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Aliases for LAMTOR5 Gene

Aliases for LAMTOR5 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5 2 3 5
  • HBx-Interacting Protein 2 3 4
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 5 3 4
  • Hepatitis B Virus X-Interacting Protein (9.6kD) 2 3
  • Hepatitis B Virus X Interacting Protein 2 3
  • HBV X-Interacting Protein 3 4
  • HBXIP 3 4
  • XIP 3 4
  • Hepatitis B Virus X-Interacting Protein 4
  • Ragulator Complex Protein LAMTOR5 3

External Ids for LAMTOR5 Gene

Previous HGNC Symbols for LAMTOR5 Gene

  • HBXIP

Previous GeneCards Identifiers for LAMTOR5 Gene

  • GC01M110944

Summaries for LAMTOR5 Gene

Entrez Gene Summary for LAMTOR5 Gene

  • This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMTOR5 Gene

LAMTOR5 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5) is a Protein Coding gene. Diseases associated with LAMTOR5 include Hepatitis B and Hepatitis. Among its related pathways are RET signaling and PI3K / Akt Signaling. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR5 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Wiki entry for LAMTOR5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR5 Gene

Genomics for LAMTOR5 Gene

Regulatory Elements for LAMTOR5 Gene

Enhancers for LAMTOR5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G110383 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +23.2 23228 3.1 PKNOX1 YY1 FOS RELB IKZF2 CREM SMARCA5 ZNF362 HCFC1 CBFB PROK1 RBM15 SLC16A4 LAMTOR5 LOC440600 LAMTOR5-AS1 STRIP1 CD53 GC01P110380
GH01G110334 1.7 FANTOM5 ENCODE dbSUPER 8.6 +69.3 69293 7.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 PPARGC1A PROK1 ENSG00000258634 LAMTOR5 LAMTOR5-AS1 SLC16A4 CSF1 RBM15 PIR47446
GH01G110307 1.2 Ensembl ENCODE dbSUPER 9.6 +98.9 98920 3.2 CTCF BHLHE40 CEBPB CEBPG ZFHX2 ZNF316 CEBPA HMBOX1 SMC3 FOS LOC440600 RBM15 KCNC4 KCNC4-AS1 SLC16A4 ENSG00000200536 ENSG00000235526 LOC105378897 PROK1 KCNA10
GH01G110346 2 dbSUPER 4.4 +58.8 58757 5.6 PKNOX1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GATA2 JUNB ZNF518A ZNF592 PROK1 KCNC4 KCNC4-AS1 SLC16A4 LAMTOR5-AS1 LAMTOR5 GC01M110350
GH01G110436 0.7 ENCODE 8.8 -29.0 -28966 1.1 LEF1 PKNOX1 L3MBTL2 ARNT FEZF1 ATF2 ZFHX2 CTBP1 GLIS1 CREB1 KCNA10 LAMTOR5 LAMTOR5-AS1 PROK1 GC01M110420
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LAMTOR5 on UCSC Golden Path with GeneCards custom track

Promoters for LAMTOR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011269 542 2001 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for LAMTOR5 Gene

Chromosome:
1
Start:
110,401,249 bp from pter
End:
110,407,942 bp from pter
Size:
6,694 bases
Orientation:
Minus strand

Genomic View for LAMTOR5 Gene

Genes around LAMTOR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMTOR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMTOR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR5 Gene

Proteins for LAMTOR5 Gene

  • Protein details for LAMTOR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43504-LTOR5_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR5
    Protein Accession:
    O43504
    Secondary Accessions:
    • Q6IBD8

    Protein attributes for LAMTOR5 Gene

    Size:
    91 amino acids
    Molecular mass:
    9614 Da
    Quaternary structure:
    • Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.
    Miscellaneous:
    • Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.
    SequenceCaution:
    • Sequence=AAH62619.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LAMTOR5 Gene

neXtProt entry for LAMTOR5 Gene

Post-translational modifications for LAMTOR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAMTOR5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LAMTOR5 (HBXIP)
  • Abcam antibodies for LAMTOR5
  • Santa Cruz Biotechnology (SCBT) Antibodies for LAMTOR5

No data available for DME Specific Peptides for LAMTOR5 Gene

Domains & Families for LAMTOR5 Gene

Gene Families for LAMTOR5 Gene

Protein Domains for LAMTOR5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMTOR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43504

UniProtKB/Swiss-Prot:

LTOR5_HUMAN :
  • Belongs to the LAMTOR5 family.
Family:
  • Belongs to the LAMTOR5 family.
genes like me logo Genes that share domains with LAMTOR5: view

Function for LAMTOR5 Gene

Molecular function for LAMTOR5 Gene

UniProtKB/Swiss-Prot Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Ontology (GO) - Molecular Function for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 protein binding IPI 12773388
GO:0032947 contributes_to protein complex scaffold IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view
genes like me logo Genes that share phenotypes with LAMTOR5: view

