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Aliases for LAMTOR4 Gene

Aliases for LAMTOR4 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4 2 3 5
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4 3 4
  • C7orf59 3 4
  • Chromosome 7 Open Reading Frame 59 2
  • Ragulator Complex Protein LAMTOR4 3
  • UPF0539 Protein C7orf59 3

External Ids for LAMTOR4 Gene

Previous HGNC Symbols for LAMTOR4 Gene

  • C7orf59

Previous GeneCards Identifiers for LAMTOR4 Gene

  • GC07P099747

Summaries for LAMTOR4 Gene

GeneCards Summary for LAMTOR4 Gene

LAMTOR4 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4) is a Protein Coding gene. Among its related pathways are RET signaling and PI3K / Akt Signaling. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR4 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR4 Gene

Genomics for LAMTOR4 Gene

Regulatory Elements for LAMTOR4 Gene

Enhancers for LAMTOR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100364 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +222.1 222062 12.5 HDGF PKNOX1 ATF1 AGO1 WRNIP1 SIN3A YBX1 ZBTB7B ZNF121 ZNF143 PILRA ZCWPW1 MEPCE MOSPD3 LAMTOR4 C7orf43 PVRIG ENSG00000241357 STAG3 GPC2
GH07G100153 1.1 ENCODE 20.6 +7.4 7423 6.4 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 AP4M1 ZSCAN25 ENSG00000242798 MBLAC1 ZNF655 GIGYF1 PILRA LAMTOR4 STAG3L5P PPP1R35
GH07G100343 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +196.1 196125 3.0 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A FEZF1 GLI4 ZNF2 TCF12 PILRA MBLAC1 ZCWPW1 MEPCE LAMTOR4 ENSG00000241357 GPC2 GAL3ST4 C7orf43 PVRIG
GH07G100199 1.5 Ensembl ENCODE dbSUPER 11.8 +51.8 51766 1.5 HDGF PKNOX1 ATF1 ARNT SIN3A GATA2 KLF13 TBX21 ZNF592 MEF2D PVRIG GPC2 STAG3 GAL3ST4 C7orf43 LAMTOR4 LOC102724025 PIR36589 GC07M100212
GH07G100190 1.3 Ensembl ENCODE dbSUPER 12 +43.4 43415 2.8 HDGF NFRKB ZMYM3 MAX EBF1 RAD21 YY1 SCRT2 TRIM24 ZNF584 PVRIG AP4M1 GATS GAL3ST4 C7orf43 LAMTOR4 RPL7P60 ZCWPW1 LOC102724025 GC07M100212
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LAMTOR4 on UCSC Golden Path with GeneCards custom track

Promoters for LAMTOR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215748 293 1601 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for LAMTOR4 Gene

Chromosome:
7
Start:
100,148,907 bp from pter
End:
100,155,944 bp from pter
Size:
7,038 bases
Orientation:
Plus strand

Genomic View for LAMTOR4 Gene

Genes around LAMTOR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMTOR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMTOR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR4 Gene

Proteins for LAMTOR4 Gene

  • Protein details for LAMTOR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VGL1-LTOR4_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR4
    Protein Accession:
    Q0VGL1

    Protein attributes for LAMTOR4 Gene

    Size:
    99 amino acids
    Molecular mass:
    10741 Da
    Quaternary structure:
    • Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).

neXtProt entry for LAMTOR4 Gene

Post-translational modifications for LAMTOR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LAMTOR4 Gene

Domains & Families for LAMTOR4 Gene

Gene Families for LAMTOR4 Gene

Protein Domains for LAMTOR4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMTOR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VGL1

UniProtKB/Swiss-Prot:

LTOR4_HUMAN :
  • Belongs to the LAMTOR4 family.
Family:
  • Belongs to the LAMTOR4 family.
genes like me logo Genes that share domains with LAMTOR4: view

Function for LAMTOR4 Gene

Molecular function for LAMTOR4 Gene

UniProtKB/Swiss-Prot Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

Gene Ontology (GO) - Molecular Function for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 protein binding IPI 23414517
GO:0032947 contributes_to protein complex scaffold IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view
genes like me logo Genes that share phenotypes with LAMTOR4: view

