Aliases for LAMTOR4 Gene
External Ids for LAMTOR4 Gene
Previous HGNC Symbols for LAMTOR4 Gene
Previous GeneCards Identifiers for LAMTOR4 Gene
GeneCards Summary for LAMTOR4 Gene
LAMTOR4 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4) is a Protein Coding gene. Among its related pathways are RET signaling and Cellular Senescence (REACTOME). GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.
UniProtKB/Swiss-Prot for LAMTOR4 Gene
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.