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Aliases for LAMTOR5 Gene

Aliases for LAMTOR5 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5 2 3
  • HBXIP 3 4 6
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 5 3 4
  • Hepatitis B Virus X-Interacting Protein (9.6kD) 2 3
  • Hepatitis B Virus X Interacting Protein 2 3
  • HBV X-Interacting Protein 3 4
  • HBx-Interacting Protein 2 3
  • XIP 3 4
  • Hepatitis B Virus X-Interacting Protein 4
  • Ragulator Complex Protein LAMTOR5 3
  • HBX-Interacting Protein 4

External Ids for LAMTOR5 Gene

Previous Symbols for LAMTOR5 Gene

  • HBXIP

Summaries for LAMTOR5 Gene

Entrez Gene Summary for LAMTOR5 Gene

  • This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMTOR5 Gene

LAMTOR5 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5) is a Protein Coding gene. Diseases associated with LAMTOR5 include hepatitis b and hepatitis. Among its related pathways are Toll-like receptor signaling pathway. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR5 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Wiki entry for LAMTOR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR5 Gene

Genomics for LAMTOR5 Gene

Genomic Location for LAMTOR5 Gene

Start:
110,401,249 bp from pter
End:
110,407,942 bp from pter
Size:
6,694 bases
Orientation:
Minus strand

Genomic View for LAMTOR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMTOR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR5 Gene

No data available for Regulatory Elements for LAMTOR5 Gene

Proteins for LAMTOR5 Gene

  • Protein details for LAMTOR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43504-LTOR5_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR5
    Protein Accession:
    O43504
    Secondary Accessions:
    • Q6IBD8

    Protein attributes for LAMTOR5 Gene

    Size:
    91 amino acids
    Molecular mass:
    9614 Da
    Quaternary structure:
    • Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.
    Miscellaneous:
    • Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX
    SequenceCaution:
    • Sequence=AAH62619.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LAMTOR5 Gene

neXtProt entry for LAMTOR5 Gene

Proteomics data for LAMTOR5 Gene at MOPED

Post-translational modifications for LAMTOR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAMTOR5 Gene

No data available for DME Specific Peptides for LAMTOR5 Gene

Domains for LAMTOR5 Gene

Protein Domains for LAMTOR5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

LTOR5_HUMAN
Family:
  • Belongs to the LAMTOR5 family.:
    • O43504
genes like me logo Genes that share domains with LAMTOR5: view

No data available for Gene Families for LAMTOR5 Gene

Function for LAMTOR5 Gene

Molecular function for LAMTOR5 Gene

UniProtKB/Swiss-Prot Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Ontology (GO) - Molecular Function for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 protein binding IPI 12773388
GO:0032947 contributes_to protein complex scaffold IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view

miRNA for LAMTOR5 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LAMTOR5 Gene

Localization for LAMTOR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR5 Gene

Cytoplasm. Lysosome.

Gene Ontology (GO) - Cellular Components for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005764 lysosome IDA 22980980
GO:0005829 cytosol IDA 12773388
GO:0071986 Ragulator complex IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view

Pathways for LAMTOR5 Gene

SuperPathways for LAMTOR5 Gene

Superpath Contained pathways
1 Toll-like receptor signaling pathway
genes like me logo Genes that share pathways with LAMTOR5: view

Pathways by source for LAMTOR5 Gene

1 KEGG pathway for LAMTOR5 Gene

Gene Ontology (GO) - Biological Process for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008361 regulation of cell size IMP 22980980
GO:0009615 response to virus TAS 9499022
GO:0019079 viral genome replication IEA --
GO:0032008 positive regulation of TOR signaling IMP 22980980
GO:0043066 negative regulation of apoptotic process IDA 12773388
genes like me logo Genes that share ontologies with LAMTOR5: view

Compounds for LAMTOR5 Gene

(3) Novoseek inferred chemical compound relationships for LAMTOR5 Gene

Compound -log(P) Hits PubMed IDs
sulfosuccinimidyl acetate 92.9 3
calcium 33.8 16
lipid 0 1
genes like me logo Genes that share compounds with LAMTOR5: view

