LANCL2 Gene
protein-coding GIFtS: 50
GC07P055400
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LanC lantibiotic synthetase component C-like 2 (bacterial) (Previous name: LanC (bacterial lantibiotic synthetase component C)-like 2 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: GPR69B)
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Aliases & Descriptions for LANCL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
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| GPR69B 2, 3 | | MGC87139 2 | | OTTHUMP00000159664 2 | | TASP 1, 2, 3 |
| | | Descriptions |
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| G protein-coupled receptor 69B 2 | | LanC (bacterial lantibiotic synthetase component C)-like 2 1, 2 | | LanC lantibiotic synthetase component C-like 2 2 | | LanC lantibiotic synthetase component C-like 2 (bacterial) 2 | | Testis-specific adriamycin sensitivity protein 2, 3 |
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| | Search outside databases for aliases for LANCL2 genePrevious GC identifers: GC07P054897 GC07P055140 GC07P055175 GC07P055174 GC07P055207 |
Summaries for LANCL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for LANCL2 |
Genomic Location for LANCL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LANCL2 gene 
Entrez Gene cytogenetic band: 7q31.1-q31.33 Ensembl cytogenetic band: 7p11.2 HGNC cytogenetic band: 7q31.1-q31.33LANCL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P055400:
(about GC identifiers)
Start:
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55,400,635 bp from pter |
End:
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55,468,929 bp from pter |
Size:
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68,295 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 55,437,426-55,505,717 |
RefSeq DNA sequence:- NC_000007.12 NT_033968.5 NT_079592.2
| Proteins for LANCL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86 (See
protein sequence)Recommended Name: LanC-like protein 2 Size: 450 amino acids; 50854 Da
Subcellular location: Nucleus. Cytoplasm. Cell membrane
Miscellaneous: Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin)
Secondary accessions: B2R8D4 Q8TCQ3 Q9BSR1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061167.1
ENSEMBL proteins: ENSP00000254770
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: LANCL2 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LANCL2: Assays for LANCL2: | Protein
Domains/ Families for LANCL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NS86
ProtoNet protein and cluster: Q9NS86 UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86Similarity: Belongs to the LanC-like protein family | Gene Function for LANCL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018697
Applied Biosystems Silencer® siRNAs for LANCL2
Sigma-Aldrich siRNA for LANCL2  Sigma-Aldrich shRNA for LANCL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018697                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018697                                  untagged cDNA clone in CMV expression vector: NM_018697 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018697
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LANCL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016481 | negative regulation of transcription |
IDA | 12566319 | About this table
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Drugs & Compounds for LANCL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for LANCL2 2 Novoseek chemical compound relationships for LANCL2 gene
About this table
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Transcripts for LANCL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018697
Sigma-Aldrich siRNA for LANCL2  Sigma-Aldrich shRNA for LANCL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018697 REFSEQ mRNAs for LANCL2 gene: NM_018697.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018697               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018697                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018697                                  untagged cDNA clone in CMV expression vector: NM_018697  Additional cDNA sequence: AB035966.1 AF353942.1 AJ278245.1 AK095857.1 AK225958.1 AK301747.1 AK307204.1 AK313326.1 AL713665.2 BC004887.2 BC070049.1 CR619072.1 CR620619.1 8 DOTS entries: DT.416642 DT.100843345 DT.91740994 DT.101971681 DT.91766015 DT.100662075 DT.121063861 DT.121063855 24/204 AceView cDNA sequences (see all 204
):CA748759 AI033320 CB130957 BM749624 AI363001 AI934794 AL713665 BE393100 AI886933 AI497981 CD251311 BI090221 AA761260 Z43514 AI361688 BQ962599 AW675178 F07998 AA731900 AL079719 AI867426 AI243995 AW071885 CR620619
highest scoring ESTs for LANCL2:AI799479 AI807804 AI936654 AA004506 AA004507 AA011647 AA078530 AA362766 AA653729 AA666352 Unigene Cluster for LANCL2: LanC lantibiotic synthetase component C-like 2 (bacterial) Hs.595384 [show with all ESTs]Unigene Representative Sequence: NM_018697
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000254770
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Expression for LANCL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LANCL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LANCL2
1 / 2 / 3 10 probe-sets matching LANCL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGTGACCGAA
SOURCE GeneReport for Unigene cluster: Hs.595384 UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86Tissue specificity: Expressed in brain and testis |
Orthologs for LANCL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for LANCL2 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for LANCL2
ENSEMBL Gene Tree for LANCL2 | Paralogs for LANCL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LANCL2 gene
- LANCL12 LANCL32
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SNPs/Variants for LANCL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for LANCL2 (up to first 250kb)
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Disorders & Mutations for LANCL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| UniProtKB/Swiss-Prot: LANC2_HUMAN, Q9NS86
Is a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas |
Medical News for LANCL2(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for LANCL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for LANCL2 gene (see all 13
):- Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. (PubMed id 11762191)2, 3, 4 Mayer H.... Prohaska R. (2001)
- Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P- glycoprotein through a transcription-mediated mechanism. (PubMed id 12566319)1, 3, 4 Park S. and James C.D. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)3 Martins-de-Souza D....Turck C.W. (2009)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)3 Suzuki Y.... Sugano S. (1997)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)3 Maruyama K. and Sugano S. (1994)
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Search for LANCL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing LANCL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
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| Other Databases showing LANCL2
(According to HUGE)
About This Section
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Specialized Databases showing LANCL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Services for LANCL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for LANCL2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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