168741,2
    A--31205031(+) gtgggC/Ggtgtg 1 -- ds50010--------
    rs1113472921,2
    C--31205125(+) TGTGGA/GGAGGG 1 -- ds50010--------
    rs1116728541,2
    C--31205126(+) GTGGGA/GAGGGT 1 -- ds50010--------
    rs74152921,2
    A--31205162(+) gtgtgG/Tgtgtt 1 -- ds50010--------
    rs1116823741,2
    C--31205196(+) GGGTGA/GGTGTG 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs3777137161,2
    C--31205207(+) AGTGT-/GTGGAGGG 1 -- ds50010--------
    rs751023601,2
    C,F--31205279(+) ACCCTC/TCCTAC 1 -- ds50011Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for LAPTM5 (31205315 - 31230683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LAPTM5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv512731CNV Insertion21212237
    nsv509124CNV Insertion20534489
    nsv871304CNV Loss21882294
    nsv460995CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LAPTM5
    DNA2.0 Custom Variant and Variant Library Synthesis for LAPTM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601476    OMIM disorders: --

    8 diseases for LAPTM5:    About MalaCards
    villonodular synovitis    synovitis    pigmented villonodular synovitis    multiple myeloma
    myeloma    neuroblastoma    hepatocellular carcinoma    lung cancer

    1 disease from the University of Copenhagen DISEASES database for LAPTM5:
    Pigmented villonodular synovitis

    LAPTM5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LAPTM5
    Human Genome Epidemiology (HuGE) Navigator: LAPTM5 (1 document)

    Export disorders for LAPTM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAPTM5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with LAPTM5)
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    1. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. (PubMed id 8661146)1, 2, 3 Adra C.N.... Lim B. (1996)
    2. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas. (PubMed id 12527926)1, 3 Seimiya M....Tagawa M. (2003)
    3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
    4. Lysosomal-associated protein multispanning transmembr ane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas . (PubMed id 19787053)1, 9 Inoue J....Inazawa J. (2009)
    5. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. (PubMed id 12886255)1, 9 Hayami Y....Ueda R. (2003)
    6. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    7. Lysosomal-associated transmembrane protein 5 (LAPTM5) is a molecular partner of CD1e. (PubMed id 22880058)1 Angenieux C....de la Salle H. (2012)
    8. LAPTM5 protein is a positive regulator of proinflammat ory signaling pathways in macrophages. (PubMed id 22733818)1 Glowacka W.K....Rotin D. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7805 HGNC: 29612 AceView: LAPTM5 Ensembl:ENSG00000162511 euGenes: HUgn7805
    ECgene: LAPTM5 Kegg: 7805 H-InvDB: LAPTM5

    (According to HUGE)
    About This Section
    HUGE: KIAA0085

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAPTM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LAPTM5 gene:
    Search GeneIP for patents involving LAPTM5

    GeneCards and IP:
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