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LANCL1 Gene

protein-coding   GIFtS: 56

GC02M211004
LanC lantibiotic synthetase component C-like 1 (bacterial)
(Previous name: LanC (bacterial lantibiotic synthetase component C)-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPR69A)
Services    

Aliases &
Descriptions
for LANCL1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
GPR69A 2, 3, 5
p40 1, 2, 3
Descriptions
40 kDa erythrocyte membrane protein 3
G protein-coupled receptor 69A 2
LanC (bacterial lantibiotic synthetase component C)-like 1 1, 2
LanC (bacterial lantibiotic synthetase component) 2
LanC lantibiotic synthetase component C-like 1 (bacterial) 2
lanthionine synthetase C-like protein 1 2
External Ids
HGNC: 65081
Entrez Gene: 103142
UniProtKB: O438133
Ensembl: ENSG000001153657
Search outside databases for aliases for LANCL1 gene

Previous GC identifers: GC02M209571 GC02M210020 GC02M211259 GC02M211498 GC02M211121

Summaries
for LANCL1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for LANCL1:
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of
bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides.
This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells.
Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now
in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been
identified. [provided by RefSeq]

Genomic Location
for LANCL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LANCL1 gene  

Entrez Gene cytogenetic band: 2q33-q35   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q33-q35

LANCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M211004:     (about GC identifiers)

Start:
 211,004,220 bp from pter
End:
 211,049,676 bp from pter
Size:
 45,457 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  

Proteins
for LANCL1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LANC1_HUMAN, O43813 (See protein sequence)
Recommended Name: LanC-like protein 1  
Size: 399 amino acids; 45283 Da
Subunit: Interacts with the C-terminal of STOM
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein
Miscellaneous: Was originally (PubMed:9512664) thought to be a G-protein coupled receptor

Post-translational modifications:

  • The N-terminus is blocked1


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001130046.1  NP_001130047.1  NP_006046.1  


    ENSEMBL proteins: 
    ENSP00000233714 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LANCL1)
    Human Recombinant Proteins from Abnova (LANCL1)
                  OriGene Purified Recombinant Human Protein: LANCL1 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005887 integral to plasma membrane TAS9512664
    GO:0016020 membrane IEA--
    About this table

    Antibodies for LANCL1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LANCL1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LANCL1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LANCL1)
    Novus Biologicals Antibodies for LANCL1

    Assays for LANCL1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for LANCL1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR007822 LANC-like


       GeneDecks  LANCL1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O43813

    ProtoNet protein and cluster: O43813

    UniProtKB/Swiss-Prot: LANC1_HUMAN, O43813
    Similarity: Belongs to the LanC-like protein family

    Gene Function
    for LANCL1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LANCL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LANCL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006055

                  Applied Biosystems Silencer® siRNAs for LANCL1

                  Sigma-Aldrich siRNA for LANCL1  
                         Sigma-Aldrich shRNA Panels and shRNA for LANCL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001136574
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001136574
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001136574 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001136574

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824 catalytic activity IEA--
    GO:0004930 G-protein coupled receptor activity TAS9512664
    GO:0050750 low-density lipoprotein receptor binding IDA15082773
    About this table

    Pathways & Interactions
    for LANCL1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for LANCL1 (O438132 ENSP000002337143) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042MINT-3308377
    STOMENSP000002867133STRING (score=.823)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS9512664
    About this table

    Drugs & Compounds
    for LANCL1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LANCL1
    1 Novoseek chemical compound relationship for LANCL1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lanthionine 94.14 7 11376939 (2), 11762191 (1), 11474189 (1)
    About this table


    Transcripts
    for LANCL1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LANCL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LANCL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006055

                  Sigma-Aldrich siRNA for LANCL1  
                         Sigma-Aldrich shRNA Panels and shRNA for LANCL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001136574  NM_001136575  NM_006055  

    REFSEQ mRNAs for LANCL1 gene (3 alternative transcripts): 

    NM_001136574.1   NM_001136575.1   NM_006055.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001136574  NM_001136575  NM_006055  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001136574
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001136574
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001136574 

    Additional cDNA sequence: 

    AK294674.1 AK309295.1 AK312381.1 BC007041.2 BC028685.2 CR541777.1 CR608947.1 Y11395.1 

    12 DOTS entries:

    DT.418163  DT.100830577  DT.100008076  DT.100822817  DT.95308070  DT.100822821  DT.121035123  DT.92438736 
    DT.103011  DT.95097752  DT.95167871  DT.95167875 

    24/281 AceView cDNA sequences (see all 281 ):

    Z42368 BM713122 BM718042 BE327013 BC028685 AA287607 BF035308 CR608947 
    BQ694980 CD672817 R11791 BU186964 CR541777 BP356629 BX279818 AI537810 
    AI670052 AI368077 BU175904 CB141634 AA287441 F01884 AI982564 AI393598 

    highest scoring ESTs for LANCL1:

    Y11395 AL589469 AL589544 BC028685 BG398669 BG700949 BG722059 BG723772 BI552819 BI757083 

    Unigene Cluster for LANCL1:

