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Aliases for LAMTOR3 Gene

Aliases for LAMTOR3 Gene

  • Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3 2 3 5
  • Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 2 3
  • Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 3 3 4
  • Mitogen-Activated Protein Kinase Scaffold Protein 1 3 4
  • MAPK Scaffold Protein 1 2 3
  • MAP2K1IP1 3 4
  • MAPKSP1 3 4
  • MP1 3 4
  • Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1 4
  • Ragulator Complex Protein LAMTOR3 3
  • MEK Binding Partner 1 3
  • MEK-Binding Partner 1 4
  • MEK Partner 1 2
  • Ragulator3 3
  • PRO0633 3
  • MAPBP 3

External Ids for LAMTOR3 Gene

Previous HGNC Symbols for LAMTOR3 Gene

  • MAP2K1IP1
  • MAPKSP1

Previous GeneCards Identifiers for LAMTOR3 Gene

  • GC04M100800

Summaries for LAMTOR3 Gene

Entrez Gene Summary for LAMTOR3 Gene

  • This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

GeneCards Summary for LAMTOR3 Gene

LAMTOR3 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein complex scaffold.

UniProtKB/Swiss-Prot for LAMTOR3 Gene

  • As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Gene Wiki entry for LAMTOR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMTOR3 Gene

Genomics for LAMTOR3 Gene

Regulatory Elements for LAMTOR3 Gene

Enhancers for LAMTOR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F099944 0.4 ENCODE 19.9 -53.6 -53606 6.6 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 LAMTOR3 LINC01216 PCNAP1 LINC01218 FAM177A1P1 C4orf17 DNAJB14 DAPP1 LOC256880
GH04F099842 0.6 ENCODE 11.1 +51.9 51874 1.3 ATF1 PKNOX1 ARNT CREB3L1 ELK1 GATA2 NCOA1 CREB3 MBD2 MEF2D DAPP1 LAMTOR3 MTTP TRMT10A DNAJB14 ENSG00000279913 LOC285556
GH04F099819 1.2 FANTOM5 ENCODE 10.5 +73.1 73115 3.2 CTCF TBP CBX3 TAL1 RAD21 EED ETV6 TRIM24 CREM ZNF654 DNAJB14 TRMT10A DAPP1 H2AFZ MTTP LOC256880 LAMTOR3 DDIT4L LOC285556
GH04F099845 1.1 FANTOM5 Ensembl ENCODE 10 +47.9 47913 3.3 HDGF MXI1 TBL1XR1 WRNIP1 CHD4 BMI1 RELA POLR2A EED ETV6 DAPP1 TRMT10A MTTP LAMTOR3 DNAJB14 ENSG00000279913
GH04F099860 0.7 FANTOM5 9.9 +33.8 33809 0.3 ATF2 DAPP1 TRMT10A MTTP LAMTOR3 ADH7 ENSG00000279913
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LAMTOR3 on UCSC Golden Path with GeneCards custom track

Promoters for LAMTOR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001246165 346 2001 PKNOX1 ATF1 ARID4B SIN3A ETS1 ELK1 KDM4B ZNF263 REST PPARG

Genomic Location for LAMTOR3 Gene

Chromosome:
4
Start:
99,878,336 bp from pter
End:
99,894,546 bp from pter
Size:
16,211 bases
Orientation:
Minus strand

Genomic View for LAMTOR3 Gene

Genes around LAMTOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMTOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMTOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMTOR3 Gene

Proteins for LAMTOR3 Gene

  • Protein details for LAMTOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHA4-LTOR3_HUMAN
    Recommended name:
    Ragulator complex protein LAMTOR3
    Protein Accession:
    Q9UHA4
    Secondary Accessions:
    • B2R4A1
    • J3KMX4
    • Q9H364

    Protein attributes for LAMTOR3 Gene

    Size:
    124 amino acids
    Molecular mass:
    13623 Da
    Quaternary structure:
    • Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. Interacts with MAP2K1/MEK1 and MAPK2 (By similarity). Interacts with MORG1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for LAMTOR3 Gene

    Alternative splice isoforms for LAMTOR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMTOR3 Gene

Post-translational modifications for LAMTOR3 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMTOR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LAMTOR3 (LAMTOR3)
  • Cloud-Clone Corp. Antibodies for LAMTOR3

No data available for DME Specific Peptides for LAMTOR3 Gene

Domains & Families for LAMTOR3 Gene

Gene Families for LAMTOR3 Gene

Protein Domains for LAMTOR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMTOR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHA4

UniProtKB/Swiss-Prot:

LTOR3_HUMAN :
  • Belongs to the LAMTOR3 family.
Family:
  • Belongs to the LAMTOR3 family.
genes like me logo Genes that share domains with LAMTOR3: view

Function for LAMTOR3 Gene

Molecular function for LAMTOR3 Gene

UniProtKB/Swiss-Prot Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Gene Ontology (GO) - Molecular Function for LAMTOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 protein binding IPI 20381137
GO:0019209 kinase activator activity IEA --
GO:0032947 contributes_to protein complex scaffold IDA 22980980
genes like me logo Genes that share ontologies with LAMTOR3: view
genes like me logo Genes that share phenotypes with LAMTOR3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMTOR3 Gene

