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Aliases for LAMP3 Gene

Aliases for LAMP3 Gene

  • Lysosomal Associated Membrane Protein 3 2 3
  • Lysosomal-Associated Membrane Protein 3 2 3 4 5
  • DC-Lysosome-Associated Membrane Glycoprotein 3 4
  • DC LAMP 3 4
  • LAMP-3 3 4
  • DCLAMP 3 4
  • TSC403 3 4
  • Protein TSC403 4
  • CD208 Antigen 4
  • DC-LAMP 3
  • CD208 3
  • LAMP 3

External Ids for LAMP3 Gene

Previous GeneCards Identifiers for LAMP3 Gene

  • GC03M179608
  • GC03M183695
  • GC03M184242
  • GC03M184160
  • GC03M184322
  • GC03M182840
  • GC03M180244

Summaries for LAMP3 Gene

Entrez Gene Summary for LAMP3 Gene

  • Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

GeneCards Summary for LAMP3 Gene

LAMP3 (Lysosomal Associated Membrane Protein 3) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is LAMP2.

UniProtKB/Swiss-Prot for LAMP3 Gene

  • May play a role in dendritic cell function and in adaptive immunity.

Gene Wiki entry for LAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP3 Gene

Genomics for LAMP3 Gene

Regulatory Elements for LAMP3 Gene

Enhancers for LAMP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LAMP3 on UCSC Golden Path with GeneCards custom track

Promoters for LAMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAMP3 Gene

Chromosome:
3
Start:
183,122,213 bp from pter
End:
183,163,839 bp from pter
Size:
41,627 bases
Orientation:
Minus strand

Genomic View for LAMP3 Gene

Genes around LAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP3 Gene

Proteins for LAMP3 Gene

  • Protein details for LAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQV4-LAMP3_HUMAN
    Recommended name:
    Lysosome-associated membrane glycoprotein 3
    Protein Accession:
    Q9UQV4
    Secondary Accessions:
    • D3DNS4
    • O94781
    • Q8NEC8

    Protein attributes for LAMP3 Gene

    Size:
    416 amino acids
    Molecular mass:
    44346 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LAMP3 Gene

neXtProt entry for LAMP3 Gene

Proteomics data for LAMP3 Gene at MOPED

Post-translational modifications for LAMP3 Gene

  • Glycosylation at Thr 40, Thr 80, Asn 112, Asn 158, Asn 164, Asn 200, Asn 232, Asn 266, and Asn 291
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMP3 Gene

Antibody Products

No data available for DME Specific Peptides for LAMP3 Gene

Domains & Families for LAMP3 Gene

Gene Families for LAMP3 Gene

Protein Domains for LAMP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQV4

UniProtKB/Swiss-Prot:

LAMP3_HUMAN :
  • Belongs to the LAMP family.
Family:
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP3: view

Function for LAMP3 Gene

Molecular function for LAMP3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in dendritic cell function and in adaptive immunity.
genes like me logo Genes that share phenotypes with LAMP3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMP3 Gene

Localization for LAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP3 Gene

Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269 PubMed:9768752}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMP3 Gene COMPARTMENTS Subcellular localization image for LAMP3 gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21810281
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 25681212
genes like me logo Genes that share ontologies with LAMP3: view

Pathways & Interactions for LAMP3 Gene

SuperPathways for LAMP3 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAMP3: view

Pathways by source for LAMP3 Gene

1 KEGG pathway for LAMP3 Gene

Gene Ontology (GO) - Biological Process for LAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035455 response to interferon-alpha IMP 23651994
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 25681212
GO:0046718 NOT viral entry into host cell IMP 21810281
GO:1901799 negative regulation of proteasomal protein catabolic process IMP 25681212
genes like me logo Genes that share ontologies with LAMP3: view

No data available for SIGNOR curated interactions for LAMP3 Gene

Drugs & Compounds for LAMP3 Gene

(1) Drugs for LAMP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LAMP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMP3: view

Transcripts for LAMP3 Gene

Unigene Clusters for LAMP3 Gene

Lysosomal-associated membrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for LAMP3 Gene

GeneLoc Exon Structure for
LAMP3
ECgene alternative splicing isoforms for
LAMP3

Expression for LAMP3 Gene

mRNA expression in normal human tissues for LAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAMP3 Gene

This gene is overexpressed in Lung (x23.0).

