LAMP2 Gene

Aliases
for LAMP2 gene

Previous GC identifers: GC0XM114382 GC0XM116550 GC0XM117540 GC0XM118318 GC0XM119346 GC0XM119448 GC0XM109011

Summaries
for LAMP2 gene

Genomic Views
for LAMP2 gene

RefSeq DNA sequence:

NC_000023.10  NC_018934.1  NT_011786.16  

SwitchGear Promoter luciferase reporter plasmid: LAMP2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMP2

LAMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM119560:  view genomic region     (about GC identifiers)

Proteins
for LAMP2 gene

Explore the universe of human proteins at neXtProt for LAMP2: NX_P13473

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for LAMP2 (LAMP2/CD107b)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): LAMP2 OriGene Protein Over-expression Lysate (see all 2): LAMP2 OriGene Custom Protein Services for LAMP2
	GenScript Custom Purified and Recombinant Proteins Services for LAMP2
	Novus Biologicals LAMP2 Proteins Novus Biologicals LAMP2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for LAMP2
	Uscn Proteins for LAMP2

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for LAMP2 (LAMP2/CD107b)
	OriGene Antibodies (see all 2): LAMP2 OriGene Custom Antibody Services for LAMP2
	GenScript Custom Superior Antibodies Services for LAMP2
	Novus Biologicals LAMP2 Antibodies
	Abcam antibodies for LAMP2
	Uscn Antibodies for LAMP2
	ThermoFisher Antibody for LAMP2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAMP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LAMP2

Protein Domains /
Families
for LAMP2 gene

ProtoNet protein and cluster: P13473

Function
for LAMP2 gene

Pathways & Interactions
for LAMP2 gene

	Super-pathway	contained gene-specific pathways
1	Platelet degranulation	Platelet degranulation 1.00 Response to elevated platelet cytosolic Ca2+ 0.94
2	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation 1.00 Hemostasis 0.43
3	Senescence and Autophagy	Senescence and Autophagy 1.00
4	Tuberculosis	Tuberculosis 1.00
5	Phagosome	Phagosome 1.00

1 BioSystems Pathway for LAMP2

Senescence and Autophagy

4        Reactome Pathways for LAMP2

	Hemostasis
	Platelet degranulation
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+

3         Kegg Pathways  (Kegg details for LAMP2)

	Lysosome
	Phagosome
	Tuberculosis

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for LAMP2 gene

Transcripts
for LAMP2 gene

Expression
for LAMP2 gene

LAMP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCATTATAA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LAMP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP2

Orthologs
for LAMP2 gene

Paralogs
for LAMP2 gene

Paralogs for LAMP2 gene

LAMP1²  LAMP3²  CD68²  

1 SIMAP similar gene for LAMP2 using alignment to 4 protein entries:     LAMP2_HUMAN (see all proteins):

LAMP1

LAMP2 for paralogs           About GeneDecksing

Genomic Variants
for LAMP2 gene

10/526 NCBI SNPs in LAMP2 are shown (see all 526)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1048948591,2	C	pathogenic	119575717(-)	GCTACC/TGGGAT	6	R W	mis1		0	--	--	--	--
rs1048948581,2	C	pathogenic	119576454(-)	GCTCCA/GGTAAG	6	I V	mis1		0	--	--	--	--
rs1048948571,2	C	pathogenic	119582861(-)	TTGTAC/TAAGCT	6	Q *	stg1		0	--	--	--	--
rs128344701,2	C,F,A,	--	119559562(+)	AAATTG/AAGCAT	2	--	ds5001		5		NA WA CSA	8
rs128403861,2	C,F,A,	--	119559588(+)	GGAATG/TTAAAG	2	--	ds5001		3		NA CSA	5
rs1508259061,2	C,	--	119559712(+)	ATACGC/TGGAAA	2	--	ds5001		0	--	--	--	--
rs1904559521,2		--	119559929(+)	ATTCAA/CGAAAC	2	--	ds5001		0	--	--	--	--
rs1132850131,2	C,	--	119560130(+)	ATACAT/ACCAAA	2	--	ut31		1		WA	2
rs27481,2	C,F,O,A,H,	--	119560140(+)	AACTTT/CAGTTA	2	--	ut31		17		MN NS EA NA	2353
rs1851565711,2		--	119560172(+)	AAAGCA/TGCTTA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for LAMP2 (119560003 - 119603220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LAMP2
     1 CNV: 4168
Human Gene Mutation Database (HGMD): LAMP2

