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LAMP1 Gene

protein-coding   GIFtS: 67
GCID: GC13P113951

Lysosomal-Associated Membrane Protein 1

  See LAMP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysosomal-Associated Membrane Protein 11 2     LAMPA2
Lysosome-Associated Membrane Protein 12 3     LGP1202
LAMP-12 3     Lysosome-Associated Membrane Glycoprotein 12
CD107 Antigen-Like Family Member A2 3     CD107a Antigen3
CD107a2     

External Ids:    HGNC: 64991   Entrez Gene: 39162   Ensembl: ENSG000001858967   OMIM: 1533305   UniProtKB: P112793   

Export aliases for LAMP1 gene to outside databases

Previous GC identifers: GC13P112561 GC13P108588 GC13P113038 GC13P111899 GC13P112999 GC13P094391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LAMP1 Gene:
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides
selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. (provided by RefSeq, Jul
2008)

GeneCards Summary for LAMP1 Gene:
LAMP1 (lysosomal-associated membrane protein 1) is a protein-coding gene. Diseases associated with LAMP1 include salla disease, and chediak-higashi syndrome. An important paralog of this gene is LAMP3.

UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279
Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

Gene Wiki entry for LAMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_027140.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAMP1 gene promoter:
         Max1   N-Myc   USF1   S8   USF-1   USF2   USF-1:USF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMP1 promoter sequence
   Search Chromatin IP Primers for LAMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

LAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMP1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113951:  view genomic region     (about GC identifiers)

Start:
113,951,469 bp from pter      End:
113,977,987 bp from pter
Size:
26,519 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279 (See protein sequence)
Recommended Name: Lysosome-associated membrane glycoprotein 1 precursor  
Size: 417 amino acids; 44882 Da
Secondary accessions: Q8WU33 Q96I40 Q9BRD2 Q9NP13

Explore the universe of human proteins at neXtProt for LAMP1: NX_P11279

Explore proteomics data for LAMP1 at MOPED

Post-translational modifications: 

  • O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans1
  • Glycosylation2 at Asn37, Asn45, Asn62, Asn76, Asn84, Asn103, Asn107, Asn121, Asn130, Asn165,
                                 Asn181, Ser197, Thr199, Thr200, Ser207, Ser209, Ser211, Asn223, Asn228, Asn241 (see all 25)
  • Modification sites at PhosphoSitePlus

  • See LAMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005552.3  
    ENSEMBL proteins: 
     ENSP00000333298   ENSP00000415354  

    LAMP1 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LAMP1
    OriGene Protein Over-expression Lysate for LAMP1
    OriGene MassSpec for LAMP1
    OriGene Custom Protein Services for LAMP1
    GenScript Custom Purified and Recombinant Proteins Services for LAMP1
    Novus Biologicals LAMP1 Proteins
    Novus Biologicals LAMP1 Lysates
    Sino Biological Recombinant Protein for LAMP1
    Sino Biological Cell Lysate for LAMP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LAMP1

     
    Search eBioscience for Proteins for LAMP1 

     
    antibodies-online proteins for LAMP1 (13 products) 

     
    antibodies-online peptides for LAMP1

    LAMP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMP1
    R&D Systems Antibodies for LAMP1 (LAMP1/CD107a)
    Cell Signaling Technology (CST) Antibodies for LAMP1 
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    Novus Biologicals LAMP1 Antibodies
    Abcam antibodies for LAMP1
    Cloud-Clone Corp. Antibodies for LAMP1
    ThermoFisher Antibody for LAMP1
    antibodies-online antibodies for LAMP1 (199 products) 

    LAMP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LAMP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LAMP1
    Cloud-Clone Corp. CLIAs for LAMP1
    Search eBioscience for ELISAs for LAMP1 
    antibodies-online kits for LAMP1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR018134 LAMP_CS
     IPR002000 Lysosome-assoc_membr_glycop

