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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAMP1 Gene

protein-coding GIFtS: 65
GCID: GC13P113951

lysosomal-associated membrane protein 1

Explore 46 diseases affiliated with
LAMP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysosomal-Associated Membrane Protein 1¹ ²		LAMPA²
CD107a¹ ²		LGP120²
Lysosome-Associated Membrane Protein 1² ³		Lysosome-Associated Membrane Glycoprotein 1²
LAMP-1² ³		CD107a Antigen³
CD107 Antigen-Like Family Member A² ³

External Ids:	HGNC: 6499¹	Entrez Gene: 3916²	Ensembl: ENSG00000185896⁷	OMIM: 153330⁵	UniProtKB: P11279³

Export aliases for LAMP1 gene to outside databases

Previous GC identifers: GC13P112561 GC13P108588 GC13P113038 GC13P111899 GC13P112999 GC13P094391

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAMP1:

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides

selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279

Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

Gene Wiki entry for LAMP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_027140.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAMP1 gene promoter:
Max1 N-Myc USF1 S8 USF-1 USF2 USF-1:USF-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMP1 promoter sequence

Search SABiosciences Chromatin IP Primers for LAMP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

LAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMP1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P113951: view genomic region (about GC identifiers)

Start:	113,951,469 bp from pter	End:	113,977,987 bp from pter
Size:	26,519 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279 (See protein sequence)

Recommended Name: Lysosome-associated membrane glycoprotein 1 precursor

Size: 417 amino acids; 44882 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I

membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles

between lysosomes, endosomes, and the plasma membrane. Co-localizes with OSBPL1A at the late endosome

Secondary accessions: Q8WU33 Q96I40 Q9BRD2 Q9NP13

Explore the universe of human proteins at neXtProt for LAMP1: NX_P11279

Post-translational modifications:

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11279

LAMP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005552.3

ENSEMBL proteins:

ENSP00000333298 ENSP00000415354

Human Recombinant Protein Products for LAMP1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals LAMP1 Proteins Novus Biologicals LAMP1 Lysates
	Sino Biological Recombinant Protein for LAMP1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LAMP1

Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005764	colocalizes with lysosome	IDA	15613468
GO:0005765	lysosomal membrane	IEA	--
GO:0005768	endosome	--	--
GO:0005770	late endosome	IDA	18388320

LAMP1 for ontologies About GeneDecksing

LAMP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMP1
	R&D Systems Antibodies for LAMP1 (LAMP1/CD107a)
	Cell Signaling Technology (CST) Antibodies for LAMP1
	OriGene Antibodies (see all 2): LAMP1 OriGene Custom Antibody Services for LAMP1
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	Novus Biologicals LAMP1 Antibodies
	Abcam antibodies for LAMP1
	Uscn Antibodies for LAMP1
	ThermoFisher Antibody for LAMP1

Assay Products for LAMP1:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for LAMP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LAMP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAMP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR018134 LAMP_CS

IPR002000 Lysosome-assoc_membr_glycop

Graphical View of Domain Structure for InterPro Entry P11279

ProtoNet protein and cluster: P11279

1 Blocks protein family: IPB002000 Lysosome-associated membrane glycoprotein (Lamp)/CD68

UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279

Similarity: Belongs to the LAMP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LAMP1_HUMAN, P11279

Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

Genatlas biochemistry entry for LAMP1:

lysosomal associated membrane protein 1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

LAMP1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for LAMP1:

Increased S DNA content

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamp1):

cellular	craniofacial	integument	mortality/aging	nervous system
normal	skeleton

LAMP1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Lamp1^tm1Psa for LAMP1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LAMP1

miRNA Products:		OriGene 3'-UTR Clone: LAMP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMP1
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMP1 (see all 27):
		hsa-miR-21* hsa-miR-320a hsa-miR-3130-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-9 hsa-miR-204 hsa-let-7g*

		SwitchGear 3'UTR luciferase reporter plasmid: LAMP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMP1 (see all 7) OriGene shRNA RFP: LAMP1 OriGene siRNA: LAMP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against LAMP1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LAMP1
			Sirion Biotech Customized adenovirus for overexpression of LAMP1 Sirion Biotech Customized adenovirus for potent knockdown of LAMP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMP1 (NM_005561)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LAMP1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Protein Stability