Locus Specific Mutation Databases (LSDB): LAMP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAMP2

DNA2.0 Custom Variant and Variant Library Synthesis for LAMP2

Disorders / Diseases
for LAMP2 gene

20/44 diseases for LAMP2

10/16 Novoseek disease relationships for LAMP2 gene (see all 16)    About this table

Publications
for LAMP2 gene

PubMed articles for LAMP2 gene, integrated from 9 sources (see all 192) (see top 10): (articles sorted by number of sources associating them with LAMP2)

Utopia: connect your pdf to the dynamic world of online information

1. Glycogen storage diseases presenting as hypertrophic cardiomyopathy. (PubMed id 15673802)^{1, 2, 9} Arad M....Seidman J.G. (2005)
2. Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. (PubMed id 15907287)^{1, 2, 9} Musumeci O.... Toscano A. (2005)
3. The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)^{1, 2, 9} Carlsson S.R. and Fukuda M. (1990)
4. Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. (PubMed id 16190986)^{1, 2, 9} Eskelinen E.L....Saftig P. (2005)
5. The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
9. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{1, 2} Zhang H.... Aebersold R. (2003)
10. An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner. (PubMed id 7488019)^{1, 2} Konecki D.S....Lichter-Konecki U. (1995)
11. Complete cDNA sequence of human lysosome-associated membrane protein- 2. (PubMed id 7999007)^{1, 2} Konecki D.S.... Lichter-Konecki U. (1994)
12. The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. (PubMed id 8517882)^{1, 2} Sawada R.... Fukuda M. (1993)
13. Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. (PubMed id 8323299)^{1, 2} Carlsson S.R.... Fukuda M. (1993)
14. Purification and characterization of human lysosomal membrane glycoproteins. (PubMed id 2912382)^{1, 2} Mane S.M.... August J.T. (1989)
15. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h- lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. (PubMed id 3198605)^{1, 2} Fukuda M.... Carlsson S.R. (1988)
16. The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes. (PubMed id 8743190)^{1, 9} Israels S.J....McNicol A. (1996)
17. Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium. (PubMed id 8660832)^{1, 9} Kannan K....Holcombe R.F. (1996)
18. LAMP2 microdeletions in patients with Danon disease. (PubMed id 20173215)^{1, 9} Yang Z....Vatta M. (2010)
19. Impaired autolysosome formation correlates with Lamp- 2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. (PubMed id 19362087)^{1, 9} Fortunato F....Werner J. (2009)
20. Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2. (PubMed id 17506821)^{1, 9} Binker M.G....Gray-Owen S.D. (2007)
21. Differential expression of the lysosome-associated membrane proteins in normal human tissues. (PubMed id 10222041)^{1, 9} Furuta K....August J.T. (1999)
22. Effects of lysosomal membrane protein depletion on the Salmonella-containing vacuole. (PubMed id 18958159)^{1, 9} Roark E.A. and Haldar K. (2008)
23. The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils. (PubMed id 7487911)^{1, 9} Dahlgren C....Sjolin C. (1995)
24. Danon disease due to a novel splice mutation in the LAMP2 gene. (PubMed id 18004770)^{1, 9} Nadeau A....Sinnreich M. (2008)
25. Lysosomal membrane-associated glycoproteins are differentially expressed in acute and chronic human thymic involution. (PubMed id 17048695)^{1, 9} Sarafian V.S. and Marinova T.T. (2006)
26. Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents. (PubMed id 9746610)^{1, 9} Ayala P....So M. (1998)
27. A 13-year-old girl with proximal weakness and hypertr ophic cardiomyopathy with Danon disease. (PubMed id 20513107)^{1, 9} Kim H....Chae J.H. (2010)
28. Novel LAMP-2 mutation in a family with Danon disease presenting with hypertrophic cardiomyopathy. (PubMed id 19057086)^{1, 9} Dougu N....Inoue H. (2009)
29. Differential expression of LAMPs and ubiquitin in human thymus. (PubMed id 19343823)^{1, 9} Sarafian V.S....Gulubova M.V. (2009)
30. Retinopathy in Danon disease. (PubMed id 17296900)^{1, 9} Schorderet D.F....Munier F.L. (2007)
