Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LANCL2 Gene

Aliases for LANCL2 Gene

  • LanC Like 2 2 3 5
  • Testis-Specific Adriamycin Sensitivity Protein 2 3 4
  • LanC (Bacterial Lantibiotic Synthetase Component C)-Like 2 2 3
  • G Protein-Coupled Receptor 69B 2 3
  • GPR69B 3 4
  • Tasp 3 4
  • LanC Lantibiotic Synthetase Component C-Like 2 (Bacterial) 2
  • LanC Lantibiotic Synthetase Component C-Like 2 3
  • LanC-Like Protein 2 3

External Ids for LANCL2 Gene

Previous HGNC Symbols for LANCL2 Gene

  • GPR69B

Previous GeneCards Identifiers for LANCL2 Gene

  • GC07P054897
  • GC07P055140
  • GC07P055175
  • GC07P055174
  • GC07P055207
  • GC07P055400
  • GC07P055433

Summaries for LANCL2 Gene

GeneCards Summary for LANCL2 Gene

LANCL2 (LanC Like 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is LANCL1.

UniProtKB/Swiss-Prot for LANCL2 Gene

  • Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Gene Wiki entry for LANCL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LANCL2 Gene

Genomics for LANCL2 Gene

Regulatory Elements for LANCL2 Gene

Enhancers for LANCL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G055406 0.4 ENCODE 11.6 +40.9 40942 0.5 POLR2A LANCL2 SEC61G LOC100996654 LOC100129276 VOPP1 PIR45139
GH07G055405 0.2 ENCODE 11.6 +40.6 40615 0.2 LANCL2 LOC100996654 SEC61G PIR45139
GH07G055364 1.1 ENCODE 0.7 +0.7 694 3.4 HDGF HNRNPUL1 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC100129276 LANCL2 PIR45139
GH07G055368 0.9 Ensembl ENCODE 0.7 +4.3 4316 2.2 JUN ZSCAN4 SIN3A MAFG ATF2 JUND ZNF316 EGR1 FOS MAFK LOC100129276 LANCL2 PIR45139
GH07G055438 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +74.0 74019 1.5 FOSL1 JUND PKNOX1 POLR2A CREB1 FOS ATF2 LOC100129276 PIR45139 LANCL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LANCL2 on UCSC Golden Path with GeneCards custom track

Promoters for LANCL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212678 652 2201 HDGF HNRNPUL1 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for LANCL2 Gene

Chromosome:
7
Start:
55,365,448 bp from pter
End:
55,433,742 bp from pter
Size:
68,295 bases
Orientation:
Plus strand

Genomic View for LANCL2 Gene

Genes around LANCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LANCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LANCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LANCL2 Gene

Proteins for LANCL2 Gene

  • Protein details for LANCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS86-LANC2_HUMAN
    Recommended name:
    LanC-like protein 2
    Protein Accession:
    Q9NS86
    Secondary Accessions:
    • B2R8D4
    • Q6NSL4
    • Q8TCQ3
    • Q9BSR1

    Protein attributes for LANCL2 Gene

    Size:
    450 amino acids
    Molecular mass:
    50854 Da
    Quaternary structure:
    • Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.
    Miscellaneous:
    • Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin).

neXtProt entry for LANCL2 Gene

Post-translational modifications for LANCL2 Gene

Other Protein References for LANCL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LANCL2 Gene

Domains & Families for LANCL2 Gene

Protein Domains for LANCL2 Gene

Suggested Antigen Peptide Sequences for LANCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS86

UniProtKB/Swiss-Prot:

LANC2_HUMAN :
  • Belongs to the LanC-like protein family.
Family:
  • Belongs to the LanC-like protein family.
genes like me logo Genes that share domains with LANCL2: view

No data available for Gene Families for LANCL2 Gene

Function for LANCL2 Gene

Molecular function for LANCL2 Gene

UniProtKB/Swiss-Prot Function:
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Gene Ontology (GO) - Molecular Function for LANCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0005524 ATP binding NAS 11762191
GO:0005525 GTP binding NAS 11762191
GO:0010314 phosphatidylinositol-5-phosphate binding IDA 16979580
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 16979580
genes like me logo Genes that share ontologies with LANCL2: view
genes like me logo Genes that share phenotypes with LANCL2: view

Animal Models for LANCL2 Gene

MGI Knock Outs for LANCL2:

Animal Model Products

CRISPR Products

miRNA for LANCL2 Gene

miRTarBase miRNAs that target LANCL2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LANCL2 Gene

Localization for LANCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LANCL2 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580). {ECO:0000269 PubMed:16979580}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LANCL2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for LANCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12566319
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 12566319
GO:0005886 plasma membrane IDA,IEA 12566319
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LANCL2: view

