LAMP2 Gene
protein-coding GIFtS: 67
GCID: GC0XM119560
|
|
lysosomal-associated membrane protein 2
| |
Aliases
for LAMP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lysosomal-Associated Membrane Protein 21 2 | | LAMPB2 5 | | CD107b1 2 | | LGP1102 | | Lysosome-Associated Membrane Protein 22 3 | | Lysosome-Associated Membrane Glycoprotein 22 | | LAMP-22 3 | | CD107b Antigen3 | | CD107 Antigen-Like Family Member B2 3 | | |
Export aliases for LAMP2 gene to outside databasesPrevious GC identifers: GC0XM114382 GC0XM116550 GC0XM117540 GC0XM118318 GC0XM119346 GC0XM119448 GC0XM109011 |
Summaries
for LAMP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LAMP2:
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein providesselectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in theprotection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multipletranscript variants encoding distinct proteins. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion,maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane),and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens
Gene Wiki entry for LAMP2
|
Genomic Views
for LAMP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LAMP2 gene promoter:
TBP RFX1 AP-2alpha isoform 3 Nkx2-2 NCX/Ncx AP-2alpha isoform 2 TFIID AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for LAMP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24-q25LAMP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM119560: view genomic region
(about GC identifiers)
Start:
|
119,560,003 bp from pter |
End:
|
119,603,220 bp from pter |
Size:
|
43,218 bases |
Orientation:
|
minus strand |
|
Proteins
for LAMP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473 (See
protein sequence)Recommended Name: Lysosome-associated membrane glycoprotein 2 precursor Size: 410 amino acids; 44961 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type Imembrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles betweenlysosomes, endosomes, and the plasma membrane
Secondary accessions: A8K4X5 D3DTF0 Q16641 Q6Q3G8 Q96J30 Q99534 Q9UD93Alternative splicing: 3 isoforms: P13473-1 P13473-2 P13473-3 Explore the universe of human proteins at neXtProt for LAMP2: NX_P13473
Post-translational modifications:
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13473
LAMP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001116078.1 NP_002285.1 NP_054701.1
ENSEMBL proteins: ENSP00000408411 ENSP00000200639 ENSP00000431526 ENSP00000360386 ENSP00000440506 ENSP00000440479 Reactome Protein details: P13473
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
LAMP2 for ontologies About GeneDecksing
LAMP2 Antibody Products:
Assay Products for LAMP2: |
Protein
Domains /
Families
for LAMP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LAMP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P13473ProtoNet protein and cluster: P13473 1 Blocks protein family: IPB002000 Lysosome-associated membrane glycoprotein (Lamp)/CD68
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473Similarity: Belongs to the LAMP family |
Function
for LAMP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion,maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane),and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens Genatlas biochemistry entry for LAMP2:lysosomal associated membrane protein 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): LAMP2 (NM_013995) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LAMP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP2 |
1 GenomeRNAi human phenotype for LAMP2:
Animal Models:
Mouse knock-out Lamp2tm1Psa for LAMP2
13 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lamp2):
