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LAPTM4B Gene

protein-coding   GIFtS: 56
GCID: GC08P098787

Lysosomal Protein Transmembrane 4 Beta

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysosomal Protein Transmembrane 4 Beta1 2
Lysosome-Associated Transmembrane Protein 4-Beta2 3
LAPTM4beta2
LC272
Lysosomal Associated Protein Transmembrane 4 Beta2
Lysosomal-Associated Transmembrane Protein 4B2

External Ids:    HGNC: 136461   Entrez Gene: 553532   Ensembl: ENSG000001043417   OMIM: 6132965   UniProtKB: Q86VI43   

Export aliases for LAPTM4B gene to outside databases

Previous GC identifers: GC08P098861 GC08P098457 GC08P098744 GC08P098856 GC08P093993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LAPTM4B Gene:
LAPTM4B (lysosomal protein transmembrane 4 beta) is a protein-coding gene. An important paralog of this gene is LAPTM4A.

Gene Wiki entry for LAPTM4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAPTM4B gene promoter:
         Brachyury   Lmo2   E4BP4   GATA-1   MEF-2A   RORalpha1   Pax-3   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAPTM4B promoter sequence
   Search Chromatin IP Primers for LAPTM4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAPTM4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

LAPTM4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAPTM4B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P098787:  view genomic region     (about GC identifiers)

Start:
98,787,285 bp from pter      End:
98,865,241 bp from pter
Size:
77,957 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LAP4B_HUMAN, Q86VI4 (See protein sequence)
Recommended Name: Lysosomal-associated transmembrane protein 4B  
Size: 370 amino acids; 41146 Da
Sequence caution: Sequence=CAB66876.2; Type=Erroneous initiation;
Secondary accessions: Q3ZCV5 Q7L909 Q86VH8 Q9H060
Alternative splicing: 3 isoforms:  Q86VI4-1   Q86VI4-2   Q86VI4-3   

Explore the universe of human proteins at neXtProt for LAPTM4B: NX_Q86VI4

Explore proteomics data for LAPTM4B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LAPTM4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060877.3  
    ENSEMBL proteins: 
     ENSP00000402301   ENSP00000428409   ENSP00000429868  

    LAPTM4B Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LAPTM4B 

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    LSBio Antibodies in human, mouse, rat for LAPTM4B

    LAPTM4B Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for LAPTM4B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004687 LAPTM4/5
     IPR018401 Lysosomal-assoc_TM_prot4B

    Graphical View of Domain Structure for InterPro Entry Q86VI4

    ProtoNet protein and cluster: Q86VI4

    1 Blocks protein domain: IPB004687 Golgi 4-transmembrane spanning transporter

    UniProtKB/Swiss-Prot: LAP4B_HUMAN, Q86VI4
    Similarity: Belongs to the LAPTM4/LAPTM5 transporter family


    Find genes that share domains with LAPTM4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with LAPTM4B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LAPTM4B:
     Increased G1 DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAPTM4B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAPTM4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAPTM4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAPTM4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAPTM4B:
    hsa-mir-24-3p (MIRT030456), hsa-mir-93-5p (MIRT028065), hsa-mir-183-5p (MIRT024999), hsa-mir-27b-3p (MIRT046220), hsa-mir-16-5p (MIRT051281)

    Block miRNA regulation of human, mouse, rat LAPTM4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LAPTM4B (see all 10):
    hsa-miR-3673 hsa-miR-137 hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-302f hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidLAPTM4B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat LAPTM4B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: LAPTM4B (NM_018407)
    Sino Biological Human cDNA Clone for LAPTM4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM4B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LAPTM4B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAP4B_HUMAN, Q86VI4: Endomembrane system; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    lysosome2
    vacuole2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LAPTM4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAPTM4B About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome


    Find genes that share SuperPaths with LAPTM4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for LAPTM4B):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LAPTM4B
    Interactions:

        Search GeneGlobe Interaction Network for LAPTM4B

    2 Interacting proteins for LAPTM4B (Q86VI41, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB1P081831, 3EBI-3267258,EBI-1057359 I2D: score=1 
    PIK3R1P279861EBI-3267286,EBI-79464
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    Find genes that share ontologies with LAPTM4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAPTM4B (LAP4B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAPTM4B gene: 
    NM_018407.4  

    Unigene Cluster for LAPTM4B:

    Lysosomal protein transmembrane 4 beta
    Hs.492314  [show with all ESTs]
    Unigene Representative Sequence: BC038117
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445593(uc003yia.3 uc010mbg.3) ENST00000521545 ENST00000517924

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LAPTM4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LAPTM4B (see all 10):
    hsa-miR-3673 hsa-miR-137 hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-302f hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidLAPTM4B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LAPTM4B
    Predesigned siRNA for gene silencing in human, mouse, rat LAPTM4B
    Clone
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    OriGene clones in human, mouse for LAPTM4B (see all 6)
    OriGene ORF clones in mouse, rat for LAPTM4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAPTM4B (NM_018407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAPTM4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAPTM4B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LAPTM4B
    OriGene qSTAR qPCR primer pairs in human, mouse for LAPTM4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAPTM4B
      QuantiTect SYBR Green Assays in human, mouse, rat LAPTM4B
      QuantiFast Probe-based Assays in human, mouse, rat LAPTM4B

    Additional mRNA sequence: 

    AF317417.1 AF527412.1 AK075326.1 AK311377.1 AL136942.1 AY057051.2 AY261384.1 BC014129.2 
    BC031021.1 BC038117.1 

    24 DOTS entries:

    DT.95156544  DT.95252067  DT.100840368  DT.100840374  DT.92465203  DT.100767964  DT.97862572  DT.99993086 
    DT.100840377  DT.121484435  DT.121484480  DT.95333670  DT.100697313  DT.100840376  DT.121484443  DT.121484444 
    DT.121484475  DT.121484476  DT.121484505  DT.92465187  DT.95156541  DT.95156545  DT.95291176  DT.121239577 

    Selected AceView cDNA sequences (see all 858):

    BU165554 CR618053 AI418680 BG829898 BM826047 BQ684852 BE905182 CB129176 
    BM555277 AF317417 BG395809 H44849 BM849643 BM763975 CB215526 CR624328 
    BU176448 AI084555 BG026322 BM747592 BU187510 CR594459 BQ636249 BM841994 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:        -     -     -     -     -               


    ECgene alternative splicing isoforms for LAPTM4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAPTM4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGGGTT
    LAPTM4B Expression
    About this image


    LAPTM4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Megakaryocyte-Erythroid Precursor Cells Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Brain (Nervous System)
             Choroid Plexus
    LAPTM4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAPTM4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492314
        Custom PCR Arrays for LAPTM4B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAPTM4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LAPTM4B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Laptm4b1 , 5 lysosomal-associated protein transmembrane 4B1, 5 88.64(n)1
    92.48(a)1
      15 (13.98 cM)5
    1141281  NM_033521.31  NP_277056.11 
     342380265 
    chicken
    (Gallus gallus)
    Aves LAPTM4B1 lysosomal protein transmembrane 4 beta 77.87(n)
    81.9(a)
      770893  XM_001233338.3  XP_001233339.2 
    lizard
    (Anolis carolinensis)
    Reptilia LAPTM4B6
    lysosomal protein transmembrane 4 beta
    66(a)
    1 ↔ 1
    4(20513100-20570208)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.177802 Xenopus laevis transcribed sequence with moderate similarity more 77.55(n)    CF548227.1 
    zebrafish
    (Danio rerio)
    Actinopterygii laptm4b2 lysosomal associated protein transmembrane 4 beta 75.14(n)   368911  BC059484.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147676
    --
    15(a)
    1 → many
    2R(4605522-4611342)


