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LAMP2 Gene

protein-coding GIFtS: 62

GC0XM119346

lysosomal-associated membrane protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD107b ^¹, ²
LAMP-2 ^³
LAMPB ^², ⁵
LGP110 ^²
OTTHUMP00000023943 ^²
OTTHUMP00000023944 ^²

Descriptions
CD107 antigen-like family member B ^³
CD107b antigen ^³
lysosomal-associated membrane protein 2 ^²
lysosome-associated membrane protein 2 ^²

External Ids
HGNC: 6501¹
Entrez Gene: 3920²
UniProtKB: P13473³
Ensembl: ENSG00000005893⁷

Search outside databases for aliases for LAMP2 gene

Previous GC identifers: GC0XM114382 GC0XM116550 GC0XM117540 GC0XM118318

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMP2:

The protein encoded by this gene is a member of a family of membrane glycoproteins. This

glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell

metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome.

Alternative splicing of this gene results in multiple transcript variants encoding distinct

proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473

Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane

from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed

on the cell surface (plasma membrane), and inter- and intracellular signal transduction

Gene Wiki entry for LAMP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMP2 gene

Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24-q25

LAMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM119346: (about GC identifiers)

Start:	119,446,367 bp from pter
End:	119,487,189 bp from pter
Size:	40,823 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473 (See protein sequence)

Recommended Name: Lysosome-associated membrane glycoprotein 2 precursor

Size: 410 amino acids; 44961 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane;

Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane

Secondary accessions: Q16641 Q96J30 Q99534

Alternative splicing: 2 isoforms: P13473-1 P13473-2

Post-translational modifications:

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans¹

REFSEQ proteins (3 alternative transcripts):

NP_001116078.1 NP_002285.1 NP_054701.1

ENSEMBL proteins:

ENSP00000360386 ENSP00000200639 ENSP00000360396

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LAMP2a, LAMP2b, LAMP2)
	Human Recombinant Proteins from Abnova (LAMP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IDA	15297306
GO:0005765	lysosomal membrane	IDA	15297306
GO:0005770	late endosome	IDA	15229288
GO:0005886	plasma membrane	IEA	--
GO:0010008	endosome membrane	IEA	--

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Antibodies for LAMP2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LAMP2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LAMP2a, LAMP2b, LAMP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAMP2)
	Novus Biologicals Antibodies for LAMP2

Assays for LAMP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13473

ProtoNet protein and cluster: P13473

1 Blocks protein family: IPB002000 Lysosome-associated membrane glycoprotein (Lamp)/CD68

UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473

Similarity: Belongs to the LAMP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_013995

Applied Biosystems Silencer® siRNAs for LAMP2

Sigma-Aldrich siRNA and siRNA Panels for LAMP2

Sigma-Aldrich shRNA for LAMP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LAMP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001122606
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001122606
untagged cDNA clones in CMV expression vector (see all 3): NM_001122606

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001122606

UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473

Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane

from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed

on the cell surface (plasma membrane), and inter- and intracellular signal transduction

Genatlas biochemistry entry for LAMP2:

lysosomal associated membrane protein 2

14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamp2):

	cellular	craniofacial	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	muscle
nervous system	reproductive system	skeleton	touch/vibrissae

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for LAMP2

5/17 Interacting proteins for LAMP2 (ENSP00000360396³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD63	ENSP00000257857³	STRING (score=.93)
GAA	ENSP00000305692³	STRING (score=.897)
FIG4	ENSP00000230124³	STRING (score=.861)
SCARB2	ENSP00000264896³	STRING (score=.835)
PRKAG2	ENSP00000287878³	STRING (score=.828)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005977	glycogen metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMP2
6 Novoseek chemical compound relationships for LAMP2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose 6-phosphate	56.73	2	1845800 (1), 11404461 (1)
n-acetyllactosamine	54.04	3	2243102 (1), 2243101 (1)
glycogen	51.54	6	11552028 (1), 15907287 (1), 17642461 (1), 18691923 (1) (see all 5)
dextran	12.30	1	11067894 (1)
sucrose	3.52	2	1845800 (1), 1520873 (1)
cholesterol	0.00	2	10666334 (1), 11032830 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_013995

Sigma-Aldrich siRNA and siRNA Panels for LAMP2

Sigma-Aldrich shRNA for LAMP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001122606 NM_002294 NM_013995

REFSEQ mRNAs for LAMP2 gene (3 alternative transcripts):

NM_001122606.1 NM_002294.2 NM_013995.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001122606 NM_002294 NM_013995

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001122606
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001122606
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001122606

Additional cDNA sequence:

AK126232.1 AK291090.1 AK293931.1 AK295038.1 AK304405.1 AY561849.1 BC002965.1 BC040653.2

BX648255.1 CR606114.1 CR607757.1 CR616621.1 J04183.1 S79873.1 U36336.1 X77196.1

24/50 DOTS entries (see all 50 ):

