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Aliases for LAPTM4B Gene

Aliases for LAPTM4B Gene

  • Lysosomal Protein Transmembrane 4 Beta 2 3 5
  • Lysosome-Associated Transmembrane Protein 4-Beta 3 4
  • Lysosomal Associated Protein Transmembrane 4 Beta 3
  • Lysosomal-Associated Transmembrane Protein 4B 3
  • LAPTM4beta 3
  • LC27 3

External Ids for LAPTM4B Gene

Previous GeneCards Identifiers for LAPTM4B Gene

  • GC08P098861
  • GC08P098457
  • GC08P098744
  • GC08P098856
  • GC08P093993
  • GC08P098787

Summaries for LAPTM4B Gene

GeneCards Summary for LAPTM4B Gene

LAPTM4B (Lysosomal Protein Transmembrane 4 Beta) is a Protein Coding gene. Diseases associated with LAPTM4B include Hepatocellular Carcinoma. Among its related pathways are Lysosome. An important paralog of this gene is LAPTM4A.

Gene Wiki entry for LAPTM4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAPTM4B Gene

Genomics for LAPTM4B Gene

Regulatory Elements for LAPTM4B Gene

Enhancers for LAPTM4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G097830 1.1 FANTOM5 ENCODE 30.1 +56.4 56431 2.0 HDGF PKNOX1 NFIB SUZ12 BMI1 ZBTB7B ZKSCAN1 MTA3 CTBP1 GATA3 LAPTM4B MATN2 ENSG00000202399 RPS23P1 ENSG00000245970 RPL30 SNORA72 ERICH5 POP1 PIR33604
GH08G097804 1.3 Ensembl ENCODE dbSUPER 20.9 +29.9 29945 0.4 PKNOX1 NFIB CEBPG ZBTB40 ZKSCAN1 MTA3 GATA3 ZNF316 CTBP1 ELK1 LAPTM4B PIR33604 ENSG00000270682
GH08G097798 1.3 Ensembl ENCODE dbSUPER 19.5 +23.9 23875 2.7 PKNOX1 ATF1 ZNF766 GATA2 CBX5 FOS CREM JUNB NR2F2 MEF2D LAPTM4B MATN2 ENSG00000270682 PIR33604
GH08G097774 1.4 ENCODE dbSUPER 13.8 +2.1 2117 5.0 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF766 LAPTM4B MTDH ENSG00000270682
GH08G097846 0.7 ENCODE 26.1 +72.4 72403 1.3 PKNOX1 JUN ARID3A GATA2 FOS IKZF2 CREM EGR2 MTA2 NR2F1 LAPTM4B ENSG00000202399 ERICH5 MATN2 GC08M097844 GC08M097854
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LAPTM4B on UCSC Golden Path with GeneCards custom track

Promoters for LAPTM4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227577 1143 2401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 FOS SP5 ZHX2

Genomic Location for LAPTM4B Gene

Chromosome:
8
Start:
97,775,057 bp from pter
End:
97,853,013 bp from pter
Size:
77,957 bases
Orientation:
Plus strand

Genomic View for LAPTM4B Gene

Genes around LAPTM4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAPTM4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAPTM4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAPTM4B Gene

Proteins for LAPTM4B Gene

  • Protein details for LAPTM4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI4-LAP4B_HUMAN
    Recommended name:
    Lysosomal-associated transmembrane protein 4B
    Protein Accession:
    Q86VI4
    Secondary Accessions:
    • Q3ZCV5
    • Q7L909
    • Q86VH8
    • Q9H060

    Protein attributes for LAPTM4B Gene

    Size:
    370 amino acids
    Molecular mass:
    41146 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66876.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LAPTM4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAPTM4B Gene

Post-translational modifications for LAPTM4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAPTM4B Gene

No data available for DME Specific Peptides for LAPTM4B Gene

Domains & Families for LAPTM4B Gene

Protein Domains for LAPTM4B Gene

Graphical View of Domain Structure for InterPro Entry

Q86VI4

UniProtKB/Swiss-Prot:

LAP4B_HUMAN :
  • Belongs to the LAPTM4/LAPTM5 transporter family.
Family:
  • Belongs to the LAPTM4/LAPTM5 transporter family.
genes like me logo Genes that share domains with LAPTM4B: view

No data available for Gene Families for LAPTM4B Gene

Function for LAPTM4B Gene

Gene Ontology (GO) - Molecular Function for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20711237
genes like me logo Genes that share ontologies with LAPTM4B: view
genes like me logo Genes that share phenotypes with LAPTM4B: view

Animal Models for LAPTM4B Gene

MGI Knock Outs for LAPTM4B:

Animal Model Products

  • Taconic Biosciences Mouse Models for LAPTM4B

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAPTM4B Gene

Localization for LAPTM4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAPTM4B Gene

Endomembrane system; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAPTM4B gene
Compartment Confidence
plasma membrane 3
nucleus 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LAPTM4B: view

