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LAMC1 Gene

protein-coding   GIFtS: 68
GCID: GC01P182992

Laminin, Gamma 1 (Formerly LAMB2)


(Previous symbol: LAMB2)
  See LAMC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Laminin, Gamma 1 (Formerly LAMB2)1 2     Laminin-6 Subunit Gamma2 3
LAMB21 2 3 5     Laminin-7 Subunit Gamma2 3
Laminin B2 Chain2 3     Laminin-8 Subunit Gamma2 3
Laminin-10 Subunit Gamma2 3     Laminin-9 Subunit Gamma2 3
Laminin-11 Subunit Gamma2 3     S-LAM Gamma2 3
Laminin-2 Subunit Gamma2 3     S-Laminin Subunit Gamma2 3
Laminin-3 Subunit Gamma2 3     Laminin Subunit Gamma-12
Laminin-4 Subunit Gamma2 3     Laminin-1 Subunit Gamma3

External Ids:    HGNC: 64921   Entrez Gene: 39152   Ensembl: ENSG000001358627   OMIM: 1502905   UniProtKB: P110473   

Export aliases for LAMC1 gene to outside databases

Previous GC identifers: GC01P180518 GC01P178420 GC01P179512 GC01P180231 GC01P179724 GC01P181259 GC01P154228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LAMC1 Gene:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement
membranes. They have been implicated in a wide variety of biological processes including cell adhesion,
differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical
chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure
consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each
laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been
described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin
isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1
heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely
unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably
reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1
chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks
the short alpha region separating domains I and II. The structural organization of this gene also suggested that
it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the
gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that
laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the
strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are
utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. (provided
by RefSeq, Aug 2011)

GeneCards Summary for LAMC1 Gene:
LAMC1 (laminin, gamma 1 (formerly LAMB2)) is a protein-coding gene. Diseases associated with LAMC1 include junctional epidermolysis bullosa inversa, and diffuse mesangial sclerosis. GO annotations related to this gene include extracellular matrix structural constituent and glycosphingolipid binding. An important paralog of this gene is LAMA5.

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components

Gene Wiki entry for LAMC1 (Laminin, gamma 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAMC1 gene promoter:
         FOXF2   AP-1   NRSF form 1   ATF-2   NRSF form 2   NF-kappaB   S8   POU2F1a   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMC1 promoter sequence
   Search Chromatin IP Primers for LAMC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q31

LAMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P182992:  view genomic region     (about GC identifiers)

Start:
182,992,595 bp from pter      End:
183,114,727 bp from pter
Size:
122,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047 (See protein sequence)
Recommended Name: Laminin subunit gamma-1 precursor  
Size: 1609 amino acids; 177603 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2
(laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6
(laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9
(laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521)
Secondary accessions: Q5VYE7

Explore the universe of human proteins at neXtProt for LAMC1: NX_P11047

Explore proteomics data for LAMC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn60, Asn134, Asn576, Asn650, Asn1022, Asn1107, Asn1161, Asn1175, Asn1205, Asn1223,
                                 Asn1241, Asn1380, Asn1395, Asn1439, Thr1603
  • Modification sites at PhosphoSitePlus

  • See LAMC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002284.3  
    ENSEMBL proteins: 
     ENSP00000258341   ENSP00000473583  
    Reactome Protein details: P11047

    LAMC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LAMC1

     
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    antibodies-online proteins for LAMC1 (5 products) 

     
    antibodies-online peptides for LAMC1

    LAMC1 Antibody Products:

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    antibodies-online antibodies for LAMC1 (60 products) 

    LAMC1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LAM: Laminins

    Selected InterPro protein domains (see all 6):
     IPR018031 Laminin_B_subgr
     IPR000034 Laminin_B_type_IV
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry P11047

    ProtoNet protein and cluster: P11047

    3 Blocks protein domains:
    IPB000034 Laminin B
    IPB002049 Laminin-type EGF-like domain
    IPB008212 Laminin


    UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI and IV are globular
    Similarity: Contains 11 laminin EGF-like domains
    Similarity: Contains 1 laminin IV type A domain
    Similarity: Contains 1 laminin N-terminal domain


    Find genes that share domains with LAMC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMC1_HUMAN, P11047
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMC1:
    laminin,gamma 1 polypeptide,component of cutaneous basement membrane zone

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent IMP15159456
    GO:0005515protein binding ----
    GO:0043208glycosphingolipid binding IEA--
         
