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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAMP1 Gene

protein-coding   GIFtS: 66
GCID: GC13P113951

Lysosomal-Associated Membrane Protein 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysosomal-Associated Membrane Protein 11 2     LAMPA2
Lysosome-Associated Membrane Protein 12 3     LGP1202
LAMP-12 3     Lysosome-Associated Membrane Glycoprotein 12
CD107 Antigen-Like Family Member A2 3     CD107a Antigen3
CD107a2     

External Ids:    HGNC: 64991   Entrez Gene: 39162   Ensembl: ENSG000001858967   OMIM: 1533305   UniProtKB: P112793   

Export aliases for LAMP1 gene to outside databases

Previous GC identifers: GC13P112561 GC13P108588 GC13P113038 GC13P111899 GC13P112999 GC13P094391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAMP1 Gene:
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides
selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. (provided by RefSeq, Jul
2008)

GeneCards Summary for LAMP1 Gene: 
LAMP1 (lysosomal-associated membrane protein 1) is a protein-coding gene. Diseases associated with LAMP1 include arc syndrome, and salla disease. An important paralog of this gene is LAMP3.

UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279
Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

Gene Wiki entry for LAMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_027140.6  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAMP1 gene promoter:
         Max1   N-Myc   USF1   S8   USF-1   USF2   USF-1:USF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

LAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMP1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113951:  view genomic region     (about GC identifiers)

Start:
113,951,469 bp from pter      End:
113,977,987 bp from pter
Size:
26,519 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279 (See protein sequence)
Recommended Name: Lysosome-associated membrane glycoprotein 1 precursor  
Size: 417 amino acids; 44882 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein
shuttles between lysosomes, endosomes, and the plasma membrane. Co-localizes with OSBPL1A at the late endosome
Secondary accessions: Q8WU33 Q96I40 Q9BRD2 Q9NP13

Explore the universe of human proteins at neXtProt for LAMP1: NX_P11279

Explore proteomics data for LAMP1 at MOPED 

Post-translational modifications:

  • UniProtKB: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11279

  • LAMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LAMP1 Protein Expression
    REFSEQ proteins: NP_005552.3  
    ENSEMBL proteins: 
     ENSP00000333298   ENSP00000415354  

    Human Recombinant Protein Products for LAMP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LAMP1 (LAMP1/CD107a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LAMP1
    OriGene Protein Over-expression Lysate for LAMP1
    OriGene MassSpec for LAMP1 
    OriGene Custom Protein Services for LAMP1
    GenScript Custom Purified and Recombinant Proteins Services for LAMP1
    Novus Biologicals LAMP1 Proteins
    Novus Biologicals LAMP1 Lysates
    Sino Biological Recombinant Protein for LAMP1
    Sino Biological Cell Lysate for LAMP1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LAMP1 

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764colocalizes with lysosome IDA15613468
    GO:0005765lysosomal membrane IEA--
    GO:0005768endosome ----
    GO:0005770late endosome IDA15052268
    GO:0005771multivesicular body IEA--

    LAMP1 for ontologies           About GeneDecksing



    LAMP1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMP1
    R&D Systems Antibodies for LAMP1 (LAMP1/CD107a)
    Cell Signaling Technology (CST) Antibodies for LAMP1 
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    OriGene Custom Antibody Services for LAMP1
    GenScript Custom Superior Antibodies Services for LAMP1
    Novus Biologicals LAMP1 Antibodies
    Abcam antibodies for LAMP1
    Cloud-Clone Corp. Antibodies for LAMP1 
    ThermoFisher Antibody for LAMP1
    LSBio Antibodies in human, mouse, rat for LAMP1 

    Assay Products for LAMP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LAMP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LAMP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LAMP1 
    Cloud-Clone Corp. CLIAs for LAMP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    2 InterPro protein domains:
     IPR018134 LAMP_CS
     IPR002000 Lysosome-assoc_membr_glycop

    Graphical View of Domain Structure for InterPro Entry P11279

    ProtoNet protein and cluster: P11279

    1 Blocks protein domain: IPB002000 Lysosome-associated membrane glycoprotein (Lamp)/CD68

    UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279
    Similarity: Belongs to the LAMP family


    LAMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMP1_HUMAN, P11279
    Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

         Genatlas biochemistry entry for LAMP1:
    lysosomal associated membrane protein 1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    LAMP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LAMP1:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lamp1):
     cellular  craniofacial  integument  mortality/aging  nervous system 
     normal  skeleton 

    LAMP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lamp1tm1Psa for LAMP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LAMP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAMP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAMP1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMP1
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMP1 (see all 27):
    hsa-miR-21* hsa-miR-320a hsa-miR-3130-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-9 hsa-miR-204 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidLAMP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LAMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMP1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LAMP1
    Sirion Biotech Customized adenovirus for overexpression of LAMP1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LAMP1 (see all 9)
    OriGene ORF clones in mouse, rat for LAMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMP1 (NM_005561)
    Sino Biological Human cDNA Clone for LAMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP1
    Sirion Biotech Customized lentivirus for stable overexpression of LAMP1 
                         Customized lentivirus expression plasmids for stable overexpression of LAMP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for LAMP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LAMP1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Tuberculosis
    Tuberculosis
    2Senescence and Autophagy
    Senescence and Autophagy
    3Protein Stability
    Protein Stability
    4Lysosome
    Lysosome
    5Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for LAMP1
        Cytoskeletal Signaling
    Protein Stability

