Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LAP3 Gene

Aliases for LAP3 Gene

  • Leucine Aminopeptidase 3 2 3 4 5
  • Peptidase S 2 3 4
  • Proline Aminopeptidase 3 4
  • Leucyl Aminopeptidase 3 4
  • Prolyl Aminopeptidase 3 4
  • EC 3.4.11.1 4 63
  • LAP-3 3 4
  • LAPEP 3 4
  • PEPS 3 4
  • Epididymis Secretory Protein Li 106 3
  • EC 3.4.11.5 4
  • HEL-S-106 3
  • EC 3.4.11 63
  • LAP 3

External Ids for LAP3 Gene

Previous HGNC Symbols for LAP3 Gene

  • PEPS

Previous GeneCards Identifiers for LAP3 Gene

  • GC04P017393
  • GC04P017520
  • GC04P017267
  • GC04P017329
  • GC04P017255
  • GC04P016933

Summaries for LAP3 Gene

GeneCards Summary for LAP3 Gene

LAP3 (Leucine Aminopeptidase 3) is a Protein Coding gene. Diseases associated with LAP3 include cercarial dermatitis. Among its related pathways are Arginine and proline metabolism and Glutathione metabolism. GO annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is NPEPL1.

UniProtKB/Swiss-Prot for LAP3 Gene

  • Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAP3 Gene

Genomics for LAP3 Gene

Regulatory Elements for LAP3 Gene

Enhancers for LAP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LAP3 on UCSC Golden Path with GeneCards custom track

Promoters for LAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAP3 Gene

Chromosome:
4
Start:
17,577,192 bp from pter
End:
17,607,972 bp from pter
Size:
30,781 bases
Orientation:
Plus strand

Genomic View for LAP3 Gene

Genes around LAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAP3 Gene

Proteins for LAP3 Gene

  • Protein details for LAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28838-AMPL_HUMAN
    Recommended name:
    Cytosol aminopeptidase
    Protein Accession:
    P28838
    Secondary Accessions:
    • B3KMQ3
    • Q6IAM6
    • Q6P0L6
    • Q9UQE3

    Protein attributes for LAP3 Gene

    Size:
    519 amino acids
    Molecular mass:
    56166 Da
    Quaternary structure:
    • Homohexamer.

    Alternative splice isoforms for LAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAP3 Gene

Proteomics data for LAP3 Gene at MOPED

Selected DME Specific Peptides for LAP3 Gene

Post-translational modifications for LAP3 Gene

  • Ubiquitination at Lys 118, Lys 188, and Lys 476
  • Modification sites at PhosphoSitePlus

Other Protein References for LAP3 Gene

Domains & Families for LAP3 Gene

Gene Families for LAP3 Gene

Suggested Antigen Peptide Sequences for LAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28838

UniProtKB/Swiss-Prot:

AMPL_HUMAN :
  • Belongs to the peptidase M17 family.
Family:
  • Belongs to the peptidase M17 family.
genes like me logo Genes that share domains with LAP3: view

Function for LAP3 Gene

Molecular function for LAP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal amino acid, Xaa- -Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal proline from a peptide.
UniProtKB/Swiss-Prot Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Enzyme Numbers (IUBMB) for LAP3 Gene

genes like me logo Genes that share phenotypes with LAP3: view

Animal Models for LAP3 Gene

MGI Knock Outs for LAP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LAP3

miRNA for LAP3 Gene

miRTarBase miRNAs that target LAP3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAP3 Gene

Localization for LAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAP3 Gene COMPARTMENTS Subcellular localization image for LAP3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 4
golgi apparatus 2
lysosome 2
plasma membrane 2
vacuole 2
chloroplast 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for LAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005802 trans-Golgi network IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LAP3: view

Pathways & Interactions for LAP3 Gene

genes like me logo Genes that share pathways with LAP3: view

Pathways by source for LAP3 Gene

Gene Ontology (GO) - Biological Process for LAP3 Gene

None

No data available for SIGNOR curated interactions for LAP3 Gene

Drugs & Compounds for LAP3 Gene

(28) Drugs for LAP3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
Glycine Approved Nutra Full agonist, Agonist Endogenous potentiator, co-transmitter 197
L-Cysteine Approved Nutra 0
L-Proline Approved Nutra 0
(2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Experimental Pharma Target 0

(24) Additional Compounds for LAP3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
19246-18-5
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with LAP3: view

Transcripts for LAP3 Gene

Unigene Clusters for LAP3 Gene

Leucine aminopeptidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - - - -
SP8:
SP9:
SP10: - -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for LAP3 Gene

GeneLoc Exon Structure for
LAP3
ECgene alternative splicing isoforms for
LAP3

Expression for LAP3 Gene

mRNA expression in normal human tissues for LAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LAP3 Gene

This gene is overexpressed in Liver, secretome (14.3) and Lymph node (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAP3 Gene



