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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAMC1 Gene

protein-coding   GIFtS: 68
GCID: GC01P182992

laminin, gamma 1 (formerly LAMB2)


(Previous symbol: LAMB2)
 Explore 33 diseases affiliated with
LAMC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LAMC1    

Aliases
for LAMC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Laminin, Gamma 1 (Formerly LAMB2)1 2     Laminin-6 Subunit Gamma2 3
LAMB21 2 3 5     Laminin-7 Subunit Gamma2 3
Laminin B2 Chain2 3     Laminin-8 Subunit Gamma2 3
Laminin-10 Subunit Gamma2 3     Laminin-9 Subunit Gamma2 3
Laminin-11 Subunit Gamma2 3     S-LAM Gamma2 3
Laminin-2 Subunit Gamma2 3     S-Laminin Subunit Gamma2 3
Laminin-3 Subunit Gamma2 3     Laminin Subunit Gamma-12
Laminin-4 Subunit Gamma2 3     Laminin-1 Subunit Gamma3

External Ids:    HGNC: 64921   Entrez Gene: 39152   Ensembl: ENSG000001358627   OMIM: 1502905   UniProtKB: P110473   

Export aliases for LAMC1 gene to outside databases

Previous GC identifers: GC01P180518 GC01P178420 GC01P179512 GC01P180231 GC01P179724 GC01P181259 GC01P154228


Summaries
for LAMC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LAMC1:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement
membranes. They have been implicated in a wide variety of biological processes including cell adhesion,
differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains:
laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short
arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain
protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and
gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic
numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions
of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ
with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the
gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural
domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural
organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of
transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked
basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been
inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple
polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern
analysis. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and
organization of cells into tissues during embryonic development by interacting with other extracellular matrix
components

Gene Wiki entry for LAMC1 (Laminin, gamma 1)


Genomic Views
for LAMC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAMC1 gene promoter:
         FOXF2   AP-1   NRSF form 1   ATF-2   NRSF form 2   NF-kappaB   S8   POU2F1a   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAMC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q31

LAMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P182992:  view genomic region     (about GC identifiers)

Start:
 182,992,595 bp from pter      End:
 183,114,727 bp from pter
Size:
 122,133 bases      Orientation:
 plus strand

Proteins
for LAMC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047 (See protein sequence)
Recommended Name: Laminin subunit gamma-1 precursor  
Size: 1609 amino acids; 177603 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms
with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or
merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or
K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10
(laminin-511) and laminin-11 (laminin-521)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane
Secondary accessions: Q5VYE7

Explore the universe of human proteins at neXtProt for LAMC1: NX_P11047

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P11047

    • LAMC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002284.3  
    ENSEMBL proteins: 
     ENSP00000258341  
    Reactome Protein details: P11047
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: LAMC1
    OriGene Protein Over-expression Lysate: LAMC1
    OriGene Custom Protein Services for LAMC1 
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    Novus Biologicals LAMC1 Protein
    Novus Biologicals LAMC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LAMC1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IDA14557481
    GO:0005605basal lamina ----
    GO:0005606laminin-1 complex TAS14557481
    GO:0005615extracellular space NAS10964500


    LAMC1 for ontologies           About GeneDecksing



    LAMC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMC1
    R&D Systems Antibodies for LAMC1 (Laminin gamma 1)
    OriGene Antibodies: LAMC1
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    Novus Biologicals LAMC1 Antibodies
    Abcam antibodies for LAMC1 
    Uscn Antibodies for LAMC1
    Search ThermoFisher Antibodies for LAMC1

    Assay Products for LAMC1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for LAMC1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LAMC1

    Protein Domains /
    Families
    for LAMC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LAMC1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000034 Laminin_B_type_IV
     IPR008211 Laminin_N
     IPR002049 EGF_laminin
     IPR018031 Laminin_B_subgr
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P11047

