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LAMC1 Gene

protein-coding GIFtS: 69

GC01P181259

laminin, gamma 1 (formerly LAMB2)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LAMB2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LAMB2 ^², ³, ⁵
MGC87297 ^²
OTTHUMP00000033450 ^²

Descriptions
Laminin B2 chain ^³
laminin, gamma 1 ^²
laminin, gamma 1 (formerly LAMB2) ^²

External Ids
HGNC: 6492¹
Entrez Gene: 3915²
UniProtKB: P11047³
Ensembl: ENSG00000135862⁷

Search outside databases for aliases for LAMC1 gene

Previous GC identifers: GC01P180518 GC01P178420 GC01P179512 GC01P180231 GC01P179724

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMC1:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent

of basement membranes. They have been implicated in a wide variety of biological processes

including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.

Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1,

and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed

by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain

protein encoded by a distinct gene. Several isoforms of each chain have been described. Different

alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin

isoforms which are designated by Arabic numerals in the order of their discovery, i.e.

alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and

trimer molecules are largely unknown, but some of the chains have been shown to differ with

respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene

encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta

chain, contains structural domains similar to beta chains, however, lacks the short alpha region

separating domains I and II. The structural organization of this gene also suggested that it had

diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles

of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes,

indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been

inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1

cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized

mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMC1 (Laminin%2C_gamma_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMC1 gene

Entrez Gene cytogenetic band: 1q31 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q31

LAMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P181259: (about GC identifiers)

Start:	181,259,218 bp from pter
End:	181,381,350 bp from pter
Size:	122,133 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047 (See protein sequence)

Recommended Name: Laminin subunit gamma-1 precursor

Size: 1609 amino acids; 177603 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains

(alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped

molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit

of laminin-1 (EHS laminin), laminin-2 (merosin), laminin-3 (S-laminin), laminin-4 (S-merosin),

laminin-6 (K-laminin) and laminin-7 (KS-laminin)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane

Secondary accessions: Q5VYE7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002284.3

ENSEMBL proteins:

ENSP00000258341

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Laminin, Laminin gamma 1, Laminin B2 gamma 1, Laminin 1+2)
	Human Recombinant Proteins from Abnova (LAMC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005605	basal lamina	IEA	--
GO:0005606	laminin-1 complex	TAS	14557481
GO:0005737	cytoplasm	IDA	18029348
GO:0005783	endoplasmic reticulum	IDA	18029348

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Antibodies for LAMC1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LAMC1
	Sigma-Aldrich Antibodies for LAMC1
	R&D Systems Antibodies for LAMC1 (Laminin gamma 1)
	Antibodies from Abcam (Laminin, Laminin gamma 1, Laminin B2 gamma 1, Laminin 1+2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAMC1)
	Novus Biologicals Antibodies for LAMC1

Assays for LAMC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11047

ProtoNet protein and cluster: P11047

3 Blocks protein families:

IPB000034 Laminin B

IPB002049 Laminin-type EGF-like domain

IPB008212 Laminin

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to

form a coiled coil structure

Domain: Domains VI and IV are globular

Similarity: Contains 11 laminin EGF-like domains

Similarity: Contains 1 laminin IV type A domain

Similarity: Contains 1 laminin N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002293

Applied Biosystems Silencer® siRNAs for LAMC1

Sigma-Aldrich siRNA for LAMC1

Sigma-Aldrich shRNA Panels and shRNA for LAMC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LAMC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002293
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002293
untagged cDNA clone in CMV expression vector: NM_002293

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002293

UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMC1:

laminin,gamma 1 polypeptide,component of cutaneous basement membrane zone

13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lamc1):

	behavior/neurological	embryogenesis	endocrine/exocrine gland	growth/size
lethality-prenatal/perinatal	nervous system	normal	other	renal/urinary system
reproductive system	respiratory system	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	IMP	15159456
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for LAMC1 (Your Favorite Gene powered by Ingenuity)

Agrin Interactions at Neuromuscular Junction
CDK5 Signaling

GeneDecks LAMC1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for LAMC1

5/102 Interacting proteins for LAMC1 (ENSP00000258341³ P11047²) via UniProtKB, MINT, and/or STRING (see all 102 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²	MINT-61907
CCDC53	Q9Y3C0²	MINT-65844
PDIA3	P30101²	MINT-4301406
SNAPIN	O95295²	MINT-63276
LAMA5	ENSP00000252999³	STRING (score=.968)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	IDA	15159456
GO:0007155	cell adhesion	IDA	15159456
GO:0007492	endoderm development	TAS	9885251
GO:0016477	cell migration	IMP	15561105
GO:0022617	extracellular matrix disassembly	IMP	15159456

