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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAMC1 Gene

protein-coding   GIFtS: 68
GCID: GC01P182992

Laminin, Gamma 1 (Formerly LAMB2)


(Previous symbol: LAMB2)
Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Laminin, Gamma 1 (Formerly LAMB2)1 2     Laminin-6 Subunit Gamma2 3
LAMB21 2 3 5     Laminin-7 Subunit Gamma2 3
Laminin B2 Chain2 3     Laminin-8 Subunit Gamma2 3
Laminin-10 Subunit Gamma2 3     Laminin-9 Subunit Gamma2 3
Laminin-11 Subunit Gamma2 3     S-LAM Gamma2 3
Laminin-2 Subunit Gamma2 3     S-Laminin Subunit Gamma2 3
Laminin-3 Subunit Gamma2 3     Laminin Subunit Gamma-12
Laminin-4 Subunit Gamma2 3     Laminin-1 Subunit Gamma3

External Ids:    HGNC: 64921   Entrez Gene: 39152   Ensembl: ENSG000001358627   OMIM: 1502905   UniProtKB: P110473   

Export aliases for LAMC1 gene to outside databases

Previous GC identifers: GC01P180518 GC01P178420 GC01P179512 GC01P180231 GC01P179724 GC01P181259 GC01P154228


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAMC1 Gene:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement
membranes. They have been implicated in a wide variety of biological processes including cell adhesion,
differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical
chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure
consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each
laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been
described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin
isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1
heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely
unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably
reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1
chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks
the short alpha region separating domains I and II. The structural organization of this gene also suggested that
it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the
gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that
laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the
strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are
utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. (provided
by RefSeq, Aug 2011)

GeneCards Summary for LAMC1 Gene: 
LAMC1 (laminin, gamma 1 (formerly LAMB2)) is a protein-coding gene. Diseases associated with LAMC1 include junctional epidermolysis bullosa inversa, and diffuse mesangial sclerosis, and among its related super-pathways are ECM-receptor interaction and Focal Adhesion. GO annotations related to this gene include extracellular matrix structural constituent and glycosphingolipid binding. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components

Gene Wiki entry for LAMC1 (Laminin, gamma 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAMC1 gene promoter:
         FOXF2   AP-1   NRSF form 1   ATF-2   NRSF form 2   NF-kappaB   S8   POU2F1a   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAMC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q31

LAMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P182992:  view genomic region     (about GC identifiers)

Start:
182,992,595 bp from pter      End:
183,114,727 bp from pter
Size:
122,133 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047 (See protein sequence)
Recommended Name: Laminin subunit gamma-1 precursor  
Size: 1609 amino acids; 177603 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2
(laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6
(laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9
(laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane
Secondary accessions: Q5VYE7

Explore the universe of human proteins at neXtProt for LAMC1: NX_P11047

Explore proteomics data for LAMC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11047

  • LAMC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LAMC1 Protein Expression
    REFSEQ proteins: NP_002284.3  
    ENSEMBL proteins: 
     ENSP00000258341   ENSP00000473583  
    Reactome Protein details: P11047
    Human Recombinant Protein Products for LAMC1: 
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    Novus Biologicals LAMC1 Protein
    Novus Biologicals LAMC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LAMC1 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IDA14557481
    GO:0005605basal lamina ----
    GO:0005606laminin-1 complex TAS14557481
    GO:0005615extracellular space NAS10964500

    LAMC1 for ontologies           About GeneDecksing



    LAMC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMC1
    R&D Systems Antibodies for LAMC1 (Laminin gamma 1)
    OriGene Antibodies for LAMC1
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    Novus Biologicals LAMC1 Antibodies
    Abcam antibodies for LAMC1
    Cloud-Clone Corp. Antibodies for LAMC1 
    ThermoFisher Antibodies for LAMC1
    LSBio Antibodies in human, mouse, rat for LAMC1 

    Assay Products for LAMC1: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LAMC1
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    Cloud-Clone Corp. ELISAs for LAMC1 
    Cloud-Clone Corp. CLIAs for LAMC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LAM: Laminins

    5/6 InterPro protein domains (see all 6):
     IPR018031 Laminin_B_subgr
     IPR000034 Laminin_B_type_IV
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry P11047

    ProtoNet protein and cluster: P11047

    3 Blocks protein domains:
    IPB000034 Laminin B
    IPB002049 Laminin-type EGF-like domain
    IPB008212 Laminin


    UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI and IV are globular
    Similarity: Contains 11 laminin EGF-like domains
    Similarity: Contains 1 laminin IV type A domain
    Similarity: Contains 1 laminin N-terminal domain


    LAMC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMC1_HUMAN, P11047
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMC1:
    laminin,gamma 1 polypeptide,component of cutaneous basement membrane zone

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent IMP15159456
    GO:0005515protein binding ----
    GO:0043208glycosphingolipid binding IEA--
         