    ProtoNet protein and cluster: P11047

    3 Blocks protein families:
    IPB000034 Laminin B
    IPB002049 Laminin-type EGF-like domain
    IPB008212 Laminin


    UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI and IV are globular
    Similarity: Contains 11 laminin EGF-like domains
    Similarity: Contains 1 laminin IV type A domain
    Similarity: Contains 1 laminin N-terminal domain


    Function
    for LAMC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and
    organization of cells into tissues during embryonic development by interacting with other extracellular matrix
    components

         Genatlas biochemistry entry for LAMC1:
    laminin,gamma 1 polypeptide,component of cutaneous basement membrane zone

    miRNA
    Products:            		miRTarBase miRNAs that target LAMC1:
    hsa-mir-16 (MIRT001446), hsa-mir-124 (MIRT002720), hsa-mir-29c (MIRT001923)

    OriGene 3'-UTR Clone: LAMC1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMC1
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMC1 (see all 61):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-429 hsa-miR-376b hsa-miR-548k hsa-miR-15a hsa-miR-29a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: LAMC1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMC1 (see all 4)
    OriGene shRNA RFP: LAMC1
    OriGene siRNA: LAMC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMC1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LAMC1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMC1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMC1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LAMC1 (NM_002293)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMC1 

    Cell Line
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    Search LifeMap BioReagents cell lines for LAMC1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMC1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent IMP15159456
    GO:0005515protein binding ----
    GO:0043208glycosphingolipid binding IEA--


    LAMC1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for LAMC1:
     Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
         Mouse knock-out Lamc1tm1Umr for LAMC1
         15/16 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lamc1) (see all 16):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  other  renal/urinary system  reproductive system  respiratory system 

    LAMC1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LAMC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Integrin outside-in signaling0.37
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cell adhesion_Endothelial cell contacts by non-junctional mechanisms0.21
    		Cytoskeleton remodeling_Integrin outside-in signaling0.37
    		Cell adhesion Endothelial cell contacts by non-junctional mechanisms0.21
    2Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    5Cell adhesion_ECM remodeling
    		Cell adhesion ECM remodeling1.00
    		Metalloproteases in connective tissue degradation0.31
    		Cell adhesion_ECM remodeling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for LAMC1 (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMC1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    5/6 GeneGo (Thomson Reuters) Pathways for LAMC1 (see all 6)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion ECM remodeling

    4 BioSystems Pathways for LAMC1 
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Inflammatory Response Pathway
    Regulation of nuclear SMAD2/3 signaling

    5        Reactome Pathways for LAMC1
        L1CAM interactions
    Developmental Biology
    Integrin cell surface interactions
    Signal Transduction
    Axon guidance


    5/7         Kegg Pathways  (Kegg details for LAMC1) (see all 7):
        Focal adhesion
    ECM-receptor interaction
    Prion diseases
    Toxoplasmosis
    Amoebiasis


    LAMC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LAMC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for LAMC1 (P110472, 3 ENSP000002583414) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC53Q9Y3C02, 3MINT-65844 I2D: score=5 
    ATF7IPQ6VMQ62, 3MINT-61907 I2D: score=3 
    PDIA3P301012, 3MINT-4301406 I2D: score=1 
    MLF1IPQ71F232, 3, ENSP000002814534MINT-8263203 I2D: score=2 STRING: ENSP00000281453
    SNAPINO952952, 3, ENSP000003576744MINT-63276 I2D: score=5 STRING: ENSP00000357674
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly IDA15159456
    GO:0007155cell adhesion IDA15159456
    GO:0007411axon guidance TAS--
    GO:0007492endoderm development TAS9885251
    GO:0016477cell migration IMP15561105


    LAMC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LAMC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LAMC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAMC1
    2 Novoseek chemical compound relationships for LAMC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 74.4 1 8306988 (1)
    heparin 0 1 8093049 (1)

    Search CenterWatch for drugs/clinical trials and news about LAMC1 

    Transcripts
    for LAMC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LAMC1 gene: 
    NM_002293.3  

