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Aliases & Descriptions for LAMP3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CD208 1, 2 | | DC-LAMP 1, 2 | | DCLAMP 1, 2, 3 | | LAMP 1, 2 | | LAMP-3 3 | | TSC403 1, 2, 3 |
| | | Descriptions |
|---|
| CD208 antigen 3 | | DC LAMP 3 | | DC-lysosome-associated membrane glycoprotein 3 | | Protein TSC403 3 | | lysosomal-associated membrane protein 3 2, 3 |
|
| | Search outside databases for aliases for LAMP3 genePrevious GC identifers: GC03M179608 GC03M183695 GC03M184242 GC03M184160 |
Summaries for LAMP3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: LAMP3_HUMAN, Q9UQV4Function: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cellsGene Wiki entry for LAMP3 |
Genomic Location for LAMP3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAMP3 gene 
Entrez Gene cytogenetic band: 3q26.3-q27 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q26.3-q27LAMP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M184322:
(about GC identifiers)
Start:
|
184,322,697 bp from pter |
End:
|
184,363,361 bp from pter |
Size:
|
40,665 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for LAMP3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAMP3_HUMAN, Q9UQV4 (See
protein sequence)Recommended Name: Lysosome-associated membrane glycoprotein 3 precursor Size: 416 amino acids; 44346 Da
Subcellular location: Lysosome membrane; Single-pass type I membrane protein
Secondary accessions: O94781 Q8NEC8REFSEQ proteins: NP_055213.2
ENSEMBL proteins: ENSP00000265598
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LAMP3: Assays for LAMP3: | Protein
Domains/ Families for LAMP3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UQV4
ProtoNet protein and cluster: Q9UQV4 UniProtKB/Swiss-Prot: LAMP3_HUMAN, Q9UQV4Similarity: Belongs to the LAMP family | Gene Function for LAMP3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014398
Applied Biosystems Silencer® siRNAs for LAMP3
Sigma-Aldrich siRNA for LAMP3  Sigma-Aldrich shRNA for LAMP3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014398                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014398                                  untagged cDNA clone in CMV expression vector: NM_014398 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014398
UniProtKB/Swiss-Prot: LAMP3_HUMAN, Q9UQV4Function: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells | Pathways & Interactions for LAMP3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/17 Interacting proteins for LAMP3 (ENSP000002655983) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for LAMP3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAMP3 1 Novoseek chemical compound relationship for LAMP3 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycogen |
8.04 |
1 |
16899762 (1) |
About this table
|
Transcripts for LAMP3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014398
Sigma-Aldrich siRNA for LAMP3  Sigma-Aldrich shRNA for LAMP3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014398 REFSEQ mRNAs for LAMP3 gene: NM_014398.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014398               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014398                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014398                                  untagged cDNA clone in CMV expression vector: NM_014398  Additional cDNA sequence: AB013924.1 AJ005766.1 AK302894.1 AK313172.1 BC032940.2 5 DOTS entries: DT.312133 DT.100754307 DT.95270377 DT.75135130 DT.95208861 24/58 AceView cDNA sequences (see all 58
):BF061943 AW014530 AI304250 BM997858 BM758382 AI285648 AA382983 BI822806 NM_014398 BX116004 AA314075 BM985389 BQ013434 AA416838 BQ029162 T92658 H65113 T61471 BG777048 BU678297 AA416689 BG771499 AJ005766 BM996446
highest scoring ESTs for LAMP3:AB013924 AJ005766 BC032940 BG506872 BG536203 BG717885 BG723996 BG771499 BI462212 BI559933 Unigene Cluster for LAMP3: Lysosomal-associated membrane protein 3 Hs.518448 [show with all ESTs]Unigene Representative Sequence: NM_014398
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for LAMP3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LAMP3
1 Ensembl transcript including schematic representation: ENST00000265598
|
Expression for LAMP3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAMP3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAMP3
1 / 2 / 3 3 probe-sets matching LAMP3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTTTCCTTA
SOURCE GeneReport for Unigene cluster: Hs.518448
Expression variation in blood from EXPOLDB for LAMP3 UniProtKB/Swiss-Prot: LAMP3_HUMAN, Q9UQV4Tissue specificity: Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues |
Orthologs for LAMP3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAMP3 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for LAMP3
ENSEMBL Gene Tree for LAMP3 | Paralogs for LAMP3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAMP3 gene
- LAMP12 CD682 LAMP22
|
SNPs/Variants for LAMP3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAMP3 (up to first 250kb)
|
Disorders & Mutations for LAMP3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605883
5 Novoseek disease relationships for LAMP3 gene
About this table
1 PharmGKB disease relationship for LAMP3 gene
| Disease |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| Weight gain | GN   | 12668921 | About this table
Human Genome Epidemiology Navigator: LAMP3 (1 document)
|
Medical News for LAMP3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAMP3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/64 PubMed articles for LAMP3 gene (see all 64
):- Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues. (PubMed id 9721848)2, 3, 4 Ozaki K.... Nakamura Y. (1998)
- A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. (PubMed id 9768752)1, 3, 4 de Saint-Vis B.M.... Lebecque S. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. (PubMed id 16204031)1, 3 Kanao H....Murata Y. (2005)
- Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes. (PubMed id 16887987)1, 3 Arruda L.B....Marques E.T. (2006)
- Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes. (PubMed id 15111122)1, 3 Akasaki K....August J.T. (2004)
- Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)3 Ollila H.M....Paunio T. (2009)
- Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles. (PubMed id 18292234)3 Lebre M.C....Tak P.P. (2008)
- Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma. (PubMed id 17606713)3 Elliott B....Spatz A. (2007)
- DC-LAMP stains pulmonary adenocarcinoma with bronchiolar Clara cell differentiation. (PubMed id 17056097)3 Zhu L.C....Moreira A.L. (2007)
|
Search for LAMP3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAMP3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAMP3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAMP3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAMP3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAMP3:

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Incremental update: 13 Oct 2009
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