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Aliases & Descriptions for LAMP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CD107a 1, 2 | | LAMP-1 3 | | LAMPA 2 | | LGP120 2 | | OTTHUMP00000040663 2 |
| | | Descriptions |
|---|
| CD107 antigen-like family member A 3 | | CD107a antigen 3 | | lysosomal-associated membrane protein 1 2 |
|
| | Search outside databases for aliases for LAMP1 genePrevious GC identifers: GC13P112561 GC13P108588 GC13P113038 GC13P111899 |
Summaries for LAMP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LAMP1: The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq] UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisGene Wiki entry for LAMP1 |
Genomic Location for LAMP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAMP1 gene 
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34LAMP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P112999:
(about GC identifiers)
Start:
|
112,999,470 bp from pter |
End:
|
113,025,746 bp from pter |
Size:
|
26,277 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000013.9 NT_027140.6
| Proteins for LAMP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279 (See
protein sequence)Recommended Name: Lysosome-associated membrane glycoprotein 1 precursor Size: 417 amino acids; 44882 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane
Secondary accessions: Q8WU33 Q96I40 Q9BRD2 Q9NP13Post-translational modifications:
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005552.3
ENSEMBL proteins: ENSP00000364581 ENSP00000333298
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8
): About this table
Antibodies for LAMP1: Assays for LAMP1: | Protein
Domains/ Families for LAMP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P11279
ProtoNet protein and cluster: P11279 1 Blocks protein family: IPB002000 Lysosome-associated membrane glycoprotein (Lamp)/CD68
UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279Similarity: Belongs to the LAMP family | Gene Function for LAMP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005561
Applied Biosystems Silencer® siRNAs for LAMP1
Sigma-Aldrich siRNA for LAMP1  Sigma-Aldrich shRNA for LAMP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005561                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005561                                  untagged cDNA clones in CMV expression vector (see all 3): BC021288 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005561
UniProtKB/Swiss-Prot: LAMP1_HUMAN, P11279Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisGenatlas biochemistry entry for LAMP1:lysosomal associated membrane protein 17 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lamp1):
| Pathways & Interactions for LAMP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for LAMP1 
5/32 Interacting proteins for LAMP1 (ENSP000003332983 P112792) via UniProtKB, MINT, and/or STRING (see all 32
)About this table
|
Drugs & Compounds for LAMP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAMP1 10/11 Novoseek chemical compound relationships for LAMP1 gene (see all 11
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mannose 6-phosphate |
79.52 |
12 |
9531552 (1), 18485117 (1), 8601581 (1), 17959629 (1) (see all 12) |
| n-acetyllactosamine |
54.95 |
4 |
2243102 (1), 2243101 (1), 16132574 (1) |
| dopachrome |
49.83 |
1 |
15632015 (1) |
| adp |
26.14 |
3 |
2211717 (1), 16546241 (1), 18410487 (1) |
| sucrose |
22.73 |
6 |
10640418 (2), 1845800 (2), 2211717 (1), 1520873 (1) |
| latex |
21.58 |
1 |
8077232 (1) |
| ganglioside |
10.29 |
1 |
17204262 (1) |
| calcium |
4.51 |
4 |
11298650 (3) |
| mannose |
1.79 |
1 |
9099947 (1) |
| iron |
0.00 |
2 |
15792797 (1) |
About this table
|
Transcripts for LAMP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005561
Sigma-Aldrich siRNA for LAMP1  Sigma-Aldrich shRNA for LAMP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005561 REFSEQ mRNAs for LAMP1 gene: NM_005561.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005561               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005561                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005561                                  untagged cDNA clones in CMV expression vector (see all 3): BC021288  Additional cDNA sequence: AK092398.1 AK301584.1 BC006345.2 BC007845.2 BC021288.2 BC025335.1 BC093044.1 CR593667.1 CR598041.1 CR613424.1 CR626636.1 J03263.1 J04182.1 22 DOTS entries: DT.100879739 DT.455661 DT.97799738 DT.100879721 DT.75173321 DT.100879737 DT.91773622 DT.120770591 DT.100879733 DT.120770576 DT.120770608 DT.100879742 DT.100879720 DT.91773644 DT.95091380 DT.100879729 DT.100879736 DT.120770555 DT.120770619 DT.120770628 DT.95152999 DT.100039013 24/722 AceView cDNA sequences (see all 722
):CA415231 BQ878122 AA186612 AI261273 CD558279 AW006939 AI858558 AW294219 CR598041 AL121289 BX417547 AA976547 BQ681891 BQ678701 BQ287840 BU163409 BQ677083 AW471177 BQ683352 BU844521 CR626636 BU838186 BE872172 CD243638
highest scoring ESTs for LAMP1:AI984264 J04182 AA009442 AA022680 AA039886 AA039971 AA040751 AA064889 AA069986 AA070220 Unigene Cluster for LAMP1: Lysosomal-associated membrane protein 1 Hs.494419 [show with all ESTs]Unigene Representative Sequence: NM_005561
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LAMP1 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LAMP1
2 Ensembl transcripts including schematic representations: ENST00000375432
ENST00000332556
|
Expression for LAMP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAMP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAMP1
1 / 2 / 3 10 probe-sets matching LAMP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTCACACATT
SOURCE GeneReport for Unigene cluster: Hs.494419
Expression variation in blood from EXPOLDB for LAMP1 |
Orthologs for LAMP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAMP1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for LAMP1
ENSEMBL Gene Tree for LAMP1 | Paralogs for LAMP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAMP1 gene
- LAMP32 CD682 LAMP22
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for LAMP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAMP1 (up to first 250kb)
|
Disorders & Mutations for LAMP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 153330
10/17 Novoseek disease relationships for LAMP1 gene (see all 17
)
About this table
1 PharmGKB disease relationship for LAMP1 geneAbout this table
Genetic Association Database: LAMP1
|
Medical News for LAMP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAMP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/207 PubMed articles for LAMP1 gene (see all 207
):- The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. (PubMed id 8517882)1, 3, 4 Sawada R.... Fukuda M. (1993)
- The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PubMed id 2243102)1, 3, 4 Carlsson S.R. and Fukuda M. (1990)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)3, 4 Zhang H.... Aebersold R. (2003)
- Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. (PubMed id 8323299)3, 4 Carlsson S.R.... Fukuda M. (1993)
- Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement. (PubMed id 2584229)3, 4 Carlsson S.R. and Fukuda M. (1989)
- Purification and characterization of human lysosomal membrane glycoproteins. (PubMed id 2912382)3, 4 Mane S.M.... August J.T. (1989)
- Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h- lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. (PubMed id 3198605)3, 4 Fukuda M.... Carlsson S.R. (1988)
- Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000. (PubMed id 3131762)3, 4 Viitala J.... Fukuda M. (1988)
- Relationship between CD107a expression and cytotoxic activity. (PubMed id 18835598)1, 3 Aktas E....Deniz G. (2009)
|
Search for LAMP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAMP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAMP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAMP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAMP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAMP1:

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Incremental update: 13 Oct 2009
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