31. Molecular analysis of PRKAG2, LAMP2, and NKX2-5 genes in a cohort of 125 patients with accessory atrioventricular connection. (PubMed id 19533775)^{1, 9} Esposito G....Dallapiccola B. (2009)
32. Danon disease: a novel Lamp-2 gene mutation in a family with four affected members. (PubMed id 18061453)^{1, 9} Tunon T....Imizcoz M.A. (2008)
33. Shared genetic causes of cardiac hypertrophy in children and adults. (PubMed id 18403758)^{1, 9} Morita H.... Seidman C.E. (2008)
34. Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. (PubMed id 15894275)^{1, 9} Zhou D....Blum J.S. (2005)
35. Danon disease as an underrecognized cause of hypertrophic cardiomyopathy in children. (PubMed id 16144992)^{1, 9} Yang Z....Bowles N.E. (2005)
36. Characterization of Danon disease in a male patient and his affected mother. (PubMed id 14561493)^{1, 9} Sugie K....Nishino I. (2003)
37. A novel vacuolar myopathy with dilated cardiomyopathy. (PubMed id 17873513)^{1, 9} Sugimoto S. (2007)
38. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
39. Danon disease caused by two novel mutations of the LAM P2 gene: implications for two ends of the clinical spectrum. (PubMed id 22541782)¹ Hong D....Yuan Y. (2012)
40. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
41. Genetic analysis of the LAMP-2 gene promoter in patien ts with sporadic Parkinson's disease. (PubMed id 22867958)¹ Pang S....Yan B. (2012)
42. Danon disease: a focus on processing of the novel LAMP 2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency. (PubMed id 22365987)¹ Majer F....Sikora J. (2012)
43. Age-related decrease of the LAMP-2 gene expression in human leukocytes. (PubMed id 22732524)¹ Huang J....Yan B. (2012)
44. Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism. (PubMed id 22593165)¹ Doehle B.P....Gale M. (2012)
45. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
46. Altered expression of autophagic genes in the periphe ral leukocytes of patients with sporadic Parkinson's disease. (PubMed id 21514572)¹ Wu G....Yan B. (2011)
47. LAMP-2 gene expression in peripheral leukocytes is in creased in patients with coronary artery disease. (PubMed id 21462217)¹ Wu G....Yan B. (2011)
48. ErbB2-associated changes in the lysosomal proteome. (PubMed id 21674799)¹ Nylandsted J....Jaattela M. (2011)
49. Danon disease: intrafamilial phenotypic variability r elated to a novel LAMP-2 mutation. (PubMed id 21161685)¹ Cottinet S.L....Labarthe F. (2011)
50. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
51. The Mycobacterium bovis bacille Calmette-Guerin phago some proteome. (PubMed id 19815536)¹ Lee B.Y....Horwitz M.A. (2010)
52. Distribution of lysosome-associated membrane proteins -1 and -2, and cathepsin D in eosinophilic granular bodies: possible relationsh ip to cyst development in pilocytic astrocytomas. (PubMed id 20926008)¹ Tung J.N....Jiang M.C. (2010)
53. HIV Nef is secreted in exosomes and triggers apoptosi s in bystander CD4+ T cells. (PubMed id 19912576)¹ Lenassi M....Peterlin B.M. (2010)
54. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
55. Hispolon promotes MDM2 downregulation through chapero ne-mediated autophagy. (PubMed id 20540933)¹ Lu T.L....Lu T.J. (2010)
56. Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. (PubMed id 20920663)¹ Maron B.J....Feldman D.S. (2010)
57. Characterization of PXK as a protein involved in epid ermal growth factor receptor trafficking. (PubMed id 20086096)¹ Takeuchi H....Hirata M. (2010)
58. LAMP-2-deficient human B cells exhibit altered MHC cl ass II presentation of exogenous antigens. (PubMed id 20518820)¹ Crotzer V.L....Blum J.S. (2010)
59. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
60. Deficiency of niemann-pick type C-1 protein impairs r elease of human immunodeficiency virus type 1 and results in Gag accumulation i n late endosomal/lysosomal compartments. (PubMed id 19474101)¹ Tang Y....Hildreth J.E. (2009)
61. Altered expression of glycoproteins on the cell surfa ce of Jurkat cells during etoposide-induced apoptosis: shedding and intracellul ar translocation of glycoproteins. (PubMed id 19524015)¹ Sato H....Matsumoto K. (2009)
62. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
