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LAP3 Gene

protein-coding GIFtS: 57

GC04P017255

leucine aminopeptidase 3
(Previous name: peptidase S )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PEPS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.11.1,EC 3.4.11.5 ^³
LAP ^¹, ², ³
LAPEP ^¹, ², ³
PEPS ^², ³

Descriptions
Leucine aminopeptidase ^³
Leucyl aminopeptidase ^³
Peptidase S ^¹, ², ³
Proline aminopeptidase ^³
Prolyl aminopeptidase ^³
leucine aminopeptidase 3 ^², ³

External Ids
HGNC: 18449¹
Entrez Gene: 51056²
UniProtKB: P28838³
Ensembl: ENSG00000002549⁷

Search outside databases for aliases for LAP3 gene

Previous GC identifers: GC04P017393 GC04P017520 GC04P017267 GC04P017329

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AMPL_HUMAN, P28838

Function: Presumably involved in the processing and regular turnover of intracellular proteins.

Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAP3 gene

Entrez Gene cytogenetic band: 4p15.32 Ensembl cytogenetic band: 4p15.32 HGNC cytogenetic band: 4p15.33

LAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P017255: (about GC identifiers)

Start:	17,188,025 bp from pter
End:	17,218,688 bp from pter
Size:	30,664 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006316.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AMPL_HUMAN, P28838 (See protein sequence)

Recommended Name: Cytosol aminopeptidase

Size: 519 amino acids; 56166 Da

Cofactor: Binds 2 zinc ions per subunit. One zinc ion is tightly bound and essential for enzyme

activity, while the second metal coordination site can be occupied by zinc, magnesium or manganese

to give enzymes of different activities (By similarity)

Subunit: Homohexamer

Subcellular location: Cytoplasm

Secondary accessions: Q6IAM6 Q6P0L6 Q9UQE3

Alternative initiation: 2 isoforms: P28838-1 P28838-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_056991.2

ENSEMBL proteins:

ENSP00000226299

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LAP3)
	Human Recombinant Proteins from Abnova (LAP3)

OriGene Purified Recombinant Human Protein: LAP3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	NAS	--
GO:0005739	mitochondrion	IEA	--

About this table

Antibodies for LAP3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LAP3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LAP3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAP3)
	Novus Biologicals Antibodies for LAP3

Assays for LAP3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P28838

ProtoNet protein and cluster: P28838

1 Blocks protein family: IPB000819 Cytosol aminopeptidase

UniProtKB/Swiss-Prot: AMPL_HUMAN, P28838

Similarity: Belongs to the peptidase M17 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAP3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015907

Applied Biosystems Silencer® siRNAs for LAP3

Sigma-Aldrich siRNA and siRNA Panels for LAP3

Sigma-Aldrich shRNA for LAP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LAP3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015907
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015907
untagged cDNA clones in CMV expression vector (see all 2): NM_015907

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015907

UniProtKB/Swiss-Prot: AMPL_HUMAN, P28838

Function: Presumably involved in the processing and regular turnover of intracellular proteins.

Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

Catalytic activity: Release of an N-terminal amino acid, Xaa- -Yaa-, in which Xaa is preferably

Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino

acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly

low

Catalytic activity: Release of N-terminal proline from a peptide

Enzyme Number (IUBMB): EC 3.4.11.1,EC

1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Lap3):

immune system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	NAS	--
GO:0004177	aminopeptidase activity	NAS	1908238
GO:0008233	peptidase activity	IEA	--
GO:0008235	metalloexopeptidase activity	NAS	1908238
GO:0008270	zinc ion binding	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for LAP3 (Your Favorite Gene powered by Ingenuity)

Lysine Degradation
Arginine and Proline Metabolism

GeneDecks LAP3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for LAP3

5/28 Interacting proteins for LAP3 (ENSP00000226299³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRODH	ENSP00000334726³	STRING (score=.912)
EPRS	ENSP00000355890³	STRING (score=.899)
P4HA1	ENSP00000362099³	STRING (score=.899)
P4HA2	ENSP00000351611³	STRING (score=.899)
P4HA3	ENSP00000332170³	STRING (score=.899)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	1908238
GO:0019538	protein metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for LAP3

Sigma-Aldrich Small Molecules for LAP3:

Inhibitor

Browse Tocris compounds for LAP3
10/18 Novoseek chemical compound relationships for LAP3 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	92.62	336	7690169 (4), 9777099 (4), 11846784 (3), 8670787 (3) (see all 99)
bestatin	78.28	7	1786199 (2), 7871971 (1), 9477117 (1), 1912369 (1)
heptanoate	77.94	1	16125815 (1)
proline	51.94	24	1892204 (7), 18476142 (3), 18475340 (2), 7988901 (2) (see all 13)
1,10-phenanthroline	48.60	2	18155948 (1), 12568801 (1)
p-nitroaniline	44.09	1	10805534 (1)
zinc	23.88	4	1793007 (1), 8872532 (1), 11743734 (1), 14695154 (1)
putrescine	10.45	1	8357044 (1)
epoxide	10.12	2	8951032 (1), 11601994 (1)
flavonoid	6.77	2	7673925 (1), 9793838 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAP3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015907