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMC1
1 Novoseek chemical compound relationship for LAMC1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
kalinin	75.22	1	8306988 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002293

Sigma-Aldrich siRNA for LAMC1

Sigma-Aldrich shRNA Panels and shRNA for LAMC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002293

REFSEQ mRNAs for LAMC1 gene:

NM_002293.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002293

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002293
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002293
                                 untagged cDNA clone in CMV expression vector: NM_002293

Additional cDNA sequence:

BC015586.2 BC035429.1 BC067813.1 CR593573.1 J03202.1 M27654.1 X13939.1

11 DOTS entries:

DT.449842 DT.95149578 DT.101971664 DT.40234973 DT.100685117 DT.92452392 DT.100791165 DT.100791172

DT.101963075 DT.92452403 DT.95124002

24/476 AceView cDNA sequences (see all 476 ):

BF448018 AI754908 CA310056 CB216170 BF436491 CR593573 AI985158 CA424260

BM664886 CB215601 AW004971 BM562700 BM907557 BQ020657 AW069533 BU627391

BM748169 BM784122 H24649 CB143194 AI419268 AA022971 AA349553 BM993300

highest scoring ESTs for LAMC1:

AA022903 AA022971 AA032191 AA035488 AA037120 AA069151 AA091063 AA091134 AA094916 AA131447

Unigene Cluster for LAMC1:

Laminin, gamma 1 (formerly LAMB2)

Hs.609663 [show with all ESTs]

Unigene Representative Sequence: NM_002293

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000258341

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LAMC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMC1

¹ / ² / ³

5 probe-sets matching LAMC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
232_at²^{, 3}	U95-A	1	0.81	1.00	1.00	1.00	M55210	0.20	1.00	0.72	1
200771_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002293	0.60	1.00	0.82	1
200770_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J03202	0.80	0.88	0.84	1
200771_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200770_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMC1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTATAGAAT

SOURCE GeneReport for Unigene cluster: Hs.609663
Expression variation in blood from EXPOLDB for LAMC1
UniProtKB/Swiss-Prot: LAMC1_HUMAN, P11047
Tissue specificity: Found in the basement membranes (major component)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMC1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMC1¹	--	laminin, gamma 1 (formerly LAMB2)	90.93(n) 95.06(a)	480034 XM_537156.2 XP_537156.2
chimpanzee (Pan troglodytes)	LAMC1¹	--	laminin, gamma 1 (formerly LAMB2)	99.34(n) 99.32(a)	457570 XM_001162648.1 XP_001162648.1
cow (Bos taurus)	LAMC1¹	--	laminin, gamma 1 (formerly LAMB2)	90.1(n) 94.09(a)	532572 XM_611689.3 XP_611689.3
rat (Rattus norvegicus)	Lamc1¹	--	laminin, gamma 1	86.5(n) 92.41(a)	117036 XM_341133.3 XP_341134.2
mouse (Mus musculus)	Lamc1^{1, 5}	1 (81.10 cM)⁵	laminin, gamma 1^{1, 5}	86.95(n)¹ 92.72(a)¹	226519¹ NM_010683.1¹ NP_034813.1¹ AI323447⁵ AK141201⁵ (see all 21)

About this table Species with no ortholog for LAMC1

ENSEMBL Gene Tree for LAMC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMC1 gene

LAMC3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/832 NCBI SNPs in LAMC1 are shown (see all 832 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 322)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs944970^1,2	A,C,F,H,O	181379189(-)	`CCTGGG/AGACTT`	1	--	ut3¹ ese³		9	MN EA NA EU WA	2044
	rs1547715^1,2	A,C,F,H,O	181380575(-)	`ACCCAT/CCAGTA`	1	--	ut3¹ ese³		16	EA NA MN EU WA	1244
	rs1051473^1,2	A,C,F,H,O	181380769(-)	`GAAACG/AATGAC`	1	--	ut3¹		11	MN EU EA WA NA	2370
--	rs3359^1,2	A,C,F,H,O	181378664(+)	`TCCATC/GACTGT`	1	--	ut3¹ ese³		6	MN WA EA NA	1934
	rs944971^1,2	A,C,F,H,O	181379128(-)	`TAATAA/GCTAAA`	1	--	ut3¹		8	MN NA EU EA WA	736
	rs10911262^1,2	A,C,F,H	181381579(+)	`gagctG/Agatag`	1	--	ng3¹		3	EU EA	280
	rs1062044^1,2	A,C,F,H	181379035(-)	`AGGGGC/TAGGAG`	1	--	ut3¹ ese³		9	NA EA MN EU WA	2328
	rs3738829^1,2	A,C,F,H	181380485(-)	`TGCCAA/GAAAGG`	1	--	ut3¹ ese³		12	EA NA EU WA	2398
	rs6658501^1,2	A,C,F,H	181258040(+)	`ATTAAA/GTTCCT`	1	--	ng5¹ tfbs³		9	EU EA WA NA	928
	rs6695837^1,2	A,C,F,H	181258085(+)	`CTATGT/CGCATC`	1	--	ng5¹		4	EU EA WA	414