    Unigene Cluster for LAMC1:

    Laminin, gamma 1 (formerly LAMB2)
    Hs.609663  [show with all ESTs]
    Unigene Representative Sequence: NM_002293
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258341(uc001gpx.3 uc001gpy.4) ENST00000484114 ENST00000479499
    ENST00000466964 ENST00000478064 ENST00000495918

    miRNA
    Products:             		 OriGene 3'-UTR Clone: LAMC1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMC1
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMC1 (see all 61):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-429 hsa-miR-376b hsa-miR-548k hsa-miR-15a hsa-miR-29a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: LAMC1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMC1 (see all 4)
    OriGene shRNA RFP: LAMC1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMC1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMC1

    Additional cDNA sequence: 

    BC015586.2 BC035429.1 BC067813.1 J03202.1 M27654.1 X13939.1 

    11 DOTS entries:

    DT.449842  DT.95149578  DT.101971664  DT.40234973  DT.100685117  DT.92452392  DT.100791165  DT.101963075 
    DT.100791172  DT.92452403  DT.95124002 

    24/476 AceView cDNA sequences (see all 476):

    BI160987 AI985158 BU784519 AA411373 BF692303 CB216170 BF448018 AI753859 
    BQ007357 BU153573 AA485598 BM562700 BU627391 BM784122 BM973052 BQ020657 
    BG677457 H24649 AA335083 AW004971 BG116512 AI753653 BQ003600 BI092472 

    GeneLoc Exon Structure


    Expression
    for LAMC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATAGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LAMC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeCiliary Marginal ZoneCiliary Marginal Zone CellsNeural Ectoderm
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See LAMC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAMC1

    SOURCE GeneReport for Unigene cluster: Hs.609663

    UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
    Tissue specificity: Found in the basement membranes (major component)

        SABiosciences Expression via Pathway-Focused PCR Arrays including LAMC1: 
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    Orthologs
    for LAMC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LAMC1 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LAMC11 laminin, gamma 1 (formerly LAMB2) 75.98(n)
    82.08(a)    		   424442  XM_001234658.2  XP_001234659.2 
    lizard
    (Anolis carolinensis)    		 Reptilia LAMC16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343203.1(4407499-4553332)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.19222 Xenopus laevis transcribed sequence with moderate similarity more 74.1(n)    BU914721.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lamc12 laminin, gamma 1 75.71(n)   286832  AF468048.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta LanB21 , 3 embryonic morphogenesis3
    Laminin B21    		 40(a)3
    51.09(n)1
    42.48(a)1    		   67C23
    391181  NM_079282.11  NP_524006.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C54D1.53
    lam-21    		 Protein LAM-21 40(a)3
    49.9(n)1
    42.87(a)1    		   X(7180191-7186397)3
    1809801  NM_076803.41  NP_509204.21 


    ENSEMBL Gene Tree for LAMC1 (if available)
    TreeFam Gene Tree for LAMC1 (if available) 

    Paralogs
    for LAMC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAMC1 gene
    NTN42  LAMA12  NTN52  LAMA32  LAMA22  LAMB22  LAMC22  LAMA52  
    NTN32  LAMB32  LAMC32  LAMA42  NTN12  NTNG12  USH2A2  LAMB42  
    NTNG22  LAMB12  
    4 SIMAP similar genes for LAMC1 using alignment to 2 protein entries:     LAMC1_HUMAN (see all proteins):
    LAMC3    LAMC2    LAMA1    LAMA2

