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LANCL3 Gene

protein-coding GIFtS: 40

GC0XP037315

LanC lantibiotic synthetase component C-like 3 (bacterial)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ42925 ^¹, ²
OTTHUMP00000031917 ^²

Descriptions
LanC lantibiotic synthetase component C-like 3 ^²
LanC lantibiotic synthetase component C-like 3 (bacterial) ^²

External Ids
HGNC: 24767¹
Entrez Gene: 347404²
UniProtKB: Q6ZV70³
Ensembl: ENSG00000147036⁷

Search outside databases for aliases for LANCL3 gene

Previous GC identifer: GC0XP037188

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LANCL3 gene

Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp21.1 HGNC cytogenetic band: Xp21.1

LANCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP037315: (about GC identifiers)

Start:	37,315,741 bp from pter
End:	37,421,668 bp from pter
Size:	105,928 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LANC3_HUMAN, Q6ZV70 (See protein sequence)

Recommended Name: LanC-like protein 3

Size: 420 amino acids; 46319 Da

Secondary accessions: A6NHE3

Alternative splicing: 2 isoforms: Q6ZV70-1 Q6ZV70-2

REFSEQ proteins: NP_940913.1

ENSEMBL proteins:

ENSP00000367885 ENSP00000367882

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for LANCL3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LANCL3
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LANCL3

Assays for LANCL3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6ZV70

ProtoNet protein and cluster: Q6ZV70

UniProtKB/Swiss-Prot: LANC3_HUMAN, Q6ZV70

Similarity: Belongs to the LanC-like protein family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LANCL3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_198511

Applied Biosystems Silencer® siRNAs for LANCL3

Sigma-Aldrich siRNA for LANCL3

Sigma-Aldrich shRNA for LANCL3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_198511
Myc/DDK tagged cDNA clone in CMV expression vector: NM_198511
untagged cDNA clone in CMV expression vector: NM_198511

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198511

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LANCL3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LANCL3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_198511

Sigma-Aldrich siRNA for LANCL3

Sigma-Aldrich shRNA for LANCL3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_198511

REFSEQ mRNAs for LANCL3 gene:

NM_198511.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_198511

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198511
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_198511
                                 untagged cDNA clone in CMV expression vector: NM_198511

Additional cDNA sequence:

AK124915.1 BC093667.1 BC093669.1 BC143528.1

1 DOTS entry:

DT.95249792

10 AceView cDNA sequences:

AK124915 BX106565 NM_198511 AI638760 AI989993 CB141599 AA292415 AA682630

W26539 AA394251

highest scoring ESTs for LANCL3:

AI638760 AK124915 BG944288 AA292415 AA394251 AA682630 AI989993 BC093667 BC093669 BX106565

Unigene Cluster for LANCL3:

LanC lantibiotic synthetase component C-like 3 (bacterial)

Hs.521932 [show with all ESTs]

Unigene Representative Sequence: AK124915

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000378621 ENST00000378619

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LANCL3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LANCL3

¹ / ² / ³

1 probe-set matching LANCL3 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	82015_at²^{, 3}	U95-D	1	1.00	1.00	1.00	1.00	AI638760	0.80	1.00	0.91	1

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATCCAAA

SOURCE GeneReport for Unigene cluster: Hs.521932

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LANCL3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LANCL3¹	--	LanC lantibiotic synthetase component C-like 3 (bacterial)	93.01(n) 98.09(a)	491823 XM_548943.2 XP_548943.2
chimpanzee (Pan troglodytes)	LANCL3¹	--	LanC lantibiotic synthetase component C-like 3 (bacterial)	99.74(n) 100(a)	473561 XM_528933.2 XP_528933.2
cow (Bos taurus)	LANCL3¹	--	similar to LanC lantibiotic synthetase component C-like more	91.1(n) 98.3(a)	519239 XM_597454.3 XP_597454.3
rat (Rattus norvegicus)	Lancl3¹	--	LanC lantibiotic synthetase component C-like 3 (bacterial)	88.74(n) 96.73(a)	302540 XM_228739.4 XP_228739.2
mouse (Mus musculus)	Lancl3^{1, 5}	X⁵	LanC lantibiotic synthetase component C-like 3 (bacterial)^{1, 5}	88.83(n)¹ 95.1(a)¹	236285¹ NM_173414.2¹ NP_775590.1¹ AK031623⁵ AK043841⁵ (see all 8)