Animal Models for LAMTOR5 Gene

MGI Knock Outs for LAMTOR5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAMTOR5 Gene

Localization for LAMTOR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR5 Gene

Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAMTOR5 gene
Compartment Confidence
cytosol 5
lysosome 5
endosome 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IDA,IEA 22980980
GO:0005765 lysosomal membrane TAS --
GO:0005829 cytosol IDA 12773388
GO:0071986 Ragulator complex IEA,IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view

Pathways & Interactions for LAMTOR5 Gene

genes like me logo Genes that share pathways with LAMTOR5: view

Pathways by source for LAMTOR5 Gene

2 KEGG pathways for LAMTOR5 Gene

Gene Ontology (GO) - Biological Process for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0008361 regulation of cell size IMP 22980980
GO:0009615 response to virus TAS 9499022
GO:0016236 macroautophagy TAS --
GO:0016241 regulation of macroautophagy TAS --
genes like me logo Genes that share ontologies with LAMTOR5: view

No data available for SIGNOR curated interactions for LAMTOR5 Gene

Drugs & Compounds for LAMTOR5 Gene

(1) Drugs for LAMTOR5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LAMTOR5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMTOR5: view

Transcripts for LAMTOR5 Gene

Unigene Clusters for LAMTOR5 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for LAMTOR5 Gene

GeneLoc Exon Structure for
LAMTOR5
ECgene alternative splicing isoforms for
LAMTOR5

Expression for LAMTOR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAMTOR5 Gene

Protein differential expression in normal tissues from HIPED for LAMTOR5 Gene

This gene is overexpressed in Amniocyte (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMTOR5 Gene



Protein tissue co-expression partners for LAMTOR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of LAMTOR5 Gene:

LAMTOR5

SOURCE GeneReport for Unigene cluster for LAMTOR5 Gene:

Hs.439815

mRNA Expression by UniProt/SwissProt for LAMTOR5 Gene:

O43504-LTOR5_HUMAN
Tissue specificity: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

Evidence on tissue expression from TISSUES for LAMTOR5 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Adrenal gland(2.9)
  • Nervous system(2.6)
  • Kidney(2.3)
  • Heart(2.1)
  • Muscle(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with LAMTOR5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMTOR5 Gene

Orthologs for LAMTOR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HBXIP 34
  • 99.23 (n)
LAMTOR5 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMTOR5 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAMTOR5 34 35
  • 95.97 (n)
dog
(Canis familiaris)
Mammalia LAMTOR5 35
  • 93 (a)
OneToOne
LOC102156380 34
  • 91.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR5 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamtor5 34 16 35
  • 83.68 (n)
rat
(Rattus norvegicus)
Mammalia Lamtor5 34
  • 82.76 (n)
chicken
(Gallus gallus)
Aves HBXIP 34 35
  • 78.39 (n)
lizard
(Anolis carolinensis)
Reptilia LAMTOR5 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamtor5 34
  • 75.09 (n)
Str.18287 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8111 34
zebrafish
(Danio rerio)
Actinopterygii lamtor5 34 35
  • 69.23 (n)
Species where no ortholog for LAMTOR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR5 Gene

ENSEMBL:
Gene Tree for LAMTOR5 (if available)
TreeFam:
Gene Tree for LAMTOR5 (if available)

Paralogs for LAMTOR5 Gene

Pseudogenes.org Pseudogenes for LAMTOR5 Gene

genes like me logo Genes that share paralogs with LAMTOR5: view

No data available for Paralogs for LAMTOR5 Gene

Variants for LAMTOR5 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000550829 -- 110,407,305(+) TGACC(A/G)TAAAG intron-variant, upstream-variant-2KB
rs1000583292 -- 110,407,508(+) GTACT(C/T)GCAGC intron-variant, upstream-variant-2KB
rs1001168298 -- 110,401,015(+) ACGTA(A/G)AACAT downstream-variant-500B
rs1001249039 -- 110,407,239(+) CACTG(C/T)ACAAC intron-variant, upstream-variant-2KB
rs1001585531 -- 110,408,827(+) CTGTA(C/G)CTGGC intron-variant, upstream-variant-2KB

Variation tolerance for LAMTOR5 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMTOR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAMTOR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LAMTOR5 Gene

Disorders for LAMTOR5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LAMTOR5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LAMTOR5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMTOR5
genes like me logo Genes that share disorders with LAMTOR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMTOR5 Gene

Publications for LAMTOR5 Gene

  1. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 2 3 4 64
  2. HBXIP functions as a cofactor of survivin in apoptosis suppression. (PMID: 12773388) Marusawa H. … Reed J.C. (EMBO J. 2003) 3 4 22 64
  3. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. (PMID: 9499022) Melegari M. … Wands J.R. (J. Virol. 1998) 2 3 4 64
  4. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 3 4 64
  5. Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma. (PMID: 19885569) Krepela E. … Benkova K. (Int. J. Oncol. 2009) 3 22 64

Products for LAMTOR5 Gene

Sources for LAMTOR5 Gene

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