    LAMC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LAMC1:
     Increased S DNA content  Increased number of mitotic ce 

         15/16 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Lamc1) (see all 16):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  other  renal/urinary system  reproductive system  respiratory system 

    LAMC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LAMC1: Lamc1tm1Umr Lamc1tm1.2Strl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LAMC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAMC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAMC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAMC1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAMC1:
    hsa-mir-16 (MIRT001446), hsa-mir-124 (MIRT002720), hsa-mir-29c (MIRT001923)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMC1
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMC1 (see all 61):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-429 hsa-miR-376b hsa-miR-548k hsa-miR-15a hsa-miR-29a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidLAMC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LAMC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LAMC1
    Sirion Biotech Customized adenovirus for overexpression of LAMC1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for LAMC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMC1 (NM_002293)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMC1

    Cell Line
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    Search LifeMap BioReagents cell lines for LAMC1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LAMC1 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM proteoglycans0.38
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    2Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    3Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    Metalloproteases in connective tissue degradation0.31
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for LAMC1 (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMC1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    5/6 GeneGo (Thomson Reuters) Pathways for LAMC1 (see all 6)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion ECM remodeling

    4 BioSystems Pathways for LAMC1
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling
    Inflammatory Response Pathway

    5/8        Reactome Pathways for LAMC1 (see all 8)
        ECM proteoglycans
    L1CAM interactions
    Developmental Biology
    Extracellular matrix organization
    Integrin cell surface interactions


    5/8         Kegg Pathways  (Kegg details for LAMC1) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Prion diseases
    Toxoplasmosis


    LAMC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LAMC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for LAMC1 (P110472, 3 ENSP000002583414) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC53Q9Y3C02, 3MINT-65844 I2D: score=5 
    ATF7IPQ6VMQ62, 3MINT-61907 I2D: score=3 
    PDIA3P301012, 3MINT-4301406 I2D: score=1 
    MLF1IPQ71F232, 3, ENSP000002814534MINT-8263203 I2D: score=2 STRING: ENSP00000281453
    SNAPINO952952, 3, ENSP000003576744MINT-63276 I2D: score=5 STRING: ENSP00000357674
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly IDA15159456
    GO:0007155cell adhesion IDA15159456
    GO:0007411axon guidance TAS--
    GO:0007492endoderm development TAS9885251
    GO:0016477cell migration IMP15561105

    LAMC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LAMC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAMC1

    2 Novoseek inferred chemical compound relationships for LAMC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 74.4 1 8306988 (1)
    heparin 0 1 8093049 (1)

    Search CenterWatch for drugs/clinical trials and news about LAMC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAMC1 gene: 
    NM_002293.3  

    Unigene Cluster for LAMC1:

    Laminin, gamma 1 (formerly LAMB2)
    Hs.609663  [show with all ESTs]
    Unigene Representative Sequence: NM_002293
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258341(uc001gpx.3 uc001gpy.4) ENST00000484114 ENST00000479499
    ENST00000466964 ENST00000478064 ENST00000495918

    miRNA
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    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMC1 (see all 61):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-429 hsa-miR-376b hsa-miR-548k hsa-miR-15a hsa-miR-29a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidLAMC1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMC1

    Additional mRNA sequence: 

    BC015586.2 BC035429.1 BC067813.1 J03202.1 M27654.1 X13939.1 

    11 DOTS entries:

    DT.449842  DT.95149578  DT.101971664  DT.40234973  DT.100685117  DT.92452392  DT.100791165  DT.101963075 
    DT.100791172  DT.92452403  DT.95124002 

    24/476 AceView cDNA sequences (see all 476):

    CB215601 AI419268 BF438640 BX464775 AA411373 H24649 AA294863 BM784122 
    AI754908 BF692303 BI160987 BF507385 CA437890 CA430405 AA335083 CB216170 
    BM562700 CR593573 BM702191 BG116512 BI092472 AA022971 AA349553 AW004971 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAMC1 expression in normal human tissues (normalized intensities)      LAMC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATAGAAT
    LAMC1 Expression
    About this image


    LAMC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 15 entries
             Multinuclear Myocytes Lumbar Back Muscles
             skeletal muscle ; myocytes   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
             limb/hindlimb   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             heart muscle ; myocytes   
             heart/atrium   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Medulla Oblongata
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             spinal cord/lateral wall/ventricular layer   

    See LAMC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAMC1

    SOURCE GeneReport for Unigene cluster: Hs.609663

    UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Tissue specificity: Found in the basement membranes (major component)

