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Aliases & Descriptions for LAPTM4A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases HUMORF13 1 , 2 KIAA0108 1 , 2 , 3 LAPTM4 1 , 2 , 3 MBNT 2 , 3 MTRP 3 Mtrp 1 , 2
Descriptions Golgi 4-transmembrane spanning transporter MTP 3 lysosomal protein transmembrane 4 alpha 2 lysosomal-associated protein transmembrane 4 alpha 1 , 2 membrane nucleoside transporter 2
Search outside databases for aliases for LAPTM4A genePrevious GC identifers: GC02M020123 GC02M020300 GC02M020216
Summaries for LAPTM4A (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for LAPTM4A : This gene encodes a protein that has four predicted transmembrane domains. The function of thisgene has not yet been determined; however, studies in the mouse homolog suggest a role in thetransport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq] UniProtKB/Swiss-Prot: LAP4A_HUMAN, Q15012 Function : May function in the transport of nucleosides and/or nucleoside derivatives between thecytosol and the lumen of an intracellular membrane-bound compartment (By similarity)
Genomic Location for LAPTM4A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the LAPTM4A gene Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p24.1 LAPTM4A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M020154:
(about GC identifiers )
Start:
20,095,894 bp from pter
End:
20,114,926 bp from pter
Size:
19,033 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_015926.14 Proteins for LAPTM4A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: LAP4A_HUMAN, Q15012 (See
protein sequence )Recommended Name: Lysosomal-associated transmembrane protein 4A Size : 233 amino acids; 26801 Da
Subcellular location : Endomembrane system; Multi-pass membrane protein (Potential). Note=May residein an intracellular membrane-bound compartment (Potential)
Sequence caution : Sequence=AAQ89387.1; Type=Frameshift; Positions=206;
Secondary accessions : Q6UW22
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_055528.1 ENSEMBL proteins: ENSP00000175091 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for LAPTM4A: Assays for LAPTM4A:
Protein
Domains/ Families for LAPTM4A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15012 ProtoNet protein and cluster: Q15012
1 Blocks protein family : IPB004687 Golgi 4-transmembrane spanning transporter UniProtKB/Swiss-Prot: LAP4A_HUMAN, Q15012 Domain : The C-terminal domain is necessary for retention within intracelllular membranes (Bysimilarity) Similarity : Belongs to the LAPTM4/LAPTM5 transporter family
Gene Function for LAPTM4A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014713 Applied Biosystems Silencer ® siRNAs for LAPTM4A Sigma-Aldrich siRNA for LAPTM4A Sigma-Aldrich shRNA for LAPTM4A Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014713                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014713                                  untagged cDNA clone in CMV expression vector: NM_014713  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014713 UniProtKB/Swiss-Prot: LAP4A_HUMAN, Q15012 Function : May function in the transport of nucleosides and/or nucleoside derivatives between thecytosol and the lumen of an intracellular membrane-bound compartment (By similarity)
Pathways & Interactions for LAPTM4A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
IEA --
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Drugs & Compounds for LAPTM4A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for LAPTM4A 1 Novoseek chemical compound relationship for LAPTM4A gene
About this table
Transcripts for LAPTM4A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014713 Sigma-Aldrich siRNA for LAPTM4A Sigma-Aldrich shRNA for LAPTM4A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_014713
REFSEQ mRNAs for LAPTM4A gene: NM_014713.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014713
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014713                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014713                                  untagged cDNA clone in CMV expression vector: NM_014713  
Additional cDNA sequence: AK129875.1 AK304433.1 AY359028.1 BC000421.2 BC003158.1 BC093075.1 CR456758.1 CR594890.1 CR597537.1 CR599013.1 CR599755.1 CR602246.1 CR604791.1 CR604820.1 CR605678.1 CR607529.1 CR607775.1 CR607830.1 CR608072.1 CR611436.1 CR612473.1 CR613521.1 CR615552.1 CR618524.1 CR618630.1 CR619265.1 CR621011.1 CR621170.1 CR622236.1 CR623001.1 CR624947.1 D14696.1
24/39 DOTS entries (see all 39
): DT.85104883 DT.100699105 DT.100640749 DT.100045326 DT.100699087 DT.91871506 DT.95363945 DT.100699110 DT.100799582 DT.92012889 DT.121034068 DT.121033998 DT.95211206 DT.95363985 DT.100699088 DT.121034059 DT.91987790 DT.100699090 DT.100699117 DT.121034072 DT.91778869 DT.100699097 DT.100699107 DT.100699116
24/1386 AceView cDNA sequences (see all 1386
):CR597537 AI560796 BQ883726 AL583634 BG701441 BQ677577 BM994108 BM771159 AW275242 BP375651 AI687325 R60939 CR624947 BU616856 AA149492 AI240867 AW513584 BM678432 AA382820 BM888345 AW411242 W57820 AI744902 AA370515
highest scoring ESTs for LAPTM4A :D14696 AA027778 AA053657 AA093846 AA121281 AA206647 AA207212 AA214362 AA300283 AA300717
Unigene Cluster for LAPTM4A: Lysosomal protein transmembrane 4 alpha Hs.467807 [show with all ESTs ] Unigene Representative Sequence: NM_014713 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for LAPTM4A ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b SP1 :                               SP2 :                               SP3 :             -                   SP4 :   -   -   -   -                       SP5 :               -                
About this scheme ECgene alternative splicing isoforms for LAPTM4A 1 Ensembl transcript including schematic representation : ENST00000175091
Expression for LAPTM4A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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LAPTM4A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for LAPTM4A 1 / 2 / 3
3 probe-sets matching LAPTM4A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTTCTAGTTTSOURCE GeneReport for Unigene cluster: Hs.467807 Expression variation in blood from EXPOLDB for LAPTM4A
Orthologs for LAPTM4A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for LAPTM4A gene from 5/10 species (see all 10
)
About this table Species with no ortholog for LAPTM4A ENSEMBL Gene Tree for LAPTM4A Paralogs for LAPTM4A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for LAPTM4A gene LAPTM4B 2
SNPs/Variants for LAPTM4A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for LAPTM4A (up to first 250kb)
Disorders & Mutations for LAPTM4A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for LAPTM4A (Possibly Related Articles in
Doctor's Guide )
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--
Publications for LAPTM4A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for LAPTM4A gene (see all 14
): Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527) 2, 3, 4 Nagase T....Kotani H. (1995) Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae. (PubMed id 8621662) 1, 2, 3 Hogue D.L....Cass C.E. (1996) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107) 4 Rikova K....Comb M.J. (2007) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 3 Stelzl U....Wanker E.E. (2005) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 3 Suzuki Y.... Sugano S. (2004) Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PubMed id 12766061) 3 Tomarev S.I....Malyukova I. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) A visual intracellular classification strategy for uncharacterized human proteins. (PubMed id 10942595) 3 Hoja M.R....Hoog C. (2000)
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Genome Databases showing LAPTM4A
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing LAPTM4A
(According to HUGE )
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Specialized Databases showing LAPTM4A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for LAPTM4A (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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