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Aliases for LAMTOR4 Gene

Aliases for LAMTOR4 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4 2 3
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4 3 4
  • C7orf59 3 4
  • Chromosome 7 Open Reading Frame 59 2
  • Ragulator Complex Protein LAMTOR4 3
  • UPF0539 Protein C7orf59 3

External Ids for LAMTOR4 Gene

Previous Symbols for LAMTOR4 Gene

  • C7orf59

Summaries for LAMTOR4 Gene

GeneCards Summary for LAMTOR4 Gene

LAMTOR4 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR4 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR4 Gene

Genomics for LAMTOR4 Gene

Genomic Location for LAMTOR4 Gene

Start:
100,148,907 bp from pter
End:
100,155,944 bp from pter
Size:
7,038 bases
Orientation:
Plus strand

Genomic View for LAMTOR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMTOR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR4 Gene

No data available for Regulatory Elements for LAMTOR4 Gene

Proteins for LAMTOR4 Gene

  • Protein details for LAMTOR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VGL1-LTOR4_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR4
    Protein Accession:
    Q0VGL1
    Secondary Accessions:

    Protein attributes for LAMTOR4 Gene

    Size:
    99 amino acids
    Molecular mass:
    10741 Da
    Quaternary structure:
    • Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).

neXtProt entry for LAMTOR4 Gene

Proteomics data for LAMTOR4 Gene at MOPED

Post-translational modifications for LAMTOR4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LAMTOR4 Gene

Domains for LAMTOR4 Gene

Protein Domains for LAMTOR4 Gene

ProtoNet:

UniProtKB/Swiss-Prot:

LTOR4_HUMAN
Family:
  • Belongs to the LAMTOR4 family.:
    • Q0VGL1
genes like me logo Genes that share domains with LAMTOR4: view

No data available for Gene Families for LAMTOR4 Gene

Function for LAMTOR4 Gene

Molecular function for LAMTOR4 Gene

UniProtKB/Swiss-Prot Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

Gene Ontology (GO) - Molecular Function for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 protein binding IPI 23414517
GO:0032947 contributes_to protein complex scaffold IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

miRNA for LAMTOR4 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LAMTOR4 Gene

Localization for LAMTOR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR4 Gene

Lysosome.

Gene Ontology (GO) - Cellular Components for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 22980980
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0071986 Ragulator complex IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

Pathways for LAMTOR4 Gene

SuperPathways for LAMTOR4 Gene

Superpath Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with LAMTOR4: view

Pathways by source for LAMTOR4 Gene

1 Cell Signaling Technology pathway for LAMTOR4 Gene

Gene Ontology (GO) - Biological Process for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008361 regulation of cell size IMP 22980980
GO:0032008 positive regulation of TOR signaling IMP 22980980
GO:0043547 positive regulation of GTPase activity IDA 22980980
GO:0061462 protein localization to lysosome IMP 22980980
GO:0071230 cellular response to amino acid stimulus IMP 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

Transcripts for LAMTOR4 Gene

Unigene Clusters for LAMTOR4 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -

Relevant External Links for LAMTOR4 Gene

GeneLoc Exon Structure for
LAMTOR4
ECgene alternative splicing isoforms for
LAMTOR4

Expression for LAMTOR4 Gene

mRNA expression in normal human tissues for LAMTOR4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMTOR4 Gene

SOURCE GeneReport for Unigene cluster for LAMTOR4 Gene Hs.406520

genes like me logo Genes that share expressions with LAMTOR4: view

Orthologs for LAMTOR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMTOR4 37
  • 30 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAMTOR4 36
  • 91.25 (n)
  • 97.98 (a)
LAMTOR4 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMTOR4 36
  • 92.93 (n)
  • 94.95 (a)
LAMTOR4 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamtor4 36
  • 89.9 (n)
  • 95.96 (a)
Lamtor4 16
Lamtor4 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMTOR4 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR4 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamtor4 36
  • 90.57 (n)
  • 96.97 (a)
zebrafish
(Danio rerio)
Actinopterygii LAMTOR4 37
  • 66 (a)
OneToOne
si:dkey-159a18.7 36
  • 65.66 (n)
  • 65.66 (a)
Species with no ortholog for LAMTOR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR4 Gene

ENSEMBL:
Gene Tree for LAMTOR4 (if available)
TreeFam:
Gene Tree for LAMTOR4 (if available)

Paralogs for LAMTOR4 Gene

No data available for Paralogs for LAMTOR4 Gene

Variants for LAMTOR4 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12878 -- 100,149,507(-) GTCAG(C/T)GCAGA synonymous-codon, reference
rs1059864 -- 100,153,910(+) GGACA(A/G)AGGGT synonymous-codon, reference
rs3736590 -- 100,153,658(-) GATAC(A/C)AGGGA intron-variant
rs3736591 -- 100,153,394(-) CTGCA(C/T)GCAGA intron-variant
rs7785392 -- 100,149,755(+) TCTTA(G/T)TCTCC intron-variant

Relevant External Links for LAMTOR4 Gene

HapMap Linkage Disequilibrium report
LAMTOR4

No data available for Structural Variations from Database of Genomic Variants (DGV) for LAMTOR4 Gene

Disorders for LAMTOR4 Gene

No disorders were found for LAMTOR4 Gene.

No data available for UniProtKB/Swiss-Prot for LAMTOR4 Gene

Publications for LAMTOR4 Gene

  1. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 2 3 4
  2. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. (PMID: 23414517) Blandin G. … Richard I. (Skelet Muscle 2013) 3
  3. An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19. (PMID: 23500468) Velasco K. … Lindsten K. (Biochem. Biophys. Res. Commun. 2013) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for LAMTOR4 Gene

Sources for LAMTOR4 Gene

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