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Aliases & Descriptions for LAMB4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Laminin beta-1-related protein 3 | | laminin, beta 4 2 |
|
| | Search outside databases for aliases for LAMB4 genePrevious GC identifers: GC07M106148 GC07M107210 GC07M107224 GC07M107257 |
Summaries for LAMB4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components |
Genomic Location for LAMB4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAMB4 gene 
Entrez Gene cytogenetic band: 7q22-q31.2 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31LAMB4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M107451:
(about GC identifiers)
Start:
|
107,451,232 bp from pter |
End:
|
107,558,037 bp from pter |
Size:
|
106,806 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 107,025,127-107,131,988 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for LAMB4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4 (See
protein sequence)Recommended Name: Laminin subunit beta-4 precursor Size: 1761 amino acids; 193540 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane
Secondary accessions: A5PKU6 B2RTT3 Q86TP7 Q86XN2 Q8NBX5Alternative splicing: 4 isoforms: A4D0S4-1 A4D0S4-2 A4D0S4-3 A4D0S4-4 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_031382.2
ENSEMBL proteins: ENSP00000373432 ENSP00000373433 ENSP00000205386
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005604 | basement membrane |
IEA | -- | About this table
Antibodies for LAMB4: Assays for LAMB4: | Protein
Domains/ Families for LAMB4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry A4D0S4
ProtoNet protein and cluster: A4D0S4 UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structureDomain: Domains VI and IV are globularSimilarity: Contains 13 laminin EGF-like domainsSimilarity: Contains 1 laminin IV type B domainSimilarity: Contains 1 laminin N-terminal domain | Gene Function for LAMB4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007356
Applied Biosystems Silencer® siRNAs for LAMB4
Sigma-Aldrich siRNA for LAMB4  Sigma-Aldrich shRNA Panels and shRNA for LAMB4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007356                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007356                                  untagged cDNA clone in CMV expression vector: NM_007356 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007356
UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix componentsGenatlas biochemistry entry for LAMB4:laminin,beta 4,with two alternatively spliced1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for LAMB4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/90 Interacting proteins for LAMB4 (ENSP000003734323) via UniProtKB, MINT, and/or STRING (see all 90
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for LAMB4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAMB4
|
Transcripts for LAMB4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007356
Sigma-Aldrich siRNA for LAMB4  Sigma-Aldrich shRNA Panels and shRNA for LAMB4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007356 REFSEQ mRNAs for LAMB4 gene: NM_007356.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007356               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007356                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007356                                  untagged cDNA clone in CMV expression vector: NM_007356  Additional cDNA sequence: AF028816.1 AK300385.1 AK301777.1 BC045172.2 BC140804.1 BC142619.1 BC144591.1 6 DOTS entries: DT.40113979 DT.100698738 DT.100736500 DT.40114466 DT.91700592 DT.100009859 14 AceView cDNA sequences:NM_007356 BC045172 BX095174 AF028816 AI803176 BI459439 BG480015 W69706 BI461103 AF029325 BG216241 W69707 BV193712 AK075165
highest scoring ESTs for LAMB4:AF028816 AF029325 BC045172 BG216241 BG480015 NM_007356 W69707 AI803176 BI459439 BI461103 Unigene Cluster for LAMB4: Laminin, beta 4 Hs.62022 [show with all ESTs]Unigene Representative Sequence: AF028816
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000388780
ENST00000388781
ENST00000205386
|
Expression for LAMB4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAMB4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAMB4
1 / 2 / 3 7 probe-sets matching LAMB4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GATAAAAATA
SOURCE GeneReport for Unigene cluster: Hs.62022
Expression variation in blood from EXPOLDB for LAMB4 |
Orthologs for LAMB4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAMB4 gene from 4 species
About this table Species with no ortholog for LAMB4
ENSEMBL Gene Tree for LAMB4 | Paralogs for LAMB4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAMB4 gene
- LAMB12 LAMB22
|
SNPs/Variants for LAMB4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAMB4 (up to first 250kb)
|
Disorders & Mutations for LAMB4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| Human Genome Epidemiology Navigator: LAMB4 (1 document)
|
Medical News for LAMB4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAMB4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for LAMB4 gene (see all 11
): |
Search for LAMB4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAMB4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAMB4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAMB4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAMB4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAMB4:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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