Transcripts for LAMTOR5 Gene

Unigene Clusters for LAMTOR5 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for LAMTOR5 Gene

GeneLoc Exon Structure for
LAMTOR5
ECgene alternative splicing isoforms for
LAMTOR5

Expression for LAMTOR5 Gene

mRNA expression in normal human tissues for LAMTOR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LAMTOR5 Gene

SOURCE GeneReport for Unigene cluster for LAMTOR5 Gene Hs.439815

mRNA Expression by UniProt/SwissProt for LAMTOR5 Gene

O43504-LTOR5_HUMAN
Tissue specificity: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection
genes like me logo Genes that share expressions with LAMTOR5: view

Orthologs for LAMTOR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HBXIP 36
  • 99.23 (n)
  • 99.42 (a)
LAMTOR5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAMTOR5 36
  • 95.97 (n)
  • 100 (a)
LAMTOR5 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMTOR5 37
  • 93 (a)
OneToOne
LOC102156380 36
  • 91.21 (n)
  • 98.9 (a)
mouse
(Mus musculus)
Mammalia Lamtor5 36
  • 83.68 (n)
  • 78.62 (a)
Lamtor5 16
Lamtor5 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMTOR5 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR5 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamtor5 36
  • 82.76 (n)
  • 77.24 (a)
chicken
(Gallus gallus)
Aves HBXIP 36
  • 78.39 (n)
  • 91.21 (a)
HBXIP 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMTOR5 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8111 36
tropical clawed frog
(Silurana tropicalis)
Amphibia lamtor5 36
  • 75.09 (n)
  • 83.52 (a)
Str.18287 36
zebrafish
(Danio rerio)
Actinopterygii lamtor5 36
  • 69.23 (n)
  • 74.73 (a)
lamtor5 37
  • 74 (a)
OneToOne
Species with no ortholog for LAMTOR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR5 Gene

ENSEMBL:
Gene Tree for LAMTOR5 (if available)
TreeFam:
Gene Tree for LAMTOR5 (if available)

Paralogs for LAMTOR5 Gene

Pseudogenes.org Pseudogenes for LAMTOR5 Gene

genes like me logo Genes that share paralogs with LAMTOR5: view

No data available for Paralogs for LAMTOR5 Gene

Variants for LAMTOR5 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1161 -- 110,401,465(-) TTAAT(A/C/T)ACCTT utr-variant-3-prime
rs1802101 -- 110,403,957(-) GACCC(C/T)ACTGA reference, synonymous-codon
rs2270686 -- 110,401,500(-) CAGCA(G/T)CCTGT utr-variant-3-prime
rs3765139 -- 110,404,213(-) TTTTC(A/G)TACCT intron-variant
rs11102098 -- 110,404,512(+) CTGCA(C/T)GTTAA intron-variant

Relevant External Links for LAMTOR5 Gene

HapMap Linkage Disequilibrium report
LAMTOR5

No data available for Structural Variations from Database of Genomic Variants (DGV) for LAMTOR5 Gene

Disorders for LAMTOR5 Gene

(2) MalaCards Diseases for LAMTOR5 Gene

Search for LAMTOR5 Gene in MalaCards »

(1) Novoseek inferred disease relationships for LAMTOR5 Gene

Disease -log(P) Hits PubMed IDs
hepatitis b 48.1 9
genes like me logo Genes that share disorders with LAMTOR5: view

No data available for UniProtKB/Swiss-Prot for LAMTOR5 Gene

Publications for LAMTOR5 Gene

  1. HBXIP functions as a cofactor of survivin in apoptosis suppression. (PMID: 12773388) Marusawa H. … Reed J.C. (EMBO J. 2003) 3 4 23
  2. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 2 3 4
  3. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. (PMID: 9499022) Melegari M. … Wands J.R. (J. Virol. 1998) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells. (PMID: 11925594) Li Y. … Lu Y.Y. (World J. Gastroenterol. 2002) 3 23

Products for LAMTOR5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate LAMTOR5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for LAMTOR5
    • Block miRNA regulation of LAMTOR5 using miScript Target Protectors

    Sources for LAMTOR5 Gene

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