63. Printor, a novel torsinA-interacting protein implicat ed in dystonia pathogenesis. (PubMed id 19535332)¹ Giles L.M....Chin L.S. (2009)
64. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
65. 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a ne w pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. (PubMed id 19458911)¹ Olmos G....Lucio-CazaA+a J. (2009)
66. The PA-TM-RING protein RING finger protein 13 is an e ndosomal integral membrane E3 ubiquitin ligase whose RING finger domain is rele ased to the cytoplasm by proteolysis. (PubMed id 19292867)¹ Bocock J.P....Erickson A.H. (2009)
67. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. (PubMed id 18550537)¹ Kabuta T....Wada K. (2008)
68. Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy. (PubMed id 18635949)¹ Kabuta T. and Wada K. (2008)
69. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)² Schroeder B.... Hasilik A. (2007)
70. Danon disease presenting with dilated cardiomyopathy and a complex phenotype. (PubMed id 17899313)¹ Taylor M.R....Mestroni L. (2007)
71. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
72. Differential expression of ABH histo-blood group antigens and LAMPs in infantile hemangioma. (PubMed id 16570122)¹ Sarafian V....Stefanova P. (2005)
73. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
74. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. (PubMed id 15297306)¹ Jedlitschky G....Kroemer H.K. (2004)
75. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. (PubMed id 15229288)¹ Coumailleau F....Cohen-Tannoudji M. (2004)
76. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. (PubMed id 15333840)¹ Cuervo A.M....Sulzer D. (2004)
77. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)¹ Gurung R.... Mitchell C.A. (2003)
78. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. (PubMed id 12505983)¹ Cuervo A.M....Dice J.F. (2003)
79. CD107a (LAMP-1) and CD107b (LAMP-2). (PubMed id 12144129)¹ Chang M.H....Meikle P.J. (2002)
80. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
81. Signal-binding specificity of the mu4 subunit of the adaptor protein complex, AP-4. (PubMed id 11139587)¹ Aguilar R.C.... Bonifacino J.S. (2001)
82. Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). (PubMed id 10972294)¹ Nishino I....Hirano M. (2000)
83. Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network. (PubMed id 9668075)¹ Karlsson K. and Carlsson S.R. (1998)
84. Distribution and subcellular localization of a lysosome-associated protein in human genital organs. (PubMed id 8995204)¹ Aumuller G....Hasilik A. (1997)
85. Biosynthetic transport of a major lysosome-associated membrane glycoprotein 2, lamp-2: a significant fraction of newly synthesized lamp-2 is delivered to lysosomes by way of early endosomes. (PubMed id 9010755)¹ Akasaki K....Tsuji H. (1996)
86. Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains. (PubMed id 8407947)² Fritz G.... Kaina B. (1993)
87. Isolation of dense granules from human platelets. (PubMed id 1435334)¹ Fukami M.H. (1992)
88. The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human lysosomal membrane protein lamp2 and assigns the gene to Xq24. (PubMed id 2032724)¹ Manoni M....Vezzoni P. (1991)
89. Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease. (PubMed id 1959930)¹ Schleutker J....Aula P. (1991)
90. Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively. (PubMed id 2332441)¹ Mattei M.G....Fukuda M. (1990)
91. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. (PubMed id 16973206)⁹ Eskelinen E.L. (2006)
92. Generalized lysosome-associated membrane protein-2 defect explains multisystem clinical involvement and allows leukocyte diagnostic screening in Danon disease. (PubMed id 16565504)⁹ Fanin M....Angelini C. (2006)
93. Disease model: LAMP-2 enlightens Danon disease. (PubMed id 11427988)⁹ Saftig P....von Figura K. (2001)
94. Evaluation of the lysosome-associated membrane protein LAMP-2 as a marker for lysosomal storage disorders. (PubMed id 9761240)⁹ Hua C.T....Meikle P.J. (1998)
95. Cell surface expression of lysosome-associated membrane proteins (LAMPs) in scleroderma: relationship of lamp2 to disease duration, anti-Sc170 antibodies, serum interleukin-8, and soluble interleukin-2 receptor levels. (PubMed id 8443983)⁹ Holcombe R.F....Wolf R.E. (1993)