Protein differential expression in normal tissues from HIPED for LAMP3 Gene

This gene is overexpressed in Lung (46.7) and Lymph node (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMP3 Gene



SOURCE GeneReport for Unigene cluster for LAMP3 Gene Hs.518448

mRNA Expression by UniProt/SwissProt for LAMP3 Gene

Q9UQV4-LAMP3_HUMAN
Tissue specificity: Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyers patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
genes like me logo Genes that share expression patterns with LAMP3: view

Protein tissue co-expression partners for LAMP3 Gene

Primer Products

In Situ Assay Products

Orthologs for LAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAMP3 35
  • 72.59 (n)
  • 62.04 (a)
LAMP3 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMP3 35
  • 81.04 (n)
  • 72.77 (a)
mouse
(Mus musculus)
Mammalia Lamp3 35
  • 71.71 (n)
  • 54.09 (a)
Lamp3 16
Lamp3 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAMP3 35
  • 93.08 (n)
  • 91.79 (a)
LAMP3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamp3 35
  • 71.17 (n)
  • 53.77 (a)
oppossum
(Monodelphis domestica)
Mammalia LAMP3 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMP3 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMP3 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMP3 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamp3 35
  • 46.93 (n)
  • 34.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003043 35
  • 49.02 (n)
  • 31.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
Species with no ortholog for LAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMP3 Gene

ENSEMBL:
Gene Tree for LAMP3 (if available)
TreeFam:
Gene Tree for LAMP3 (if available)

Paralogs for LAMP3 Gene

Paralogs for LAMP3 Gene

genes like me logo Genes that share paralogs with LAMP3: view

Variants for LAMP3 Gene

Sequence variations from dbSNP and Humsavar for LAMP3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs482912 - 183,135,882(-) AGACA(A/G)TTTAC nc-transcript-variant, reference, missense
rs17853113 - 183,154,346(+) TGGTT(C/T)CTGGA nc-transcript-variant, reference, missense
rs12353 -- 183,122,234(-) TTTTG(C/T)AATAA utr-variant-3-prime
rs481410 -- 183,151,321(+) TGGGA(A/T)GACCA intron-variant
rs483150 -- 183,151,459(+) TTTTG(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMP3 Gene

Variant ID Type Subtype PubMed ID
nsv508970 CNV Insertion 20534489
nsv507143 CNV Insertion 20534489

Variation tolerance for LAMP3 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMP3 Gene

HapMap Linkage Disequilibrium report
LAMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP3 Gene

Disorders for LAMP3 Gene

Relevant External Links for LAMP3

Genetic Association Database (GAD)
LAMP3
Human Genome Epidemiology (HuGE) Navigator
LAMP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMP3

No disorders were found for LAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAMP3 Gene

Publications for LAMP3 Gene

  1. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues. (PMID: 9721848) Ozaki K. … Nakamura Y. (Cancer Res. 1998) 2 3 4 67
  2. Increased expression of CD208 (DC-LAMP) in epidermal keratinocytes of psoriatic lesions. (PMID: 19335688) Higaki M. … Kawashima M. (J. Dermatol. 2009) 3 23
  3. Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes. (PMID: 16887987) Arruda L.B. … Marques E.T. (J. Immunol. 2006) 3 23
  4. Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. (PMID: 16204031) Kanao H. … Murata Y. (Cancer Res. 2005) 3 23
  5. Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes. (PMID: 15111122) Akasaki K. … August J.T. (Arch. Biochem. Biophys. 2004) 3 23

Products for LAMP3 Gene

Sources for LAMP3 Gene

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