        SABiosciences Expression via Pathway-Focused PCR Arrays including LAMC1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LAMC1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lamc11 , 5 laminin, gamma 11, 5 87.18(n)1
    93.03(a)1
      1 (65.30 cM)5
    2265191  NM_010683.21  NP_034813.21 
     1532189225 
    chicken
    (Gallus gallus)
    Aves LAMC11 laminin, gamma 1 (formerly LAMB2) 75.98(n)
    82.08(a)
      424442  XM_001234658.2  XP_001234659.2 
    lizard
    (Anolis carolinensis)
    Reptilia LAMC16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343203.1(4407499-4553332)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19222 Xenopus laevis transcribed sequence with moderate similarity more 74.1(n)    BU914721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lamc12 laminin, gamma 1 75.71(n)   286832  AF468048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LanB21 , 3 embryonic morphogenesis3
    Laminin B21
    40(a)3
    51.09(n)1
    42.48(a)1
      67C23
    391181  NM_079282.11  NP_524006.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C54D1.53
    lam-21
    Protein LAM-21 40(a)3
    49.9(n)1
    42.87(a)1
      X(7180191-7186397)3
    1809801  NM_076803.41  NP_509204.21 


    ENSEMBL Gene Tree for LAMC1 (if available)
    TreeFam Gene Tree for LAMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAMC1 gene
    LAMC22  NTN32  NTN42  LAMB32  NTN52  LAMC32  NTN12  NTNG12  
    USH2A2  NTNG22  LAMB42  LAMB22  LAMB12  
    4 SIMAP similar genes for LAMC1 using alignment to 3 protein entries:     LAMC1_HUMAN (see all proteins):
    LAMC3    LAMC2    LAMA1    LAMA2

    LAMC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2679 SNPs in LAMC1 are shown (see all 2679)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358214
    A colorectal cancer sample4--see VAR_0358212 R H mis40--------
    rs741296371,2
    C,F--154226665(+) TCAAGG/TTCTCT 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs109111931,2
    C,F,A,H--154226715(+) AGTTAC/TGGAAA 1 -- us2k114Minor allele frequency- T:0.12NA NS EA WA 930
    rs1161007951,2
    F--154226727(+) TTCGCA/GTAAGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1465140461,2
    --154226762(+) ATTAGA/GACTCA 1 -- us2k10--------
    rs107528871,2
    C,F,A,H--154226901(+) AATAAC/TGCAAA 1 -- us2k1 tfbs313Minor allele frequency- T:0.50EA NA WA 586
    rs107978141,2
    C,F,A,H--154226996(+) ATATGC/ACCACG 1 -- us2k114Minor allele frequency- A:0.45NS EA NA WA CSA 792
    rs1903079481,2
    --154227090(+) ATGTAC/TGAAAG 1 -- us2k10--------
    rs1824829201,2
    --154227249(+) TAACAA/TGACCC 1 -- us2k10--------
    rs1866080361,2
    --154227287(+) CAGAAA/CATTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LAMC1 (182992595 - 183114727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LAMC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819917CNV Loss19587683


    Human Gene Mutation Database (HGMD): LAMC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150290    OMIM disorders: --

    20/30 diseases for LAMC1 (see all 30):    About MalaCards
    junctional epidermolysis bullosa inversa    diffuse mesangial sclerosis    junctional epidermolysis bullosa    epidermolysis bullosa
    prion disease    fibromatosis    duchenne muscular dystrophy    keratoconus
    toxoplasmosis    premature ovarian failure    sporadic breast cancer    muscular dystrophy
    endometriosis    lateral sclerosis    amyotrophic lateral sclerosis    infertility
    esophageal squamous cell carcinoma    glioblastoma    melanoma    endotheliitis


    LAMC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for LAMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epidermolysis bullosa junctional 61.9 2 7987320 (2)
    glioma 3 1 9055641 (1)
    tumors 0 2 7967523 (1)
    melanoma 0 1 8521420 (1)

    Genetic Association Database (GAD): LAMC1
    Human Genome Epidemiology (HuGE) Navigator: LAMC1 (4 documents)

    Export disorders for LAMC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAMC1 gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with LAMC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31. (PubMed id 3234037)1, 2, 3 Fukushima Y.... Shows T.B. (1988)
    2. Is laminin gamma-1 a candidate gene for advanced pelv ic organ prolapse? (PubMed id 20223449)1, 4, 9 Chen C....Matthews C.A. (2010)
    3. Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PubMed id 15370542)1, 4, 9 Hayashi M....Allikmets R. (2004)
    4. Differences in human laminin B2 sequences. (PubMed id 1806043)1, 2, 9 Santos C.L.S.... Brentani R. (1991)
    5. Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. (PubMed id 1985895)1, 2, 9 Kallunki T.... Tryggvason K. (1991)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    7. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    9. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    10. Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains. (PubMed id 3360804)1, 2 Pikkarainen T.... Tryggvason K. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3915 HGNC: 6492 AceView: LAMC1 Ensembl:ENSG00000135862 euGenes: HUgn3915
    ECgene: LAMC1 Kegg: 3915 H-InvDB: LAMC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAMC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LAMC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LAMC1 gene:
    Search GeneIP for patents involving LAMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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