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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAMB4 Gene

protein-coding   GIFtS: 48
GCID: GC07M107663

laminin, beta 4

 Explore 7 diseases affiliated with
LAMB4 via our new
 Human Malady Compendium 
Biological research products
for LAMB4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Laminin, Beta 41 2
Laminin Beta-1-Related Protein2 3
Laminin Subunit Beta-42

External Ids:    HGNC: 64911   Entrez Gene: 227982   Ensembl: ENSG000000911287   UniProtKB: A4D0S43   

Export aliases for LAMB4 gene to outside databases

Previous GC identifers: GC07M106148 GC07M107210 GC07M107224 GC07M107257 GC07M107451 GC07M102026


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and
organization of cells into tissues during embryonic development by interacting with other extracellular matrix
components




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAMB4 gene promoter:
         HOXA9   Nkx3-1   Nkx3-1 v4   C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAMB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31

LAMB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M107663:  view genomic region     (about GC identifiers)

Start:
107,663,993 bp from pter      End:
107,770,801 bp from pter
Size:
106,809 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 107,025,127-107,131,988     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4 (See protein sequence)
Recommended Name: Laminin subunit beta-4 precursor  
Size: 1761 amino acids; 193540 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms
with globules at each end
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane
Secondary accessions: A5PKU6 B2RTT3 B5MEB9 Q86TP7 Q86XN2 Q8NBX5
Alternative splicing: 3 isoforms:  A4D0S4-1   A4D0S4-2   A4D0S4-3   

Explore the universe of human proteins at neXtProt for LAMB4: NX_A4D0S4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A4D0S4

  • LAMB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031382.2  
    ENSEMBL proteins: 
     ENSP00000205386   ENSP00000416562   ENSP00000402353   ENSP00000373433   ENSP00000373432  
     ENSP00000402265  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--


    LAMB4 for ontologies           About GeneDecksing



    LAMB4 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LAMB4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008211 Laminin_N
     IPR002049 EGF_laminin
     IPR013015 Laminin_IV
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry A4D0S4

    ProtoNet protein and cluster: A4D0S4

    UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI and IV are globular
    Similarity: Contains 13 laminin EGF-like domains
    Similarity: Contains 1 laminin IV type B domain
    Similarity: Contains 1 laminin N-terminal domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and
    organization of cells into tissues during embryonic development by interacting with other extracellular matrix
    components

         Genatlas biochemistry entry for LAMB4:
    laminin,beta 4,with two alternatively spliced

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    Integrin Pathway1.00
    UPA-UPAR Pathway0.51
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    Inhibition of Angiogenesis by TSP10.37
    2Rho Family GTPases
    Rho Family GTPases1.00
    MAPK Signaling0.51
    ERK Signaling0.61
    ILK Signaling0.45
    Molecular Mechanisms of Cancer0.51
    3PTEN Pathway
    PTEN Pathway1.00
    Phospholipase-C Pathway0.56
    4Small cell lung cancer
    Small cell lung cancer1.00
    5Pathways in cancer
    Pathways in cancer1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMB4 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes


    5/6         Kegg Pathways  (Kegg details for LAMB4) (see all 6):
        Focal adhesion
    ECM-receptor interaction
    Toxoplasmosis
    Amoebiasis
    Pathways in cancer


    LAMB4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LAMB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for LAMB4 (A4D0S43 ENSP000002053864) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCTD13Q8WZ193, ENSP000003112024I2D: score=2 STRING: ENSP00000311202
    PRKAG2Q9UGJ03I2D: score=1 
    CD44ENSP000002783854STRING: ENSP00000278385
    DAG1ENSP000003124354STRING: ENSP00000312435
    ITGA1ENSP000002825884STRING: ENSP00000282588
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--


    LAMB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAMB4
    Search CenterWatch for drugs/clinical trials and news about LAMB4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAMB4 gene: 
    NM_007356.2  

    Unigene Cluster for LAMB4:

    Laminin, beta 4
    Hs.62022  [show with all ESTs]
    Unigene Representative Sequence: AF028816
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000205386 ENST00000483484 ENST00000422975(uc010ljp.1) ENST00000475572
    ENST00000471677 ENST00000475469 ENST00000418464 ENST00000388781(uc010ljo.1 uc003vey.2)
    ENST00000388780 ENST00000414450

    miRNA
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    hsa-miR-219-2-3p hsa-miR-766
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    Inhib. RNA
    Products:
         
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    OriGene siRNA: LAMB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMB4
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMB4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMB4

    Additional cDNA sequence: 