LAMP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LAMP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Platelet degranulation | | | 2 | Platelet activation, signaling and aggregation | | | 3 | Senescence and Autophagy | | | 4 | Tuberculosis | | | 5 | Phagosome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for LAMP2
4 
Reactome Pathways for LAMP2
3 
Kegg Pathways (Kegg details for LAMP2):
LAMP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LAMP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/25 Interacting proteins for LAMP2 (P134732, 3 ENSP000004084114) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
LAMP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for LAMP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LAMP2 for compounds About GeneDecksing
 Browse Tocris compounds for LAMP2
6 Novoseek chemical compound relationships for LAMP2 gene About this table
Search CenterWatch for drugs/clinical trials and news about LAMP2
|
Transcripts
for LAMP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LAMP2 gene (3 alternative transcripts): NM_001122606.1 NM_002294.2 NM_013995.2 Unigene Cluster for LAMP2: Lysosomal-associated membrane protein 2 Hs.496684 [show with all ESTs]Unigene Representative Sequence: NM_0022946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434600(uc004est.4 uc004ess.4 uc011mtz.2) ENST00000200639
ENST00000486593 ENST00000371335(uc011mua.1 uc010nqp.1) ENST00000538785
ENST00000540603
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): LAMP2 (NM_013995) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LAMP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP2 |
Additional cDNA sequence: AK126232.1 AK291090.1 AK293931.1 AK295038.1 AK304405.1 AY561849.1 BC002965.1 BC040653.2 BX648255.1 J04183.1 S79873.1 U36336.1 X77196.1 24/51 DOTS entries (see all 51): DT.92457710 DT.95371837 DT.95371865 DT.314812 DT.121318838 DT.100673206 DT.120007 DT.92457699 DT.121318831 DT.95215613 DT.95371856 DT.121318841 DT.121318801 DT.95371845 DT.92457712 DT.100033580 DT.121318813 DT.100858615 DT.100886554 DT.121318819 DT.91744068 DT.121318774 DT.100733496 DT.121318814 809 AceView cDNA sequences (see top 24): AI954107 AI911152 H48596 AA917919 AW027976 AI092262 BM667236 BM966891 AA358755 AL602712 BM972440 BQ721319 CD370599 AA707470 BG169056 BQ017830 BQ576115 CR606114 BF933211 T40586 AA448882 AY561849 AA788977 BX482027 BX399393 AL549180 N24741 BE222200 CA314017 AI422766 BG109715 CD614473 CA772061 BE819564 AI521971 CB141496 BX399392 CB266012 AA227262 CD365703 AI356009 AI459107 AV709000 CA419391 AA598735 BX280335 CR616621 AI697388 AI868727 AA127074 CA443712 AA348116 BC040653 Z39048 AI826194 AW072676 AA359609 AW071679 AA909130 BM676071 BU686522 AI282785 AA593892 AW874643 AL708507 BU742669 F04863 BM975466 CA432942 BE327660 AW578349 AA280873 CN479036 BM967103 AW058394 CB157104 CD678610 BU674076 AA992994 T69951 BU789521 AA148755 BQ006028 AA938644 AI767340 BM857490 AW292432 CB857888 BU181960 CB159917 AI221464 AI753952 AI372901 AW513834 AI277990 BU633811 AI025835 CR607757 AW189066 AI361127 BM784356 Z41475 CB121644 CB051868 AW237255 BQ613776 AA350363 AI379418 Z45838 AI682862 AI094861 AA771741 BX471492 BU156133 AA481559 BQ010045 BE894736 BE463641 BM981955 AA825745 T83661 AA342406 BU689910 N42209 BI711868 CB118186 AI810331 AA662780 AW576464 BU183786 CD654035 CB958146 N62847 BM544064 BI552296 AI424472 BG249656 BX414543 AI052288 BQ417289 BU929556 BM728751 CD104697 AW606991 D29162 BM718041 BV179119 AA314150 CA435621 BU955321 AI301997 AU122484 CB956626 BE501916 CA942791 CA777013 AW837054 BV199703 AW890336 CD694708 BG436364 BF674583 CF128705 BF670271 AU139006 BI492346 AI917044 BG035632 AW503456 AU136875 BQ018918 AW016087 AW518997 CA445607 D63026 AI269232 AU156678 AI623255 BI910670 H77564 N94781 AI685331 BE348530 BQ006455 BM055241 CD298869 BG430862 AA125797 AA360621 AI624013 BM786781 AU136365 AA825760 AV694063 BE880985 X77196 AI150000 AA481625 BE326751 CB111949 