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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAMC3 Gene

protein-coding GIFtS: 59
GCID: GC09P133884

laminin, gamma 3

Explore 11 diseases affiliated with
LAMC3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Laminin, Gamma 3¹ ²		DKFZp434E202¹
Laminin-12 Subunit Gamma² ³		OCCM²
Laminin-14 Subunit Gamma² ³		Laminin Subunit Gamma-3²
Laminin-15 Subunit Gamma² ³

External Ids:	HGNC: 6494¹	Entrez Gene: 10319²	Ensembl: ENSG00000050555⁷	OMIM: 604349⁵	UniProtKB: Q9Y6N6³

Export aliases for LAMC3 gene to outside databases

Previous GC identifers: GC09P124899 GC09P125431 GC09P127238 GC09P129160 GC09P130914 GC09P132874 GC09P103375

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAMC3:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement

membranes. They have been implicated in a wide variety of biological processes including cell adhesion,

differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical

chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure

consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin

chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described.

Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which

are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1.

The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have

been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This

gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and

contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly

expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the

dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of

ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of

gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the

morphogenesis and structural stability of the ciliated processes of these cells. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Gene Wiki entry for LAMC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_035014.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAMC3 gene promoter:
TBP N-Myc MEF-2A p53 MyoD aMEF-2 ITF-2 Tal-1beta
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for LAMC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31-q34 Ensembl cytogenetic band: 9q34.12 HGNC cytogenetic band: 9q31-q34

LAMC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMC3 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P133884: view genomic region (about GC identifiers)

Start:	133,884,469 bp from pter	End:	133,969,860 bp from pter
Size:	85,392 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6 (See protein sequence)

Recommended Name: Laminin subunit gamma-3 precursor

Size: 1575 amino acids; 171227 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms

with globules at each end. Gamma-3 is a subunit of laminin-12 (laminin-213), laminin-14 (laminin-423) and laminin-15

(laminin-523)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane

Sequence caution: Sequence=AAD36991.1; Type=Frameshift; Positions=598, 609;

Secondary accessions: B1APX9 B1APY0 Q59H72

Explore the universe of human proteins at neXtProt for LAMC3: NX_Q9Y6N6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6N6

LAMC3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006050.3

ENSEMBL proteins:

ENSP00000354360 ENSP00000347156 ENSP00000347627

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	Uscn Proteins for LAMC3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	TAS	10225960
GO:0005604	basement membrane	IEA	--
GO:0016020	membrane	TAS	10225960

LAMC3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LAMC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAMC3 for domains About GeneDecksing

3 InterPro domains/families:

IPR000034 Laminin_B_type_IV

IPR008211 Laminin_N

IPR002049 EGF_laminin

Graphical View of Domain Structure for InterPro Entry Q9Y6N6

ProtoNet protein and cluster: Q9Y6N6

3 Blocks protein families:

IPB000034 Laminin B

IPB002049 Laminin-type EGF-like domain

IPB008212 Laminin

UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil

structure

Domain: Domain IV is globular

Similarity: Contains 11 laminin EGF-like domains

Similarity: Contains 1 laminin IV type A domain

Similarity: Contains 1 laminin N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Genatlas biochemistry entry for LAMC3:

laminin ,gamma 3 polypeptide,prominent element of the apical surface of cialiated epithelial cells of

lung,oviduct,epididymis,ductus deferens,seminiferous tubules,also component of cutaneous basement membrane

zone,heterotrimerizing (laminin 12) with alpha 2 and beta 1

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMC3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	TAS	10225960

LAMC3 for ontologies About GeneDecksing

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamc3):

nervous system

vision/eye

LAMC3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

Small cell lung cancer

Small cell lung cancer

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMC3 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	CDK5 Pathway
	Transendothelial Migration of Leukocytes

1 BioSystems Pathway for LAMC3

Focal Adhesion

5/6 Kegg Pathways (Kegg details for LAMC3) (see all 6):

	Focal adhesion
	ECM-receptor interaction
	Toxoplasmosis
	Amoebiasis
	Pathways in cancer

LAMC3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LAMC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for LAMC3 (Q9Y6N6^{2, 3} ENSP00000354360⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LAMA4	Q16363³, ENSP00000230538⁴	I2D: score=1 STRING: ENSP00000230538
LAMA5	O15230³, ENSP00000252999⁴	I2D: score=1 STRING: ENSP00000252999
LAMA2	P24043³, ENSP00000400365⁴	I2D: score=1 STRING: ENSP00000400365
ITGB1	ENSP00000364094⁴	STRING: ENSP00000364094
ITGA2	ENSP00000296585⁴	STRING: ENSP00000296585

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000904	cell morphogenesis involved in differentiation	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007601	visual perception	IEA	--
GO:0014002	astrocyte development	IEA	--
GO:0060041	retina development in camera-type eye	IEA	--

LAMC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAMC3
Search CenterWatch for drugs/clinical trials and news about LAMC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAMC3 gene:

NM_006059.3

Unigene Cluster for LAMC3:

Laminin, gamma 3

Hs.201805 [show with all ESTs]

Unigene Representative Sequence: NM_006059

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361069(uc004caa.1 uc010mze.1) ENST00000355048 ENST00000480883

ENST00000355452 ENST00000462567

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Additional cDNA sequence:

