Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LAMP3 Gene

Aliases for LAMP3 Gene

  • Lysosomal Associated Membrane Protein 3 2 3 5
  • DC-Lysosome-Associated Membrane Glycoprotein 3 4
  • Lysosomal-Associated Membrane Protein 3 2 4
  • DC LAMP 3 4
  • LAMP-3 3 4
  • DCLAMP 3 4
  • TSC403 3 4
  • Lysosome-Associated Membrane Glycoprotein 3 3
  • Protein TSC403 4
  • CD208 Antigen 4
  • DC-LAMP 3
  • CD208 3
  • LAMP 3

External Ids for LAMP3 Gene

Previous GeneCards Identifiers for LAMP3 Gene

  • GC03M179608
  • GC03M183695
  • GC03M184242
  • GC03M184160
  • GC03M184322
  • GC03M182840
  • GC03M180244

Summaries for LAMP3 Gene

Entrez Gene Summary for LAMP3 Gene

  • Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

GeneCards Summary for LAMP3 Gene

LAMP3 (Lysosomal Associated Membrane Protein 3) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is LAMP1.

UniProtKB/Swiss-Prot for LAMP3 Gene

  • May play a role in dendritic cell function and in adaptive immunity.

Gene Wiki entry for LAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP3 Gene

Genomics for LAMP3 Gene

Regulatory Elements for LAMP3 Gene

Enhancers for LAMP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F183169 0.5 FANTOM5 16.9 -5.9 -5885 0.2 LAMP3 MCCC1 MCF2L2 YEATS2 B3GNT5 KLHL6 RNU3P4
GH03F183098 0.4 ENCODE 12 +64.4 64415 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS MCCC1 EEF1A1P8 LAMP3 LOC105374247 MCCC1-AS1
GH03F183122 0.2 Ensembl 11.7 +41.1 41139 0.2 CTCF ZNF654 TRIM22 REST RAD21 GATA3 GATA2 SMC3 LAMP3 RNA5SP151 B3GNT5 MCF2L2 MCCC1
GH03F183123 0.7 ENCODE 11.7 +41.5 41452 0.2 CTCF ZNF654 GATA2 JUN SMC3 TRIM22 REST RAD21 LAMP3 RNA5SP151 B3GNT5 MCF2L2 MCCC1
GH03F183202 0.2 Ensembl 11.4 -38.5 -38462 0.2 GATA3 PKNOX1 ZNF589 FEZF1 IRF1 ZNF24 ZKSCAN1 B3GNT5 RNA5SP151 LAMP3 MCCC1 RNU3P4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LAMP3 on UCSC Golden Path with GeneCards custom track

Promoters for LAMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381023 1139 1400 TBL1XR1 SIN3A ARID4B ZNF2 GLIS2 SCRT2 ZNF207 ETV6 SP3 CBFB

Genomic Location for LAMP3 Gene

183,122,213 bp from pter
183,163,839 bp from pter
41,627 bases
Minus strand

Genomic View for LAMP3 Gene

Genes around LAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP3 Gene

Proteins for LAMP3 Gene

  • Protein details for LAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosome-associated membrane glycoprotein 3
    Protein Accession:
    Secondary Accessions:
    • D3DNS4
    • O94781
    • Q8NEC8

    Protein attributes for LAMP3 Gene

    416 amino acids
    Molecular mass:
    44346 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LAMP3 Gene

neXtProt entry for LAMP3 Gene

Post-translational modifications for LAMP3 Gene

  • Glycosylation at Thr 40, Thr 80, Asn 112, Asn 158, Asn 164, Asn 200, Asn 232, Asn 266, and Asn 291
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMP3 Gene

Antibody Products

  • Abcam antibodies for LAMP3
  • Cloud-Clone Corp. Antibodies for LAMP3

No data available for DME Specific Peptides for LAMP3 Gene

Domains & Families for LAMP3 Gene

Gene Families for LAMP3 Gene

Protein Domains for LAMP3 Gene

Suggested Antigen Peptide Sequences for LAMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LAMP family.
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP3: view

Function for LAMP3 Gene

Molecular function for LAMP3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in dendritic cell function and in adaptive immunity.
genes like me logo Genes that share phenotypes with LAMP3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMP3 Gene

Localization for LAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP3 Gene

Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269 PubMed:9768752}.

