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Aliases for LANCL1 Gene

Aliases for LANCL1 Gene

  • LanC Like 1 2 3
  • LanC (Bacterial Lantibiotic Synthetase Component C)-Like 1 2 3
  • LanC Lantibiotic Synthetase Component C-Like 1 (Bacterial) 2 5
  • 40 KDa Erythrocyte Membrane Protein 3 4
  • GPR69A 3 4
  • P40 3 4
  • LanC (Bacterial Lantibiotic Synthetase Component) 3
  • LanC Lantibiotic Synthetase Component C-Like 1 3
  • G Protein-Coupled Receptor 69A 3

External Ids for LANCL1 Gene

Previous HGNC Symbols for LANCL1 Gene

  • GPR69A

Previous GeneCards Identifiers for LANCL1 Gene

  • GC02M209571
  • GC02M210020
  • GC02M211259
  • GC02M211498
  • GC02M211121
  • GC02M211004
  • GC02M203142

Summaries for LANCL1 Gene

Entrez Gene Summary for LANCL1 Gene

  • This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

GeneCards Summary for LANCL1 Gene

LANCL1 (LanC Like 1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and low-density lipoprotein particle receptor binding. An important paralog of this gene is LANCL3.

UniProtKB/Swiss-Prot for LANCL1 Gene

  • May play a role in EPS8 signaling. Binds glutathione.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LANCL1 Gene

Genomics for LANCL1 Gene

Regulatory Elements for LANCL1 Gene

Enhancers for LANCL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LANCL1 on UCSC Golden Path with GeneCards custom track

Promoters for LANCL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LANCL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LANCL1 Gene

Chromosome:
2
Start:
210,431,249 bp from pter
End:
210,477,652 bp from pter
Size:
46,404 bases
Orientation:
Minus strand

Genomic View for LANCL1 Gene

Genes around LANCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LANCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LANCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LANCL1 Gene

Proteins for LANCL1 Gene

  • Protein details for LANCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43813-LANC1_HUMAN
    Recommended name:
    LanC-like protein 1
    Protein Accession:
    O43813

    Protein attributes for LANCL1 Gene

    Size:
    399 amino acids
    Molecular mass:
    45283 Da
    Quaternary structure:
    • Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. Interacts with P.falciparum SBP1.

    Three dimensional structures from OCA and Proteopedia for LANCL1 Gene

neXtProt entry for LANCL1 Gene

Proteomics data for LANCL1 Gene at MOPED

Post-translational modifications for LANCL1 Gene

  • Ubiquitination at Lys 128
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LANCL1 Gene

Domains & Families for LANCL1 Gene

Protein Domains for LANCL1 Gene

Suggested Antigen Peptide Sequences for LANCL1 Gene

Graphical View of Domain Structure for InterPro Entry

O43813

UniProtKB/Swiss-Prot:

LANC1_HUMAN :
  • Belongs to the LanC-like protein family.
Family:
  • Belongs to the LanC-like protein family.
genes like me logo Genes that share domains with LANCL1: view

No data available for Gene Families for LANCL1 Gene

Function for LANCL1 Gene

Molecular function for LANCL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in EPS8 signaling. Binds glutathione.

Gene Ontology (GO) - Molecular Function for LANCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 9512664
GO:0005515 protein binding IPI 19528316
GO:0017124 SH3 domain binding IPI 19528316
GO:0043295 glutathione binding IDA 19528316
genes like me logo Genes that share ontologies with LANCL1: view
genes like me logo Genes that share phenotypes with LANCL1: view

Animal Models for LANCL1 Gene

MGI Knock Outs for LANCL1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LANCL1 Gene

Localization for LANCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LANCL1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LANCL1 Gene COMPARTMENTS Subcellular localization image for LANCL1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
cytosol 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for LANCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LANCL1: view

Pathways & Interactions for LANCL1 Gene

SuperPathways for LANCL1 Gene

No Data Available

Interacting Proteins for LANCL1 Gene

Gene Ontology (GO) - Biological Process for LANCL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LANCL1 Gene

Drugs & Compounds for LANCL1 Gene

(1) Additional Compounds for LANCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LANCL1: view

Transcripts for LANCL1 Gene

Unigene Clusters for LANCL1 Gene

LanC lantibiotic synthetase component C-like 1 (bacterial):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LANCL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for LANCL1 Gene

GeneLoc Exon Structure for
LANCL1
ECgene alternative splicing isoforms for
LANCL1

Expression for LANCL1 Gene

mRNA expression in normal human tissues for LANCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LANCL1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.4).