    AF028816.1 AK300385.1 AK301777.1 BC045172.2 BC140804.1 BC142619.1 BC144591.1 

    6 DOTS entries:

    DT.40113979  DT.100698738  DT.100736500  DT.91700592  DT.100009859  DT.40114466 

    14 AceView cDNA sequences:

    NM_007356 BX095174 BC045172 AF028816 AI803176 BG480015 BI461103 W69706 
    BI459439 AF029325 BG216241 W69707 BV193712 AK075165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAMB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATAAAAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See LAMB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAMB4

    SOURCE GeneReport for Unigene cluster: Hs.62022
        SABiosciences Custom PCR Arrays for LAMB4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LAMB4 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LAMB41 laminin, beta 4 65.7(n)
    59.45(a)
      396076  NM_001199313.1  NP_001186242.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMB46
    NTNG26
    --
    56(a)
    13(a)
    1 ↔ 1
    possible ortholog
    5(97909281-97981067)
    GL343812.1(183328-201709)
    zebrafish
    (Danio rerio)
    Actinopterygii AF468050.12   -- 76.08(n)   286831  AF468050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LanB16
    LanB1
    35(a)
    1 → many
    2L(7811440-7820771)
    worm
    (Caenorhabditis elegans)
    Secernentea lam-16
    LAMinin related. See also lmb- family member (lam-...
    42(a)
    1 → many
    IV(5173272-5179263)


    ENSEMBL Gene Tree for LAMB4 (if available)
    TreeFam Gene Tree for LAMB4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAMB4 gene
    NTN42  LAMA12  NTN52  LAMA32  LAMA22  LAMB22  LAMC12  LAMC22  
    LAMA52  NTN32  LAMB32  LAMC32  LAMA42  NTN12  NTNG12  USH2A2  
    NTNG22  LAMB12  
    18/48 SIMAP similar genes for LAMB4 using alignment to 5 protein entries:     LAMB4_HUMAN (see all proteins) (see all similar genes):
    unknown    HMGA2    C4orf22    CHID1    FKBP3    RNF217
    AURA2    NF2    PTPLA    ZNF74    TCEB1    ZNF212
    FP1523    SHANK2    QRICH2    ZNF564    LYRM4    TMEM14B

    LAMB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1950 NCBI SNPs in LAMB4 are shown (see all 1950    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481599441,2
    --107663548(+) GTCACC/TATGCC 1 -- ds50010--------
    rs1852114691,2
    --107663563(+) TTTAAA/TTCTAT 1 -- ds50010--------
    rs1923706081,2
    --107663595(+) TGGAAA/TTGCTC 1 -- ds50010--------
    rs1820460911,2
    --107663639(+) ATGTAC/TATTAT 1 -- ds50010--------
    rs1871507381,2
    --107663690(+) ACTTTA/CTGAAG 1 -- ds50010--------
    rs17321511,2
    C,F,A,H,--107663741(+) TCATAC/TGTGCA 1 -- ds500111Minor allele frequency- T:0.27NS EA NA WA CSA 664
    rs671670151,2
    C,--107663751(+) AAAAA-/TAGT  
            
    TAGTA
    1 -- ds50011Minor allele frequency- TAGT:0.00CSA 2
    rs17321521,2
    C,F,A,H,--107663947(+) AGAATT/CCCCTG 1 -- ds500112Minor allele frequency- C:0.27NS EA WA NA CSA 660
    rs1178511881,2
    F,--107663975(+) AGGAAC/TGTAGG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1915312761,2
    --107664001(+) CATTTC/TGAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LAMB4 (107663993 - 107770801 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for LAMB4
         1 CNV: 100072
         3 Indels: 12956 47203 41518

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LAMB4 for disorders           About GeneDecksing

    7 diseases for LAMB4:    About MalaCards
    cicatricial pemphigoid    invasive aspergillosis    aspergillosis    dilated cardiomyopathy
    toxoplasmosis    cardiomyopathy    lung cancer

    Human Genome Epidemiology (HuGE) Navigator: LAMB4 (2 documents)

    Export disorders for LAMB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAMB4 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with LAMB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analysis of coffee drinking su ggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)1 Amin N....van Duijn C.M. (2012)
    2. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1 Maestrini E....Monaco A.P. (2009)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. A novel locus for autosomal-dominant dilated cardiomyopathy maps to chromosome 7q22.3-31.1. (PubMed id 16228230)1 Schonberger J....Zimmer M. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. (PubMed id 11483367)1 Dry K.... Platzer M. (2001)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22798 HGNC: 6491 AceView: LAMB4 Ensembl:ENSG00000091128 euGenes: HUgn22798
    ECgene: LAMB4 Kegg: 22798 H-InvDB: LAMB4

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAMB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LAMB4 gene:
    Search GeneIP for patents involving LAMB4

    GeneCards and IP:
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