Protein Stability

1.00

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Senescence and Autophagy

Senescence and Autophagy

1.00

Tuberculosis

Tuberculosis

1.00

Lysosome

Lysosome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for LAMP1

	Cytoskeletal Signaling
	Protein Stability

1 BioSystems Pathway for LAMP1

Senescence and Autophagy

3 Kegg Pathways (Kegg details for LAMP1):

	Lysosome
	Phagosome
	Tuberculosis

LAMP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LAMP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/27 Interacting proteins for LAMP1 (P11279^{2, 3} ENSP00000333298⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SUMF1	Q8NBK3²^,³, ENSP00000272902⁴	MINT-4793837 I2D: score=1 STRING: ENSP00000272902
GBA	P04062²^,³, ENSP00000314508⁴	MINT-7555398 MINT-7555338 MINT-7555323 I2D: score=1 STRING: ENSP00000314508
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-8152900 I2D: score=1 STRING: ENSP00000275493
NCSTN	Q92542²^,³, ENSP00000294785⁴	MINT-6174932 I2D: score=1 STRING: ENSP00000294785
TNFAIP3	P21580³, ENSP00000237289⁴	I2D: score=1 STRING: ENSP00000237289

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	IEA	--
GO:0048102	autophagic cell death	IEA	--

LAMP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LAMP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAMP1
10/15 Novoseek chemical compound relationships for LAMP1 gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose 6-phosphate	78.7	12	9531552 (1), 18485117 (1), 8601581 (1), 17959629 (1) (see all 12)
n-acetyllactosamine	53.9	4	2243102 (1), 2243101 (1), 16132574 (1)
dopachrome	48.5	1	15632015 (1)
adp	32.3	3	2211717 (1), 16546241 (1), 18410487 (1)
valsartan	25	1	16368298 (1)
sucrose	20.9	6	10640418 (2), 1845800 (2), 2211717 (1), 1520873 (1)
latex	19.6	1	8077232 (1)
mannose	13.1	1	9099947 (1)
ganglioside	8.69	1	17204262 (1)
calcium	4.39	4	11298650 (3)

Search CenterWatch for drugs/clinical trials and news about LAMP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAMP1 gene:

NM_005561.3

Unigene Cluster for LAMP1:

Lysosomal-associated membrane protein 1

Hs.494419 [show with all ESTs]

Unigene Representative Sequence: NM_005561

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000332556(uc001vtm.1 uc010tka.1) ENST00000472564 ENST00000471046

ENST00000397181

miRNA Products:		OriGene 3'-UTR Clone: LAMP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMP1
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMP1 (see all 27):
		hsa-miR-21* hsa-miR-320a hsa-miR-3130-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-9 hsa-miR-204 hsa-let-7g*

		SwitchGear 3'UTR luciferase reporter plasmid: LAMP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against LAMP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMP1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMP1 (NM_005561)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMP1

Additional cDNA sequence:

AK092398.1 AK301584.1 BC006345.2 BC007845.2 BC021288.2 BC025335.1 BC093044.1 J03263.1

J04182.1

23 DOTS entries:

DT.100879739 DT.455661 DT.97799738 DT.100879721 DT.75173321 DT.100879737 DT.91773622 DT.120770591

DT.120770576 DT.100879733 DT.120770608 DT.100879742 DT.100879720 DT.100879729 DT.91773644 DT.95091380

DT.100879736 DT.120770555 DT.120770619 DT.120770628 DT.95152999 DT.99933095 DT.100039013

24/722 AceView cDNA sequences (see all 722):

CR626636 AA976547 BU931621 BM829763 BQ684034 AW006939 BQ878776 BQ287840

BU844521 BU849686 BQ677083 AL121289 BQ888711 BQ678701 BQ681675 CA415231

BQ683352 BQ878122 CD558279 AW294219 CR613424 AA186612 BU163409 AA494118

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LAMP1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9
SP1:							-																						-
SP2:
SP3:
SP4:							-								-
SP5:							-		-

ECgene alternative splicing isoforms for LAMP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCACACATT

About this image

LAMP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Medulla Oblongata

Brain

Neural Tube

Mesencephalic Floor Plate

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LAMP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMP1

SOURCE GeneReport for Unigene cluster: Hs.494419

SABiosciences Expression via Pathway-Focused PCR Array including LAMP1:

Autophagy in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LAMP1 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LAMP1¹	lysosomal-associated membrane protein 1	58.25(n) 51.52(a)		396220 NM_205283.1 NP_990614.1
lizard (Anolis carolinensis)	Reptilia	LAMP1⁶	--	45(a)	1 ↔ 1	3(106069380-106077417)
zebrafish (Danio rerio)	Actinopterygii	BC064667.1²	--	79.43(n)		324985 BC064667.1
fruit fly (Drosophila melanogaster)	Insecta	Lamp1⁶	Lamp1	25(a)	1 → many	2L(21573389-21577103)

ENSEMBL Gene Tree for LAMP1 (if available)
TreeFam Gene Tree for LAMP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LAMP1 gene