Protein differential expression in normal tissues from HIPED for LANCL1 Gene

This gene is overexpressed in Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LANCL1 Gene



SOURCE GeneReport for Unigene cluster for LANCL1 Gene Hs.13351

mRNA Expression by UniProt/SwissProt for LANCL1 Gene

O43813-LANC1_HUMAN
Tissue specificity: Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.
genes like me logo Genes that share expression patterns with LANCL1: view

Protein tissue co-expression partners for LANCL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LANCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LANCL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LANCL1 35
  • 89.06 (n)
  • 89.97 (a)
LANCL1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LANCL1 35
  • 88.89 (n)
  • 91.23 (a)
LANCL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lancl1 35
  • 87.39 (n)
  • 91.48 (a)
Lancl1 16
Lancl1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LANCL1 35
  • 99.42 (n)
  • 99.5 (a)
LANCL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lancl1 35
  • 86.63 (n)
  • 91.48 (a)
oppossum
(Monodelphis domestica)
Mammalia LANCL1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LANCL1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LANCL1 35
  • 75.05 (n)
  • 80.54 (a)
LANCL1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LANCL1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lancl1 35
  • 66.83 (n)
  • 67.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52973 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1004 35
lancl1 35
  • 64.74 (n)
  • 65.74 (a)
lancl1 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8239 35
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD28247 37
  • 35 (a)
CG2061 36
  • 31 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003148 35
  • 46.91 (n)
  • 37.63 (a)
Species with no ortholog for LANCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LANCL1 Gene

ENSEMBL:
Gene Tree for LANCL1 (if available)
TreeFam:
Gene Tree for LANCL1 (if available)

Paralogs for LANCL1 Gene

Paralogs for LANCL1 Gene

(2) SIMAP similar genes for LANCL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LANCL1: view

Variants for LANCL1 Gene

Sequence variations from dbSNP and Humsavar for LANCL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2887900 -- 210,471,040(+) TTCTT(C/T)GATTT intron-variant
rs3036487 -- 210,471,036(+) TTTCT(-/TCT)TTGAt intron-variant
rs3770685 -- 210,474,108(-) AATCA(A/G)TATTC intron-variant
rs5838206 -- 210,471,038(+) TCTTC(-/TTT)GATTT intron-variant
rs3856342 -- 210,470,875(-) TTTGA(G/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LANCL1 Gene

Variant ID Type Subtype PubMed ID
nsv875767 CNV Gain 21882294
nsv3147 CNV Loss 18451855

Variation tolerance for LANCL1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LANCL1 Gene

HapMap Linkage Disequilibrium report
LANCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LANCL1 Gene

Disorders for LANCL1 Gene

Relevant External Links for LANCL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LANCL1

No disorders were found for LANCL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LANCL1 Gene

Publications for LANCL1 Gene

  1. Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. (PMID: 9512664) Mayer H. … Prohaska R. (Biochim. Biophys. Acta 1998) 2 3 4 23 67
  2. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine I^-synthase: a target for neuronal antioxidant defense. (PMID: 22891245) Zhong W.X. … Luo J.H. (J. Biol. Chem. 2012) 2 3
  3. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. (PMID: 19528316) Zhang W. … Zhang X.C. (Genes Dev. 2009) 3 23
  4. Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1). (PMID: 11474189) Mayer H. … Prohaska R. (Cytogenet. Cell Genet. 2001) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for LANCL1 Gene

Sources for LANCL1 Gene

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