    LAMC1 for paralogs           About GeneDecksing



    Genomic Variants
    for LAMC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2212 NCBI SNPs in LAMC1 are shown (see all 2212)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs741296371,2
    		C,--154226665(+) TCAAGG/TTCTCT 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs618080701,2
    		--154228106(+) GGCGCG/AAGGCC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1113027641,2
    		--154229430(+) GCTCTC/GTGTTC 1 -- int14Minor allele frequency- G:0.06CSA WA NA 241
    rs773483751,2
    		--154229614(+) TTTCCC/TCCTTT 1 -- int11Minor allele frequency- T:0.01EA 120
    rs776196621,2
    		--154230011(+) CCTTTT/ACTGTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs782540351,2
    		F,--154230123(+) ATTGAG/AGATGG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs763956571,2
    		C,--154230445(+) TTTTGA/TTCATG 1 -- int12Minor allele frequency- T:0.06WA 120
    rs1112424261,2
    		--154231361(+) TCATAT/AAACTA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs730499841,2
    		C,--154231474(+) CTAGGA/TTACTT 1 -- int12Minor allele frequency- T:0.04WA 120
    rs781001761,2
    		--154231946(+) TTTAAA/GTACAG 1 -- int13Minor allele frequency- G:0.05CSA WA NA 240

    HapMap Linkage Disequilibrium report for LAMC1 (182992595 - 183114727 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for LAMC1
         8 CNVs: 84699 84696 74807 84700 84701 74808 84697 84698
         1 Indel: 58350
    Human Gene Mutation Database (HGMD): LAMC1

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    Disorders / Diseases
    for LAMC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LAMC1 for disorders           About GeneDecksing

    OMIM gene information: 150290    OMIM disorders: --

    20/33 diseases for LAMC1 (see all 33):    About MalaCards
    epidermolysis bullosa inversa    junctional epidermolysis bullosa inversa    junctional epidermolysis bullosa    epidermolysis bullosa
    mesangial sclerosis    diffuse mesangial sclerosis    duchenne muscular dystrophy    amyotrophic lateral sclerosis
    muscular dystrophy    lateral sclerosis    sporadic breast cancer    prion disease
    maculopathy    fibromatosis    keratoconus    embryonal carcinoma
    glomerulosclerosis    toxoplasmosis    breast cancer    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for LAMC1:
    Junctional epidermolysis bullosa

    4 Novoseek disease relationships for LAMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epidermolysis bullosa junctional 61.9 2 7987320 (2)
    glioma 3 1 9055641 (1)
    tumors 0 2 7967523 (1)
    melanoma 0 1 8521420 (1)

    Genetic Association Database (GAD): LAMC1
    Human Genome Epidemiology (HuGE) Navigator: LAMC1 (4 documents)

    Export disorders for LAMC1 gene to outside databases

    Publications
    for LAMC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAMC1 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with LAMC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31. (PubMed id 3234037)1, 2, 3 Fukushima Y.... Shows T.B. (1988)
    2. Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PubMed id 15370542)1, 4, 9 Hayashi M....Allikmets R. (2004)
    3. Differences in human laminin B2 sequences. (PubMed id 1806043)1, 2, 9 Santos C.L.S.... Brentani R. (1991)
    4. Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. (PubMed id 1985895)1, 2, 9 Kallunki T.... Tryggvason K. (1991)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    7. Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains. (PubMed id 3360804)1, 2 Pikkarainen T.... Tryggvason K. (1988)
    8. Is laminin gamma-1 a candidate gene for advanced pelv ic organ prolapse? (PubMed id 20223449)1, 9 Chen C....Matthews C.A. (2010)
    9. Gamma 1 laminin and its biologically active KDI-domain may guide axons in the floor plate of human embryonic spinal cord. (PubMed id 12526023)1, 9 Wiksten M....Liesi P. (2003)
    10. Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. (PubMed id 17021862)1, 9 Nikolova G....Rodriguez L.V. (2007)

    External Searches for LAMC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LAMC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3915 HGNC: 6492 AceView: LAMC1 Ensembl:ENSG00000135862 euGenes: HUgn3915
    ECgene: LAMC1 Kegg: 3915 H-InvDB: LAMC1

    Other Databases showing LAMC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LAMC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAMC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LAMC1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for LAMC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LAMC1 gene:
    Search GeneIP for patents involving LAMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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