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Aliases for LAMTOR4 Gene

Aliases for LAMTOR4 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4 2 3 5
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4 3 4
  • C7orf59 3 4
  • Chromosome 7 Open Reading Frame 59 2
  • UPF0539 Protein C7orf59 3

External Ids for LAMTOR4 Gene

Previous HGNC Symbols for LAMTOR4 Gene

  • C7orf59

Previous GeneCards Identifiers for LAMTOR4 Gene

  • GC07P099747

Summaries for LAMTOR4 Gene

GeneCards Summary for LAMTOR4 Gene

LAMTOR4 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR4 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR4 Gene

Genomics for LAMTOR4 Gene

Regulatory Elements for LAMTOR4 Gene

Promoters for LAMTOR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAMTOR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAMTOR4 Gene

Chromosome:
7
Start:
100,148,907 bp from pter
End:
100,155,944 bp from pter
Size:
7,038 bases
Orientation:
Plus strand

Genomic View for LAMTOR4 Gene

Genes around LAMTOR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMTOR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMTOR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR4 Gene

Proteins for LAMTOR4 Gene

  • Protein details for LAMTOR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VGL1-LTOR4_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR4
    Protein Accession:
    Q0VGL1

    Protein attributes for LAMTOR4 Gene

    Size:
    99 amino acids
    Molecular mass:
    10741 Da
    Quaternary structure:
    • Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).

neXtProt entry for LAMTOR4 Gene

Proteomics data for LAMTOR4 Gene at MOPED

Post-translational modifications for LAMTOR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LAMTOR4 Gene

Domains & Families for LAMTOR4 Gene

Gene Families for LAMTOR4 Gene

Protein Domains for LAMTOR4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LAMTOR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VGL1

UniProtKB/Swiss-Prot:

LTOR4_HUMAN :
  • Belongs to the LAMTOR4 family.
Family:
  • Belongs to the LAMTOR4 family.
genes like me logo Genes that share domains with LAMTOR4: view

Function for LAMTOR4 Gene

Molecular function for LAMTOR4 Gene

UniProtKB/Swiss-Prot Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

Gene Ontology (GO) - Molecular Function for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23414517
genes like me logo Genes that share ontologies with LAMTOR4: view
genes like me logo Genes that share phenotypes with LAMTOR4: view

Animal Model Products

miRNA for LAMTOR4 Gene

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMTOR4 Gene

Localization for LAMTOR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR4 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMTOR4 Gene COMPARTMENTS Subcellular localization image for LAMTOR4 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
extracellular 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071986 Ragulator complex IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

Pathways & Interactions for LAMTOR4 Gene

genes like me logo Genes that share pathways with LAMTOR4: view

Gene Ontology (GO) - Biological Process for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007050 cell cycle arrest TAS --
GO:0008361 regulation of cell size IMP 22980980
GO:0032008 positive regulation of TOR signaling IMP 22980980
GO:0043547 positive regulation of GTPase activity IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

No data available for SIGNOR curated interactions for LAMTOR4 Gene

Drugs & Compounds for LAMTOR4 Gene

No Compound Related Data Available

Transcripts for LAMTOR4 Gene

Unigene Clusters for LAMTOR4 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -

Relevant External Links for LAMTOR4 Gene

GeneLoc Exon Structure for
LAMTOR4
ECgene alternative splicing isoforms for
LAMTOR4

Expression for LAMTOR4 Gene

mRNA expression in normal human tissues for LAMTOR4 Gene

Protein differential expression in normal tissues from HIPED for LAMTOR4 Gene

This gene is overexpressed in Monocytes (10.4), Hair follicle (9.3), and Bone marrow stromal cell (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMTOR4 Gene



SOURCE GeneReport for Unigene cluster for LAMTOR4 Gene Hs.406520

genes like me logo Genes that share expression patterns with LAMTOR4: view

Protein tissue co-expression partners for LAMTOR4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LAMTOR4 Gene

Orthologs for LAMTOR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAMTOR4 35
  • 91.25 (n)
  • 97.98 (a)
LAMTOR4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMTOR4 35
  • 92.93 (n)
  • 94.95 (a)
LAMTOR4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamtor4 35
  • 89.9 (n)
  • 95.96 (a)
Lamtor4 16
Lamtor4 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamtor4 35
  • 90.57 (n)
  • 96.97 (a)
oppossum
(Monodelphis domestica)
Mammalia LAMTOR4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR4 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAMTOR4 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-159a18.7 35
  • 65.66 (n)
  • 65.66 (a)
LAMTOR4 36
  • 66 (a)
OneToOne
Species with no ortholog for LAMTOR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR4 Gene

ENSEMBL:
Gene Tree for LAMTOR4 (if available)
TreeFam:
Gene Tree for LAMTOR4 (if available)

Paralogs for LAMTOR4 Gene

No data available for Paralogs for LAMTOR4 Gene

Variants for LAMTOR4 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12878 -- 100,149,507(-) GTCAG(C/T)GCAGA reference, synonymous-codon
rs1059864 -- 100,153,910(+) GGACA(A/G)AGGGT reference, synonymous-codon, utr-variant-3-prime
rs3736590 -- 100,153,658(-) GATAC(A/C)AGGGA intron-variant
rs3736591 -- 100,153,394(-) CTGCA(C/T)GCAGA intron-variant
rs7785392 -- 100,149,755(+) TCTTA(G/T)TCTCC intron-variant

Variation tolerance for LAMTOR4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMTOR4 Gene

HapMap Linkage Disequilibrium report
LAMTOR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LAMTOR4 Gene

Disorders for LAMTOR4 Gene

Relevant External Links for LAMTOR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMTOR4

No disorders were found for LAMTOR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAMTOR4 Gene

Publications for LAMTOR4 Gene

  1. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 2 3 4 67
  2. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. (PMID: 23414517) Blandin G. … Richard I. (Skelet Muscle 2013) 3

Products for LAMTOR4 Gene

Sources for LAMTOR4 Gene

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