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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAPTM4B Gene

protein-coding   GIFtS: 55
GCID: GC08P098787

lysosomal protein transmembrane 4 beta
 Explore 11 diseases affiliated with
LAPTM4B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LAPTM4B    

Aliases
for LAPTM4B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lysosomal Protein Transmembrane 4 Beta1 2
LC271 2
Lysosome-Associated Transmembrane Protein 4-Beta2 3
LAPTM4beta2
Lysosomal Associated Protein Transmembrane 4 Beta2
Lysosomal-Associated Transmembrane Protein 4B2

External Ids:    HGNC: 136461   Entrez Gene: 553532   Ensembl: ENSG000001043417   OMIM: 6132965   UniProtKB: Q86VI43   

Export aliases for LAPTM4B gene to outside databases

Previous GC identifers: GC08P098861 GC08P098457 GC08P098744 GC08P098856 GC08P093993


Summaries
for LAPTM4B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for LAPTM4B


Genomic Views
for LAPTM4B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAPTM4B gene promoter:
         Brachyury   Lmo2   E4BP4   GATA-1   MEF-2A   RORalpha1   Pax-3   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAPTM4B promoter sequence
   Search SABiosciences Chromatin IP Primers for LAPTM4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAPTM4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

LAPTM4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAPTM4B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P098787:  view genomic region     (about GC identifiers)

Start:
 98,787,285 bp from pter      End:
 98,865,241 bp from pter
Size:
 77,957 bases      Orientation:
 plus strand

Proteins
for LAPTM4B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LAP4B_HUMAN, Q86VI4 (See protein sequence)
Recommended Name: Lysosomal-associated transmembrane protein 4B  
Size: 370 amino acids; 41146 Da
Subcellular location: Endomembrane system; Multi-pass membrane protein
Sequence caution: Sequence=CAB66876.2; Type=Erroneous initiation;
Secondary accessions: Q3ZCV5 Q7L909 Q86VH8 Q9H060
Alternative splicing: 3 isoforms:  Q86VI4-1   Q86VI4-2   Q86VI4-3   

Explore the universe of human proteins at neXtProt for LAPTM4B: NX_Q86VI4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VI4

    • LAPTM4B Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_060877.3  
    ENSEMBL proteins: 
     ENSP00000402301   ENSP00000429868   ENSP00000428409  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: LAPTM4B
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    Novus Biologicals LAPTM4B Protein
    Novus Biologicals LAPTM4B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--


    LAPTM4B for ontologies           About GeneDecksing



    LAPTM4B Antibody Products: 
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    Novus Biologicals LAPTM4B Antibody
    Search for Antibodies for LAPTM4B at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for LAPTM4B

    Assay Products for LAPTM4B: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for LAPTM4B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LAPTM4B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018401 Lysosomal-assoc_TM_prot4B
     IPR004687 LAPTM4/5

    Graphical View of Domain Structure for InterPro Entry Q86VI4

    ProtoNet protein and cluster: Q86VI4

    1 Blocks protein family: IPB004687 Golgi 4-transmembrane spanning transporter

    UniProtKB/Swiss-Prot: LAP4B_HUMAN, Q86VI4
    Similarity: Belongs to the LAPTM4/LAPTM5 transporter family


    Function
    for LAPTM4B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: LAPTM4B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAPTM4B
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate LAPTM4B (see all 10):
    hsa-miR-3673 hsa-miR-137 hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-302f hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmid: LAPTM4B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAPTM4B (see all 7)
    OriGene shRNA RFP: LAPTM4B
    OriGene siRNA: LAPTM4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAPTM4B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LAPTM4B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM4B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM4B
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    GenScript: all cDNA clones in your preferred vector: LAPTM4B (NM_018407)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM4B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LAPTM4B
    Search LifeMap BioReagents cell lines for LAPTM4B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM4B

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    LAPTM4B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for LAPTM4B:
     Increased G1 DNA content  Synthetic lethal with imatinib 


    Pathways & Interactions
    for LAPTM4B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for LAPTM4B):
        Lysosome


