Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LAPTM4B Gene

Aliases for LAPTM4B Gene

  • Lysosomal Protein Transmembrane 4 Beta 2 3
  • Lysosome-Associated Transmembrane Protein 4-Beta 3 4
  • Lysosomal Associated Protein Transmembrane 4 Beta 3
  • Lysosomal-Associated Transmembrane Protein 4B 3
  • LAPTM4beta 3
  • LC27 3

External Ids for LAPTM4B Gene

Previous GeneCards Identifiers for LAPTM4B Gene

  • GC08P098861
  • GC08P098457
  • GC08P098744
  • GC08P098856
  • GC08P093993
  • GC08P098787

Summaries for LAPTM4B Gene

GeneCards Summary for LAPTM4B Gene

LAPTM4B (Lysosomal Protein Transmembrane 4 Beta) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is LAPTM4A.

Gene Wiki entry for LAPTM4B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAPTM4B Gene

Genomics for LAPTM4B Gene

Regulatory Elements for LAPTM4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LAPTM4B Gene

97,775,057 bp from pter
97,853,013 bp from pter
77,957 bases
Plus strand

Genomic View for LAPTM4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAPTM4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAPTM4B Gene

Proteins for LAPTM4B Gene

  • Protein details for LAPTM4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosomal-associated transmembrane protein 4B
    Protein Accession:
    Secondary Accessions:
    • Q3ZCV5
    • Q7L909
    • Q86VH8
    • Q9H060

    Protein attributes for LAPTM4B Gene

    370 amino acids
    Molecular mass:
    41146 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB66876.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LAPTM4B Gene


neXtProt entry for LAPTM4B Gene

Proteomics data for LAPTM4B Gene at MOPED

Post-translational modifications for LAPTM4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAPTM4B Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for LAPTM4B

No data available for DME Specific Peptides for LAPTM4B Gene

Domains for LAPTM4B Gene

Protein Domains for LAPTM4B Gene

Suggested Antigen Peptide Sequences for LAPTM4B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86VI4
  • Belongs to the LAPTM4/LAPTM5 transporter family.
genes like me logo Genes that share domains with LAPTM4B: view

No data available for Gene Families for LAPTM4B Gene

Function for LAPTM4B Gene

Gene Ontology (GO) - Molecular Function for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20711237
genes like me logo Genes that share ontologies with LAPTM4B: view

Phenotypes for LAPTM4B Gene

GenomeRNAi human phenotypes for LAPTM4B:
genes like me logo Genes that share phenotypes with LAPTM4B: view

Animal Model Products

CRISPR Products

miRNA for LAPTM4B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAPTM4B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LAPTM4B Gene

Localization for LAPTM4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAPTM4B Gene

Endomembrane system; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LAPTM4B Gene COMPARTMENTS Subcellular localization image for LAPTM4B gene
Compartment Confidence
plasma membrane 3
lysosome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LAPTM4B: view

Pathways for LAPTM4B Gene

SuperPathways for LAPTM4B Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAPTM4B: view

Pathways by source for LAPTM4B Gene

1 KEGG pathway for LAPTM4B Gene

Gene Ontology (GO) - Biological Process for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LAPTM4B: view

Transcripts for LAPTM4B Gene

mRNA/cDNA for LAPTM4B Gene

Unigene Clusters for LAPTM4B Gene

Lysosomal protein transmembrane 4 beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAPTM4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP2: - - - - -

Relevant External Links for LAPTM4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAPTM4B Gene

mRNA expression in normal human tissues for LAPTM4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAPTM4B Gene

This gene is overexpressed in Heart - Left Ventricle (5.3) and Heart - Atrial Appendage (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LAPTM4B Gene

SOURCE GeneReport for Unigene cluster for LAPTM4B Gene Hs.492314

genes like me logo Genes that share expressions with LAPTM4B: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for LAPTM4B Gene

Orthologs for LAPTM4B Gene

This gene was present in the common ancestor of animals.

Orthologs for LAPTM4B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LAPTM4B 35
  • 91.15 (n)
  • 93.81 (a)
-- 36
  • 74 (a)
  • 94 (a)
(Canis familiaris)
Mammalia LAPTM4B 35
  • 91.59 (n)
  • 96.9 (a)
  • 75 (a)
(Mus musculus)
Mammalia Laptm4b 35
  • 88.64 (n)
  • 92.48 (a)
Laptm4b 16
Laptm4b 36
  • 92 (a)
(Pan troglodytes)
Mammalia LAPTM4B 35
  • 99.05 (n)
  • 99.05 (a)
  • 74 (a)
(Rattus norvegicus)
Mammalia Laptm4b 35
  • 87.32 (n)
  • 93.36 (a)
(Monodelphis domestica)
Mammalia LAPTM4B 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia LAPTM4B 36
  • 84 (a)
(Gallus gallus)
Aves LAPTM4B 35
  • 77.87 (n)
  • 81.9 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia LAPTM4B 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia laptm4b 35
  • 76.15 (n)
  • 81.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17780 35
(Danio rerio)
Actinopterygii laptm4b 35
  • 68.91 (n)
  • 72.2 (a)
laptm4b 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14767 36
  • 15 (a)
Species with no ortholog for LAPTM4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAPTM4B Gene

Gene Tree for LAPTM4B (if available)
Gene Tree for LAPTM4B (if available)

Paralogs for LAPTM4B Gene

Paralogs for LAPTM4B Gene

Selected SIMAP similar genes for LAPTM4B Gene using alignment to 3 proteins: Pseudogenes for LAPTM4B Gene

genes like me logo Genes that share paralogs with LAPTM4B: view

Variants for LAPTM4B Gene

Sequence variations from dbSNP and Humsavar for LAPTM4B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3412 -- 97,852,566(-) CAAAC(A/G)ACTTA utr-variant-3-prime
rs8796 -- 97,851,874(+) TTCCA(G/T)CATAG utr-variant-3-prime
rs8879 -- 97,852,095(+) CATCT(A/G)CTGAC utr-variant-3-prime
rs14516 -- 97,852,532(-) ACCAA(C/T)AGGAG utr-variant-3-prime
rs936664 -- 97,839,263(+) GATCT(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAPTM4B Gene

Variant ID Type Subtype PubMed ID
nsv526913 CNV Loss 19592680
nsv517493 CNV Loss 19592680
nsv891213 CNV Loss 21882294
esv2666910 CNV Deletion 23128226
esv2737346 CNV Deletion 23290073
nsv891214 CNV Gain 21882294
esv2658992 CNV Deletion 23128226
esv23644 CNV Loss 19812545

Relevant External Links for LAPTM4B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAPTM4B Gene

Disorders for LAPTM4B Gene

(2) University of Copenhagen DISEASES for LAPTM4B Gene

(1) Novoseek inferred disease relationships for LAPTM4B Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 55 5

Relevant External Links for LAPTM4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LAPTM4B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for LAPTM4B Gene

Publications for LAPTM4B Gene

  1. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (PMID: 12902989) Shao G.-Z. … Ye D.X. (Oncogene 2003) 3 4 23
  2. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers. (PMID: 17965115) Cheng X.J. … Zhou R.L. (Ann. Oncol. 2008) 3 23 48
  3. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells. (PMID: 19843073) Liu X. … Zhou R. (Cancer Sci. 2009) 3 23
  4. Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. (PMID: 15162524) Liu X.R. … Ye D.X. (World J. Gastroenterol. 2004) 3 23
  5. The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. (PMID: 15911104) Kasper G. … Mennerich D. (Cancer Lett. 2005) 3 23

Products for LAPTM4B Gene

Sources for LAPTM4B Gene

Back to Top