96. Danon disease: A novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. (PubMed id 18990578)⁹ Di Blasi C....Mora M. (2008)
97. LAMP-2: a control step for phagosome and autophagosome maturation. (PubMed id 18376150)⁹ Saftig P....Eskelinen E.L. (2008)
98. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. (PubMed id 18836458)⁹ Kain R....Kerjaschki D. (2008)
99. Phagosome maturation in unicellular eukaryote Paramecium: the presence of RILP, Rab7 and LAMP-2 homologues. (PubMed id 17921111)⁹ Wyroba E....Wiejak J. (2007)
100. Phenotypic heterogeneity in two unrelated Danon patients associated with the same LAMP-2 gene mutation. (PubMed id 16217705)⁹ Bertini E....Bruno C. (2005)
101. Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma. (PubMed id 11815981)⁹ Kunzli B.M....Buchler M.W. (2002)
102. Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy. (PubMed id 19318653)⁹ Maron B.J....Seidman C.E. (2009)
103. New advances in the pathogenesis of ANCA-associated v asculitides. (PubMed id 19646356)⁹ Chen M. and Kallenberg C.G. (2009)
104. Danon disease with typical early-onset cardiomyopathy in a male: focus on a novel LAMP-2 mutation. (PubMed id 18282207)⁹ Bui Y.K....Alejos J.C. (2008)
105. LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. (PubMed id 15351990)⁹ Gruetzkau A....Henz B.M. (2004)
106. Identification of a novel LAMP2 mutation responsible for X-chromosomal dominant Danon disease. (PubMed id 14598234)⁹ Horvath J....Omran H. (2003)
107. Expression patterns of murine lysosome-associated membrane protein 2 (Lamp-2) transcripts during morphogenesis. (PubMed id 10448712)⁹ Lichter-Konecki U....Konecki D.S. (1999)
108. Cell surface expression of lysosome-associated membrane protein-2 (lamp2) and CD63 as markers of in vivo platelet activation in malignancy. (PubMed id 7672086)⁹ Kannan K....Holcombe R.F. (1995)
109. [Morphological and clinical aspects of Danon disease] (PubMed id 18393115)⁹ Fidzianska A....Kuch M. (2008)
110. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. (PubMed id 10972293)⁹ Tanaka Y....Saftig P. (2000)
111. Quantitation of CD62, soluble CD62, and lysosome-associated membrane proteins 1 and 2 for evaluation of the quality of stored platelet concentrates. (PubMed id 7535481)⁹ Divers S.G....Holcombe R.F. (1995)
112. Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. (PubMed id 1520873)⁹ Silverstein R.L. and Febbraio M. (1992)
113. Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins. (PubMed id 2243101)⁹ Lee N....Fukuda M. (1990)
114. Disease-causing mutations within the lysosomal integr al membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase. (PubMed id 19933215)⁹ Blanz J....Schwake M. (2010)
115. Dissection of Rab7 localization on Mycobacterium tube rculosis phagosome. (PubMed id 19580780)⁹ Seto S....Koide Y. (2009)
116. Impaired autophagosome-lysosome fusion in the pathoge nesis of pancreatitis. (PubMed id 19458481)⁹ Fortunato F. and Kroemer G. (2009)
117. Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy. (PubMed id 17485520)⁹ Schroen B....Pinto Y.M. (2007)
118. LAMP-2 positive vacuolar myopathy with dilated cardiomyopathy. (PubMed id 17541230)⁹ Sugimoto S....Ohi T. (2007)
119. [Danon disease: a case report and literature overview] (PubMed id 17642461)⁹ Catovic S. and Otasevic P. (2007)
120. Intracellular transport of acid beta-glucosidase and lysosome-associated membrane proteins is affected in Gaucher's disease (G202R mutation). (PubMed id 10440752)⁹ Zimmer K.P....Naim H.Y. (1999)
121. Characterization of glycoprotein II from bovine adrenal medullary chromaffin granules. Identification of components representing the secretory vesicle counterparts of the lysosomal-associated membrane glycoproteins (lamp-1 and lamp-2). (PubMed id 8496169)⁹ Hieber A.D. and Christie D.L. (1993)
122. Pathogenesis of small vessel vasculitis associated wi th autoantibodies to neutrophil cytoplasmic antigens: new insights from animal models. (PubMed id 19823088)⁹ Kain R....Rees A.J. (2010)
123. [Eludication of pathomechanism of and development of therapy for autophagic vacuolar myopathies] (PubMed id 20120346)⁹ Nishino I. (2010)