Pathways & Interactions for LAPTM4B Gene

SuperPathways for LAPTM4B Gene

SuperPathway Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAPTM4B: view

Pathways by source for LAPTM4B Gene

1 KEGG pathway for LAPTM4B Gene

Gene Ontology (GO) - Biological Process for LAPTM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LAPTM4B: view

No data available for SIGNOR curated interactions for LAPTM4B Gene

Drugs & Compounds for LAPTM4B Gene

No Compound Related Data Available

Transcripts for LAPTM4B Gene

Unigene Clusters for LAPTM4B Gene

Lysosomal protein transmembrane 4 beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: - - - - -

Relevant External Links for LAPTM4B Gene

GeneLoc Exon Structure for
LAPTM4B
ECgene alternative splicing isoforms for
LAPTM4B

Expression for LAPTM4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAPTM4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAPTM4B Gene

This gene is overexpressed in Heart - Left Ventricle (x5.3) and Heart - Atrial Appendage (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAPTM4B Gene



NURSA nuclear receptor signaling pathways regulating expression of LAPTM4B Gene:

LAPTM4B

SOURCE GeneReport for Unigene cluster for LAPTM4B Gene:

Hs.492314

Evidence on tissue expression from TISSUES for LAPTM4B Gene

  • Nervous system(4.9)
  • Eye(4.8)
  • Lung(4.7)
  • Skin(3.3)
  • Kidney(3)
  • Heart(2.8)
  • Pancreas(2.7)
  • Intestine(2.5)
  • Liver(2.4)
  • Stomach(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with LAPTM4B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAPTM4B Gene

Orthologs for LAPTM4B Gene

This gene was present in the common ancestor of animals.

Orthologs for LAPTM4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAPTM4B 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia LAPTM4B 34 35
  • 91.59 (n)
cow
(Bos Taurus)
Mammalia LAPTM4B 34 35
  • 91.15 (n)
-- 35
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Laptm4b 34 16 35
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia Laptm4b 34
  • 87.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LAPTM4B 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAPTM4B 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAPTM4B 34 35
  • 77.87 (n)
lizard
(Anolis carolinensis)
Reptilia LAPTM4B 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia laptm4b 34
  • 76.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17780 34
zebrafish
(Danio rerio)
Actinopterygii laptm4b 34 35
  • 68.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14767 35
  • 15 (a)
OneToMany
Species where no ortholog for LAPTM4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAPTM4B Gene

ENSEMBL:
Gene Tree for LAPTM4B (if available)
TreeFam:
Gene Tree for LAPTM4B (if available)

Paralogs for LAPTM4B Gene

Paralogs for LAPTM4B Gene

(2) SIMAP similar genes for LAPTM4B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for LAPTM4B Gene

genes like me logo Genes that share paralogs with LAPTM4B: view

Variants for LAPTM4B Gene

Sequence variations from dbSNP and Humsavar for LAPTM4B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000044533 -- 97,788,474(+) CAACT(C/T)CTGAC intron-variant
rs1000056402 -- 97,776,407(+) CGCGG(C/G/T)CTCGC intron-variant
rs1000059421 -- 97,789,579(+) CTGGA(A/G)TGCAA intron-variant
rs1000061901 -- 97,804,325(+) GGAAG(A/G)ATAAA intron-variant
rs1000118760 -- 97,813,220(+) CAGTG(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAPTM4B Gene

Variant ID Type Subtype PubMed ID
esv23644 CNV loss 19812545
esv2658992 CNV deletion 23128226
esv2666910 CNV deletion 23128226
esv2737346 CNV deletion 23290073
esv3618141 CNV loss 21293372
esv3618142 CNV loss 21293372
nsv1017596 CNV gain 25217958
nsv1018567 CNV gain 25217958
nsv1116574 OTHER inversion 24896259
nsv1140922 CNV deletion 24896259
nsv517493 CNV loss 19592680
nsv526913 CNV loss 19592680
nsv971687 CNV duplication 23825009
nsv971688 CNV duplication 23825009

Variation tolerance for LAPTM4B Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAPTM4B Gene

Human Gene Mutation Database (HGMD)
LAPTM4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAPTM4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAPTM4B Gene

Disorders for LAPTM4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LAPTM4B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LAPTM4B

Genetic Association Database (GAD)
LAPTM4B
Human Genome Epidemiology (HuGE) Navigator
LAPTM4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAPTM4B
genes like me logo Genes that share disorders with LAPTM4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAPTM4B Gene

Publications for LAPTM4B Gene

  1. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers. (PMID: 17965115) Cheng X.J. … Zhou R.L. (Ann. Oncol. 2008) 3 22 46 64
  2. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (PMID: 12902989) Shao G.-Z. … Ye D.X. (Oncogene 2003) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells. (PMID: 19843073) Liu X. … Zhou R. (Cancer Sci. 2009) 3 22 64
  5. Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer. (PMID: 17074969) Liu Y. … Zhou R.L. (Ann. Oncol. 2007) 3 46 64

Products for LAPTM4B Gene

Sources for LAPTM4B Gene

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