    1 BioSystems Pathway for LAMP1
        Senescence and Autophagy



    3         Kegg Pathways  (Kegg details for LAMP1):
        Lysosome
    Phagosome
    Tuberculosis


    LAMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LAMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/27 Interacting proteins for LAMP1 (P112792, 3 ENSP000003332984) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMF1Q8NBK32, 3, ENSP000002729024MINT-4793837 I2D: score=1 STRING: ENSP00000272902
    GBAP040622, 3, ENSP000003145084MINT-7555398 MINT-7555338 MINT-7555323 I2D: score=1 STRING: ENSP00000314508
    EGFRP005332, 3, ENSP000002754934MINT-8152900 I2D: score=1 STRING: ENSP00000275493
    NCSTNQ925422, 3, ENSP000002947854MINT-6174932 I2D: score=1 STRING: ENSP00000294785
    TNFAIP3P215803, ENSP000002372894I2D: score=1 STRING: ENSP00000237289
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0048102autophagic cell death IEA--

    LAMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LAMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAMP1

    10/15 Novoseek inferred chemical compound relationships for LAMP1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 78.7 12 9531552 (1), 18485117 (1), 8601581 (1), 17959629 (1) (see all 12)
    n-acetyllactosamine 53.9 4 2243102 (1), 2243101 (1), 16132574 (1)
    dopachrome 48.5 1 15632015 (1)
    adp 32.3 3 2211717 (1), 16546241 (1), 18410487 (1)
    valsartan 25 1 16368298 (1)
    sucrose 20.9 6 10640418 (2), 1845800 (2), 2211717 (1), 1520873 (1)
    latex 19.6 1 8077232 (1)
    mannose 13.1 1 9099947 (1)
    ganglioside 8.69 1 17204262 (1)
    calcium 4.39 4 11298650 (3)

    Search CenterWatch for drugs/clinical trials and news about LAMP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAMP1 gene: 
    NM_005561.3  

    Unigene Cluster for LAMP1:

    Lysosomal-associated membrane protein 1
    Hs.494419  [show with all ESTs]
    Unigene Representative Sequence: NM_005561
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332556(uc001vtm.1 uc010tka.1) ENST00000472564 ENST00000471046
    ENST00000397181
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMP1
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMP1 (see all 27):
    hsa-miR-21* hsa-miR-320a hsa-miR-3130-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-9 hsa-miR-204 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidLAMP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LAMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMP1
    Clone
    Products:
         
    OriGene clones in human, mouse for LAMP1 (see all 9)
    OriGene ORF clones in mouse, rat for LAMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMP1 (NM_005561)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP1
    Sirion Biotech Customized lentivirus for stable overexpression of LAMP1 
                         Customized lentivirus expression plasmids for stable overexpression of LAMP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LAMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LAMP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMP1

    Additional mRNA sequence: 

    AK092398.1 AK301584.1 BC006345.2 BC007845.2 BC021288.2 BC025335.1 BC093044.1 J03263.1 
    J04182.1 

    22 DOTS entries:

    DT.100879739  DT.455661  DT.97799738  DT.100879721  DT.75173321  DT.100879737  DT.91773622  DT.120770591 
    DT.100879733  DT.120770576  DT.120770608  DT.100879742  DT.100879720  DT.91773644  DT.95091380  DT.100879729 
    DT.100879736  DT.120770555  DT.120770619  DT.120770628  DT.95152999  DT.100039013 

    24/722 AceView cDNA sequences (see all 722):

    BQ681891 AI261273 BU838186 AW006939 BU849686 BU931621 BU844521 BQ678701 
    BQ880968 BM829763 BQ878776 AW471177 CR598041 CA415231 BQ683352 BQ888711 
    CR626636 AA186612 CR593667 BE872172 CD243638 BQ677099 AA976547 CR613424 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LAMP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                    -                                                                 -         
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                    -                       -                                                   
    SP5:                    -     -                                                                     


    ECgene alternative splicing isoforms for LAMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAMP1 expression in normal human tissues (normalized intensities)      LAMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACACATT
    LAMP1 Expression
    About this image


    LAMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See LAMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAMP1

    SOURCE GeneReport for Unigene cluster: Hs.494419
        SABiosciences Expression via Pathway-Focused PCR Array including LAMP1: 
              Autophagy in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LAMP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lamp11 , 5 lysosomal-associated membrane protein 11, 5 74.71(n)1
    69.46(a)1
      8 (5.73 cM)5
    167831  NM_010684.21  NP_034814.21 
     131591355 
    chicken
    (Gallus gallus)
    Aves LAMP11 lysosomal-associated membrane protein 1 58.25(n)
    51.52(a)
      396220  NM_205283.1  NP_990614.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMP16
    lysosomal-associated membrane protein 1
    46(a)
    1 ↔ 1
    3(106059663-106077417)
    zebrafish
    (Danio rerio)
    Actinopterygii BC064667.12   -- 79.43(n)   324985  BC064667.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lamp16
    Lamp1
    22(a)
    1 → many
    2L(21573389-21577103)