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HapMap Linkage Disequilibrium images for LAMC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 150290 disorders: 176780

4 Novoseek disease relationships for LAMC1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
epidermolysis bullosa junctional	63.02	2	7987320 (2)
glioma	5.72	1	9055641 (1)
melanoma	0.00	1	8521420 (1)
tumors	0.00	2	7967523 (1)

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Human Gene Mutation Database: LAMC1
Genetic Association Database: LAMC1
Human Genome Epidemiology Navigator: LAMC1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/101 PubMed articles for LAMC1 gene (see all 101 ):

Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31. (PubMed id 3234037)^{2, 3, 4} Fukushima Y.... Shows T.B. (1988)
Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PubMed id 15370542)^{1, 3, 6} Hayashi M....Allikmets R. (2004)
Differences in human laminin B2 sequences. (PubMed id 1806043)^{1, 3, 4} Santos C.L.S.... Brentani R. (1991)
Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. (PubMed id 1985895)^{1, 3, 4} Kallunki T.... Tryggvason K. (1991)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{3, 4} Zhang H.... Aebersold R. (2003)
Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains. (PubMed id 3360804)^{3, 4} Pikkarainen T.... Tryggvason K. (1988)
Gamma 1 laminin and its biologically active KDI-domain may guide axons in the floor plate of human embryonic spinal cord. (PubMed id 12526023)^{1, 3} Wiksten M....Liesi P. (2003)
Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. (PubMed id 17021862)^{1, 3} Nikolova G....Rodriguez L.V. (2007)
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow. (PubMed id 18073332)^{1, 3} Jakobsson L....Claesson-Welsh L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3915	HGNC: 6492	AceView: LAMC1	Ensembl:ENSG00000135862	euGenes: HUgn3915
ECgene: LAMC1	H-InvDB: LAMC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LAMC1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LAMC1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAMC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAMC1		Antibodies for LAMC1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAMC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LAMC1)
	Antibodies (LAMC1)
	Chimera RNAi (LAMC1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Laminin, Laminin gamma 1, Laminin B2 gamma 1, Laminin 1+2)
	Antibodies (Laminin, Laminin gamma 1, Laminin B2 gamma 1, Laminin 1+2)

Search OriGene for LAMC1

Search Tocris compounds for LAMC1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LAMC1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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LAMC1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for LAMC1

Summaries
for LAMC1

Genomic Location
for LAMC1

Proteins
for LAMC1

Protein Domains/
Families
for LAMC1

Gene Function
for LAMC1

Pathways & Interactions
for LAMC1

Drugs & Compounds
for LAMC1

Transcripts
for LAMC1

Expression
for LAMC1

Orthologs
for LAMC1

Paralogs
for LAMC1

SNPs/Variants
for LAMC1

Disorders & Mutations
for LAMC1

Medical News
for LAMC1

Publications
for LAMC1

Search for LAMC1

Genome Databases showing LAMC1

Other Databases showing LAMC1

Specialized Databases showing LAMC1

Licensable Technologies
for LAMC1

Services
for LAMC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMC1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor LAMC1

Summariesfor LAMC1

Genomic Locationfor LAMC1

Proteinsfor LAMC1

Protein Domains/Familiesfor LAMC1

Gene Functionfor LAMC1

Pathways & Interactionsfor LAMC1

Drugs & Compoundsfor LAMC1

Transcriptsfor LAMC1

Expression for LAMC1

Orthologsfor LAMC1

Paralogsfor LAMC1

SNPs/Variantsfor LAMC1

Disorders & Mutationsfor LAMC1

Medical Newsfor LAMC1

Publicationsfor LAMC1

Search for LAMC1

Genome Databases showing LAMC1

Other Databases showing LAMC1

Specialized Databases showing LAMC1

Licensable Technologiesfor LAMC1

Servicesfor LAMC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMC1

Summaries
for LAMC1

Genomic Location
for LAMC1

Proteins
for LAMC1

Protein Domains/
Families
for LAMC1

Gene Function
for LAMC1

Pathways & Interactions
for LAMC1

Drugs & Compounds
for LAMC1

Transcripts
for LAMC1

Expression
for LAMC1

Orthologs
for LAMC1

Paralogs
for LAMC1

SNPs/Variants
for LAMC1

Disorders & Mutations
for LAMC1

Medical News
for LAMC1

Publications
for LAMC1

Licensable Technologies
for LAMC1

Services
for LAMC1