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Aliases for LAMTOR5 Gene

Aliases for LAMTOR5 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5 2 3 5
  • HBx-Interacting Protein 2 3 4
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 5 3 4
  • Hepatitis B Virus X-Interacting Protein (9.6kD) 2 3
  • Hepatitis B Virus X Interacting Protein 2 3
  • HBV X-Interacting Protein 3 4
  • HBXIP 3 4
  • XIP 3 4
  • Hepatitis B Virus X-Interacting Protein 4
  • Ragulator Complex Protein LAMTOR5 3

External Ids for LAMTOR5 Gene

Previous HGNC Symbols for LAMTOR5 Gene

  • HBXIP

Previous GeneCards Identifiers for LAMTOR5 Gene

  • GC01M110944

Summaries for LAMTOR5 Gene

Entrez Gene Summary for LAMTOR5 Gene

  • This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMTOR5 Gene

LAMTOR5 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5) is a Protein Coding gene. Diseases associated with LAMTOR5 include Hepatitis B and Hepatitis. Among its related pathways are Gene Expression and RET signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold activity.

UniProtKB/Swiss-Prot for LAMTOR5 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Wiki entry for LAMTOR5 Gene

Additional gene information for LAMTOR5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR5 Gene

Genomics for LAMTOR5 Gene

GeneHancer (GH) Regulatory Elements for LAMTOR5 Gene

Promoters and enhancers for LAMTOR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I110406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.1 108 3.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 LAMTOR5 CEPT1 ENSG00000258634 PROK1 SLC16A4 GNAI3 RBM15 DRAM2 LAMTOR5-AS1
GH01I110334 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.6 +69.3 69293 7.4 CLOCK FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D RBM15 GC01P110337 PIR47446 RBM15-AS1 ENSG00000258634 CEPT1 STRIP1 DRAM2 ENSG00000273373 UBL4B
GH01I110383 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +23.2 23228 3.1 PKNOX1 CEBPG EBF1 GATA3 ZNF316 POLR2A FOSL2 FOS NFE2 IKZF2 PROK1 RBM15 SLC16A4 LAMTOR5 RBM15-AS1 LAMTOR5-AS1 STRIP1 CD53 GC01P110380
GH01I110307 Enhancer 1 Ensembl ENCODE dbSUPER 9.6 +98.9 98920 3.2 RFX5 SP1 ZFHX2 ZNF316 FOS EMSY MAFK ZBTB17 EGR2 SPI1 RBM15-AS1 RBM15 KCNC4 KCNC4-AS1 SLC16A4 ENSG00000200536 LOC105378897 ENSG00000235526 PROK1 KCNA10
GH01I110389 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 4.8 +17.2 17236 2 ZNF146 PKNOX1 SIN3A MZF1 ZNF335 ZFHX2 POLR2A PATZ1 PRDM10 FOS SLC16A4 PROK1 LAMTOR5 GC01P110380 LAMTOR5-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LAMTOR5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LAMTOR5 Gene

Genomic Locations for LAMTOR5 Gene
chr1:110,401,249-110,407,942
(GRCh38/hg38)
Size:
6,694 bases
Orientation:
Minus strand
chr1:110,943,871-110,950,564
(GRCh37/hg19)

Genomic View for LAMTOR5 Gene

Genes around LAMTOR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMTOR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMTOR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR5 Gene

Proteins for LAMTOR5 Gene

  • Protein details for LAMTOR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43504-LTOR5_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR5
    Protein Accession:
    O43504
    Secondary Accessions:
    • Q6IBD8

    Protein attributes for LAMTOR5 Gene

    Size:
    91 amino acids
    Molecular mass:
    9614 Da
    Quaternary structure:
    • Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.
    Miscellaneous:
    • Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.
    SequenceCaution:
    • Sequence=AAH62619.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LAMTOR5 Gene

neXtProt entry for LAMTOR5 Gene

Post-translational modifications for LAMTOR5 Gene

No Post-translational modifications

Other Protein References for LAMTOR5 Gene

No data available for DME Specific Peptides for LAMTOR5 Gene

Domains & Families for LAMTOR5 Gene

Gene Families for LAMTOR5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LAMTOR5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMTOR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43504

UniProtKB/Swiss-Prot:

LTOR5_HUMAN :
  • Belongs to the LAMTOR5 family.
Family:
  • Belongs to the LAMTOR5 family.
genes like me logo Genes that share domains with LAMTOR5: view

Function for LAMTOR5 Gene

Molecular function for LAMTOR5 Gene

UniProtKB/Swiss-Prot Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Ontology (GO) - Molecular Function for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 protein binding IPI 12773388
GO:0032947 contributes_to protein complex scaffold activity IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view
genes like me logo Genes that share phenotypes with LAMTOR5: view

Animal Models for LAMTOR5 Gene

MGI Knock Outs for LAMTOR5:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAMTOR5 Gene