    ENSEMBL Gene Tree for LAMP1 (if available)
    TreeFam Gene Tree for LAMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAMP1 gene
    LAMP32  CD682  LAMP22  
    1 SIMAP similar gene for LAMP1 using alignment to 2 protein entries:     LAMP1_HUMAN (see all proteins):
    LAMP2

    LAMP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for LAMP1
    PGOHUM00000239292 PGOHUM00000235096 PGOHUM00000241693


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 SNPs in LAMP1 are shown (see all 693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726652521,2
    C,F--94388434(+) TACTTC/ATAGCC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs726652531,2
    C--94388435(+) ACTTCG/TAGCCT 1 -- us2k10--------
    rs1478498421,2
    --94388471(+) GTCCCC/TGAATT 1 -- us2k10--------
    rs1488910791,2
    --94388477(+) GAATTG/TAAACC 1 -- us2k10--------
    rs1486419771,2
    C--94388486(+) CCTCC-/AGAGTTT 1 -- us2k10--------
    rs1436074581,2
    --94388510(+) TCATTA/CCACTG 1 -- us2k10--------
    rs1997152561,2
    --94388544(+) TTCTT-/TCTCTCT 1 -- us2k10--------
    rs1420989961,2
    C--94388548(+) TTCTC-/TCTT  
            
    TATTA
    1 -- us2k10--------
    rs95774961,2
    C,F,A--94388645(+) TGAGAG/AGCCTC 1 -- us2k12Minor allele frequency- A:0.15WA EA 238
    rs95493801,2
    C,F,A,H--94388652(+) CCTCAG/ATTCAG 1 -- us2k110Minor allele frequency- A:0.19NS NA WA EA 484

    HapMap Linkage Disequilibrium report for LAMP1 (113951469 - 113977987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LAMP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748273CNV Deletion23290073
    nsv509521CNV Insertion20534489
    dgv1802n71CNV Loss21882294
    nsv901049CNV Loss21882294
    nsv901039CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153330    OMIM disorders: --

    20/40 diseases for LAMP1 (see all 40):    About MalaCards
    arc syndrome    salla disease    danon disease    tularemia
    hemophagocytic lymphohistiocytosis    gaucher's disease    chediak-higashi syndrome    hermansky-pudlak syndrome
    batten disease    pilocytic astrocytoma    churg-strauss syndrome    rabies
    lysosomal storage disease    primary biliary cirrhosis    hemangioma    tuberculosis
    vaccinia    papilloma    cholestasis    astrocytoma

    1 disease from the University of Copenhagen DISEASES database for LAMP1:
    Chediak-Higashi syndrome

    LAMP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/17 Novoseek inferred disease relationships for LAMP1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysosomal acid phosphatase 69.1 2 8370478 (1), 15469932 (1)
    melanoma amelanotic 42 1 7886004 (1)
    melanoma 29.5 6 9877101 (1), 8020595 (1), 17600626 (1), 7886004 (1) (see all 5)
    gaucher disease 22.3 1 11825063 (1)
    senile plaques 16.1 1 16972884 (1)
    papilloma 15.9 1 8548765 (1)
    tuberculosis 13.9 9 16495533 (2), 16200349 (1), 7807006 (1), 9497492 (1) (see all 6)
    shock 0 2 16200349 (1), 12960321 (1)
    inflammation 0 2 19206459 (1)
    ovarian carcinoma 0 4 8077232 (2), 8347196 (1)

    Genetic Association Database (GAD): LAMP1

    Export disorders for LAMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAMP1 gene, integrated from 9 sources (see all 254):
    (articles sorted by number of sources associating them with LAMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. (PubMed id 8517882)1, 2, 9 Sawada R.... Fukuda M. (1993)
    2. The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)1, 2, 9 Carlsson S.R. and Fukuda M. (1990)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    5. Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. (PubMed id 8323299)1, 2 Carlsson S.R.... Fukuda M. (1993)
    6. Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement. (PubMed id 2584229)1, 2 Carlsson S.R. and Fukuda M. (1989)
    7. Purification and characterization of human lysosomal membrane glycoproteins. (PubMed id 2912382)1, 2 Mane S.M.... August J.T. (1989)
    8. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h- lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. (PubMed id 3198605)1, 2 Fukuda M.... Carlsson S.R. (1988)
    9. Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000. (PubMed id 3131762)1, 2 Viitala J.... Fukuda M. (1988)
    10. Relationship between CD107a expression and cytotoxic activity. (PubMed id 18835598)1, 9 Aktas E....Deniz G. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3916 HGNC: 6499 AceView: LAMP1 Ensembl:ENSG00000185896 euGenes: HUgn3916
    ECgene: LAMP1 Kegg: 3916 H-InvDB: LAMP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LAMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LAMP1 gene:
    Search GeneIP for patents involving LAMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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