    LanC lantibiotic synthetase component C-like 1 (bacterial)
    Hs.13351  [show with all ESTs]
    Unigene Representative Sequence: NM_006055


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LANCL1

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for LANCL1

    1 Ensembl transcript including schematic representation:
    ENST00000233714  

    Expression
    for LANCL1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LANCL1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LANCL1

    1 / 2 / 3

    5 probe-sets matching LANCL1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		39441_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Y11395 1.00 1.00 1.00 1

    		202019_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI935255 0.40 1.00 0.76 1

    		202020_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006055 0.60 1.00 0.82 1

    		202019_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		202020_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATACTCCTT

    SOURCE GeneReport for Unigene cluster: Hs.13351

    Expression variation in blood from EXPOLDB for LANCL1

    UniProtKB/Swiss-Prot: LANC1_HUMAN, O43813
    Tissue specificity: Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney,
    heart, skeletal muscle, pancreas, ovary and testis

    Orthologs
    for LANCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for LANCL1 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LANCL11   -- LanC lantibiotic synthetase component C-like 1 (bacterial) 88.89(n)
    91.23(a)    		 478897  XM_536055.2  XP_536055.1 
    chimpanzee
    (Pan troglodytes)    		 LANCL11   -- LanC lantibiotic synthetase component C-like 1 (bacterial) 99.42(n)
    99.5(a)    		 459917  XM_516065.2  XP_516065.1 
    cow
    (Bos taurus)    		 LANCL11   -- LanC lantibiotic synthetase component C-like 1 (bacterial) 89.06(n)
    89.97(a)    		 540559  NM_001076227.1  NP_001069695.1 
    rat
    (Rattus norvegicus)    		 Lancl11   -- LanC lantibiotic synthetase component C-like 1 (bacterial) 86.63(n)
    91.48(a)    		 114515  NM_053723.1  NP_446175.1 
    mouse
    (Mus musculus)    		 Lancl11, 5 15
    		 LanC (bacterial lantibiotic synthetase component C)-like more1, 5 87.39(n)1
    91.48(a)1    		 147681  NM_021295.21  NP_067270.11 
     AA5305415  AJ2896035  (see all 27)
    About this table        Species with no ortholog for LANCL1

    ENSEMBL Gene Tree for LANCL1

    Paralogs
    for LANCL1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LANCL1 gene
    LANCL22  LANCL32  

    SNPs/Variants
    for LANCL1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/265 NCBI SNPs in LANCL1 are shown (see all 265 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 105)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs22874171,2
    		A,C,F,O211049844(-) AAATAA/CCCTGC 1 -- ng3110Minor allele frequency- C:0.46EA NA MN 2386
    rs109323351,2
    		A,C,F,H211049976(+) TATATT/ATTTTT 1 -- ng313Minor allele frequency- A:0.07EU EA 266
    rs109323341,2
    		A,C,F,H211049594(+) CCGGAC/TAAAGA 1 -- ut51 ese34Minor allele frequency- T:0.44EU EA WA 380
    rs78931,2
    		A,C,F,H211004484(-) GAACTT/CATCTG 1 -- ut3110Minor allele frequency- C:0.44MN EA EU WA NA 2394
    rs10447101,2
    		A,C,F,H211005600(+) GTAACG/ACAGCT 1 -- ut31 ese311Minor allele frequency- A:0.33MN EU EA WA NA 1202
    rs10447081,2
    		C,F,H211006425(-) TAAAAC/AGGGGA 1 -- ut31 trp310Minor allele frequency- A:0.22EA MN EU WA 2520
    rs37551821,2
    		C,F,H211050383(-) GTTTCA/CGATAG 1 -- ng31 tfbs315Minor allele frequency- C:0.44NA EU EA WA 1400
    --
    rs75750051,2
    		A,C211004019(+) cgcagA/Gaccag 1 -- ng510--------
    --
    rs76016671,2
    		A,C211004030(+) aaggcA/Ggtgac 1 -- ng510--------
    rs67519221,2
    		H211049793(+) TCTCTC/ATTACA 1 -- ng31 trp34Minor allele frequency- A:0.00EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for LANCL1 (up to first 250kb)

    Disorders & Mutations
    for LANCL1

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604155

    Medical News
    for LANCL1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for LANCL1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/13 PubMed articles for LANCL1 gene (see all 13 ):

    Search for LANCL1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LANCL1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 10314 HGNC: 6508 AceView: LANCL1 Ensembl:ENSG00000115365 euGenes: HUgn10314
    ECgene: LANCL1 H-InvDB: LANCL1

    Other Databases showing LANCL1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing LANCL1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for LANCL1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for LANCL1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for LANCL1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LANCL1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LANCL1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LANCL1 Antibodies for LANCL1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LANCL1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (LANCL1)
     Antibodies (LANCL1)
     Chimera RNAi (LANCL1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (LANCL1)
     Antibodies (LANCL1)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for LANCL1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LANCL1

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