DT.92457710 DT.95371837 DT.95371865 DT.314812 DT.121318838 DT.120007 DT.100673206 DT.92457699

DT.121318831 DT.95215613 DT.95371856 DT.121318841 DT.92457712 DT.121318801 DT.95371845 DT.100033580

DT.121318813 DT.121318819 DT.100858615 DT.100886554 DT.91744068 DT.121318774 DT.100733496 DT.121318814

24/809 AceView cDNA sequences (see all 809 ):

BG109715 BU674076 AA707470 AI379418 BE894736 AW027976 CD370599 BQ721319

AI221464 BM784356 AA788977 AA598735 AA909130 AI911152 BM667236 AI422766

AI767340 BU181960 CB157104 AA148755 Z39048 BM967103 AI753952 BG169056

highest scoring ESTs for LAMP2:

U36336 AA569228 BE302726 BG702350 BG771468 BI668152 R13247 R14336 R31719 AA148995

Unigene Cluster for LAMP2:

Lysosomal-associated membrane protein 2

Hs.496684 [show with all ESTs]

Unigene Representative Sequence: NM_002294

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for LAMP2 (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	^	9	^	10a	·
SP1:																									-
SP2:																									-
SP3:
SP4:																					-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:																	-		-		-		-		-		-		-		-		-		-		-

ExUns:	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13
SP1:			-		-
SP2:			-		-		-		-		-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LAMP2

3 Ensembl transcripts including schematic representations:

ENST00000371335 ENST00000200639 ENST00000371345

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LAMP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMP2

¹ / ² / ³

11 probe-sets matching LAMP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38402_at²^{, 3}	U95-A	1	1.00	1.00	0.50	0.93	U36336	1.00	0.87	0.94	1
50235_at²^{, 3}	U95-B	1	1.00	1.00	0.89	1.14	AA207254	0.60	0.78	0.69	1
38403_at²^{, 3}	U95-A	1	1.00	1.00	0.77	0.95	X77196	0.80	0.83	0.82	1
203041_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J04183	0.80	0.83	0.82	1
226671_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI150000	0.40	0.67	0.55	1
203042_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002294	0.60	0.78	0.69	1
200821_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013995	0.60	0.78	0.69	1
203041_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226671_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203042_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200821_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMP2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCATTATAA

SOURCE GeneReport for Unigene cluster: Hs.496684
Expression variation in blood from EXPOLDB for LAMP2
UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473
Tissue specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney
and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal
muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for LAMP2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMP2¹	--	lysosomal-associated membrane protein 2	87.8(n) 84.39(a)	481037 XM_859449.1 XP_864542.1
cow (Bos taurus)	LAMP2¹	--	lysosomal-associated membrane protein 2	86.77(n) 82.88(a)	529148 NM_001034570.1 NP_001029742.1
rat (Rattus norvegicus)	Lamp2¹	--	lysosomal-associated membrane protein 2	74.73(n) 63.34(a)	24944 NM_017068.2 NP_058764.2
mouse (Mus musculus)	Lamp2^{1, 5}	X (13.00 cM)⁵	lysosomal-associated membrane protein 2^{1, 5}	78.88(n)¹ 67.08(a)¹	16784¹ NM_010685.3¹ NP_034815.2¹ AK012149⁵ AK032974⁵ (see all 27)
chicken (Gallus gallus)	LAMP2¹	--	lysosomal-associated membrane protein 2	59.95(n) 50.63(a)	414800 NM_001001749.1 NP_001001749.1

About this table Species with no ortholog for LAMP2

ENSEMBL Gene Tree for LAMP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMP2 gene

LAMP1² LAMP3² CD68²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/193 NCBI SNPs in LAMP2 are shown (see all 193 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2748^1,2	A,C,F,H,O	119444168(+)	`AACTTT/CAGTTA`	2	--	ut3¹		5	MN EU EA WA	606
	rs42889^1,2	A,C,F,H,O	119455569(+)	`CATAAC/TGAATA`	2	--	int¹ ut3¹		10	EA NA EU WA	808
	rs10127182^1,2	A,C,F,H	119446746(+)	`GAGAAT/CTGCGC`	1	--	ut3¹		8	EU EA WA	626
	rs5957387^1,2	A,C,F,H	119455582(+)	`AACAAC/TGAAAG`	2	--	int¹ ut3¹		4	EU EA WA	418
	rs14410^1,2	A,C,F,H	119455101(-)	`TTTTCT/CGTCAC`	2	--	int¹ ut3¹ ese³		5	MN EU EA WA	602
	rs10127185^1,2	A,C,F,H	119446811(+)	`AGCCAT/CCATCT`	1	--	ut3¹		7	NA EU EA WA	520
	rs5910887^1,2	A,C,F,H	119454167(+)	`aggttG/Aatctt`	2	--	ng5¹ int¹		4	EU EA WA	418
	rs1045953^1,2	A,C,F,H	119444535(-)	`ATAAAC/TTGGAA`	2	--	ut3¹		7	MN NA EU EA	572
	rs5957383^1,2	A,C,F,H	119448720(+)	`TCTGAT/CGGGCA`	1	--	ut3¹		8	EU EA WA NA	601
--	rs8160^1,2	A,C,F,H	119448909(-)	`CTTGAA/CGTATG`	1	--	ut3¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for LAMP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 309060 disorders: 300257

UniProtKB/Swiss-Prot: LAMP2_HUMAN, P13473

Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as

glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease

characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation.

