 |
 | Services
| |
 |
Aliases & Descriptions for LAPTM5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CLAST6 2 | | FLJ97251 2 | | KIAA0085 3 | | MGC125860 2 | | MGC125861 2 | | OTTHUMP00000003806 2 |
| | | Descriptions |
|---|
| CD40-ligand-activated specific transcripts 2 | | Lysosomal-associated multitransmembrane protein 5 3 | | Retinoic acid-inducible E3 protein 3 | | human retinoic acid-inducible E3 protein 2 | | lysosomal associated multispanning membrane protein 5 2 | | lysosomal multispanning membrane protein 5 2 |
|
| | Search outside databases for aliases for LAPTM5 genePrevious GC identifers: GC01M030189 GC01M030631 GC01M030707 GC01M030700 GC01M030874 |
Summaries for LAPTM5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LAPTM5: This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq] UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571Function: May have a special functional role during embryogenesis and in adult hematopoietic cells |
Genomic Location for LAPTM5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAPTM5 gene 
Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p34LAPTM5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M030999:
(about GC identifiers)
Start:
|
30,977,903 bp from pter |
End:
|
31,003,254 bp from pter |
Size:
|
25,352 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for LAPTM5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571 (See
protein sequence)Recommended Name: Lysosomal-associated transmembrane protein 5 Size: 262 amino acids; 29937 Da
Subunit: Binds to ubiquitin
Subcellular location: Lysosome membrane; Multi-pass membrane protein
Secondary accessions: Q13240 Q14698 Q3KP54Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006753.1
ENSEMBL proteins: ENSP00000294507
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LAPTM5: Assays for LAPTM5: | Protein
Domains/ Families for LAPTM5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13571
ProtoNet protein and cluster: Q13571 1 Blocks protein family: IPB004687 Golgi 4-transmembrane spanning transporter
UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571Similarity: Belongs to the LAPTM4/LAPTM5 transporter family | Gene Function for LAPTM5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006762
Applied Biosystems Silencer® siRNAs for LAPTM5
Sigma-Aldrich siRNA for LAPTM5  Sigma-Aldrich shRNA for LAPTM5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006762                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006762                                  untagged cDNA clone in CMV expression vector: NM_006762 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006762
UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571Function: May have a special functional role during embryogenesis and in adult hematopoietic cellsInduction: By retinoic acid3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Laptm5):
| Pathways & Interactions for LAPTM5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/18 Interacting proteins for LAPTM5 (ENSP000002945073 Q135712) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | About this table
|
Drugs & Compounds for LAPTM5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAPTM5
|
Transcripts for LAPTM5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006762
Sigma-Aldrich siRNA for LAPTM5  Sigma-Aldrich shRNA for LAPTM5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006762 REFSEQ mRNAs for LAPTM5 gene: NM_006762.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006762               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006762                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006762                                  untagged cDNA clone in CMV expression vector: NM_006762  Additional cDNA sequence: AK292009.1 AK297014.1 BC106896.1 BC106897.1 CR607333.1 CR626282.1 D42042.1 U30498.1 U51240.1 12 DOTS entries: DT.447574 DT.92438025 DT.100809473 DT.121407327 DT.100840534 DT.121407323 DT.121407335 DT.95209605 DT.100715378 DT.121407347 DT.87016466 DT.91794966 24/366 AceView cDNA sequences (see all 366
):AI453635 AW059657 AA479762 AI361789 AA022995 AA382106 BM668793 BG393652 AW575972 CR607333 AW402266 AW406311 AA586871 AW574642 F12601 CD369983 AA583177 CK822044 BF001471 AW513037 AW402135 CA748549 CF242935 BU616667
highest scoring ESTs for LAPTM5:U51240 AA220214 AW404191 AW406175 BE244130 BE245144 BF663787 BF877233 BG341213 BG393652 Unigene Cluster for LAPTM5: Lysosomal multispanning membrane protein 5 Hs.371021 [show with all ESTs]Unigene Representative Sequence: NM_006762
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM5
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | |
| SP1: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LAPTM5
1 Ensembl transcript including schematic representation: ENST00000294507
|
Expression for LAPTM5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAPTM5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAPTM5
1 / 2 / 3 5 probe-sets matching LAPTM5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCGGTTGTGG
SOURCE GeneReport for Unigene cluster: Hs.371021
Expression variation in blood from EXPOLDB for LAPTM5 UniProtKB/Swiss-Prot: LAPM5_HUMAN, Q13571Tissue specificity: Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leokocytes, thymus, spleen and lung, followed by placenta, liver and kidney |
Orthologs for LAPTM5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAPTM5 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for LAPTM5
ENSEMBL Gene Tree for LAPTM5 | Paralogs for LAPTM5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for LAPTM5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAPTM5 (up to first 250kb)
|
Disorders & Mutations for LAPTM5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601476
|
Medical News for LAPTM5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAPTM5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for LAPTM5 gene: |
Search for LAPTM5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAPTM5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAPTM5
(According to HUGE)
About This Section
| |
Specialized Databases showing LAPTM5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAPTM5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAPTM5:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for LAPTM5 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|