CD657452 BP336490 AA306456 CD643308 AI700945 BE672563 AI031937 CF272351 AI269182 AW951386 AV708021 N31640 AI368840 Z33445 BM893706 BQ776350 AU157853 BU568304 BM989205 AI097661 BX118727 BM993158 AW070610 BM761145 CD655142 BI548549 AA706741 AW661994 BG385638 BV178531 AL598543 Z42930 BE394155 BF666322 BF984425 AA774464 BM450148 BU177907 AU131820 AI087121 C00545 AA209339 BI838068 W56237 CA777305 AI969208 BU789790 BF939655 BQ003064 BM747152 BQ447081 BX435019 NM_002294 BX441182 AI094571 CB051867 CA448219 AI799565 AW664395 AU138609 AI376766 BM712728 AI168514 BX648255 AA418142 T27128 AU135856 BE241968 BF899767 AU118588 BI457964 BM829285 CB217113 AA447948 T29503 BG702492 AW130220 BM845988 BQ212569 CB052410 BP871688 CB854328 BE218712 AW016891 BP872288 BI669980 T27031 BQ425930 BF373612 BF793957 AI680787 BE000919 AA609629 BF438547 H63796 AW470703 AW292574 BI668993 AA668893 BI837756 NM_013995 AW275139 BI600216 BV207928 BE270547 AI580088 N57095 BU160345 BE968681 AI223315 AA052944 AI692532 BI551439 CB163640 BG546126 AA232472 BX494566 AA361062 D62941 CF618745 BG699100 BF344345 BC002965 CD652478 BQ067732 U36336 AL521377 CD244950 AL521378 AW576569 BI551966 AA280952 BM817970 CB158859 BM455036 AA304644 AI923808 AW675331 BU430584 AA384987 AI004872 BE046130 BI549834 CB143470 BG534388 AI609407 AI826694 AW513594 CB140827 BE327962 BX379302 AV731086 AA569528 BE858845 AU117130 BM479043 BI092673 F01897 AI092292 AI492294 AI479585 AA759108 BG428181 BX113463 BE857608 N51098 AV730441 AI962107 BG771029 AA481012 AI423220 BF573487 BG572314 BM966971 BM557613 AA904328 AI074125 AK126232 CD653927 BI599743 S79873 BP873572 BE045656 AW069281 CF541058 BQ017100 AA490196 F08654 BI669660 AW873089 CB989444 AU137186 BI670241 BQ014053 BM146801 AW206034 AI811159 CD698195 AW837157 BF798819 BQ308790 BG507060 AW021738 AW780225 BX397089 BE819615 AI128270 BE880692 BI547744 AW956516 AA657830 AA826406 AW838283 BF357934 BM273000 T83825 BX378131 BI549147 BI603638 AW611496 AI761959 AA227839 BX471491 BI670055 AW996802 CD614474 AW748402 AA227840 BF762673 BG715800 AW302189 CD512269 BG163889 BF337637 BE767186 CB851858 BF087207 BG699244 BF983921 BQ025604 AI057297 BE857474 T26401 BG702772 AL598258 D79776 CD674780 BI548977 AA977167 AI701681 BM479065 BG149537 R98092 AU153491 BE819450 N28966 H77563 AA148995 BM857717 BF031958 BG719002 CD697263 AW937832 R77797 AI432614 AA515021 BQ287825 AI951916 H83687 AW505266 CD299829 BX484340 BE897635 J04183 BF126534 BU430032 BM805428 BQ631029 BG705996 AW371637 R25050 AI356787 BG506506 W32077 BQ778436 AW082690 BG707913 W93718 N63482 BF984057 BM904928 AI023453 BG714522 BG572959 BF957400 W86734 AA576273 BG427658 CF136348 BG675338 AV722439 AV652163 R40327 BE881570 BX379301 BU428452 BI601620 BG771520 BF222402 BG699327 CA772351 AI619539 BE301240 BG400273 H49813 AA568885 BV167885 AA456539 AA085744 BE677198 CA407490 BE407230 BE669880 N71940 Z36265 BF525434 N55022 BX500144 R62619 AA417965 AA306272 AA228427 BG821903 BQ309039 BF126196 N63463 BI550952 T27129 AV698379 AA948364 BP335272 AA455167 AA357492 N94756 BI549272 AI678281 BG165198 AI972316 AW955301 AW243853 CD683576 N53504 BF086427 H48790 BG697113 BF330260 H23858 BI198212 R63057 T63671 AW968679 AA576265 BU157079 BI551372 AW602947 C04197 R68253 H29263 BX642714 BE561678 BF572689 CD684217 AI674804 AA206048 BF691610 AV761223 AI366380 CD299153 AI275637 CD692514 BE891758 BF916974 H29346 N94804 BF213237 AV662051 AV688071 CF137544 BG623826 N77754 N80157 AI423449 H83707 AW068907 BI763906 AV689911 CD104948 BP336447 BE177530 N77211 T39434 AI241534 T69903 BE897971 AA577284 AV692211 CD698262 H09881 BF214505 BI907407 BF339611 AA244335 AI095427 BQ308038 BI711579 C21402 AV723706 AA883527 AW340744 N45601 AI366364 BF761907 AA309855 CD705657 AA303924 BX436451 BE819581 BU198192 BF673659 AA053501 BE925714 N58035 AW797236 BF357915 AI973078 AA854447 AA854549 