It is often associated with an accumulation of glycogen in muscle and lysosomes

10/16 Novoseek disease relationships for LAMP2 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
danon disease	98.63	43	18282207 (4), 11427988 (3), 18004770 (2), 16217705 (2) (see all 27)
myopathy	75.67	17	16565504 (2), 15907287 (2), 18376150 (1), 15889279 (1) (see all 11)
lysosomal acid phosphatase	74.60	2	9746610 (1), 8370478 (1)
glycogen storage disease	69.98	3	11552028 (1), 18691923 (1), 16973206 (1)
pompe disease	68.19	1	15673802 (1)
hermansky-pudlak syndrome	64.43	1	8743190 (1)
cardiomyopathy	63.94	11	19318653 (4), 18376150 (1), 15907287 (1), 15889279 (1) (see all 8)
protein deficiency	53.17	8	16565504 (3), 18393115 (1), 15907287 (1)
mental retardation	50.73	4	16565504 (1), 18004770 (1), 15907287 (1), 16217705 (1)
dilated cardiomyopathy	45.26	1	17541230 (1)

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1 PharmGKB disease relationship for LAMP2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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Human Gene Mutation Database: LAMP2
Human Genome Epidemiology Navigator: LAMP2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/148 PubMed articles for LAMP2 gene (see all 148 ):

Glycogen storage diseases presenting as hypertrophic cardiomyopathy. (PubMed id 15673802)^{1, 3, 4} Arad M....Seidman J.G. (2005)
Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. (PubMed id 15907287)^{1, 3, 4} Musumeci O.... Toscano A. (2005)
The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)^{1, 3, 4} Carlsson S.R. and Fukuda M. (1990)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{3, 4} Zhang H.... Aebersold R. (2003)
An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner. (PubMed id 7488019)^{3, 4} Konecki D.S....Lichter-Konecki U. (1995)
Complete cDNA sequence of human lysosome-associated membrane protein- 2. (PubMed id 7999007)^{3, 4} Konecki D.S.... Lichter-Konecki U. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3920	HGNC: 6501	AceView: LAMP2	Ensembl:ENSG00000005893	euGenes: HUgn3920
ECgene: LAMP2	H-InvDB: LAMP2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LAMP2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=LAMP2

Licensable Technologies for LAMP2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LAMP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAMP2		Antibodies for LAMP2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAMP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LAMP2)
	Antibodies (LAMP2)
	Chimera RNAi (LAMP2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (LAMP2a, LAMP2b, LAMP2)
	Antibodies (LAMP2a, LAMP2b, LAMP2)

Search OriGene for LAMP2

Search Tocris compounds for LAMP2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LAMP2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LAMP2 Gene at Home site.
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LAMP2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for LAMP2

Summaries
for LAMP2

Genomic Location
for LAMP2

Proteins
for LAMP2

Protein Domains/
Families
for LAMP2

Gene Function
for LAMP2

Pathways & Interactions
for LAMP2

Drugs & Compounds
for LAMP2

Transcripts
for LAMP2

Expression
for LAMP2

Orthologs
for LAMP2

Paralogs
for LAMP2

SNPs/Variants
for LAMP2

Disorders & Mutations
for LAMP2

Medical News
for LAMP2

Publications
for LAMP2

Search for LAMP2

Genome Databases showing LAMP2

Other Databases showing LAMP2

Specialized Databases showing LAMP2

Licensable Technologies
for LAMP2

Services
for LAMP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMP2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor LAMP2

Summariesfor LAMP2

Genomic Locationfor LAMP2

Proteinsfor LAMP2

Protein Domains/Familiesfor LAMP2

Gene Functionfor LAMP2

Pathways & Interactionsfor LAMP2

Drugs & Compoundsfor LAMP2

Transcriptsfor LAMP2

Expression for LAMP2

Orthologsfor LAMP2

Paralogsfor LAMP2

SNPs/Variantsfor LAMP2

Disorders & Mutationsfor LAMP2

Medical Newsfor LAMP2

Publicationsfor LAMP2

Search for LAMP2

Genome Databases showing LAMP2

Other Databases showing LAMP2

Specialized Databases showing LAMP2

Licensable Technologiesfor LAMP2

Servicesfor LAMP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMP2

Summaries
for LAMP2

Genomic Location
for LAMP2

Proteins
for LAMP2

Protein Domains/
Families
for LAMP2

Gene Function
for LAMP2

Pathways & Interactions
for LAMP2

Drugs & Compounds
for LAMP2

Transcripts
for LAMP2

Expression
for LAMP2

Orthologs
for LAMP2

Paralogs
for LAMP2

SNPs/Variants
for LAMP2

Disorders & Mutations
for LAMP2

Medical News
for LAMP2

Publications
for LAMP2

Licensable Technologies
for LAMP2

Services
for LAMP2