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Aliases & Descriptions for LAPTM4B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LAPTM4beta 2 | | LC27 1, 2 |
| | | Descriptions |
|---|
| Lysosome-associated transmembrane protein 4-beta 3 | | lysosomal associated protein transmembrane 4 beta 2 | | lysosomal associated transmembrane protein 4 beta 2 | | lysosomal protein transmembrane 4 beta 2 |
|
| | Search outside databases for aliases for LAPTM4B genePrevious GC identifers: GC08P098861 GC08P098457 GC08P098744 |
Summaries for LAPTM4B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for LAPTM4B |
Genomic Location for LAPTM4B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAPTM4B gene 
Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1LAPTM4B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P098856:
(about GC identifiers)
Start:
|
98,856,985 bp from pter |
End:
|
98,934,006 bp from pter |
Size:
|
77,022 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008046.15
| Proteins for LAPTM4B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAP4B_HUMAN, Q86VI4 (See
protein sequence)Recommended Name: Lysosomal-associated transmembrane protein 4B Size: 370 amino acids; 41146 Da
Subcellular location: Endomembrane system; Multi-pass membrane protein
Secondary accessions: Q3ZCV5 Q7L909 Q86VH8 Q9H060Alternative splicing: 3 isoforms: Q86VI4-1 Q86VI4-2 Q86VI4-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060877.3
ENSEMBL proteins: ENSP00000220781 ENSP00000367995
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LAPTM4B: Assays for LAPTM4B: | Protein
Domains/ Families for LAPTM4B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q86VI4
ProtoNet protein and cluster: Q86VI4 1 Blocks protein family: IPB004687 Golgi 4-transmembrane spanning transporter
UniProtKB/Swiss-Prot: LAP4B_HUMAN, Q86VI4Similarity: Belongs to the LAPTM4/LAPTM5 transporter family | Gene Function for LAPTM4B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018407
Applied Biosystems Silencer® siRNAs for LAPTM4B
Sigma-Aldrich siRNA for LAPTM4B  Sigma-Aldrich shRNA for LAPTM4B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018407                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018407                                  untagged cDNA clone in CMV expression vector: NM_018407 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018407
| Pathways & Interactions for LAPTM4B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for LAPTM4B (ENSP000003679953) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | About this table
|
Drugs & Compounds for LAPTM4B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAPTM4B
|
Transcripts for LAPTM4B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018407
Sigma-Aldrich siRNA for LAPTM4B  Sigma-Aldrich shRNA for LAPTM4B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018407 REFSEQ mRNAs for LAPTM4B gene: NM_018407.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018407               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018407                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018407                                  untagged cDNA clone in CMV expression vector: NM_018407  Additional cDNA sequence: AF317417.1 AF527412.1 AK075326.1 AK311377.1 AL136942.1 AY057051.2 AY261384.1 BC014129.2 BC031021.1 BC038117.1 CR594459.1 CR618053.1 CR623862.1 CR624328.1 24 DOTS entries: DT.95156544 DT.95252067 DT.100840368 DT.100840374 DT.92465203 DT.100767964 DT.97862572 DT.99993086 DT.100840377 DT.121484435 DT.121484480 DT.95333670 DT.100697313 DT.100840376 DT.121484443 DT.121484444 DT.121484475 DT.121484476 DT.121484505 DT.92465187 DT.95156541 DT.95156545 DT.95291176 DT.121239577 24/858 AceView cDNA sequences (see all 858
):BM669077 AA974657 AI383136 BQ425369 AW517122 BG819900 BM761083 AA406524 AA983238 BQ881647 BQ686427 BF439716 CR623862 CB068395 BM703198 BM663360 CB215526 BU535497 BQ932584 BU191508 BQ636249 BG287262 BU165554 AJ708348
highest scoring ESTs for LAPTM4B:AA009649 AA009650 AA021181 AA021576 AA024712 AA024795 AA033947 AA062553 AA063160 AA069747 Unigene Cluster for LAPTM4B: Lysosomal protein transmembrane 4 beta Hs.492314 [show with all ESTs]Unigene Representative Sequence: BC038117
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | - |   | - |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LAPTM4B
2 Ensembl transcripts including schematic representations: ENST00000220781
ENST00000378722
|
Expression for LAPTM4B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAPTM4B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAPTM4B
1 / 2 / 3 9 probe-sets matching LAPTM4B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAAAAGGGTT
SOURCE GeneReport for Unigene cluster: Hs.492314
Expression variation in blood from EXPOLDB for LAPTM4B |
Orthologs for LAPTM4B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAPTM4B gene from 5/8 species (see all 8
)
About this table Species with no ortholog for LAPTM4B
ENSEMBL Gene Tree for LAPTM4B | Paralogs for LAPTM4B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAPTM4B gene
- LAPTM4A2
|
SNPs/Variants for LAPTM4B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAPTM4B (up to first 250kb)
|
Disorders & Mutations for LAPTM4B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| 1 Novoseek disease relationship for LAPTM4B gene
About this table
Genetic Association Database: LAPTM4B Human Genome Epidemiology Navigator: LAPTM4B (3 documents)
|
Medical News for LAPTM4B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAPTM4B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/19 PubMed articles for LAPTM4B gene (see all 19
):- Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (PubMed id 12902989)1, 3, 4 Shao G.-Z.... Ye D.X. (2003)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3, 4 Otsuki T....Isogai T. (2005)
- [Relationship between LAPTM4B gene polymorphism and susceptibility of lung cancer] (PubMed id 15968325)3, 6 Deng L.J....Zhou R.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. (PubMed id 15162524)1, 3 Liu X.R....Ye D.X. (2004)
- Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers. (PubMed id 17965115)1, 3 Cheng X.J....Zhou R.L. (2008)
- The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. (PubMed id 15911104)1, 3 Kasper G....Mennerich D. (2005)
- LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. (PubMed id 18949404)3 Yang Y....Zhou R. (2008)
- Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma. (PubMed id 18334282)3 Zhou L....Yu J.C. (2008)
|
Search for LAPTM4B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAPTM4B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAPTM4B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAPTM4B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAPTM4B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAPTM4B:

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Incremental update: 13 Oct 2009
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