AV709552 BI596979 AW276273 AA207254 T32396 R78159 BE879380 AA658393 BF819195 AA148616 R65868 BF924944 AU144045 AW304751 BE540412 AW750318 AA814831 BG164302 AV754219 R33992 BF826927 BF761764 CD366465 AI468173 AL573484 CK824132 W19660 R67188 BF247226 AA609975 CB050882 CB989197 AI582014 R65700 AV732551 BG399502 T10914 AW955413 BE078205 BG951841 AW089111 AI366553 AA706295 AW242869 AU145109 CA943033 BE769379 BF701680 AA404511 BX414544 AI800108 H09796 BQ301664 AI797624 N99676 BM698076 BF089672 R45389 BI669033 AV753771 BF131759 BE185720 BF978499 BF130701 R60000 AI146872 H24010 T70913 R98093 W93719 AI557396 H83328 BE894975 BF171533 BE769391 BE931698 H22728 BE708018 BE245194 AA043891 BF956341 AA337053 BE833443 AU099706 BQ222525 CD697461 AV749031 W31585 BU160565 BF248057 AA948353 AA244384 BF330258 BG003439 AI038047 BE000942 BF030725 BG571370 N72160 AW388905 BF743910 R14336 AI476497 W03685 BF893157 R26568 BF090131 AI285170 CF144791 BG168312 BE620089 BE934775 BE831550 BG771468 BG035554 BI033816 AW997114 R97855 D58313 BE005683 BG698385 H49558 R97806 R31719 BE710300 H63755 AW518570 W21947 BE172543 BU198161 BE926076 BG702350 BE242698 BF589566 AA922026 BF030009 R23654 BQ360548 AW806190 BU166099 R13247 R40662 BF094044 BE813928 R31677 BF089416 BQ888267 BF207646 AV662088 R68547 BE245222 BF826931 AA361826 BE830680 R62670 AW602919 AA092234 BF743914 R00849 AW578968 BE694908 AV728401 AW466376 BE967372 AA148996 AI266417 BG167002 AW580056 BG290877 BG956711 BE768545 N63506
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for LAMP2 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LAMP2
|
Expression
for LAMP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LAMP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCATTATAA
About this image
See LAMP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMP2
SOURCE GeneReport for Unigene cluster: Hs.496684
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473Tissue specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, lowin brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung,kidney and pancreas, very low in liver
SABiosciences Custom PCR Arrays for LAMP2
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for LAMP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LAMP2 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LAMP21 |
lysosomal-associated membrane protein 2 |
62.81(n)
55.03(a) |
|
414800 NM_001001749.1 NP_001001749.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.308952 |
Xenopus laevis transcribed sequence with weak similarity more |
76.92(n) |
|
CA985629.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
lamp26 |
lysosomal membrane glycoprotein 2 |
29(a) |
1 ↔ 1 |
14(34448790-34456576) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Lamp16 |
Lamp1 |
18(a) |
1 → many |
2L(21573389-21577103) |
ENSEMBL Gene Tree for LAMP2 (if available)
TreeFam Gene Tree for LAMP2 (if available) |
Paralogs
for LAMP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LAMP2 gene
- LAMP12 LAMP32 CD682
1 SIMAP similar gene for LAMP2 using alignment to 4 protein entries: LAMP2_HUMAN (see all proteins):LAMP1
LAMP2 for paralogs About GeneDecksing
|
Genomic Variants
for LAMP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LAMP2 (119560003 - 119603220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LAMP2
1 CNV: 4168
Human Gene Mutation Database (HGMD): LAMP2
Locus Specific Mutation Databases (LSDB): LAMP2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAMP2 |
|
Disorders
/ Diseases
for LAMP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LAMP2 for disorders About GeneDecksing
OMIM gene information: 309060
OMIM disorders: 300257
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473
Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage diseasetype 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy,vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle andlysosomes