Pathways & Interactions for LANCL2 Gene

SuperPathways for LANCL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LANCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009789 positive regulation of abscisic acid-activated signaling pathway IDA 19667068
GO:0045892 negative regulation of transcription, DNA-templated IDA 12566319
genes like me logo Genes that share ontologies with LANCL2: view

No data available for Pathways by source and SIGNOR curated interactions for LANCL2 Gene

Drugs & Compounds for LANCL2 Gene

(3) Additional Compounds for LANCL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LANCL2: view

Transcripts for LANCL2 Gene

Unigene Clusters for LANCL2 Gene

LanC lantibiotic synthetase component C-like 2 (bacterial):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LANCL2 Gene

No ASD Table

Relevant External Links for LANCL2 Gene

GeneLoc Exon Structure for
LANCL2
ECgene alternative splicing isoforms for
LANCL2

Expression for LANCL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LANCL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LANCL2 Gene

This gene is overexpressed in Frontal cortex (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LANCL2 Gene



Protein tissue co-expression partners for LANCL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LANCL2 Gene:

LANCL2

SOURCE GeneReport for Unigene cluster for LANCL2 Gene:

Hs.706612

mRNA Expression by UniProt/SwissProt for LANCL2 Gene:

Q9NS86-LANC2_HUMAN
Tissue specificity: Expressed in brain and testis.

Evidence on tissue expression from TISSUES for LANCL2 Gene

  • Liver(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with LANCL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LANCL2 Gene

Orthologs for LANCL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LANCL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LANCL2 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia LANCL2 34 35
  • 88.32 (n)
cow
(Bos Taurus)
Mammalia LANCL2 34 35
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Lancl2 34 16 35
  • 84.78 (n)
rat
(Rattus norvegicus)
Mammalia Lancl2 34
  • 84.56 (n)
oppossum
(Monodelphis domestica)
Mammalia LANCL2 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LANCL2 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LANCL2 34 35
  • 76.49 (n)
lizard
(Anolis carolinensis)
Reptilia LANCL2 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lancl2 34
  • 72.17 (n)
zebrafish
(Danio rerio)
Actinopterygii lancl2 34 35
  • 69.12 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10119 34
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD28247 36
  • 35 (a)
CG2061 35
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GPCR 34
  • 48.13 (n)
rice
(Oryza sativa)
Liliopsida Os10g0497900 34
  • 53.28 (n)
Os.46469 34
barley
(Hordeum vulgare)
Liliopsida Hv.12135 34
wheat
(Triticum aestivum)
Liliopsida Ta.7258 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08190 34
  • 43.49 (n)
Species where no ortholog for LANCL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for LANCL2 Gene

ENSEMBL:
Gene Tree for LANCL2 (if available)
TreeFam:
Gene Tree for LANCL2 (if available)

Paralogs for LANCL2 Gene

Paralogs for LANCL2 Gene

(2) SIMAP similar genes for LANCL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LANCL2: view

Variants for LANCL2 Gene

Sequence variations from dbSNP and Humsavar for LANCL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000053898 -- 55,413,957(+) ATGTT(C/G)CCAGC intron-variant
rs1000092055 -- 55,375,927(+) GATCA(A/G)GTCAC intron-variant
rs1000116584 -- 55,391,269(+) CGCCT(C/T)GGCCT intron-variant
rs1000129356 -- 55,410,375(+) ACTAA(A/G)TATAG intron-variant
rs1000139555 -- 55,423,171(+) GTTCT(A/G)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LANCL2 Gene

Variant ID Type Subtype PubMed ID
esv23398 CNV gain 19812545
esv2734425 CNV deletion 23290073
esv3613237 CNV gain 21293372
nsv818506 CNV gain 17921354

Variation tolerance for LANCL2 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LANCL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LANCL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LANCL2 Gene

Disorders for LANCL2 Gene

Relevant External Links for LANCL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LANCL2

No disorders were found for LANCL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LANCL2 Gene

Publications for LANCL2 Gene

  1. LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. (PMID: 19667068) Sturla L. … Zocchi E. (J. Biol. Chem. 2009) 2 3 4 64
  2. Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. (PMID: 16979580) Landlinger C. … Prohaska R. (Biochim. Biophys. Acta 2006) 3 4 22 64
  3. Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P- glycoprotein through a transcription-mediated mechanism. (PMID: 12566319) Park S. … James C.D. (Cancer Res. 2003) 3 4 22 64
  4. Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. (PMID: 11762191) Mayer H. … Prohaska R. (DNA Seq. 2001) 2 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for LANCL2 Gene

Sources for LANCL2 Gene

Content
Loading form....