    Graphical View of Domain Structure for InterPro Entry P11279

    ProtoNet protein and cluster: P11279

    1 Blocks protein domain: IPB002000 Lysosome-associated membrane glycoprotein (Lamp)/CD68

    UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279
    Similarity: Belongs to the LAMP family


    Find genes that share domains with LAMP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMP1_HUMAN, P11279
    Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

         Genatlas biochemistry entry for LAMP1:
    lysosomal associated membrane protein 1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IPI--
         
    Find genes that share ontologies with LAMP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LAMP1:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lamp1):
     cellular  craniofacial  integument  mortality/aging  nervous system 
     normal  skeleton 

    Find genes that share phenotypes with LAMP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lamp1tm1Psa for LAMP1

       genOway: Develop your customized and physiologically relevant rodent model for LAMP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAMP1:
    hsa-mir-615-3p (MIRT039887), hsa-mir-122-5p (MIRT023236), hsa-mir-378a-3p (MIRT019659), hsa-mir-484 (MIRT041727), hsa-mir-1227-3p (MIRT036408)

    Block miRNA regulation of human, mouse, rat LAMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LAMP1 (see all 27):
    hsa-miR-21* hsa-miR-320a hsa-miR-3130-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-9 hsa-miR-204 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidLAMP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAMP1
    Predesigned siRNA for gene silencing in human, mouse, rat LAMP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LAMP1

    Clone
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    OriGene clones in human, mouse for LAMP1 (see all 8)
    OriGene ORF clones in mouse, rat for LAMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMP1 (NM_005561)
    Sino Biological Human cDNA Clone for LAMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP1
    Addgene plasmids for LAMP1 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12096) for LAMP1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAMP1_HUMAN, P11279: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
    membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein
    shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005764colocalizes with lysosome IDA15613468
    GO:0005765lysosomal membrane IEA--
    GO:0005768endosome ----
    GO:0005770late endosome IDA15052268

    Find genes that share ontologies with LAMP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAMP1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Tuberculosis
    Tuberculosis
    2Senescence and Autophagy
    Senescence and Autophagy
    3Protein Stability
    Protein Stability
    4Phagosome
    Phagosome
    5Lysosome
    Lysosome


    Find genes that share SuperPaths with LAMP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for LAMP1
        Cytoskeletal Signaling
    Protein Stability

    1 BioSystems Pathway for LAMP1
        Senescence and Autophagy



    3 Kegg Pathways  (Kegg details for LAMP1):
        Lysosome
    Phagosome
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Array including LAMP1: 
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LAMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAMP1 (P112791, 2, 3 ENSP000003332984) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMF1Q8NBK32, 3, ENSP000002729024MINT-4793837 I2D: score=1 STRING: ENSP00000272902
    GBAP040622, 3, ENSP000003145084MINT-7555398 MINT-7555338 MINT-7555323 I2D: score=1 STRING: ENSP00000314508
    EGFRP005332, 3, ENSP000002754934MINT-8152900 I2D: score=1 STRING: ENSP00000275493
    NCSTNQ925422, 3, ENSP000002947854MINT-6174932 I2D: score=1 STRING: ENSP00000294785
    TNFAIP3P215803, ENSP000002372894I2D: score=1 STRING: ENSP00000237289
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0008626granzyme-mediated apoptotic signaling pathway IMP--
    GO:0043323positive regulation of natural killer cell degranulation IMP--
    GO:0045954positive regulation of natural killer cell mediated cytotoxicity IMP--
    GO:0048102autophagic cell death IEA--

    Find genes that share ontologies with LAMP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAMP1

    Selected Novoseek inferred chemical compound relationships for LAMP1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 78.7 12 9531552 (1), 18485117 (1), 8601581 (1), 17959629 (1) (see all 12)
    n-acetyllactosamine 53.9 4 2243102 (1), 2243101 (1), 16132574 (1)
    dopachrome 48.5 1 15632015 (1)
    adp 32.3 3 2211717 (1), 16546241 (1), 18410487 (1)
    valsartan 25 1 16368298 (1)
    sucrose 20.9 6 10640418 (2), 1845800 (2), 2211717 (1), 1520873 (1)
    latex 19.6 1 8077232 (1)
    mannose 13.1 1 9099947 (1)
    ganglioside 8.69 1 17204262 (1)
    calcium 4.39 4 11298650 (3)