Localization for LAMTOR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMTOR3 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMTOR3 Gene COMPARTMENTS Subcellular localization image for LAMTOR3 gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LAMTOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
GO:0005770 late endosome IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with LAMTOR3: view

Pathways & Interactions for LAMTOR3 Gene

SuperPathways for LAMTOR3 Gene

SuperPathway Contained pathways
1 RET signaling
2 mTOR signalling
3 MAPK signaling pathway
4 ERK Signaling
5 Developmental Biology
genes like me logo Genes that share pathways with LAMTOR3: view

Pathways by source for LAMTOR3 Gene

1 Sino Biological pathway for LAMTOR3 Gene
1 Cell Signaling Technology pathway for LAMTOR3 Gene
1 BioSystems pathway for LAMTOR3 Gene
2 KEGG pathways for LAMTOR3 Gene
1 R&D Systems pathway for LAMTOR3 Gene
2 Qiagen pathways for LAMTOR3 Gene

SIGNOR curated interactions for LAMTOR3 Gene

Activates:

Gene Ontology (GO) - Biological Process for LAMTOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0007050 cell cycle arrest TAS --
GO:0016236 macroautophagy TAS --
GO:0032006 regulation of TOR signaling IEA --
genes like me logo Genes that share ontologies with LAMTOR3: view

Transcripts for LAMTOR3 Gene

mRNA/cDNA for LAMTOR3 Gene

Unigene Clusters for LAMTOR3 Gene

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMTOR3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for LAMTOR3 Gene

GeneLoc Exon Structure for
LAMTOR3
ECgene alternative splicing isoforms for
LAMTOR3

Expression for LAMTOR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LAMTOR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LAMTOR3 Gene

This gene is overexpressed in Nasal epithelium (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LAMTOR3 Gene



Protein tissue co-expression partners for LAMTOR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LAMTOR3 Gene:

LAMTOR3

SOURCE GeneReport for Unigene cluster for LAMTOR3 Gene:

Hs.433332
genes like me logo Genes that share expression patterns with LAMTOR3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LAMTOR3 Gene

Orthologs for LAMTOR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMTOR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMTOR3 34 35
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia LAMTOR3 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5900 35
  • 98 (a)
OneToMany
Lamtor3 34 16 35
  • 89.52 (n)
dog
(Canis familiaris)
Mammalia LAMTOR3 34 35
  • 94.89 (n)
cow
(Bos Taurus)
Mammalia LAMTOR3 34 35
  • 93.55 (n)
rat
(Rattus norvegicus)
Mammalia Lamtor3 34
  • 88.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LAMTOR3 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMTOR3 34 35
  • 79.3 (n)
lizard
(Anolis carolinensis)
Reptilia LAMTOR3 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamtor3 34
  • 77.69 (n)
zebrafish
(Danio rerio)
Actinopterygii lamtor3 34 35
  • 75.54 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4304 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000997 34
  • 52.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5110 34 35
  • 51.24 (n)
Species where no ortholog for LAMTOR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMTOR3 Gene

ENSEMBL:
Gene Tree for LAMTOR3 (if available)
TreeFam:
Gene Tree for LAMTOR3 (if available)

Paralogs for LAMTOR3 Gene

Pseudogenes.org Pseudogenes for LAMTOR3 Gene

genes like me logo Genes that share paralogs with LAMTOR3: view

No data available for Paralogs for LAMTOR3 Gene

Variants for LAMTOR3 Gene

Sequence variations from dbSNP and Humsavar for LAMTOR3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10016741 -- 99,886,064(+) GTATC(G/T)CTCAT intron-variant
rs10018046 -- 99,879,893(+) GGTAT(A/C)GCCTA nc-transcript-variant, utr-variant-3-prime
rs10029745 -- 99,879,839(+) tacta(C/T)acacc nc-transcript-variant, utr-variant-3-prime
rs111328005 -- 99,878,195(+) AGGAC(A/G)AACTT downstream-variant-500B
rs111412798 -- 99,894,169(+) CACAG(A/G)TACTC intron-variant

Variation tolerance for LAMTOR3 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 1.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMTOR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAMTOR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LAMTOR3 Gene

Disorders for LAMTOR3 Gene

Relevant External Links for LAMTOR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMTOR3

No disorders were found for LAMTOR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAMTOR3 Gene

Publications for LAMTOR3 Gene

  1. The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal MAP kinase signaling. (PMID: 15016825) Lunin V.V. … Sacher M. (J. Biol. Chem. 2004) 2 3 4 64
  2. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 3 4 64
  3. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. (PMID: 22980980) Bar-Peled L. … Sabatini D.M. (Cell 2012) 3 4 64
  4. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. (PMID: 20381137) Sancak Y. … Sabatini D.M. (Cell 2010) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for LAMTOR3 Gene

Sources for LAMTOR3 Gene

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