LAMP3² CD68² LAMP2²

1 SIMAP similar gene for LAMP1 using alignment to 2 protein entries: LAMP1_HUMAN (see all proteins):

LAMP2

LAMP1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for LAMP1
PGOHUM00000239292 PGOHUM00000235096 PGOHUM00000241693

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs41286622^1,2		--	94416839(+)	`GCAGGA/GAGAGC`	1	--	ds500¹		0	--	--	--	--
rs71101564^1,2	C	--	113950932(+)	`ACCTTCACCTTC ACCTT/-GGGCA`	1	--	us2k¹		1		NA	2
rs9549734^1,2	A	--	113955959(+)	`aaaaaA/Tatata`	1	--	int¹ trp³		0	--	--	--	--
rs73582827^1,2	C	--	113970144(+)	`TGGGCA/GCGGTG`	1	--	int¹		4		CSA WA EA	240
rs114458385^1,2	F	--	113970145(+)	`GGGCAC/TGGTGG`	1	--	int¹		1		WA	118
rs140268305^1,2		--	113970146(+)	`GGCACA/GGTGGC`	1	--	int¹		0	--	--	--	--
rs11358802^1,2	C	--	113970737(+)	`TTTTT-/TTTTTT`	1	--	int¹ trp³		1		NA	2
rs9577509^1,2	H	--	113978046(+)	`GGACAT/CGGATA`	1	--	int¹		5		NS EA	540
rs200969821^1,2	--	--	113956010(+)	`TATTT-/ACACACA`	1	--	int¹		0	--	--	--	--
rs200750375^1,2	--	--	113956010(+)	`TATTTA/TCACAC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LAMP1 (113951469 - 113977987 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LAMP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAMP1

DNA2.0 Custom Variant and Variant Library Synthesis for LAMP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LAMP1 for disorders           About GeneDecksing

OMIM gene information: 153330    OMIM disorders: --

20/46 diseases for LAMP1 (see all 46):    About MalaCards

chediak-higashi syndrome hermansky-pudlak syndrome hemophagocytic lymphohistiocytosis arc syndrome

salla disease primary biliary cirrhosis gaucher's disease danon disease

pilocytic astrocytoma systemic lupus erythematosus tularemia lupus erythematosus

batten disease retinitis pigmentosa arthrogryposis cystic fibrosis

ovarian carcinoma embryonal carcinoma alzheimer's disease hemangioma

2 diseases from the University of Copenhagen DISEASES database for LAMP1:

Chediak-Higashi syndrome Lysosomal storage disease

10/17 Novoseek disease relationships for LAMP1 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysosomal acid phosphatase	69.1	2	8370478 (1), 15469932 (1)
melanoma amelanotic	42	1	7886004 (1)
melanoma	29.5	6	9877101 (1), 8020595 (1), 17600626 (1), 7886004 (1) (see all 5)
gaucher disease	22.3	1	11825063 (1)
senile plaques	16.1	1	16972884 (1)
papilloma	15.9	1	8548765 (1)
tuberculosis	13.9	9	16495533 (2), 16200349 (1), 7807006 (1), 9497492 (1) (see all 6)
shock	0	2	16200349 (1), 12960321 (1)
inflammation	0	2	19206459 (1)
ovarian carcinoma	0	4	8077232 (2), 8347196 (1)

Genetic Association Database (GAD): LAMP1

Export disorders for LAMP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LAMP1 gene, integrated from 9 sources (see all 247):
(articles sorted by number of sources associating them with LAMP1)

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The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. (PubMed id 8517882)^{1, 2, 9} Sawada R.... Fukuda M. (1993)
The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)^{1, 2, 9} Carlsson S.R. and Fukuda M. (1990)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{1, 2} Zhang H.... Aebersold R. (2003)
Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. (PubMed id 8323299)^{1, 2} Carlsson S.R.... Fukuda M. (1993)
Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement. (PubMed id 2584229)^{1, 2} Carlsson S.R. and Fukuda M. (1989)
Purification and characterization of human lysosomal membrane glycoproteins. (PubMed id 2912382)^{1, 2} Mane S.M.... August J.T. (1989)
Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h- lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. (PubMed id 3198605)^{1, 2} Fukuda M.... Carlsson S.R. (1988)
Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000. (PubMed id 3131762)^{1, 2} Viitala J.... Fukuda M. (1988)
Relationship between CD107a expression and cytotoxic activity. (PubMed id 18835598)^{1, 9} Aktas E....Deniz G. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3916	HGNC: 6499	AceView: LAMP1	Ensembl:ENSG00000185896	euGenes: HUgn3916
ECgene: LAMP1	Kegg: 3916	H-InvDB: LAMP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LAMP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LAMP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LAMP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LAMP1 gene:
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lysosomal-associated membrane protein 1

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LAMP1 Gene

lysosomal-associated membrane protein 1

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