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Aliases for LAMP2 Gene

Aliases for LAMP2 Gene

  • Lysosomal-Associated Membrane Protein 2 2 3
  • CD107 Antigen-Like Family Member B 3 4
  • LGP110 3 6
  • LAMP-2 3 4
  • LAMPB 3 6
  • Lysosome-Associated Membrane Glycoprotein 2 3
  • Lysosome-Associated Membrane Protein 2 4
  • CD107b Antigen 4
  • CD107b 3

External Ids for LAMP2 Gene

Previous GeneCards Identifiers for LAMP2 Gene

  • GC0XM114382
  • GC0XM116550
  • GC0XM117540
  • GC0XM118318
  • GC0XM119346
  • GC0XM119448
  • GC0XM119560
  • GC0XM109011

Summaries for LAMP2 Gene

Entrez Gene Summary for LAMP2 Gene

  • The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMP2 Gene

LAMP2 (Lysosomal-Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include danon disease and vacuolar myopathy. Among its related pathways are Hemostasis and Hemostasis. An important paralog of this gene is LAMP3.

UniProtKB/Swiss-Prot for LAMP2 Gene

  • Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

Gene Wiki entry for LAMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP2 Gene

Genomics for LAMP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LAMP2 Gene

Start:
120,426,148 bp from pter
End:
120,469,365 bp from pter
Size:
43,218 bases
Orientation:
Minus strand

Genomic View for LAMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP2 Gene

Proteins for LAMP2 Gene

  • Protein details for LAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13473-LAMP2_HUMAN
    Recommended name:
    Lysosome-associated membrane glycoprotein 2
    Protein Accession:
    P13473
    Secondary Accessions:
    • A8K4X5
    • D3DTF0
    • Q16641
    • Q6Q3G8
    • Q96J30
    • Q99534
    • Q9UD93

    Protein attributes for LAMP2 Gene

    Size:
    410 amino acids
    Molecular mass:
    44961 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LAMP2 Gene

    Alternative splice isoforms for LAMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMP2 Gene

Proteomics data for LAMP2 Gene at MOPED

Post-translational modifications for LAMP2 Gene

  • O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
  • Glycosylation at Asn32, Asn38, Asn49, Asn58, Asn75, Asn101, Asn123, Asn179, Ser195, Thr196, Thr200, Thr203, Thr204, Ser207, Thr209, Thr210, Thr211, Thr213, Asn229, Asn242, Asn257, Asn275, Asn300, Asn307, Asn317, and Asn356
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LAMP2 (LAMP-2/CD107b)

No data available for DME Specific Peptides for LAMP2 Gene

Domains for LAMP2 Gene

Gene Families for LAMP2 Gene

HGNC:
  • CD :CD molecules

Protein Domains for LAMP2 Gene

Graphical View of Domain Structure for InterPro Entry

P13473

UniProtKB/Swiss-Prot:

LAMP2_HUMAN :
  • P13473
Family:
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP2: view

Function for LAMP2 Gene

Molecular function for LAMP2 Gene

GENATLAS Biochemistry: lysosomal associated membrane protein 2
UniProtKB/Swiss-Prot Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

Gene Ontology (GO) - Molecular Function for LAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 22641697
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with LAMP2: view
genes like me logo Genes that share phenotypes with LAMP2: view

Animal Models for LAMP2 Gene

MGI Knock Outs for LAMP2:

Animal Model Products

CRISPR Products

miRNA for LAMP2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMP2

Clone Products

  • Addgene plasmids for LAMP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LAMP2 Gene

Localization for LAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP2 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMP2 Gene COMPARTMENTS Subcellular localization image for LAMP2 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 12536145
GO:0005765 lysosomal membrane IDA 15297306
GO:0005770 late endosome IDA 15229288
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 15297306
genes like me logo Genes that share ontologies with LAMP2: view

Pathways for LAMP2 Gene

genes like me logo Genes that share pathways with LAMP2: view

Pathways by source for LAMP2 Gene

Gene Ontology (GO) - Biological Process for LAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
GO:0050821 protein stabilization ISS --
genes like me logo Genes that share ontologies with LAMP2: view

Compounds for LAMP2 Gene

(6) Novoseek inferred chemical compound relationships for LAMP2 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 55 2
n-acetyllactosamine 52.5 2
glycogen 49.4 5
sucrose 10.5 3
dextran 9.77 1
genes like me logo Genes that share compounds with LAMP2: view

Transcripts for LAMP2 Gene

Unigene Clusters for LAMP2 Gene

Lysosomal-associated membrane protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMP2