Sigma-Aldrich siRNA and siRNA Panels for LAP3

Sigma-Aldrich shRNA for LAP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015907

REFSEQ mRNAs for LAP3 gene:

NM_015907.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015907

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015907
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015907
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015907

Additional cDNA sequence:

AF061738.1 AK022055.1 AK130293.1 AK225511.1 AK298613.1 AK298790.1 AK307723.1 BC006199.2

BC065564.1 CR457128.1 CR593546.1 CR601185.1 CR602931.1 CR604573.1 CR605730.1 CR615225.1

CR620660.1 CR623098.1

22 DOTS entries:

DT.121239044 DT.452853 DT.99943191 DT.100844073 DT.95252831 DT.100844072 DT.100844084 DT.92445667

DT.121239032 DT.121238992 DT.121238997 DT.121239046 DT.100844079 DT.102827512 DT.121239023 DT.121239026

DT.121239033 DT.121239045 DT.121393164 DT.95110650 DT.95252835 DT.100844083

24/357 AceView cDNA sequences (see all 357 ):

BQ773241 NM_015907 BP351843 AL547557 AL556498 AL524453 BF433958 AA707177

BG944575 AI653901 BM800626 AU142824 N25999 BU154380 BM129769 CK819688

BM141945 CB151630 BQ065044 CA306348 CB127281 CR601185 AA134138 CK819689

highest scoring ESTs for LAP3:

AF034175 AA025244 AA027997 AA034306 AA034307 AA043521 AA132093 AA132193 AA134138 AA225762

Unigene Cluster for LAP3:

Leucine aminopeptidase 3

Hs.570791 [show with all ESTs]

Unigene Representative Sequence: AF061738

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LAP3 (see all 10 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16a	·
SP1:													-				-		-						-				-		-		-										-
SP2:																																											-
SP3:																													-		-		-										-
SP4:																									-				-		-		-						-		-		-
SP5:													-				-		-				-		-				-		-		-

ExUns:	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LAP3

1 Ensembl transcript including schematic representation:

ENST00000226299

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LAP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAP3

¹ / ² / ³

3 probe-sets matching LAP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45261_at²^{, 3}	U95-B	3	1.00	0.84	1.00	1.00	AF034175	1.00	1.00	1.00	1
217933_s_at²^{, 3}	U133-A	3	1.00	0.61	--	--	NM_015907	0.60	1.00	0.82	1
217933_s_at²	U133Plus2	3	1.00	0.61	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCAAACTGA

SOURCE GeneReport for Unigene cluster: Hs.570791

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAP3 gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAP3¹	--	leucine aminopeptidase 3	88.63(n) 91.91(a)	479081 XM_536228.2 XP_536228.2
chimpanzee (Pan troglodytes)	LAP3¹	--	leucine aminopeptidase 3	99.23(n) 100(a)	461132 XM_001162589.1 XP_001162589.1
cow (Bos taurus)	LAP3¹	--	leucine aminopeptidase 3	88.44(n) 90.37(a)	781648 XM_001249976.1 XP_001249977.1
rat (Rattus norvegicus)	Lap3¹	--	leucine aminopeptidase 3	86.58(n) 90.75(a)	289668 NM_001011910.1 NP_001011910.1
mouse (Mus musculus)	Lap3^{1, 5}	5 (67.00 cM)⁵	leucine aminopeptidase 3^{1, 5}	86.71(n)¹ 90.17(a)¹	66988¹ NM_024434.4¹ NP_077754.2¹ AA410100⁵ AF334160⁵ (see all 26)

About this table Species with no ortholog for LAP3

ENSEMBL Gene Tree for LAP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAP3 gene