20/44  diseases for LAMP2 (see all 44): About MalaCardshermansky-pudlak syndrome glycogen storage disease iib glycogen storage disease chediak-higashi syndrome
danon disease vacuolar myopathy lysosomal storage disease salla disease
dilated cardiomyopathy pilocytic astrocytoma systemic lupus erythematosus intellectual disability
lupus erythematosus hypertrophic cardiomyopathy zellweger syndrome cardiomyopathy
cystinosis protein s deficiency myeloproliferative disorder gaucher's disease
5 diseases from the University of Copenhagen DISEASES database for LAMP2:Lysosomal storage disease Hypertrophic cardiomyopathy Glycogen storage disease Myopathy
Intellectual disability 10/16 Novoseek disease relationships for LAMP2 gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| danon disease |
98.6 |
49 |
18282207 (4), 11427988 (3), 20173215 (3), 18004770 (2) (see all 30) |
| myopathy |
76.1 |
17 |
16565504 (2), 15907287 (2), 18376150 (1), 15889279 (1) (see all 11) |
| lysosomal acid phosphatase |
73.5 |
2 |
9746610 (1), 8370478 (1) |
| pompe disease |
69.7 |
1 |
15673802 (1) |
| glycogen storage disease |
68.4 |
3 |
11552028 (1), 18691923 (1), 16973206 (1) |
| cardiomyopathy |
62.9 |
11 |
19318653 (4), 18376150 (1), 15907287 (1), 15889279 (1) (see all 8) |
| hermansky-pudlak syndrome |
62.6 |
1 |
8743190 (1) |
| mental retardation |
53 |
4 |
16565504 (1), 18004770 (1), 15907287 (1), 16217705 (1) |
| protein deficiency |
51.3 |
8 |
16565504 (3), 18393115 (1), 15907287 (1) |
| dilated cardiomyopathy |
43 |
1 |
17541230 (1) |
Human Genome Epidemiology (HuGE) Navigator: LAMP2 (5 documents)
Export disorders for LAMP2 gene to outside databases
|
Publications
for LAMP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LAMP2 gene, integrated from 9 sources (see all 192):
(articles sorted by number of sources associating them with LAMP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Glycogen storage diseases presenting as hypertrophic cardiomyopathy. (PubMed id 15673802)1, 2, 9 Arad M....Seidman J.G. (2005)
- Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. (PubMed id 15907287)1, 2, 9 Musumeci O.... Toscano A. (2005)
- The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)1, 2, 9 Carlsson S.R. and Fukuda M. (1990)
- Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. (PubMed id 16190986)1, 2, 9 Eskelinen E.L....Saftig P. (2005)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
- An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner. (PubMed id 7488019)1, 2 Konecki D.S....Lichter-Konecki U. (1995)
|
External Searches for LAMP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LAMP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LAMP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAMP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LAMP2 gene:
Search GeneIP for patents involving LAMP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LAMP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for LAMP2 | | OriGene shRNA RFP for LAMP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMP2 | | | OriGene Protein Over-expression Lysate for LAMP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LAMP2 | | OriGene 3'-UTR Clone for LAMP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LAMP2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LAMP2 | | OriGene Custom Protein Services for LAMP2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | | Search Tocris compounds for LAMP2 |
| |  |  |  |  | | | | | | Recombinant Protein for LAMP2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP2 |
|  |  |  | | | | ThermoFisher Antibody for LAMP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP2 |
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