    LAPTM4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LAPTM4B

    2 Interacting proteins for LAPTM4B (Q86VI41, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB1P081831, 3EBI-3267258,EBI-1057359 I2D: score=1 
    PIK3R1P279861EBI-3267286,EBI-79464
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--


    LAPTM4B for ontologies           About GeneDecksing



    Drugs & Compounds
    for LAPTM4B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAPTM4B
    Search CenterWatch for drugs/clinical trials and news about LAPTM4B / LAP4B 

    Transcripts
    for LAPTM4B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LAPTM4B gene: 
    NM_018407.4  

    Unigene Cluster for LAPTM4B:

    Lysosomal protein transmembrane 4 beta
    Hs.492314  [show with all ESTs]
    Unigene Representative Sequence: BC038117
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445593(uc003yia.3 uc010mbg.3) ENST00000517924 ENST00000521545


    miRNA
    Products:             		 OriGene 3'-UTR Clone: LAPTM4B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAPTM4B
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate LAPTM4B (see all 10):
    hsa-miR-3673 hsa-miR-137 hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-302f hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmid: LAPTM4B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAPTM4B (see all 7)
    OriGene shRNA RFP: LAPTM4B
    OriGene siRNA: LAPTM4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAPTM4B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM4B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAPTM4B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LAPTM4B (NM_018407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM4B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAPTM4B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LAPTM4B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAPTM4B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAPTM4B

    Additional cDNA sequence: 

    AF317417.1 AF527412.1 AK075326.1 AK311377.1 AL136942.1 AY057051.2 AY261384.1 BC014129.2 
    BC031021.1 BC038117.1 

    24 DOTS entries:

    DT.95156544  DT.95252067  DT.100840368  DT.100840374  DT.92465203  DT.100767964  DT.97862572  DT.99993086 
    DT.100840377  DT.121484435  DT.121484480  DT.95333670  DT.100697313  DT.100840376  DT.121484443  DT.121484444 
    DT.121484475  DT.121484476  DT.121484505  DT.92465187  DT.95156541  DT.95156545  DT.95291176  DT.121239577 

    24/858 AceView cDNA sequences (see all 858):

    BQ894623 AA629658 BQ278776 BM790441 BF981356 BU191508 CA414126 BE740140 
    AI422233 AA600214 BQ686427 BG775232 CB215263 BM826047 AJ708348 AF317417 
    AA983238 BM761083 BU535497 AW248624 AW075495 BM841994 AA995410 AA379248 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:        -     -     -     -     -               


    ECgene alternative splicing isoforms for LAPTM4B

    Expression
    for LAPTM4B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAPTM4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAGGGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LAPTM4B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainChoroid PlexusBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)

    Genevestigator expression for LAPTM4B

    SOURCE GeneReport for Unigene cluster: Hs.492314
        SABiosciences Custom PCR Arrays for LAPTM4B
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM4B

    Orthologs
    for LAPTM4B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LAPTM4B gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Laptm4b1 , 5 lysosomal-associated protein transmembrane 4B1, 5 88.64(n)1
    92.48(a)1    		   15 (13.98 cM)5
    1141281  NM_033521.31  NP_277056.11 
     342380265 
    chicken
    (Gallus gallus)    		 Aves LAPTM4B1 lysosomal protein transmembrane 4 beta 79.19(n)
    84.62(a)    		   770893  XM_001233338.2  XP_001233339.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LAPTM4B6
    		 --
    		 75(a)
    		 1 ↔ 1
    		 4(20513275-20565969)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.177802 Xenopus laevis transcribed sequence with moderate similarity more 77.55(n)    CF548227.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii laptm4b2 lysosomal associated protein transmembrane 4 beta 75.14(n)   368911  BC059484.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG147676
    		 --
    		 16(a)
    		 1 → many
    		 2R(4605522-4611342)


    ENSEMBL Gene Tree for LAPTM4B (if available)
    TreeFam Gene Tree for LAPTM4B (if available) 

    Paralogs
    for LAPTM4B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAPTM4B gene
    LAPTM4A2  
    2 SIMAP similar genes for LAPTM4B using alignment to 3 protein entries:     LAP4B_HUMAN (see all proteins):
    LC27    LAPTM4A