    Find genes that share ontologies with LAMC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LAMC1:
     Increased S DNA content  Increased number of mitotic ce 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Lamc1) (see all 16):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  other  renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with LAMC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LAMC1: Lamc1tm1Umr Lamc1tm1.2Strl

       genOway: Develop your customized and physiologically relevant rodent model for LAMC1

    miRNA
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    miRTarBase miRNAs that target LAMC1:
    hsa-mir-92a-3p (MIRT049658), hsa-mir-205-5p (MIRT007075), hsa-mir-29c-3p (MIRT001923), hsa-mir-10a-5p (MIRT047628), hsa-mir-10b-5p (MIRT047473), hsa-mir-16-5p (MIRT001446), hsa-mir-124-3p (MIRT002720), hsa-mir-98-5p (MIRT027555)

    Block miRNA regulation of human, mouse, rat LAMC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LAMC1 (see all 61):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-429 hsa-miR-376b hsa-miR-548k hsa-miR-15a hsa-miR-29a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidLAMC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LAMC1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAMC1_HUMAN, P11047: Secreted, extracellular space, extracellular matrix, basement membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IDA14557481
    GO:0005605basal lamina ----
    GO:0005606laminin-1 complex TAS14557481

    Find genes that share ontologies with LAMC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAMC1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63


    Find genes that share SuperPaths with LAMC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAMC1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    Selected GeneGo (Thomson Reuters) Pathways for LAMC1 (see all 6)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion ECM remodeling

    4 BioSystems Pathways for LAMC1
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling
    Inflammatory Response Pathway

    5 Reactome Pathways for LAMC1
        L1CAM interactions
    ECM proteoglycans
    Laminin interactions
    Degradation of the extracellular matrix
    Non-integrin membrane-ECM interactions


    Selected Kegg Pathways  (Kegg details for LAMC1) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Prion diseases
    Toxoplasmosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAMC1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LAMC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAMC1 (P110472, 3 ENSP000002583414) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC53Q9Y3C02, 3MINT-65844 I2D: score=5 
    ATF7IPQ6VMQ62, 3MINT-61907 I2D: score=3 
    PDIA3P301012, 3MINT-4301406 I2D: score=1 
    CENPUQ71F232, 3, ENSP000002814534MINT-8263203 I2D: score=2 STRING: ENSP00000281453
    SNAPINO952952, 3, ENSP000003576744MINT-63276 I2D: score=5 STRING: ENSP00000357674
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly IDA15159456
    GO:0007155cell adhesion IDA15159456
    GO:0007411axon guidance TAS--
    GO:0007492endoderm development TAS9885251
    GO:0016477cell migration IMP15561105

    Find genes that share ontologies with LAMC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAMC1

    2 Novoseek inferred chemical compound relationships for LAMC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 74.4 1 8306988 (1)
    heparin 0 1 8093049 (1)



    Find genes that share compounds with LAMC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAMC1 gene: 
    NM_002293.3  

    Unigene Cluster for LAMC1:

    Laminin, gamma 1 (formerly LAMB2)
    Hs.609663  [show with all ESTs]
    Unigene Representative Sequence: NM_002293
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258341(uc001gpx.3 uc001gpy.4) ENST00000484114 ENST00000479499
    ENST00000466964 ENST00000478064 ENST00000495918
    miRNA
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    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-429 hsa-miR-376b hsa-miR-548k hsa-miR-15a hsa-miR-29a hsa-miR-124
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      QuantiFast Probe-based Assays in human, mouse, rat LAMC1

    Additional mRNA sequence: 

    BC015586.2 BC035429.1 BC067813.1 J03202.1 M27654.1 X13939.1 

    11 DOTS entries:

    DT.449842  DT.95149578  DT.101971664  DT.40234973  DT.100685117  DT.92452392  DT.100791165  DT.101963075 
    DT.100791172  DT.92452403  DT.95124002 

    Selected AceView cDNA sequences (see all 476):

    BX464775 AI754908 BF438640 BF436491 BM784122 CB143194 AA299480 CA430405 
    BM907557 BM702191 BU153573 AW069533 BF692303 BM748169 BU783215 BU784519 
    BM664886 AA485598 BM993300 AI985158 AW513099 BI160987 CA437890 AA328718 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATAGAAT
    LAMC1 Expression
    About this image


    LAMC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
    LAMC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAMC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.609663

    UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Tissue specificity: Found in the basement membranes (major component)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LAMC1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lamc11 , 5 laminin, gamma 11, 5 86.99(n)1
    92.84(a)1
      1 (65.30 cM)5
    2265191  NM_010683.21  NP_034813.21 
     1532189225 
    chicken
    (Gallus gallus)
    Aves LAMC11 laminin, gamma 1 (formerly LAMB2) 76.24(n)
    82.64(a)
      424442  XM_001234658.3  XP_001234659.2 
    lizard
    (Anolis carolinensis)
    Reptilia LAMC16
    laminin, gamma 1 (formerly LAMB2)
    81(a)
    1 ↔ 1
    GL343203.1(4407499-4553332)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19222 Xenopus laevis transcribed sequence with moderate similarity more 74.1(n)    BU914721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lamc12 laminin, gamma 1 75.71(n)   286832  AF468048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LanB21 , 3 embryonic morphogenesis3
    Laminin B21
    40(a)3
    51.03(n)1
    42.57(a)1
      67C23
    391181  NM_079282.21  NP_524006.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C54D1.53
    lam-21
    lam-21 40(a)3
    49.71(n)1
    41.61(a)1
      X(7180191-7186397)3
    1809801  NM_076803.51  NP_509204.31 


    ENSEMBL Gene Tree for LAMC1 (if available)
    TreeFam Gene Tree for LAMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LAMC1 gene
    LAMA52  LAMC22  LAMA12  LAMC32  LAMA42  LAMA32  LAMA22  USH2A2  
    LAMB42  LAMB22  LAMB12  
    4 SIMAP similar genes for LAMC1 using alignment to 3 protein entries:     LAMC1_HUMAN (see all proteins):
    LAMC3    LAMC2    LAMA1    LAMA2

    Find genes that share paralogs with LAMC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAMC1 (see all 2679)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358214
    A colorectal cancer sample4--see VAR_0358212 R H mis40--------
    rs741296371,2
    C,F--154226665(+) TCAAGG/TTCTCT 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs109111931,2
    C,F,A,H--154226715(+) AGTTAC/TGGAAA 1 -- us2k114Minor allele frequency- T:0.12NA NS EA WA 930
    rs1161007951,2
    F--154226727(+) TTCGCA/GTAAGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1465140461,2
    --154226762(+) ATTAGA/GACTCA 1 -- us2k10--------
    rs107528871,2
    C,F,A,H--154226901(+) AATAAC/TGCAAA 1 -- us2k1 tfbs313Minor allele frequency- T:0.50EA NA WA 586
    rs107978141,2
    C,F,A,H--154226996(+) ATATGC/ACCACG 1 -- us2k114Minor allele frequency- A:0.45NS EA NA WA CSA 792
    rs1903079481,2
    --154227090(+) ATGTAC/TGAAAG 1 -- us2k10--------
    rs1824829201,2
    --154227249(+) TAACAA/TGACCC 1 -- us2k10--------
    rs1866080361,2
    --154227287(+) CAGAAA/CATTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LAMC1 (182992595 - 183114727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LAMC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819917CNV Loss19587683

    Human Gene Mutation Database (HGMD): LAMC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAMC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 150290    OMIM disorders: --

    4 diseases for LAMC1:    
    About MalaCards
    junctional epidermolysis bullosa inversa    diffuse mesangial sclerosis    junctional epidermolysis bullosa    mayer-rokitansky-kuster-hauser syndrome


    Find genes that share disorders with LAMC1           About GenesLikeMe

    4 Novoseek inferred disease relationships for LAMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epidermolysis bullosa junctional 61.9 2 7987320 (2)
    glioma 3 1 9055641 (1)
    tumors 0 2 7967523 (1)
    melanoma 0 1 8521420 (1)

    Genetic Association Database (GAD): LAMC1
    Human Genome Epidemiology (HuGE) Navigator: LAMC1 (4 documents)

    Export disorders for LAMC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAMC1 gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with LAMC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31. (PubMed id 3234037)1, 2, 3 Fukushima Y.... Shows T.B. (Cytogenet. Cell Genet. 1988)
    2. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? (PubMed id 20223449)1, 4, 9 Chen C....Matthews C.A. (Am. J. Obstet. Gynecol. 2010)
    3. Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PubMed id 15370542)1, 4, 9 Hayashi M....Allikmets R. (Ophthalmic Genet. 2004)
    4. Differences in human laminin B2 sequences. (PubMed id 1806043)1, 2, 9 Santos C.L.S.... Brentani R. (DNA Seq. 1991)
    5. Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. (PubMed id 1985895)1, 2, 9 Kallunki T.... Tryggvason K. (J. Biol. Chem. 1991)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    7. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    9. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    10. Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains. (PubMed id 3360804)1, 2 Pikkarainen T.... Tryggvason K. (J. Biol. Chem. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3915 HGNC: 6492 AceView: LAMC1 Ensembl:ENSG00000135862 euGenes: HUgn3915
    ECgene: LAMC1 Kegg: 3915 H-InvDB: LAMC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAMC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LAMC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LAMC1 gene:
    Search GeneIP for patents involving LAMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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