    Find genes that share compounds with LAMP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAMP1 gene: 
    NM_005561.3  

    Unigene Cluster for LAMP1:

    Lysosomal-associated membrane protein 1
    Hs.494419  [show with all ESTs]
    Unigene Representative Sequence: NM_005561
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332556(uc001vtm.1 uc010tka.1) ENST00000472564 ENST00000471046
    ENST00000397181
    miRNA
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    Block miRNA regulation of human, mouse, rat LAMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LAMP1 (see all 27):
    hsa-miR-21* hsa-miR-320a hsa-miR-3130-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-9 hsa-miR-204 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidLAMP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LAMP1
    Clone
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    GenScript: all cDNA clones in your preferred vector: LAMP1 (NM_005561)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMP1
    Addgene plasmids for LAMP1 
    Primer
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    OriGene qPCR primer pairs and template standards for LAMP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMP1
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      QuantiFast Probe-based Assays in human, mouse, rat LAMP1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12096) for LAMP1 

    Additional mRNA sequence: 

    AK092398.1 AK301584.1 BC006345.2 BC007845.2 BC021288.2 BC025335.1 BC093044.1 J03263.1 
    J04182.1 

    22 DOTS entries:

    DT.100879739  DT.455661  DT.97799738  DT.100879721  DT.75173321  DT.100879737  DT.91773622  DT.120770591 
    DT.100879733  DT.120770576  DT.120770608  DT.100879742  DT.100879720  DT.91773644  DT.95091380  DT.100879729 
    DT.100879736  DT.120770555  DT.120770619  DT.120770628  DT.95152999  DT.100039013 

    Selected AceView cDNA sequences (see all 722):

    BQ684034 BQ287840 BQ684610 BE872172 BQ678701 BU849686 BQ681891 AW471177 
    BX417547 AW006939 BQ681675 BU931621 AI858558 BM829763 BQ878776 AA186612 
    CD558279 BU163409 CR626636 AA976547 CR613424 AL121289 CR598041 AI261273 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LAMP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                    -                                                                 -         
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                    -                       -                                                   
    SP5:                    -     -                                                                     


    ECgene alternative splicing isoforms for LAMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACACATT
    LAMP1 Expression
    About this image


    LAMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Medulla Oblongata
    LAMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAMP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494419
        Pathway & Disease-focused RT2 Profiler PCR Array including LAMP1: 
              Autophagy in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for LAMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMP1
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    QuantiFast Probe-based Assays in human, mouse, rat LAMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LAMP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lamp11 , 5 lysosomal-associated membrane protein 11, 5 73.89(n)1
    67.98(a)1
      8 (5.73 cM)5
    167831  NM_010684.21  NP_034814.21 
     131591355 
    chicken
    (Gallus gallus)
    Aves LAMP11 lysosomal-associated membrane protein 1 57.16(n)
    50.39(a)
      396220  NM_205283.1  NP_990614.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMP16
    lysosomal-associated membrane protein 1
    47(a)
    1 ↔ 1
    3(106059663-106077417)
    zebrafish
    (Danio rerio)
    Actinopterygii BC064667.12   -- 79.43(n)   324985  BC064667.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lamp16
    Lamp1
    29(a)
    1 → many
    2L(21573389-21577103)


    ENSEMBL Gene Tree for LAMP1 (if available)
    TreeFam Gene Tree for LAMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LAMP1 gene
    LAMP32  CD682  LAMP22  
    1 SIMAP similar gene for LAMP1 using alignment to 2 protein entries:     LAMP1_HUMAN (see all proteins):
    LAMP2

    Find genes that share paralogs with LAMP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for LAMP1
    PGOHUM00000239292 PGOHUM00000235096 PGOHUM00000241693


