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Aliases for LAPTM4B Gene

Aliases for LAPTM4B Gene

  • Lysosomal Protein Transmembrane 4 Beta 2 3 5
  • Lysosome-Associated Transmembrane Protein 4-Beta 3 4
  • Lysosomal Associated Protein Transmembrane 4 Beta 3
  • Lysosomal-Associated Transmembrane Protein 4B 3
  • LAPTM4beta 3
  • LC27 3

External Ids for LAPTM4B Gene

Previous GeneCards Identifiers for LAPTM4B Gene

  • GC08P098861
  • GC08P098457
  • GC08P098744
  • GC08P098856
  • GC08P093993
  • GC08P098787

Summaries for LAPTM4B Gene

GeneCards Summary for LAPTM4B Gene

LAPTM4B (Lysosomal Protein Transmembrane 4 Beta) is a Protein Coding gene. Diseases associated with LAPTM4B include Hepatocellular Carcinoma. Among its related pathways are Lysosome. An important paralog of this gene is LAPTM4A.

Gene Wiki entry for LAPTM4B Gene

Additional gene information for LAPTM4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAPTM4B Gene

Genomics for LAPTM4B Gene

Regulatory Elements for LAPTM4B Gene

Enhancers for LAPTM4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H097830 1.1 FANTOM5 ENCODE 30.1 +56.4 56431 2 HDGF PKNOX1 NFIB SUZ12 BMI1 ZBTB7B ZKSCAN1 MTA3 CTBP1 GATA3 LAPTM4B ENSG00000245970 RPL30 MATN2 ENSG00000202399 RPS23P1 SNORA72 ERICH5 POP1 PIR33604
GH08H097798 1.2 Ensembl ENCODE dbSUPER 19.5 +23.9 23875 2.7 ATF1 CEBPG FOSL1 GATA2 NCOR1 FOS ZNF600 CREM ATF2 NR2F2 LAPTM4B MATN2 ENSG00000270682 PIR33604
GH08H097774 1.4 ENCODE dbSUPER 13.8 +2.1 2117 5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF766 SP3 SP5 LAPTM4B MTDH ENSG00000270682
GH08H097804 0.9 Ensembl ENCODE dbSUPER 20.9 +29.9 29945 0.4 ZNF316 LAPTM4B ENSG00000270682 PIR33604
GH08H097846 0.7 ENCODE 26.1 +72.4 72403 1.3 PKNOX1 TBL1XR1 CBFB JUN NR2F1 JUNB ELF1 BATF IKZF1 MLLT1 LAPTM4B ENSG00000202399 ERICH5 MATN2 GC08M097844 GC08M097854
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LAPTM4B on UCSC Golden Path with GeneCards custom track

Promoters for LAPTM4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227577 1143 2401 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 FOS SP5 MXD4 ZC3H11A

Genomic Locations for LAPTM4B Gene

Genomic Locations for LAPTM4B Gene
77,957 bases
Plus strand

Genomic View for LAPTM4B Gene

Genes around LAPTM4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAPTM4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAPTM4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAPTM4B Gene

Proteins for LAPTM4B Gene

  • Protein details for LAPTM4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosomal-associated transmembrane protein 4B
    Protein Accession:
    Secondary Accessions:
    • Q3ZCV5
    • Q7L909
    • Q86VH8
    • Q9H060

    Protein attributes for LAPTM4B Gene

    370 amino acids
    Molecular mass:
    41146 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB66876.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LAPTM4B Gene


neXtProt entry for LAPTM4B Gene

Post-translational modifications for LAPTM4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAPTM4B Gene

No data available for DME Specific Peptides for LAPTM4B Gene

Domains & Families for LAPTM4B Gene

Gene Families for LAPTM4B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for LAPTM4B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LAPTM4/LAPTM5 transporter family.
  • Belongs to the LAPTM4/LAPTM5 transporter family.
genes like me logo Genes that share domains with LAPTM4B: view

Function for LAPTM4B Gene

Phenotypes From GWAS Catalog for LAPTM4B Gene

Gene Ontology (GO) - Molecular Function for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20711237
GO:0019900 kinase binding IPI 25588945
GO:0031625 ubiquitin protein ligase binding IPI 25588945
GO:0097001 ceramide binding IDA 26280656
GO:1902936 phosphatidylinositol bisphosphate binding IDA 25588945
genes like me logo Genes that share ontologies with LAPTM4B: view
genes like me logo Genes that share phenotypes with LAPTM4B: view

Animal Models for LAPTM4B Gene

MGI Knock Outs for LAPTM4B:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAPTM4B Gene

Localization for LAPTM4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAPTM4B Gene

Endomembrane system; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAPTM4B gene
Compartment Confidence
plasma membrane 3
nucleus 2
lysosome 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 25588945
GO:0005765 lysosomal membrane IDA 21224396
GO:0005768 endosome IDA 25588945
GO:0005769 early endosome IDA 25588945
GO:0005886 plasma membrane IDA 22096579
genes like me logo Genes that share ontologies with LAPTM4B: view

