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LANCL2 Gene

protein-coding   GIFtS: 50

GC07P055400
LanC lantibiotic synthetase component C-like 2 (bacterial)
(Previous name: LanC (bacterial lantibiotic synthetase component C)-like 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPR69B)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
GPR69B 2, 3
MGC87139 2
OTTHUMP00000159664 2
TASP 1, 2, 3
Descriptions
G protein-coupled receptor 69B 2
LanC (bacterial lantibiotic synthetase component C)-like 2 1, 2
LanC lantibiotic synthetase component C-like 2 2
LanC lantibiotic synthetase component C-like 2 (bacterial) 2
Testis-specific adriamycin sensitivity protein 2, 3
External Ids
HGNC: 65091
Entrez Gene: 559152
UniProtKB: Q9NS863
Ensembl: ENSG000001324347
Search outside databases for aliases for LANCL2 gene

Previous GC identifers: GC07P054897 GC07P055140 GC07P055175 GC07P055174 GC07P055207

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for LANCL2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LANCL2 gene  

Entrez Gene cytogenetic band: 7q31.1-q31.33   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7q31.1-q31.33

LANCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P055400:     (about GC identifiers)

Start:
55,400,635 bp from pter
End:
55,468,929 bp from pter
Size:
68,295 bases
Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 55,437,426-55,505,717     
RefSeq DNA sequence:
NC_000007.12  NT_033968.5  NT_079592.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86 (See protein sequence)
Recommended Name: LanC-like protein 2  
Size: 450 amino acids; 50854 Da
Subcellular location: Nucleus. Cytoplasm. Cell membrane
Miscellaneous: Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1
(P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin)
Secondary accessions: B2R8D4 Q8TCQ3 Q9BSR1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_061167.1  

    ENSEMBL proteins: 
    ENSP00000254770 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LANCL2)
    Human Recombinant Proteins from Abnova (LANCL2)
                  OriGene Purified Recombinant Human Protein: LANCL2 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA12566319
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol IDA12566319
    GO:0005886 plasma membrane IDA12566319
    About this table

    Antibodies for LANCL2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LANCL2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LANCL2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LANCL2)
    Novus Biologicals Antibodies for LANCL2

    Assays for LANCL2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR007822 LANC-like


       GeneDecks  LANCL2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NS86

    ProtoNet protein and cluster: Q9NS86

    UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86
    Similarity: Belongs to the LanC-like protein family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LANCL2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018697

                  Applied Biosystems Silencer® siRNAs for LANCL2

                  Sigma-Aldrich siRNA for LANCL2  
                         Sigma-Aldrich shRNA for LANCL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LANCL2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018697
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018697
                                     untagged cDNA clone in CMV expression vector: NM_018697 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018697

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824 catalytic activity IEA--
    GO:0005524 ATP binding NAS11762191
    GO:0005525 GTP binding NAS11762191
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016481 negative regulation of transcription IDA12566319
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LANCL2
    2 Novoseek chemical compound relationships for LANCL2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tasp 96.99 16 1303755 (6), 15174170 (4), 16979580 (1)
    lanthionine 89.98 3 16979580 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LANCL2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018697

                  Sigma-Aldrich siRNA for LANCL2  
                         Sigma-Aldrich shRNA for LANCL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018697  

    REFSEQ mRNAs for LANCL2 gene: 

    NM_018697.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018697  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018697
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018697
                                     untagged cDNA clone in CMV expression vector: NM_018697 

    Additional cDNA sequence: 

    AB035966.1 AF353942.1 AJ278245.1 AK095857.1 AK225958.1 AK301747.1 AK307204.1 AK313326.1 
    AL713665.2 BC004887.2 BC070049.1 CR619072.1 CR620619.1 

    8 DOTS entries:

    DT.416642  DT.100843345  DT.91740994  DT.101971681  DT.91766015  DT.100662075  DT.121063861  DT.121063855 

    24/204 AceView cDNA sequences (see all 204 ):

    CA748759 AI033320 CB130957 BM749624 AI363001 AI934794 AL713665 BE393100 
    AI886933 AI497981 CD251311 BI090221 AA761260 Z43514 AI361688 BQ962599 
    AW675178 F07998 AA731900 AL079719 AI867426 AI243995 AW071885 CR620619 

    highest scoring ESTs for LANCL2:

    AI799479 AI807804 AI936654 AA004506 AA004507 AA011647 AA078530 AA362766 AA653729 AA666352 

    Unigene Cluster for LANCL2:

    LanC lantibiotic synthetase component C-like 2 (bacterial)
    Hs.595384  [show with all ESTs]
    Unigene Representative Sequence: NM_018697


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000254770  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LANCL2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LANCL2