124. Shining a LAMP on pauci-immune focal segmental glomer ulonephritis. (PubMed id 19387471)⁹ Salama A.D. and Pusey C.D. (2009)
125. Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells. (PubMed id 19063910)⁹ Chung H....Kim J.G. (2009)
126. N-glycoprotein profiling of lung adenocarcinoma pleural effusions by shotgun proteomics. (PubMed id 18327805)⁹ Soltermann A....Moch H. (2008)
127. Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2. (PubMed id 18701486)⁹ Fehrenbacher N....Jaattela M. (2008)
128. Primary human keratinocytes externalize stratifin protein via exosomes. (PubMed id 18452139)⁹ Chavez-Munoz C....Ghahary A. (2008)
129. Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice. (PubMed id 18097049)⁹ Beertsen W....Saftig P. (2008)
130. Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue. (PubMed id 17868323)⁹ Pohl S....Storch S. (2007)
131. Danon disease as a cause of autophagic vacuolar myopathy. (PubMed id 18377432)⁹ Yang Z. and Vatta M. (2007)
132. LAMPs and ABH histo-blood group antigens in granulation tissue. (PubMed id 17550377)⁹ Sarafian V.S. and Dikov D.I. (2007)
133. Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages. (PubMed id 17095504)⁹ Yanagawa M....Yamamoto K. (2007)
134. Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. (PubMed id 17601634)⁹ Llorente A....Sandvig K. (2007)
135. A case of excessive autophagocytosis with multiorgan involvement and low clinical penetrance. (PubMed id 17821837)⁹ Sikora J....Elleder M. (2007)
136. Autophagic vacuolar myopathy in twin girls. (PubMed id 16640643)⁹ Holton J.L....Al-Memar A. (2006)
137. Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. (PubMed id 16372318)⁹ Echaniz-Laguna A....Tranchant C. (2006)
138. Defective platelet beta-N-acetyl hexosaminidase content and release in chronic myeloproliferative disorders. (PubMed id 16308183)⁹ Emiliani C....Gresele P. (2006)
139. Morphological, clinical and genetic aspects in a family with a novel LAMP-2 gene mutation (Danon disease). (PubMed id 15792868)⁹ Lobrinus J.A....Jeannet P.Y. (2005)
140. Effector gammadelta T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma. (PubMed id 15744346)⁹ Mariani S....Massaia M. (2005)
141. Simultaneous reconstitution of multiple cytomegalovirus-specific CD8+ cell populations with divergent functionality in hematopoietic stem-cell transplant recipients. (PubMed id 15717275)⁹ Lacey S.F....Diamond D.J. (2005)
142. Gene mutations in apical hypertrophic cardiomyopathy. (PubMed id 16267253)⁹ Arad M....Seidman C.E. (2005)
143. Danon's disease as a cause of hypertrophic cardiomyopathy: a systematic survey. (PubMed id 15253947)⁹ Charron P....Komajda M. (2004)
144. N-glycoproteins bearing beta1-6 branched oligosaccharides from the A375 human melanoma cell line analysed by tandem mass spectrometry. (PubMed id 15577318)⁹ Ochwat D....Litynska A. (2004)
145. Autophagic vacuolar myopathies. (PubMed id 12507414)⁹ Nishino I. (2003)
146. Aspirin inhibits surface glycoprotein IIb/IIIa, P-selectin, CD63, and CD107a receptor expression on human platelets. (PubMed id 12695747)⁹ McKenzie M.E....Serebruany V.L. (2003)
147. A novel method of imaging lysosomes in living human mammary epithelial cells. (PubMed id 12926235)⁹ Glunde K....Bhujwalla Z.M. (2003)
148. Danon's disease (X-linked vacuolar cardiomyopathy and myopathy): a case with a novel Lamp-2 gene mutation. (PubMed id 12398843)⁹ Lacoste-Collin L....Delisle M.B. (2002)
149. A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology. (PubMed id 12356916)⁹ Kuronita T....Tanaka Y. (2002)
150. The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif. (PubMed id 11150305)⁹ Cherqui S....Antignac C. (2001)
151. Lysosome proteins are redistributed during expression of a GTP-hydrolysis-defective rab5a. (PubMed id 11792815)⁹ Rosenfeld J.L....Knoll B.J. (2001)
152. Infantile autophagic vacuolar myopathy is distinct from Danon disease. (PubMed id 11552028)⁹ Yamamoto A....Nishino I. (2001)
153. Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes. (PubMed id 11032830)⁹ Zhang M....Blanchette-Mackie E.J. (2001)
154. NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis. (PubMed id 10666334)⁹ Watari H....Strauss J.F. (2000)
155. Dermal microvascular endothelial cells express the 180-kDa macrophage mannose receptor in situ and in vitro. (PubMed id 11067894)⁹ Groger M....Petzelbauer P. (2000)
156. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. (PubMed id 10024875)⁹ Dell'Angelica E.C....Bonifacino J.S. (1999)
157. Identification and characterization of a major lysoso mal membrane glycoprotein, LGP85/LIMP II in mouse liver. (PubMed id 9399579)⁹ Tabuchi N....Tsuji H. (1997)
158. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. (PubMed id 7807006)⁹ Clemens D.L. and Horwitz M.A. (1995)
159. Correlation of serum interleukin-8 and cell surface lysosome-associated membrane protein expression with clinical disease activity in systemic lupus erythematosus. (PubMed id 7920621)⁹ Holcombe R.F....Fukuda M. (1994)
160. Identification of human melanoma cellular and secreted ligands for galectin-3. (PubMed id 8024581)⁹ Inohara H. and Raz A. (1994)
161. Cotransfection of genes encoding human tyrosinase and tyrosinase-related protein-1 prevents melanocyte death and enhances melanin pigmentation and gene expression of Lamp-1. (PubMed id 8020595)⁹ Luo D....Jimbow K. (1994)
162. Molecular control of melanogenesis in malignant melanoma: functional assessment of tyrosinase and lamp gene families by UV exposure and gene co-transfection, and cloning of a cDNA encoding calnexin, a possible melanogenesis 'chaperone'. (PubMed id 7531726)⁹ Jimbow K....Chen H. (1994)
163. The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes. (PubMed id 7902407)⁹ Burkhardt J.K....Argon Y. (1993)
164. Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy. (PubMed id 8370478)⁹ Lin X....Tang J. (1993)
165. Chediak-Higashi lymphoblastoid cell lines: granule characteristics and expression of lysosome-associated membrane proteins. (PubMed id 1333377)⁹ Jones K.L....Holcombe R.F. (1992)
166. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. (PubMed id 2022921)⁹ Peters P.J....Geuze H.J. (1991)
167. (PubMed id 17517953)⁹ 
168. Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. (PubMed id 19208367)⁹ Dudeja V....Saluja A.K. (2009)
169. Progress in understanding the human immune responses to Mycobacterium tuberculosis. (PubMed id 20006306)⁹ Barnes P.F....Vankayalapatib R. (2009)
170. Peeling as a novel, simple, and effective method for isolation of apical membrane from intact polarized epithelial cells. (PubMed id 19679094)⁹ Fong-ngern K....Thongboonkerd V. (2009)
171. Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. (PubMed id 19349362)⁹ Wei J....Hashimoto M. (2009)
172. Unclassified polysaccharidosis of the heart and skeletal muscle in siblings. (PubMed id 18691923)⁹ Schoser B....Muller-Hocker J. (2008)
173. Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. (PubMed id 17572665)⁹ Chow C.Y....Meisler M.H. (2007)
174. Human autoantibodies to diacyl-phosphatidylethanolamine recognize a specific set of discrete cytoplasmic domains. (PubMed id 16487257)⁹ Laurino C.C....Andrade L.E. (2006)
175. Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. (PubMed id 16754800)⁹ Morita H....Benjamin E.J. (2006)
176. Familial X-linked cardiomyopathy (Danon disease): diagnostic confirmation by mutation analysis of the LAMP2gene. (PubMed id 15889279)⁹ Balmer C....Superti-Furga A. (2005)
177. Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages. (PubMed id 15845527)⁹ Santic M....Abu Kwaik Y. (2005)
178. Regulation of the vasopressin V2 receptor by vasopressin in polarized renal collecting duct cells. (PubMed id 15469988)⁹ Robben J.H....Deen P.M. (2004)
179. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. (PubMed id 15051738)⁹ Peden A.A....Klumperman J. (2004)
180. A novel form of autophagic vacuolar myopathy with late-onset and multiorgan involvement. (PubMed id 12847175)⁹ Kaneda D....Nishino I. (2003)
181. The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells. (PubMed id 11997263)⁹ Li X....Weinman S.A. (2002)
182. Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles. (PubMed id 11837748)⁹ Tsuruta Y....Iwaki T. (2002)

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