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Aliases for LAMTOR5 Gene

Aliases for LAMTOR5 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5 2 3 5
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 5 3 4
  • Hepatitis B Virus X-Interacting Protein (9.6kD) 2 3
  • Hepatitis B Virus X Interacting Protein 2 3
  • HBV X-Interacting Protein 3 4
  • HBx-Interacting Protein 2 3
  • HBXIP 3 4
  • XIP 3 4
  • Hepatitis B Virus X-Interacting Protein 4
  • HBX-Interacting Protein 4

External Ids for LAMTOR5 Gene

Previous HGNC Symbols for LAMTOR5 Gene

  • HBXIP

Previous GeneCards Identifiers for LAMTOR5 Gene

  • GC01M110944

Summaries for LAMTOR5 Gene

Entrez Gene Summary for LAMTOR5 Gene

  • This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMTOR5 Gene

LAMTOR5 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5) is a Protein Coding gene. Diseases associated with LAMTOR5 include hepatitis b and hepatitis. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR5 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Wiki entry for LAMTOR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR5 Gene

Genomics for LAMTOR5 Gene

Regulatory Elements for LAMTOR5 Gene

Promoters for LAMTOR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAMTOR5 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAMTOR5 Gene

Chromosome:
1
Start:
110,401,249 bp from pter
End:
110,407,942 bp from pter
Size:
6,694 bases
Orientation:
Minus strand

Genomic View for LAMTOR5 Gene

Genes around LAMTOR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMTOR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMTOR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR5 Gene

Proteins for LAMTOR5 Gene

  • Protein details for LAMTOR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43504-LTOR5_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR5
    Protein Accession:
    O43504
    Secondary Accessions:
    • Q6IBD8

    Protein attributes for LAMTOR5 Gene

    Size:
    91 amino acids
    Molecular mass:
    9614 Da
    Quaternary structure:
    • Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.
    Miscellaneous:
    • Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.
    SequenceCaution:
    • Sequence=AAH62619.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LAMTOR5 Gene

neXtProt entry for LAMTOR5 Gene

Proteomics data for LAMTOR5 Gene at MOPED

Post-translational modifications for LAMTOR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAMTOR5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LAMTOR5 (HBXIP)

No data available for DME Specific Peptides for LAMTOR5 Gene

Domains & Families for LAMTOR5 Gene

Gene Families for LAMTOR5 Gene

Protein Domains for LAMTOR5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMTOR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43504

UniProtKB/Swiss-Prot:

LTOR5_HUMAN :
  • Belongs to the LAMTOR5 family.
Family:
  • Belongs to the LAMTOR5 family.
genes like me logo Genes that share domains with LAMTOR5: view

Function for LAMTOR5 Gene

Molecular function for LAMTOR5 Gene

UniProtKB/Swiss-Prot Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Ontology (GO) - Molecular Function for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12773388
genes like me logo Genes that share ontologies with LAMTOR5: view
genes like me logo Genes that share phenotypes with LAMTOR5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMTOR5 Gene

Localization for LAMTOR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR5 Gene

Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMTOR5 Gene COMPARTMENTS Subcellular localization image for LAMTOR5 gene
Compartment Confidence
cytosol 5
endosome 5
lysosome 5
vacuole 5
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071986 Ragulator complex IEA,IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view

Pathways & Interactions for LAMTOR5 Gene

genes like me logo Genes that share pathways with LAMTOR5: view

Pathways by source for LAMTOR5 Gene

Gene Ontology (GO) - Biological Process for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007050 cell cycle arrest TAS --
GO:0008361 regulation of cell size IMP 22980980
GO:0016236 macroautophagy TAS --
GO:0032008 positive regulation of TOR signaling IMP 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view

No data available for SIGNOR curated interactions for LAMTOR5 Gene

Drugs & Compounds for LAMTOR5 Gene

(1) Drugs for LAMTOR5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LAMTOR5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMTOR5: view