Subcellular locations from

Jensen Localization Image for LAMP3 Gene COMPARTMENTS Subcellular localization image for LAMP3 gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,TAS --
GO:0005769 early endosome IDA 21810281
GO:0005886 plasma membrane IDA 21810281
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LAMP3: view

Pathways & Interactions for LAMP3 Gene

SuperPathways for LAMP3 Gene

SuperPathway Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAMP3: view

Pathways by source for LAMP3 Gene

1 KEGG pathway for LAMP3 Gene

Gene Ontology (GO) - Biological Process for LAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0010506 regulation of autophagy IMP 25681212
GO:0010628 positive regulation of gene expression IMP 23651994
GO:0035455 response to interferon-alpha IMP 23651994
genes like me logo Genes that share ontologies with LAMP3: view

No data available for SIGNOR curated interactions for LAMP3 Gene

Drugs & Compounds for LAMP3 Gene

(1) Drugs for LAMP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LAMP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMP3: view

Transcripts for LAMP3 Gene

Unigene Clusters for LAMP3 Gene

Lysosomal-associated membrane protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP4: -

Relevant External Links for LAMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAMP3 Gene

This gene is overexpressed in Lung (x23.0).

Protein differential expression in normal tissues from HIPED for LAMP3 Gene

This gene is overexpressed in Lung (46.7) and Lymph node (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMP3 Gene

Protein tissue co-expression partners for LAMP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LAMP3 Gene:


SOURCE GeneReport for Unigene cluster for LAMP3 Gene:


mRNA Expression by UniProt/SwissProt for LAMP3 Gene:

Tissue specificity: Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyers patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
genes like me logo Genes that share expression patterns with LAMP3: view

Primer Products

Orthologs for LAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LAMP3 34 35
  • 93.08 (n)
(Canis familiaris)
Mammalia LAMP3 34
  • 81.04 (n)
(Bos Taurus)
Mammalia LAMP3 34 35
  • 72.59 (n)
(Mus musculus)
Mammalia Lamp3 34 16 35
  • 71.71 (n)
(Rattus norvegicus)
Mammalia Lamp3 34
  • 71.17 (n)
(Ornithorhynchus anatinus)
Mammalia LAMP3 35
  • 44 (a)
(Monodelphis domestica)
Mammalia LAMP3 35
  • 42 (a)
(Gallus gallus)
Aves LAMP3 35
  • 29 (a)
(Anolis carolinensis)
Reptilia LAMP3 35
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lamp3 34
  • 46.93 (n)
(Danio rerio)
Actinopterygii LOC100003043 34
  • 49.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
-- 35
  • 15 (a)
Species where no ortholog for LAMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMP3 Gene

Gene Tree for LAMP3 (if available)
Gene Tree for LAMP3 (if available)

Paralogs for LAMP3 Gene

Paralogs for LAMP3 Gene

genes like me logo Genes that share paralogs with LAMP3: view

Variants for LAMP3 Gene

Sequence variations from dbSNP and Humsavar for LAMP3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10513791 -- 183,145,188(+) GAACT(G/T)GAAGG intron-variant
rs10663850 -- 183,156,364(+) TCAAA(-/AACAAC/AACAACAAC)AACAA intron-variant
rs10665288 -- 183,150,586(+) TTTTT(-/TT)GGAGA intron-variant
rs10937113 -- 183,135,169(+) ACTAA(A/G)ACTGA intron-variant
rs111248253 -- 183,128,738(+) GGTTT(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMP3 Gene

Variant ID Type Subtype PubMed ID
dgv960e214 CNV gain 21293372
esv3893833 CNV gain 25118596
nsv507143 OTHER sequence alteration 20534489
nsv508970 CNV insertion 20534489

Variation tolerance for LAMP3 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP3 Gene

Disorders for LAMP3 Gene

Relevant External Links for LAMP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAMP3 Gene

Publications for LAMP3 Gene

  1. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues. (PMID: 9721848) Ozaki K. … Nakamura Y. (Cancer Res. 1998) 2 3 4 64
  2. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. (PMID: 9768752) de Saint-Vis B.M. … Lebecque S. (Immunity 1998) 3 4 22 64
  3. Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx. (PMID: 22809326) Wilke S. … Bussow K. (BMC Biol. 2012) 3 4 64
  4. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 46 64
  5. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 46 64

Products for LAMP3 Gene

Sources for LAMP3 Gene

Loading form....