NPEPL1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/207 NCBI SNPs in LAP3 are shown (see all 207 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1860591^1,2	A,C,F,H	17186427(-)	`ttcaAC/TAGAAA`	1	--	ng5¹		4		EU EA WA	418
--	rs6851783^1,2	A,C	17187567(+)	`aactaA/Ggcagc`	1	--	ng5¹		0	--	--	--	--
--	rs6825133^1,2	A,C	17186874(+)	`ctccaC/Tgatta`	1	--	ng5¹		0	--	--	--	--
--	rs2098151^1,2	A,C	17186588(-)	`tgtctA/Gtagga`	1	--	ng5¹		0	--	--	--	--
--	rs1860592^1,2	A,C	17186126(-)	`ttgaaC/Gtactg`	1	--	ng5¹		0	--	--	--	--
--	rs10019482^1,2	A,C	17187177(+)	`ggcacA/Ggtggc`	1	--	ng5¹		0	--	--	--	--
--	rs2079892^1,2	A,C	17186261(-)	`ctccaC/Tccctg`	1	--	ng5¹		0	--	--	--	--
	rs13123846^1,2	C	17188181(+)	`GAGCCA/GACAAG`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs10939735^1,2	A	17187989(+)	`CCACAA/GCCGCG`	1	--	ng5¹ ese³		0	--	--	--	--
--	rs3175026^1,2	H	17217604(+)	`ATTATA/CCAAGA`	1	T/P	mis¹ ese³		4		EU EA WA	404

About this table

HapMap Linkage Disequilibrium images for LAP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 170250

10/19 Novoseek disease relationships for LAP3 gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bacterial vaginosis	59.36	13	1892204 (4), 18475340 (2), 18476142 (2), 2277372 (1) (see all 8)
cholestasis	39.52	7	8095735 (2), 1363829 (1), 16137667 (1)
albuminuria	29.60	4	7869656 (1), 7770643 (1), 8287643 (1), 7987655 (1)
diabetic nephropathies	23.88	3	1685160 (2)
proteinuria	22.35	6	7869656 (1), 8287643 (1), 7987655 (1), 8314287 (1)
choriocarcinoma	11.94	1	1786199 (1)
prostate carcinoma	8.78	3	1712242 (2), 7690169 (1)
benign prostatic hyperplasia	5.38	2	1712242 (2)
endometrial carcinoma	0.55	2	14695154 (1), 15741767 (1)
shock	0.00	6	9061419 (2), 8558037 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/212 PubMed articles for LAP3 gene (see all 212 ):

Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. (PubMed id 1908238)^{1, 3, 4} Matsushima M....Takahashi K. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Suggested assignment of peptidase S (PEPS) to 4p11-4q12 by exclusion using gene dosage, accounting for variability in fibroblasts. (PubMed id 6350155)^{2, 3} Schmutz S.M. and Simpson N.E. (1983)
Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids. (PubMed id 689684)^{2, 3} Shows T.B....Goggin A.P. (1978)
Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1. (PubMed id 16513116)^{1, 3} Goto Y....Tsujimoto M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)³ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51056	HGNC: 18449	AceView: LAP3	Ensembl:ENSG00000002549	euGenes: HUgn51056
ECgene: LAP3	H-InvDB: LAP3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LAP3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAP3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAP3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAP3		Antibodies for LAP3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAP3		Small molecules for LAP3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LAP3)
	Antibodies (LAP3)
	Chimera RNAi (LAP3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (LAP3)
	Antibodies (LAP3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for LAP3

	Drugs for LAP3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LAP3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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LAP3 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for LAP3

Summaries
for LAP3

Genomic Location
for LAP3

Proteins
for LAP3

Protein Domains/
Families
for LAP3

Gene Function
for LAP3

Pathways & Interactions
for LAP3

Drugs & Compounds
for LAP3

Transcripts
for LAP3

Expression
for LAP3

Orthologs
for LAP3

Paralogs
for LAP3

SNPs/Variants
for LAP3

Disorders & Mutations
for LAP3

Medical News
for LAP3

Publications
for LAP3

Search for LAP3

Genome Databases showing LAP3

Other Databases showing LAP3

Specialized Databases showing LAP3

Licensable Technologies
for LAP3

Services
for LAP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAP3 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor LAP3

Summariesfor LAP3

Genomic Locationfor LAP3

Proteinsfor LAP3

Protein Domains/Familiesfor LAP3

Gene Functionfor LAP3

Pathways & Interactionsfor LAP3

Drugs & Compoundsfor LAP3

Transcriptsfor LAP3

Expression for LAP3

Orthologsfor LAP3

Paralogsfor LAP3

SNPs/Variantsfor LAP3

Disorders & Mutationsfor LAP3

Medical Newsfor LAP3

Publicationsfor LAP3

Search for LAP3

Genome Databases showing LAP3

Other Databases showing LAP3

Specialized Databases showing LAP3

Licensable Technologiesfor LAP3

Servicesfor LAP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAP3

Summaries
for LAP3

Genomic Location
for LAP3

Proteins
for LAP3

Protein Domains/
Families
for LAP3

Gene Function
for LAP3

Pathways & Interactions
for LAP3

Drugs & Compounds
for LAP3

Transcripts
for LAP3

Expression
for LAP3

Orthologs
for LAP3

Paralogs
for LAP3

SNPs/Variants
for LAP3

Disorders & Mutations
for LAP3

Medical News
for LAP3

Publications
for LAP3

Licensable Technologies
for LAP3

Services
for LAP3