    ENSEMBL Gene Tree for LAPTM4B (if available)
    TreeFam Gene Tree for LAPTM4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LAPTM4B gene
    LAPTM4A2  
    2 SIMAP similar genes for LAPTM4B using alignment to 3 protein entries:     LAP4B_HUMAN (see all proteins):
    LC27    LAPTM4A

    Find genes that share paralogs with LAPTM4B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for LAPTM4B
    PGOHUM00000256866 PGOHUM00000238064


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAPTM4B (see all 2073)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887022591,2
    --93991717(+) TCCCCA/GGCTCA 1 -- us2k10--------
    rs1467206231,2
    --93991777(+) ACGTGC/TCACCA 1 -- us2k10--------
    rs1814847381,2
    --93991804(+) TCTTGC/TTTTTG 1 -- us2k10--------
    rs1488837701,2
    C--98785856(+) GCAACC/TTCTGC 1 -- us2k10--------
    rs1437048261,2
    C--98785880(+) GCCATC/TCTTCT 1 -- us2k10--------
    rs757427631,2
    C--98785927(+) CACCAA/CCACGC 1 -- us2k10--------
    rs2015277891,2
    C--98785930(+) CACCA-/CGCCCA 1 -- us2k10--------
    rs1859754631,2
    --98786157(+) CCTGGA/GGTTCT 1 -- us2k10--------
    rs23315931,2
    C,A--98786186(-) ggtccC/Aattcc 1 -- us2k15Minor allele frequency- A:0.25NA CSA WA EA 361
    rs1902627321,2
    --98786200(+) GGCCAC/TGCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LAPTM4B (98787285 - 98865241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for LAPTM4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737346CNV Deletion23290073
    esv2658992CNV Deletion23128226
    esv2666910CNV Deletion23128226
    esv23644CNV Loss19812545
    nsv526913CNV Loss19592680
    nsv517493CNV Loss19592680
    nsv891213CNV Loss21882294
    nsv891214CNV Gain21882294

    Human Gene Mutation Database (HGMD): LAPTM4B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAPTM4B
    DNA2.0 Custom Variant and Variant Library Synthesis for LAPTM4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613296    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for LAPTM4B:
    Gallbladder carcinoma     Hepatocellular carcinoma

    Find genes that share disorders with LAPTM4B           About GenesLikeMe

    1 Novoseek inferred disease relationship for LAPTM4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 55 7 12902989 (1), 15162524 (1), 15911104 (1), 17965115 (1) (see all 5)

    Genetic Association Database (GAD): LAPTM4B
    Human Genome Epidemiology (HuGE) Navigator: LAPTM4B (5 documents)

    Export disorders for LAPTM4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAPTM4B gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with LAPTM4B)
        Utopia: connect your pdf to the dynamic
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    1. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers. (PubMed id 17965115)1, 4, 9 Cheng X.J....Zhou R.L. (Ann. Oncol. 2008)
    2. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (PubMed id 12902989)1, 2, 9 Shao G.-Z.... Ye D.X. (Oncogene 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer. (PubMed id 17074969)1, 4 Liu Y.... Zhou R.L. (Ann. Oncol. 2007)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. [Relationship between LAPTM4B gene polymorphism and susceptibility of lung cancer]. (PubMed id 15968325)1, 4 Deng L.J....Zhou R.L. (Beijing Da Xue Xue Bao 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. (PubMed id 15162524)1, 9 Liu X.R....Ye D.X. (World J. Gastroenterol. 2004)
    10. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells. (PubMed id 19843073)1, 9 Liu X....Zhou R. (Cancer Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55353 HGNC: 13646 AceView: LAPTM4B Ensembl:ENSG00000104341 euGenes: HUgn55353
    ECgene: LAPTM4B Kegg: 55353 H-InvDB: LAPTM4B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAPTM4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for LAPTM4B gene:
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