    LAPTM4B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for LAPTM4B
    PGOHUM00000256866 PGOHUM00000238064


    Genomic Variants
    for LAPTM4B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1815 NCBI SNPs in LAPTM4B are shown (see all 1815)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1488837701,2
    		--98785856(+) GCAACC/TTCTGC 1 -- us2k10--------
    rs1437048261,2
    		--98785880(+) GCCATC/TCTTCT 1 -- us2k10--------
    rs757427631,2
    		C--98785927(+) CACCAA/CCACGC 1 -- us2k10--------
    rs1859754631,2
    		--98786157(+) CCTGGA/GGTTCT 1 -- us2k10--------
    rs23315931,2
    		C,A,--98786186(-) GGTCCC/AATTCC 1 -- us2k15Minor allele frequency- A:0.25NA CSA WA EA 361
    rs1902627321,2
    		--98786200(+) GGCCAC/TGCAGT 1 -- us2k10--------
    rs1481029931,2
    		--98786240(+) GTCACA/GGAAGA 1 -- us2k10--------
    rs1409917951,2
    		--98786278(+) CAGCTC/TGATTA 1 -- us2k10--------
    rs23315921,2
    		C,--98786406(-) gacttC/Tcaccc 1 -- us2k13Minor allele frequency- T:0.03NA WA 122
    rs1824428031,2
    		--98786489(+) TGTGCA/CGCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LAPTM4B (98787285 - 98865241 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for LAPTM4B
         3 CNVs: 52647 65205 52646
         1 Indel: 52648

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAPTM4B
    DNA2.0 Custom Variant and Variant Library Synthesis for LAPTM4B

    Disorders / Diseases
    for LAPTM4B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LAPTM4B for disorders           About GeneDecksing

    OMIM gene information: 613296    OMIM disorders: --

    11 diseases for LAPTM4B:    About MalaCards
    gallbladder carcinoma    hepatocellular carcinoma    cervical carcinoma    ovarian carcinoma
    esophageal cancer    carcinoma    esophagitis    cervicitis
    gastric cancer    cholangiocarcinoma    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for LAPTM4B:
    Gallbladder carcinoma     Hepatocellular carcinoma

    1 Novoseek disease relationship for LAPTM4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 55 7 12902989 (1), 15162524 (1), 15911104 (1), 17965115 (1) (see all 5)

    Genetic Association Database (GAD): LAPTM4B
    Human Genome Epidemiology (HuGE) Navigator: LAPTM4B (5 documents)

    Export disorders for LAPTM4B gene to outside databases

    Publications
    for LAPTM4B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAPTM4B gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with LAPTM4B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (PubMed id 12902989)1, 2, 9 Shao G.-Z.... Ye D.X. (2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. [Relationship between LAPTM4B gene polymorphism and susceptibility of lung cancer] (PubMed id 15968325)1, 4 Deng L.J....Zhou R.L. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. (PubMed id 15162524)1, 9 Liu X.R....Ye D.X. (2004)
    7. LAPTM4B-35, a novel tetratransmembrane protein and it s PPRP motif play critical roles in proliferation and metastatic potential of h epatocellular carcinoma cells. (PubMed id 19843073)1, 9 Liu X....Zhou R. (2009)
    8. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers. (PubMed id 17965115)1, 9 Cheng X.J....Zhou R.L. (2008)
    9. The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. (PubMed id 15911104)1, 9 Kasper G....Mennerich D. (2005)
    10. LAPTM4B polymorphisms is associated with ovarian cance r susceptibility and its prognosis. (PubMed id 22412199)1 Xu Y....Lou G. (2012)

    External Searches for LAPTM4B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing LAPTM4B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55353 HGNC: 13646 AceView: LAPTM4B Ensembl:ENSG00000104341 euGenes: HUgn55353
    ECgene: LAPTM4B Kegg: 55353 H-InvDB: LAPTM4B

    Other Databases showing LAPTM4B gene

    (According to HUGE)
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    Specialized Databases showing LAPTM4B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAPTM4B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LAPTM4B gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for LAPTM4B gene:
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