Animal Model Products

CRISPR Products

miRNA for LAMTOR4 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMTOR4 Gene

Localization for LAMTOR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR4 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAMTOR4 gene
Compartment Confidence
lysosome 5
endosome 5
extracellular 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA,IEA 22980980
GO:0005765 lysosomal membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0071986 Ragulator complex IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

Pathways & Interactions for LAMTOR4 Gene

genes like me logo Genes that share pathways with LAMTOR4: view

Pathways by source for LAMTOR4 Gene

Gene Ontology (GO) - Biological Process for LAMTOR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0008361 regulation of cell size IMP 22980980
GO:0016236 macroautophagy TAS --
GO:0016241 regulation of macroautophagy TAS --
GO:0032008 positive regulation of TOR signaling IMP 22980980
genes like me logo Genes that share ontologies with LAMTOR4: view

No data available for SIGNOR curated interactions for LAMTOR4 Gene

Drugs & Compounds for LAMTOR4 Gene

No Compound Related Data Available

Transcripts for LAMTOR4 Gene

Unigene Clusters for LAMTOR4 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -

Relevant External Links for LAMTOR4 Gene

GeneLoc Exon Structure for
LAMTOR4
ECgene alternative splicing isoforms for
LAMTOR4

Expression for LAMTOR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAMTOR4 Gene

Protein differential expression in normal tissues from HIPED for LAMTOR4 Gene

This gene is overexpressed in Monocytes (10.4), Hair follicle (9.3), and Bone marrow stromal cell (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LAMTOR4 Gene



Protein tissue co-expression partners for LAMTOR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of LAMTOR4 Gene:

LAMTOR4

SOURCE GeneReport for Unigene cluster for LAMTOR4 Gene:

Hs.406520

Evidence on tissue expression from TISSUES for LAMTOR4 Gene

  • Skin(4.4)
  • Nervous system(4.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with LAMTOR4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMTOR4 Gene

Orthologs for LAMTOR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAMTOR4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LAMTOR4 34 35
  • 92.93 (n)
cow
(Bos Taurus)
Mammalia LAMTOR4 34 35
  • 91.25 (n)
oppossum
(Monodelphis domestica)
Mammalia LAMTOR4 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamtor4 34
  • 90.57 (n)
mouse
(Mus musculus)
Mammalia Lamtor4 34 16 35
  • 89.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR4 35
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAMTOR4 35
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LAMTOR4 35
  • 66 (a)
OneToOne
si:dkey-159a18.7 34
  • 65.66 (n)
Species where no ortholog for LAMTOR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR4 Gene

ENSEMBL:
Gene Tree for LAMTOR4 (if available)
TreeFam:
Gene Tree for LAMTOR4 (if available)

Paralogs for LAMTOR4 Gene

No data available for Paralogs for LAMTOR4 Gene

Variants for LAMTOR4 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000350028 -- 100,141,316(+) CCACC(A/G)TGTCT intron-variant
rs1000365121 -- 100,147,660(+) GTATC(A/G)TTCCA intron-variant, upstream-variant-2KB
rs1000454765 -- 100,129,843(+) ACCTC(C/T)GCCTC upstream-variant-2KB
rs1000529158 -- 100,139,451(+) TCACC(A/G)TGTTA intron-variant
rs1000564622 -- 100,132,783(+) TGCAC(C/T)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMTOR4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv469687 CNV loss 16826518
nsv607931 CNV loss 21841781

Variation tolerance for LAMTOR4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMTOR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAMTOR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMTOR4 Gene

Disorders for LAMTOR4 Gene

Relevant External Links for LAMTOR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMTOR4

No disorders were found for LAMTOR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAMTOR4 Gene

Publications for LAMTOR4 Gene

  1. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 2 3 4 64
  2. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. (PMID: 25567906) Wang S. … Sabatini D.M. (Science 2015) 4 64

Products for LAMTOR4 Gene

Sources for LAMTOR4 Gene

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