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Aliases & Descriptions for LAMC3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp434E202 1, 2 | | OTTHUMP00000064565 2 |
| | | Descriptions |
|---|
| Laminin 12 gamma 3 subunit 3 | | laminin, gamma 3 2 |
|
| | Search outside databases for aliases for LAMC3 genePrevious GC identifers: GC09P124899 GC09P125431 GC09P127238 GC09P129160 GC09P130914 |
Summaries for LAMC3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LAMC3: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. However, it was also found that the gamma 3 is a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq] UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components |
Genomic Location for LAMC3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAMC3 gene 
Entrez Gene cytogenetic band: 9q31-q34 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q31-q34LAMC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P132874:
(about GC identifiers)
Start:
|
132,874,325 bp from pter |
End:
|
132,958,267 bp from pter |
Size:
|
83,943 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000009.10 NT_035014.4
| Proteins for LAMC3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6 (See
protein sequence)Recommended Name: Laminin subunit gamma-3 precursor Size: 1587 amino acids; 172458 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-3 is a subunit of laminin-12
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane
Sequence caution: Sequence=AAD36991.1; Type=Frameshift; Positions=598, 609;
Secondary accessions: B1APX9REFSEQ proteins: NP_006050.3
ENSEMBL proteins: ENSP00000325873 ENSP00000347627 ENSP00000354360 ENSP00000347156
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LAMC3: Assays for LAMC3: | Protein
Domains/ Families for LAMC3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y6N6
ProtoNet protein and cluster: Q9Y6N6 3 Blocks protein families: IPB000034 Laminin B IPB002049 Laminin-type EGF-like domain IPB008212 Laminin
UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structureDomain: Domain IV is globularSimilarity: Contains 11 laminin EGF-like domainsSimilarity: Contains 1 laminin IV type A domainSimilarity: Contains 1 laminin N-terminal domain | Gene Function for LAMC3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006059
Applied Biosystems Silencer® siRNAs for LAMC3
Sigma-Aldrich siRNA for LAMC3  Sigma-Aldrich shRNA Panels and shRNA for LAMC3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006059                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006059                                  untagged cDNA clone in CMV expression vector: NM_006059 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006059
UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix componentsGenatlas biochemistry entry for LAMC3:laminin ,gamma 3 polypeptide,prominent element of the apical surface of cialiated epithelial cells of lung,oviduct,epididymis,ductus deferens,seminiferous tubules,also component of cutaneous basement membrane zone,heterotrimerizing (laminin 12) with alpha 2 and beta 12 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LAMC3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for LAMC3 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for LAMC3 (Q9Y6N62) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for LAMC3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAMC3
|
Transcripts for LAMC3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006059
Sigma-Aldrich siRNA for LAMC3  Sigma-Aldrich shRNA Panels and shRNA for LAMC3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006059 REFSEQ mRNAs for LAMC3 gene: NM_006059.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006059               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006059                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006059                                  untagged cDNA clone in CMV expression vector: NM_006059  Additional cDNA sequence: AB208887.1 AK075536.1 AL133595.1 CR618197.1 2 DOTS entries: DT.91961659 DT.312334 24/83 AceView cDNA sequences (see all 83
):D31213 CR618197 NM_006059 AA909401 T35029 BU754408 AA778091 BU790210 AF041835 AI290116 BX089329 CD655221 BE145399 AL110446 BI161423 AA985315 CA444538 CA433082 BQ027531 AW368696 BQ643963 BU729072 AL548827 BF343520
highest scoring ESTs for LAMC3:AI025311 AL133595 AL573239 AL575168 AW368696 BM671064 BM673182 BM685344 BQ027531 R24217 Unigene Cluster for LAMC3: Laminin, gamma 3 Hs.201805 [show with all ESTs]Unigene Representative Sequence: NM_006059
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations: ENST00000320021
ENST00000355452
ENST00000361069
ENST00000355048
|
Expression for LAMC3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAMC3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAMC3
1 / 2 / 3 5 probe-sets matching LAMC3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGGCCTCTG
SOURCE GeneReport for Unigene cluster: Hs.201805 UniProtKB/Swiss-Prot: LAMC3_HUMAN, Q9Y6N6Tissue specificity: Broadly expressed in: skin, heart, lung, and the reproductive tracts |
Orthologs for LAMC3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAMC3 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for LAMC3
ENSEMBL Gene Tree for LAMC3 | Paralogs for LAMC3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAMC3 gene
- LAMC12
|
SNPs/Variants for LAMC3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAMC3 (up to first 250kb)
|
Disorders & Mutations for LAMC3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604349
|
Medical News for LAMC3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAMC3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for LAMC3 gene:- Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. (PubMed id 10225960)2, 3, 4 Koch M.... Champliaud M.-F. (1999)
- Structural analysis and mutation detection strategy for the human LAMC3 gene. (PubMed id 11162474)1, 3 Cserhalmi-Friedman P.B....Christiano A.M. (2001)
- Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains. (PubMed id 18697739)3 Ido H....Sekiguchi K. (2008)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3 Otsuki T....Isogai T. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)4 Humphray S.J.... Dunham I. (2004)
- Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. (PubMed id 11311202)3 McArthur C.P....Gustafson S. (2001)
- A new nomenclature for the laminins. (PubMed id 7921537)3 Burgeson R.E....Sanes J. (1994)
|
Search for LAMC3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAMC3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAMC3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAMC3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| Licensable Technologies for LAMC3 gene:
| Services for LAMC3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAMC3:

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Incremental update: 13 Oct 2009
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