AB208887.1 AK075536.1 AL133595.1

2 DOTS entries:

DT.91961659 DT.312334

24/83 AceView cDNA sequences (see all 83):

D31213 CR618197 NM_006059 AA909401 BQ643963 AA788921 AA985315 BQ027531

AL548827 BE145398 BU729072 AK075536 BM671064 BX089329 T35029 BG830891

CA444538 AA889116 CD655221 AF041835 T17365 R24218 AL133595 BF343520

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAMC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCTCTG

About this image

LAMC3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Elongated Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See LAMC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMC3

SOURCE GeneReport for Unigene cluster: Hs.201805

UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6

Tissue specificity: Broadly expressed in: skin, heart, lung, and the reproductive tracts

SABiosciences Custom PCR Arrays for LAMC3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LAMC3 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LAMC3¹	laminin, gamma 3	65.68(n) 58.55(a)		417180 XM_415462.3 XP_415462.3
zebrafish (Danio rerio)	Actinopterygii	lamc3¹	laminin, gamma 3	54.03(n) 44.95(a)		558958 XM_682251.5 XP_687343.4
fruit fly (Drosophila melanogaster)	Insecta	LanB2⁶	Laminin B2	34(a)	1 → many	3L(9608014-9617080)
worm (Caenorhabditis elegans)	Secernentea	C54D1.5³	--	35(a)		X(7180191-7186397) --

ENSEMBL Gene Tree for LAMC3 (if available)
TreeFam Gene Tree for LAMC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LAMC3 gene

NTN4² LAMA1² NTN5² LAMA3² LAMA2² LAMB2² LAMC1² LAMC2²

LAMA5² NTN3² LAMB3² LAMA4² NTN1² NTNG1² USH2A² LAMB4²

LAMB1² NTNG2²

7 SIMAP similar genes for LAMC3 using alignment to 3 protein entries: LAMC3_HUMAN (see all proteins):

DKFZp434E202 LAMC1 LAMB4 NTN1 LAMA1 LAMA3

NTN3

LAMC3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79168995^1,2	F,	--	103373232(+)	`TTTTTA/TAAAAA`	1	--	us2k¹		1	WA	118
rs113744995^1,2		--	103373296(+)	`CTGCAA/TCCTCT`	1	--	us2k¹		2	CSA WA	119
rs112099174^1,2		--	103373310(+)	`TCCTGA/GATTCA`	1	--	us2k¹		2	CSA WA	119
rs113835828^1,2		--	103373596(+)	`AATAGT/ACTTAG`	1	--	us2k¹		2	CSA WA	119
rs75875952^1,2	F,	--	103373652(+)	`ATATAA/CATATT`	1	--	us2k¹		1	WA	118
rs35179099^1,2	C	--	103374248(+)	`TTTTTT/-CGAGA`	1	--	us2k¹		1	NA	2
rs7047333^1,2	C,	--	103374284(+)	`tgactC/Gtgttg`	1	--	us2k¹		2	NA	4
rs111714472^1,2		--	103374507(+)	`CACCTC/TCCAAA`	1	--	us2k¹		2	CSA WA	120
rs112466719^1,2		--	103374539(+)	`GCCACC/TGCGCA`	1	--	us2k¹		2	CSA WA	119
rs115874419^1,2	C,F,	--	103374739(+)	`CAGAGC/TGCAGC`	1	--	us2k¹		1	WA	118

HapMap Linkage Disequilibrium report for LAMC3 (133884469 - 133969860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for LAMC3
3 CNVs: 3782 7728 7727
1 Indel: 13203
Human Gene Mutation Database (HGMD): LAMC3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LAMC3 for disorders About GeneDecksing

OMIM gene information: 604349 OMIM disorders: --

UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6

Defects in LAMC3 are the cause of cortical malformations occipital (OCCM) [MIM:614115]. OCCM is a disease in

which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both

pachygyria and polymicrogyria restricted to the lateral occipital lobes

11 diseases for LAMC3: About MalaCards

bladder transitional cell carcinoma transitional cell carcinoma pachygyria polymicrogyria

toxoplasmosis hepatitis b colon cancer lung cancer

hepatitis carcinoma melanoma

Human Genome Epidemiology (HuGE) Navigator: LAMC3 (4 documents)

Export disorders for LAMC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LAMC3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with LAMC3)

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Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. (PubMed id 10225960)^{1, 2, 3} Koch M.... Champliaud M.-F. (1999)
Recessive LAMC3 mutations cause malformations of occipital cortical development. (PubMed id 21572413)^{1, 2} Barak T.... Gunel M. (2011)
Structural analysis and mutation detection strategy for the human LAMC3 gene. (PubMed id 11162474)^{1, 9} Cserhalmi-Friedman P.B....Christiano A.M. (2001)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains. (PubMed id 18697739)¹ Ido H....Sekiguchi K. (2008)
Multiple functions of the integrin alpha6beta4 in epi dermal homeostasis and tumorigenesis. (PubMed id 16581764)¹ Wilhelmsen K....Sonnenberg A. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10319	HGNC: 6494	AceView: LAMC3	Ensembl:ENSG00000050555	euGenes: HUgn10319
ECgene: LAMC3	Kegg: 10319	H-InvDB: LAMC3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LAMC3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LAMC3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LAMC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LAMC3 gene:
Search GeneIP for patents involving LAMC3

Licensable Technologies for LAMC3 gene:

Tufts University:

Laminins and their functions in nervous systems

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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