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAMP1 (see all 693)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726652521,2
    C,F--94388434(+) TACTTC/ATAGCC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs726652531,2
    C--94388435(+) ACTTCG/TAGCCT 1 -- us2k10--------
    rs1478498421,2
    --94388471(+) GTCCCC/TGAATT 1 -- us2k10--------
    rs1488910791,2
    --94388477(+) GAATTG/TAAACC 1 -- us2k10--------
    rs1486419771,2
    C--94388486(+) CCTCC-/AGAGTTT 1 -- us2k10--------
    rs1436074581,2
    --94388510(+) TCATTA/CCACTG 1 -- us2k10--------
    rs1997152561,2
    --94388544(+) TTCTT-/TCTCTCT 1 -- us2k10--------
    rs1420989961,2
    C--94388548(+) TTCTC-/TCTT  
            
    TATTA
    1 -- us2k10--------
    rs95774961,2
    C,F,A--94388645(+) TGAGAG/AGCCTC 1 -- us2k12Minor allele frequency- A:0.15WA EA 238
    rs95493801,2
    C,F,A,H--94388652(+) CCTCAG/ATTCAG 1 -- us2k110Minor allele frequency- A:0.19NS NA WA EA 484

    HapMap Linkage Disequilibrium report for LAMP1 (113951469 - 113977987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LAMP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748273CNV Deletion23290073
    nsv509521CNV Insertion20534489
    dgv1802n71CNV Loss21882294
    nsv901049CNV Loss21882294
    nsv901039CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for LAMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153330    OMIM disorders: --

    2 diseases for LAMP1:    
    About MalaCards
    salla disease    chediak-higashi syndrome

    1 disease from the University of Copenhagen DISEASES database for LAMP1:
    Chediak-Higashi syndrome

    Find genes that share disorders with LAMP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LAMP1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysosomal acid phosphatase 69.1 2 8370478 (1), 15469932 (1)
    melanoma amelanotic 42 1 7886004 (1)
    melanoma 29.5 6 9877101 (1), 8020595 (1), 17600626 (1), 7886004 (1) (see all 5)
    gaucher disease 22.3 1 11825063 (1)
    senile plaques 16.1 1 16972884 (1)
    papilloma 15.9 1 8548765 (1)
    tuberculosis 13.9 9 16495533 (2), 16200349 (1), 7807006 (1), 9497492 (1) (see all 6)
    shock 0 2 16200349 (1), 12960321 (1)
    inflammation 0 2 19206459 (1)
    ovarian carcinoma 0 4 8077232 (2), 8347196 (1)

    Genetic Association Database (GAD): LAMP1

    Export disorders for LAMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAMP1 gene, integrated from 10 sources (see all 259):
    (articles sorted by number of sources associating them with LAMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. (PubMed id 8517882)1, 2, 9 Sawada R.... Fukuda M. (J. Biol. Chem. 1993)
    2. The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)1, 2, 9 Carlsson S.R. and Fukuda M. (J. Biol. Chem. 1990)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    5. Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. (PubMed id 8323299)1, 2 Carlsson S.R.... Fukuda M. (Arch. Biochem. Biophys. 1993)
    6. Purification and characterization of human lysosomal membrane glycoproteins. (PubMed id 2912382)1, 2 Mane S.M.... August J.T. (Arch. Biochem. Biophys. 1989)
    7. Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement. (PubMed id 2584229)1, 2 Carlsson S.R. and Fukuda M. (J. Biol. Chem. 1989)
    8. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h- lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. (PubMed id 3198605)1, 2 Fukuda M.... Carlsson S.R. (J. Biol. Chem. 1988)
    9. Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000. (PubMed id 3131762)1, 2 Viitala J.... Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    10. Relationship between CD107a expression and cytotoxic activity. (PubMed id 18835598)1, 9 Aktas E....Deniz G. (Cell. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3916 HGNC: 6499 AceView: LAMP1 Ensembl:ENSG00000185896 euGenes: HUgn3916
    ECgene: LAMP1 Kegg: 3916 H-InvDB: LAMP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LAMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LAMP1 gene:
    Search GeneIP for patents involving LAMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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