Pathways & Interactions for LAPTM4B Gene

SuperPathways for LAPTM4B Gene

SuperPathway Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAPTM4B: view

Pathways by source for LAPTM4B Gene

1 KEGG pathway for LAPTM4B Gene

Gene Ontology (GO) - Biological Process for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007032 endosome organization IMP 21224396
GO:0032509 endosome transport via multivesicular body sorting pathway IDA 25588945
GO:0032911 negative regulation of transforming growth factor beta1 production IDA 26126825
GO:0097213 regulation of lysosomal membrane permeability IMP 26280656
genes like me logo Genes that share ontologies with LAPTM4B: view

No data available for SIGNOR curated interactions for LAPTM4B Gene

Drugs & Compounds for LAPTM4B Gene

No Compound Related Data Available

Transcripts for LAPTM4B Gene

Unigene Clusters for LAPTM4B Gene

Lysosomal protein transmembrane 4 beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP2: - - - - -

Relevant External Links for LAPTM4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAPTM4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAPTM4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAPTM4B Gene

This gene is overexpressed in Heart - Left Ventricle (x5.3) and Heart - Atrial Appendage (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAPTM4B Gene

NURSA nuclear receptor signaling pathways regulating expression of LAPTM4B Gene:


SOURCE GeneReport for Unigene cluster for LAPTM4B Gene:


Evidence on tissue expression from TISSUES for LAPTM4B Gene

  • Nervous system(4.9)
  • Eye(4.8)
  • Lung(4.7)
  • Skin(3.3)
  • Kidney(3)
  • Heart(2.8)
  • Pancreas(2.7)
  • Intestine(2.5)
  • Liver(2.4)
  • Stomach(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with LAPTM4B: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAPTM4B Gene

Orthologs for LAPTM4B Gene

This gene was present in the common ancestor of animals.

Orthologs for LAPTM4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LAPTM4B 33 34
  • 99.05 (n)
(Canis familiaris)
Mammalia LAPTM4B 33 34
  • 91.59 (n)
(Bos Taurus)
Mammalia LAPTM4B 33 34
  • 91.15 (n)
-- 34
  • 74 (a)
(Mus musculus)
Mammalia Laptm4b 33 16 34
  • 88.64 (n)
(Rattus norvegicus)
Mammalia Laptm4b 33
  • 87.32 (n)
(Ornithorhynchus anatinus)
Mammalia LAPTM4B 34
  • 84 (a)
(Monodelphis domestica)
Mammalia LAPTM4B 34
  • 80 (a)
(Gallus gallus)
Aves LAPTM4B 33 34
  • 77.87 (n)
(Anolis carolinensis)
Reptilia LAPTM4B 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia laptm4b 33
  • 76.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17780 33
(Danio rerio)
Actinopterygii laptm4b 33 34
  • 68.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14767 34
  • 15 (a)
Species where no ortholog for LAPTM4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAPTM4B Gene

Gene Tree for LAPTM4B (if available)
Gene Tree for LAPTM4B (if available)

Paralogs for LAPTM4B Gene

Paralogs for LAPTM4B Gene

(2) SIMAP similar genes for LAPTM4B Gene using alignment to 3 proteins: Pseudogenes for LAPTM4B Gene

genes like me logo Genes that share paralogs with LAPTM4B: view

Variants for LAPTM4B Gene

Sequence variations from dbSNP and Humsavar for LAPTM4B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000044533 -- 97,788,474(+) CAACT(C/T)CTGAC intron-variant
rs1000056402 -- 97,776,407(+) CGCGG(C/G/T)CTCGC intron-variant
rs1000059421 -- 97,789,579(+) CTGGA(A/G)TGCAA intron-variant
rs1000061901 -- 97,804,325(+) GGAAG(A/G)ATAAA intron-variant
rs1000118760 -- 97,813,220(+) CAGTG(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAPTM4B Gene

Variant ID Type Subtype PubMed ID
nsv971688 CNV duplication 23825009
nsv971687 CNV duplication 23825009
nsv526913 CNV loss 19592680
nsv517493 CNV loss 19592680
nsv1140922 CNV deletion 24896259
nsv1116574 OTHER inversion 24896259
nsv1018567 CNV gain 25217958
nsv1017596 CNV gain 25217958
esv3618142 CNV loss 21293372
esv3618141 CNV loss 21293372
esv2737346 CNV deletion 23290073
esv2666910 CNV deletion 23128226
esv2658992 CNV deletion 23128226
esv23644 CNV loss 19812545

Variation tolerance for LAPTM4B Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAPTM4B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAPTM4B Gene

Disorders for LAPTM4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LAPTM4B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LAPTM4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LAPTM4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAPTM4B Gene

Publications for LAPTM4B Gene

  1. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers. (PMID: 17965115) Cheng XJ … Zhou RL (Annals of oncology : official journal of the European Society for Medical Oncology 2008) 3 22 45 60
  2. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (PMID: 12902989) Shao GZ … Ye DX (Oncogene 2003) 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells. (PMID: 19843073) Liu X … Zhou R (Cancer science 2009) 3 22 60
  5. Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer. (PMID: 17074969) Liu Y … Zhou RL (Annals of oncology : official journal of the European Society for Medical Oncology 2007) 3 45 60

Products for LAPTM4B Gene

Sources for LAPTM4B Gene

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