    1 / 2 / 3

    10 probe-sets matching LANCL2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    44732_at2, 3 U95-B 1 1.00 1.00 0.73 1.03 AI799479 1.00 1.00 1.00 1
    44731_at2, 3 U95-B 1 1.00 1.00 0.92 1.07 AI807804 1.00 1.00 1.00 1
    59972_at2, 3 U95-C 1 1.00 1.00 0.68 1.01 AI936654 1.00 1.00 1.00 1
    89239_at2, 3 U95-E 1 0.81 1.00 0.44 0.93 AI497981 0.60 1.00 0.82 1

    222561_at2, 3 U133-B 1 1.00 1.00 -- -- AJ278245 0.80 1.00 0.91 1

    218219_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018697 0.60 1.00 0.82 1

    222560_at2, 3 U133-B 1 0.82 1.00 -- -- AI363001 0.40 1.00 0.76 1

    222561_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218219_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222560_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    GeneDecks  LANCL2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGTGACCGAA

    SOURCE GeneReport for Unigene cluster: Hs.595384

    UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86
    Tissue specificity: Expressed in brain and testis

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for LANCL2 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LANCL21   -- LanC lantibiotic synthetase component C-like 2 (bacterial) 89.38(n)
    93.73(a)
    483240  XM_540359.2  XP_540359.2 
    cow
    (Bos taurus)
    LANCL21   -- LanC lantibiotic synthetase component C-like 2 (bacterial) 87.64(n)
    88.76(a)
    541142  XM_614740.3  XP_614740.3 
    rat
    (Rattus norvegicus)
    Lancl21   -- LanC lantibiotic synthetase component C-like 2 (bacterial) 85.08(n)
    88.64(a)
    362375  NM_001014187.1  NP_001014209.1 
    mouse
    (Mus musculus)
    Lancl21, 5 65
    LanC (bacterial lantibiotic synthetase component C)-like more1, 5 85.23(n)1
    89.53(a)1
    718351  NM_133737.11  NP_598498.11 
     AB0359675  AI4492435  (see all 11)
    chicken
    (Gallus gallus)
    LANCL21   -- LanC lantibiotic synthetase component C-like 2 (bacterial) 76.66(n)
    81.66(a)
    420779  XM_418874.2  XP_418874.2 
    About this table        Species with no ortholog for LANCL2

    ENSEMBL Gene Tree for LANCL2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LANCL2 gene
    LANCL12  LANCL32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/446 NCBI SNPs in LANCL2 are shown (see all 446 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 115)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs8159891,2
    A,C,F,H,O55467085(+) CTTCCT/CGTTTG 1 -- ut31 ese317Minor allele frequency- C:0.35MN EA NA EU WA 1322
    rs8159881,2
    A,C,F,H,O55466552(+) AAGCCG/ACCAGA 1 -- ut31 ese316Minor allele frequency- A:0.03MN NA EU EA WA 1578
    rs77861681,2
    A,C,F,H55399717(+) TTCCCT/CGAACT 1 -- ng51 tfbs310Minor allele frequency- C:0.22MN EA EU WA 1214
    rs12661,2
    A,C,F,H55468769(+) TTTGTG/ATTCAC 1 -- ut31 ese35Minor allele frequency- A:0.38MN EU EA WA 584
    rs8159901,2
    C,F,H,O55468139(+) GCTGTC/TGTCAA 1 -- ut31 ese38Minor allele frequency- T:0.07MN EU EA WA NA 742
    rs12671,2
    A,C,F,H55468742(+) TTCAGA/TACATC 1 -- ut31 ese33Minor allele frequency- T:0.41EA WA 272
    rs10572661,2
    C,F,H,O55400759(+) TTCCCC/AGCGGG 1 -- ut51 ese35Minor allele frequency- A:0.43MN EU EA WA 602
    rs38074351,2
    A,C,F,H55399909(-) TCGGTT/CCCTCC 1 -- ng5111Minor allele frequency- C:0.22EA MN EU WA NA 2456
    rs38074371,2
    A,C,F,H55399409(-) ATTCTC/GAGCTC 1 -- ng515Minor allele frequency- G:0.19EA EU WA 1700
    rs38235841,2
    C,F,H55467217(+) TTGGGA/GAGACT 1 -- ut31 ese38Minor allele frequency- G:0.50EA NA EU WA 2008
    About this table

    HapMap Linkage Disequilibrium images for LANCL2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86
  • Is a bystander gene coamplified and overexpressed with epidermal growth factor receptor
    (EGFR) in 20% of all glioblastomas
  • (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for LANCL2 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55915 HGNC: 6509 AceView: LANCL2 Ensembl:ENSG00000132434 euGenes: HUgn55915
    ECgene: LANCL2 H-InvDB: LANCL2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LANCL2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LANCL2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LANCL2 Antibodies for LANCL2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LANCL2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
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     Recombinant & Natural Proteins  

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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
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     Recombinant Proteins
    (LANCL2)
     Antibodies (LANCL2)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for LANCL2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LANCL2

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