Transcripts for LAMTOR5 Gene

Unigene Clusters for LAMTOR5 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for LAMTOR5 Gene

GeneLoc Exon Structure for
LAMTOR5
ECgene alternative splicing isoforms for
LAMTOR5

Expression for LAMTOR5 Gene

mRNA expression in normal human tissues for LAMTOR5 Gene

Protein differential expression in normal tissues from HIPED for LAMTOR5 Gene

This gene is overexpressed in Amniocyte (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMTOR5 Gene



SOURCE GeneReport for Unigene cluster for LAMTOR5 Gene Hs.439815

mRNA Expression by UniProt/SwissProt for LAMTOR5 Gene

O43504-LTOR5_HUMAN
Tissue specificity: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.
genes like me logo Genes that share expression patterns with LAMTOR5: view

Protein tissue co-expression partners for LAMTOR5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LAMTOR5 Gene

Orthologs for LAMTOR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAMTOR5 35
  • 95.97 (n)
  • 100 (a)
LAMTOR5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102156380 35
  • 91.21 (n)
  • 98.9 (a)
LAMTOR5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamtor5 35
  • 83.68 (n)
  • 78.62 (a)
Lamtor5 16
Lamtor5 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HBXIP 35
  • 99.23 (n)
  • 99.42 (a)
LAMTOR5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamtor5 35
  • 82.76 (n)
  • 77.24 (a)
oppossum
(Monodelphis domestica)
Mammalia LAMTOR5 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR5 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HBXIP 35
  • 78.39 (n)
  • 91.21 (a)
HBXIP 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMTOR5 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamtor5 35
  • 75.09 (n)
  • 83.52 (a)
Str.18287 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8111 35
zebrafish
(Danio rerio)
Actinopterygii lamtor5 35
  • 69.23 (n)
  • 74.73 (a)
lamtor5 36
  • 74 (a)
OneToOne
Species with no ortholog for LAMTOR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR5 Gene

ENSEMBL:
Gene Tree for LAMTOR5 (if available)
TreeFam:
Gene Tree for LAMTOR5 (if available)

Paralogs for LAMTOR5 Gene

Pseudogenes.org Pseudogenes for LAMTOR5 Gene

genes like me logo Genes that share paralogs with LAMTOR5: view

No data available for Paralogs for LAMTOR5 Gene

Variants for LAMTOR5 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1161 -- 110,401,465(-) TTAAT(A/C/T)ACCTT utr-variant-3-prime
rs1802101 -- 110,403,957(-) GACCC(C/T)ACTGA reference, synonymous-codon
rs2270686 -- 110,401,500(-) CAGCA(G/T)CCTGT utr-variant-3-prime
rs3765139 -- 110,404,213(-) TTTTC(A/G/T)TACCT intron-variant
rs11102098 -- 110,404,512(+) CTGCA(C/T)GTTAA intron-variant

Variation tolerance for LAMTOR5 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMTOR5 Gene

HapMap Linkage Disequilibrium report
LAMTOR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LAMTOR5 Gene

Disorders for LAMTOR5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LAMTOR5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LAMTOR5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMTOR5
genes like me logo Genes that share disorders with LAMTOR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMTOR5 Gene

Publications for LAMTOR5 Gene

  1. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 2 3 4 67
  2. Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma. (PMID: 19885569) Krepela E. … Benkova K. (Int. J. Oncol. 2009) 3 23
  3. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. (PMID: 18158869) Wang F.Z. … Zhang X.D. (Acta Pharmacol. Sin. 2008) 3 23
  4. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. (PMID: 17303008) Wang F.Z. … Ye L.H. (Acta Pharmacol. Sin. 2007) 3 23
  5. HBXIP functions as a cofactor of survivin in apoptosis suppression. (PMID: 12773388) Marusawa H. … Reed J.C. (EMBO J. 2003) 3 23

Products for LAMTOR5 Gene

Sources for LAMTOR5 Gene

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