SOURCE GeneReport for Unigene cluster for LAP3 Gene Hs.570791

genes like me logo Genes that share expression patterns with LAP3: view

Protein tissue co-expression partners for LAP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LAP3 Gene

Orthologs for LAP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAP3 35
  • 88.44 (n)
  • 90.37 (a)
LAP3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAP3 35
  • 88.63 (n)
  • 91.91 (a)
LAP3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lap3 35
  • 86.77 (n)
  • 90.37 (a)
Lap3 16
Lap3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lap3 35
  • 86.58 (n)
  • 90.75 (a)
oppossum
(Monodelphis domestica)
Mammalia LAP3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAP3 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAP3 36
  • 100 (a)
OneToOne
LAP3 35
  • 99.23 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LAP3 35
  • 71.26 (n)
  • 74.7 (a)
LAP3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAP3 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lap3 35
  • 70.92 (n)
  • 72.84 (a)
zebrafish
(Danio rerio)
Actinopterygii lap3 36
  • 67 (a)
OneToOne
lap3 35
  • 67 (n)
  • 71.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18369 37
  • 40 (a)
CG6372 37
  • 43 (a)
S-Lap8 36
  • 37 (a)
OneToMany
S-Lap7 36
  • 37 (a)
OneToMany
S-Lap5 36
  • 36 (a)
OneToMany
S-Lap4 36
  • 40 (a)
OneToMany
S-Lap3 36
  • 38 (a)
OneToMany
S-Lap2 36
  • 39 (a)
OneToMany
S-Lap1 36
  • 40 (a)
OneToMany
loopin-1 36
  • 38 (a)
OneToMany
Dip-B 36
  • 16 (a)
OneToMany
CG4750 37
  • 39 (a)
CG4439 37
  • 40 (a)
CG13340 37
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003869 35
  • 56.16 (n)
  • 55.32 (a)
worm
(Caenorhabditis elegans)
Secernentea lap-2 36
  • 17 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30920 35
  • 47.11 (n)
  • 40.59 (a)
soybean
(Glycine max)
eudicotyledons Gma.18061 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2753 35
rice
(Oryza sativa)
Liliopsida Os.5433 35
Os12g0434400 35
  • 47.27 (n)
  • 40.59 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2854 35
corn
(Zea mays)
Liliopsida Zm.4204 35
barley
(Hordeum vulgare)
Liliopsida Hv.429 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC13A11.05 35
  • 50.9 (n)
  • 44.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
Species with no ortholog for LAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LAP3 Gene

ENSEMBL:
Gene Tree for LAP3 (if available)
TreeFam:
Gene Tree for LAP3 (if available)

Paralogs for LAP3 Gene

Paralogs for LAP3 Gene

Pseudogenes.org Pseudogenes for LAP3 Gene

genes like me logo Genes that share paralogs with LAP3: view

Variants for LAP3 Gene

Sequence variations from dbSNP and Humsavar for LAP3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs729813 -- 17,581,377(-) TCAGA(C/T)TAGAT intron-variant
rs740887 -- 17,581,725(+) AAAAT(A/G/T)CTTGT intron-variant
rs1059826 -- 17,607,712(+) AGAAC(A/C)CAATG utr-variant-3-prime
rs1059835 -- 17,607,752(+) TTCAC(A/C)CAAAG utr-variant-3-prime
rs1059847 -- 17,607,844(+) TAATC(A/C)CTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LAP3 Gene

Variant ID Type Subtype PubMed ID
dgv1588e1 CNV Complex 17122850
nsv289804 CNV Loss 16902084
esv2666830 CNV Deletion 23128226

Variation tolerance for LAP3 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAP3 Gene

HapMap Linkage Disequilibrium report
LAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAP3 Gene

Disorders for LAP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LAP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cercarial dermatitis
  • cutaneous schistosomiasis
- elite association - COSMIC cancer census association via MalaCards
Search LAP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LAP3

Genetic Association Database (GAD)
LAP3
Human Genome Epidemiology (HuGE) Navigator
LAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAP3
genes like me logo Genes that share disorders with LAP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAP3 Gene

Publications for LAP3 Gene

  1. Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. (PMID: 1908238) Matsushima M. … Takahashi K. (Biochem. Biophys. Res. Commun. 1991) 3 4 23 67
  2. Suggested assignment of peptidase S (PEPS) to 4p11-4q12 by exclusion using gene dosage, accounting for variability in fibroblasts. (PMID: 6350155) Schmutz S.M. … Simpson N.E. (Hum. Genet. 1983) 2 3
  3. Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids. (PMID: 689684) Shows T.B. … Goggin A.P. (Hum. Genet. 1978) 2 3
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  5. LAP3 promotes glioma progression by regulating proliferation, migration and invasion of glioma cells. (PMID: 25453285) He X. … Wang D. (Int. J. Biol. Macromol. 2015) 3

Products for LAP3 Gene

Sources for LAP3 Gene

Content