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Aliases for LAMP3 Gene

Aliases for LAMP3 Gene

  • Lysosomal-Associated Membrane Protein 3 2 3 4
  • DCLAMP 3 4 6
  • DC-Lysosome-Associated Membrane Glycoprotein 3 4
  • DC LAMP 3 4
  • LAMP-3 3 4
  • TSC403 3 4
  • Lysosome-Associated Membrane Glycoprotein 3 3
  • Protein TSC403 4
  • CD208 Antigen 4
  • DC-LAMP 3
  • CD208 3
  • LAMP 3

External Ids for LAMP3 Gene

Previous GeneCards Identifiers for LAMP3 Gene

  • GC03M179608
  • GC03M183695
  • GC03M184242
  • GC03M184160
  • GC03M184322
  • GC03M182840
  • GC03M180244

Summaries for LAMP3 Gene

Entrez Gene Summary for LAMP3 Gene

  • Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

GeneCards Summary for LAMP3 Gene

LAMP3 (Lysosomal-Associated Membrane Protein 3) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is LAMP2.

UniProtKB/Swiss-Prot for LAMP3 Gene

  • May play a role in dendritic cell function and in adaptive immunity.

Gene Wiki entry for LAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP3 Gene

Genomics for LAMP3 Gene

Regulatory Elements for LAMP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LAMP3 Gene

183,122,213 bp from pter
183,163,839 bp from pter
41,627 bases
Minus strand

Genomic View for LAMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP3 Gene

Proteins for LAMP3 Gene

  • Protein details for LAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosome-associated membrane glycoprotein 3
    Protein Accession:
    Secondary Accessions:
    • D3DNS4
    • O94781
    • Q8NEC8

    Protein attributes for LAMP3 Gene

    416 amino acids
    Molecular mass:
    44346 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LAMP3 Gene

neXtProt entry for LAMP3 Gene

Proteomics data for LAMP3 Gene at MOPED

Post-translational modifications for LAMP3 Gene

  • Glycosylation at Ser37, Thr40, Thr44, Thr74, Thr77, Thr80, Asn112, Asn158, Asn164, Asn200, Asn232, Asn266, and Asn291
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMP3 Gene

Antibody Products

No data available for DME Specific Peptides for LAMP3 Gene

Domains for LAMP3 Gene

Gene Families for LAMP3 Gene

Protein Domains for LAMP3 Gene


Suggested Antigen Peptide Sequences for LAMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LAMP family.
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP3: view

Function for LAMP3 Gene

Molecular function for LAMP3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in dendritic cell function and in adaptive immunity.

Phenotypes for LAMP3 Gene

GenomeRNAi human phenotypes for LAMP3:
genes like me logo Genes that share phenotypes with LAMP3: view

Animal Model Products

miRNA for LAMP3 Gene

miRTarBase miRNAs that target LAMP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for LAMP3 Gene

Localization for LAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP3 Gene

Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.

Subcellular locations from

Jensen Localization Image for LAMP3 Gene COMPARTMENTS Subcellular localization image for LAMP3 gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0097233 alveolar lamellar body membrane IEA --
genes like me logo Genes that share ontologies with LAMP3: view

Pathways for LAMP3 Gene

SuperPathways for LAMP3 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with LAMP3: view

Pathways by source for LAMP3 Gene

1 KEGG pathway for LAMP3 Gene

Gene Ontology (GO) - Biological Process for LAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0008283 cell proliferation TAS 9721848
genes like me logo Genes that share ontologies with LAMP3: view

Drugs for LAMP3 Gene

(2) Novoseek inferred chemical compound relationships for LAMP3 Gene

Compound -log(P) Hits PubMed IDs
glycogen 5.33 1
histamine 1.58 2
genes like me logo Genes that share compounds with LAMP3: view

Transcripts for LAMP3 Gene

Unigene Clusters for LAMP3 Gene

Lysosomal-associated membrane protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP4: -

Relevant External Links for LAMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAMP3 Gene

mRNA expression in normal human tissues for LAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAMP3 Gene

This gene is overexpressed in Lung (23.0).

Protein differential expression in normal tissues for LAMP3 Gene

This gene is overexpressed in Lung (46.7) and Lymph node (22.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LAMP3 Gene

SOURCE GeneReport for Unigene cluster for LAMP3 Gene Hs.518448

mRNA Expression by UniProt/SwissProt for LAMP3 Gene

Tissue specificity: Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyers patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
genes like me logo Genes that share expressions with LAMP3: view

Expression partners for LAMP3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for LAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LAMP3 35
  • 72.59 (n)
  • 62.04 (a)
LAMP3 36
  • 60 (a)
(Canis familiaris)
Mammalia LAMP3 35
  • 81.04 (n)
  • 72.77 (a)
(Mus musculus)
Mammalia Lamp3 35
  • 71.71 (n)
  • 54.09 (a)
Lamp3 16
Lamp3 36
  • 54 (a)
(Pan troglodytes)
Mammalia LAMP3 35
  • 93.08 (n)
  • 91.79 (a)
LAMP3 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Lamp3 35
  • 71.17 (n)
  • 53.77 (a)
(Monodelphis domestica)
Mammalia LAMP3 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia LAMP3 36
  • 44 (a)
(Gallus gallus)
Aves LAMP3 36
  • 29 (a)
(Anolis carolinensis)
Reptilia LAMP3 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lamp3 35
  • 46.93 (n)
  • 34.4 (a)
(Danio rerio)
Actinopterygii LOC100003043 35
  • 49.02 (n)
  • 31.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
-- 36
  • 15 (a)
Species with no ortholog for LAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMP3 Gene

Gene Tree for LAMP3 (if available)
Gene Tree for LAMP3 (if available)

Paralogs for LAMP3 Gene

Paralogs for LAMP3 Gene

genes like me logo Genes that share paralogs with LAMP3: view

Variants for LAMP3 Gene

Sequence variations from dbSNP and Humsavar for LAMP3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs500193 -- 183,128,599(-) GCCTG(A/G)GAACa intron-variant
rs500288 -- 183,153,676(-) GTAAG(C/T)TGGGG intron-variant
rs500910 -- 183,160,244(-) CTGAG(A/T)AATCT intron-variant
rs501044 -- 183,160,194(-) TCCAG(A/G)AAATG intron-variant
rs514636 -- 183,152,648(+) CTCTC(A/G)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMP3 Gene

Variant ID Type Subtype PubMed ID
nsv508970 CNV Insertion 20534489
nsv507143 CNV Insertion 20534489

Relevant External Links for LAMP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP3 Gene

Disorders for LAMP3 Gene

(5) Novoseek inferred disease relationships for LAMP3 Gene

Disease -log(P) Hits PubMed IDs
necrosis 6.43 1
tumors 5.69 4
lupus erythematosus systemic 1.54 1
aids 0 1
cancer 0 3

Relevant External Links for LAMP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LAMP3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for LAMP3 Gene

Publications for LAMP3 Gene

  1. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. (PMID: 9768752) de Saint-Vis B.M. … Lebecque S. (Immunity 1998) 3 4 23
  2. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues. (PMID: 9721848) Ozaki K. … Nakamura Y. (Cancer Res. 1998) 2 3 4
  3. Family-based association study for bipolar affective disorder. (PMID: 20414141) Secolin R. … Lopes-Cendes I. (Psychiatr. Genet. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 48

Products for LAMP3 Gene

Sources for LAMP3 Gene

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