Clone Products

  • Addgene plasmids for LAMP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a ·
SP1: -
SP2: -
SP3:
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: -
SP7: - - - - - - -
SP8:
SP9: - -
SP10: - - - -
SP11: - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13:

ExUns: 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
SP1: - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:

Relevant External Links for LAMP2 Gene

GeneLoc Exon Structure for
LAMP2
ECgene alternative splicing isoforms for
LAMP2

Expression for LAMP2 Gene

mRNA expression in normal human tissues for LAMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMP2 Gene

SOURCE GeneReport for Unigene cluster for LAMP2 Gene Hs.496684

mRNA Expression by UniProt/SwissProt for LAMP2 Gene

P13473-LAMP2_HUMAN
Tissue specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver
genes like me logo Genes that share expressions with LAMP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LAMP2 Gene

Orthologs for LAMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMP2 35
  • 90.86 (n)
  • 87.78 (a)
cow
(Bos Taurus)
Mammalia LAMP2 35
  • 82.38 (n)
  • 77.81 (a)
LAMP2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMP2 35
  • 83.42 (n)
  • 79.41 (a)
LAMP2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamp2 35
  • 74.46 (n)
  • 61.94 (a)
Lamp2 16
Lamp2 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMP2 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMP2 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamp2 35
  • 79.16 (n)
  • 68.24 (a)
chicken
(Gallus gallus)
Aves LAMP2 35
  • 58.81 (n)
  • 49.12 (a)
LAMP2 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30895 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lamp2 35
  • 55.13 (n)
  • 44.53 (a)
zebrafish
(Danio rerio)
Actinopterygii lamp2 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
Species with no ortholog for LAMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMP2 Gene

ENSEMBL:
Gene Tree for LAMP2 (if available)
TreeFam:
Gene Tree for LAMP2 (if available)

Paralogs for LAMP2 Gene

Paralogs for LAMP2 Gene

Selected SIMAP similar genes for LAMP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LAMP2: view

Variants for LAMP2 Gene

Sequence variations from dbSNP and Humsavar for LAMP2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2748 -- 120,426,285(+) AACTT(C/T)AGTTA utr-variant-3-prime
rs8160 -- 120,431,026(-) CTTGA(A/C)GTATG intron-variant, utr-variant-3-prime
rs12097 Benign 120,456,678(-) ACAGT(A/T)CGCTA reference, synonymous-codon
rs13460 -- 120,427,048(-) ATTAA(A/C)TCATG utr-variant-3-prime
rs14152 -- 120,426,651(+) TTTCC(A/G)TTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LAMP2 Gene

Variant ID Type Subtype PubMed ID
dgv2470e1 CNV Complex 17122850
nsv528786 CNV Gain 19592680
esv2740433 CNV Deletion 23290073
esv2659227 CNV Deletion 23128226

Relevant External Links for LAMP2 Gene

HapMap Linkage Disequilibrium report
LAMP2
Human Gene Mutation Database (HGMD)
LAMP2
Locus Specific Mutation Databases (LSDB)
LAMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP2 Gene

Disorders for LAMP2 Gene

(1) OMIM Diseases for LAMP2 Gene (309060)

UniProtKB/Swiss-Prot

LAMP2_HUMAN
  • Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. {ECO:0000269 PubMed:15673802, ECO:0000269 PubMed:15907287}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(16) Novoseek inferred disease relationships for LAMP2 Gene

Disease -log(P) Hits PubMed IDs
danon disease 98.6 42
myopathy 76.1 13
lysosomal acid phosphatase 73.5 2
pompe disease 69.7 1
glycogen storage disease 68.4 3

Relevant External Links for LAMP2

Genetic Association Database (GAD)
LAMP2
Human Genome Epidemiology (HuGE) Navigator
LAMP2
genes like me logo Genes that share disorders with LAMP2: view

Publications for LAMP2 Gene

  1. The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PMID: 2243102) Carlsson S.R. … Fukuda M. (J. Biol. Chem. 1990) 3 4 23
  2. Glycogen storage diseases presenting as hypertrophic cardiomyopathy. (PMID: 15673802) Arad M. … Seidman J.G. (N. Engl. J. Med. 2005) 3 4 23
  3. Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. (PMID: 16190986) Eskelinen E.L. … Saftig P. (Traffic 2005) 3 4 23
  4. Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. (PMID: 15907287) Musumeci O. … Toscano A. (Neuromuscul. Disord. 2005) 3 4 23
  5. Danon disease as an underrecognized cause of hypertrophic cardiomyopathy in children. (PMID: 16144992) Yang Z. … Bowles N.E. (Circulation 2005) 3 23

Products for LAMP2 Gene

  • Addgene plasmids for LAMP2

Sources for LAMP2 Gene

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