Localization for LAMTOR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR5 Gene

Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAMTOR5 gene
Compartment Confidence
cytosol 5
lysosome 5
endosome 5
plasma membrane 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA,IDA 22980980
GO:0005765 lysosomal membrane TAS --
GO:0005829 cytosol IDA 12773388
GO:0071986 Ragulator complex IDA,IEA 22980980
genes like me logo Genes that share ontologies with LAMTOR5: view

Pathways & Interactions for LAMTOR5 Gene

genes like me logo Genes that share pathways with LAMTOR5: view

Pathways by source for LAMTOR5 Gene

2 KEGG pathways for LAMTOR5 Gene

Gene Ontology (GO) - Biological Process for LAMTOR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0008361 regulation of cell size IMP 22980980
GO:0009615 response to virus TAS 9499022
GO:0016241 regulation of macroautophagy TAS --
GO:0019079 viral genome replication IEA --
genes like me logo Genes that share ontologies with LAMTOR5: view

No data available for SIGNOR curated interactions for LAMTOR5 Gene

Drugs & Compounds for LAMTOR5 Gene

(1) Drugs for LAMTOR5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LAMTOR5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMTOR5: view

Transcripts for LAMTOR5 Gene

Unigene Clusters for LAMTOR5 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for LAMTOR5 Gene

GeneLoc Exon Structure for
LAMTOR5
ECgene alternative splicing isoforms for
LAMTOR5

Expression for LAMTOR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAMTOR5 Gene

Protein differential expression in normal tissues from HIPED for LAMTOR5 Gene

This gene is overexpressed in Amniocyte (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMTOR5 Gene



Protein tissue co-expression partners for LAMTOR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of LAMTOR5 Gene:

LAMTOR5

SOURCE GeneReport for Unigene cluster for LAMTOR5 Gene:

Hs.439815

mRNA Expression by UniProt/SwissProt for LAMTOR5 Gene:

O43504-LTOR5_HUMAN
Tissue specificity: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

Evidence on tissue expression from TISSUES for LAMTOR5 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Adrenal gland(2.9)
  • Nervous system(2.6)
  • Lymph node(2.4)
  • Kidney(2.3)
  • Heart(2.1)
  • Muscle(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with LAMTOR5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMTOR5 Gene

Orthologs for LAMTOR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HBXIP 33
  • 99.23 (n)
LAMTOR5 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMTOR5 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAMTOR5 33 34
  • 95.97 (n)
dog
(Canis familiaris)
Mammalia LAMTOR5 34
  • 93 (a)
OneToOne
LOC102156380 33
  • 91.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR5 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamtor5 33 16 34
  • 83.68 (n)
rat
(Rattus norvegicus)
Mammalia Lamtor5 33
  • 82.76 (n)
chicken
(Gallus gallus)
Aves HBXIP 33 34
  • 78.39 (n)
lizard
(Anolis carolinensis)
Reptilia LAMTOR5 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamtor5 33
  • 75.09 (n)
Str.18287 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8111 33
zebrafish
(Danio rerio)
Actinopterygii lamtor5 33 34
  • 69.23 (n)
Species where no ortholog for LAMTOR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR5 Gene

ENSEMBL:
Gene Tree for LAMTOR5 (if available)
TreeFam:
Gene Tree for LAMTOR5 (if available)

Paralogs for LAMTOR5 Gene

Pseudogenes.org Pseudogenes for LAMTOR5 Gene

genes like me logo Genes that share paralogs with LAMTOR5: view

No data available for Paralogs for LAMTOR5 Gene

Variants for LAMTOR5 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000550829 -- 110,407,305(-) G/A intron_variant
rs1000583292 -- 110,407,508(-) C/T intron_variant
rs1001168298 -- 110,401,015(-) A/G downstream_transcript_variant
rs1001249039 -- 110,407,239(-) C/T intron_variant
rs1001585531 -- 110,408,827(-) G/C upstream_transcript_variant

Variation tolerance for LAMTOR5 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAMTOR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAMTOR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LAMTOR5 Gene

Disorders for LAMTOR5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LAMTOR5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LAMTOR5

genes like me logo Genes that share disorders with LAMTOR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMTOR5 Gene

Publications for LAMTOR5 Gene

  1. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L … Sabatini DM (Cell 2012) 2 3 4 58
  2. HBXIP functions as a cofactor of survivin in apoptosis suppression. (PMID: 12773388) Marusawa H … Reed JC (The EMBO journal 2003) 3 4 22 58
  3. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. (PMID: 9499022) Melegari M … Wands JR (Journal of virology 1998) 2 3 4 58
  4. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M … Superti-Furga G (Nature 2015) 3 4 58
  5. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. (PMID: 25567906) Wang S … Sabatini DM (Science (New York, N.Y.) 2015) 3 4 58

Products for LAMTOR5 Gene

Sources for LAMTOR5 Gene

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