About this table Species with no ortholog for LANCL3

ENSEMBL Gene Tree for LANCL3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for LANCL3 gene

LANCL2² LANCL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/351 NCBI SNPs in LANCL3 are shown (see all 351 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 102)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6520606^1,2	A,C	37315561(+)	`GGGACC/TGGAGA`	1	--	ng5¹		0	--	--	--	--
--	rs7888955^1,2	A,H	37315545(+)	`cacttT/Agagta`	1	--	ng5¹		4		EU EA WA	420
	rs12850656^1,2	H	37420635(+)	`CCCTAG/AAACAT`	1	--	ut3¹ ese³		4		EU EA WA	414
--	rs5963721^1,2	H	37316608(+)	`ACTCGC/TCCAGG`	1	A/V	mis¹ ese³		4		EU EA WA	416
--	rs6610363^1,2	A	37315661(+)	`AGGAGC/TCGGGG`	1	--	ng5¹		0	--	--	--	--
	rs12009345^1,2	C,F,H	37403725(+)	`CAGAGC/TGTGGA`	1	S/S	syn¹ ese³		7		NA EU EA	472
	rs35042954^1,2	F	37403653(-)	`ATAGAC/TGACAA`	1	S/S	syn¹		1		NA	74
	rs1884688^1,2	A,C,F,H,O	37389059(+)	`agtgtC/Ggggtg`	1	--	int¹		10		NA EA EU WA	781
	rs5963786^1,2	A,C,F,H	37360054(+)	`ATAGCG/AATCCC`	1	--	int¹		16		EU EA WA NA	1052
	rs3952153^1,2	A,C,F,H	37350892(+)	`CGTACG/ATGTAC`	1	--	int¹		3		EU EA	270

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HapMap Linkage Disequilibrium images for LANCL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for LANCL3 gene:

The DNA sequence of the human X chromosome. (PubMed id 15772651)⁴ Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 347404	HGNC: 24767	AceView: FLJ42925	Ensembl:ENSG00000147036	euGenes: HUgn347404
ECgene: LANCL3	H-InvDB: LANCL3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LANCL3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LANCL3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LANCL3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LANCL3		Antibodies for LANCL3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LANCL3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Search for Recombinant Proteins
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Search OriGene for LANCL3

Search Tocris compounds for LANCL3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LANCL3

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LANCL3 Gene at Home site.
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LANCL3 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for LANCL3

Summaries
for LANCL3

Genomic Location
for LANCL3

Proteins
for LANCL3

Protein Domains/
Families
for LANCL3

Gene Function
for LANCL3

Pathways & Interactions
for LANCL3

Drugs & Compounds
for LANCL3

Transcripts
for LANCL3

Expression
for LANCL3

Orthologs
for LANCL3

Paralogs
for LANCL3

SNPs/Variants
for LANCL3

Disorders & Mutations
for LANCL3

Medical News
for LANCL3

Publications
for LANCL3

Search for LANCL3

Genome Databases showing LANCL3

Other Databases showing LANCL3

Specialized Databases showing LANCL3

Licensable Technologies
for LANCL3

Services
for LANCL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LANCL3 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor LANCL3

Summariesfor LANCL3

Genomic Locationfor LANCL3

Proteinsfor LANCL3

Protein Domains/Familiesfor LANCL3

Gene Functionfor LANCL3

Pathways & Interactionsfor LANCL3

Drugs & Compoundsfor LANCL3

Transcriptsfor LANCL3

Expression for LANCL3

Orthologsfor LANCL3

Paralogsfor LANCL3

SNPs/Variantsfor LANCL3

Disorders & Mutationsfor LANCL3

Medical Newsfor LANCL3

Publicationsfor LANCL3

Search for LANCL3

Genome Databases showing LANCL3

Other Databases showing LANCL3

Specialized Databases showing LANCL3

Licensable Technologiesfor LANCL3

Servicesfor LANCL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LANCL3

Summaries
for LANCL3

Genomic Location
for LANCL3

Proteins
for LANCL3

Protein Domains/
Families
for LANCL3

Gene Function
for LANCL3

Pathways & Interactions
for LANCL3

Drugs & Compounds
for LANCL3

Transcripts
for LANCL3

Expression
for LANCL3

Orthologs
for LANCL3

Paralogs
for LANCL3

SNPs/Variants
for LANCL3

Disorders & Mutations
for LANCL3

Medical News
for LANCL3

Publications
for LANCL3

Licensable Technologies
for LANCL3

Services
for LANCL3