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Aliases for LAMB4 Gene

Aliases for LAMB4 Gene

  • Laminin Subunit Beta 4 2 3 5
  • Laminin Beta-1-Related Protein 4
  • Laminin, Beta 4 2

External Ids for LAMB4 Gene

Previous GeneCards Identifiers for LAMB4 Gene

  • GC07M106148
  • GC07M107210
  • GC07M107224
  • GC07M107257
  • GC07M107451
  • GC07M107663
  • GC07M102026

Summaries for LAMB4 Gene

GeneCards Summary for LAMB4 Gene

LAMB4 (Laminin Subunit Beta 4) is a Protein Coding gene. Among its related pathways are Amoebiasis and ECM-receptor interaction. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for LAMB4 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMB4 Gene

Genomics for LAMB4 Gene

Regulatory Elements for LAMB4 Gene

Enhancers for LAMB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LAMB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAMB4 Gene

Chromosome:
7
Start:
108,003,986 bp from pter
End:
108,130,356 bp from pter
Size:
126,371 bases
Orientation:
Minus strand

Genomic View for LAMB4 Gene

Genes around LAMB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMB4 Gene

Proteins for LAMB4 Gene

  • Protein details for LAMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D0S4-LAMB4_HUMAN
    Recommended name:
    Laminin subunit beta-4
    Protein Accession:
    A4D0S4
    Secondary Accessions:
    • A5PKU6
    • B2RTT3
    • B5MEB9
    • Q86TP7
    • Q86XN2
    • Q8NBX5

    Protein attributes for LAMB4 Gene

    Size:
    1761 amino acids
    Molecular mass:
    193540 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

    Alternative splice isoforms for LAMB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMB4 Gene

Proteomics data for LAMB4 Gene at MOPED

Post-translational modifications for LAMB4 Gene

  • Glycosylation at Asn 169, Asn 229, Asn 246, Asn 1016, Asn 1055, Asn 1223, Asn 1301, Asn 1326, Asn 1333, Asn 1354, Asn 1469, Asn 1517, Asn 1587, Asn 1596, Asn 1609, and Asn 1725
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMB4 Gene

No data available for DME Specific Peptides for LAMB4 Gene

Domains & Families for LAMB4 Gene

Gene Families for LAMB4 Gene

Protein Domains for LAMB4 Gene

Suggested Antigen Peptide Sequences for LAMB4 Gene

Graphical View of Domain Structure for InterPro Entry

A4D0S4

UniProtKB/Swiss-Prot:

LAMB4_HUMAN :
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain:
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
  • Domains VI and IV are globular.
  • Contains 13 laminin EGF-like domains.
  • Contains 1 laminin IV type B domain.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with LAMB4: view

Function for LAMB4 Gene

Molecular function for LAMB4 Gene

GENATLAS Biochemistry:
laminin,beta 4,with two alternatively spliced
UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Phenotypes for LAMB4 Gene

genes like me logo Genes that share phenotypes with LAMB4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LAMB4 Gene

Localization for LAMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMB4 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMB4 Gene COMPARTMENTS Subcellular localization image for LAMB4 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for LAMB4 Gene

Pathways & Interactions for LAMB4 Gene

genes like me logo Genes that share pathways with LAMB4: view

Pathways by source for LAMB4 Gene

Gene Ontology (GO) - Biological Process for LAMB4 Gene

None

No data available for SIGNOR curated interactions for LAMB4 Gene

Drugs & Compounds for LAMB4 Gene

No Compound Related Data Available

Transcripts for LAMB4 Gene

Unigene Clusters for LAMB4 Gene

Laminin, beta 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMB4 Gene

No ASD Table

Relevant External Links for LAMB4 Gene

GeneLoc Exon Structure for
LAMB4
ECgene alternative splicing isoforms for
LAMB4

Expression for LAMB4 Gene

mRNA expression in normal human tissues for LAMB4 Gene

mRNA differential expression in normal tissues according to GTEx for LAMB4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x24.1) and Skin - Sun Exposed (Lower leg) (x22.7).

Protein differential expression in normal tissues from HIPED for LAMB4 Gene

This gene is overexpressed in Bone (22.4), Neutrophil (12.2), Tlymphocyte (12.0), Monocytes (11.7), and Blymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMB4 Gene



SOURCE GeneReport for Unigene cluster for LAMB4 Gene Hs.62022

genes like me logo Genes that share expression patterns with LAMB4: view

Protein tissue co-expression partners for LAMB4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LAMB4 Gene

Orthologs for LAMB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMB4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LAMB4 35
  • 83.36 (n)
  • 77.68 (a)
LAMB4 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAMB4 35
  • 99.32 (n)
  • 98.81 (a)
LAMB4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAMB4 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMB4 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMB4 35
  • 65.61 (n)
  • 59.31 (a)
LAMB4 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMB4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamb4 35
  • 59.07 (n)
  • 50.78 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
lamb4 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta LanB1 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lam-1 36
  • 35 (a)
OneToMany
Species with no ortholog for LAMB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMB4 Gene

ENSEMBL:
Gene Tree for LAMB4 (if available)
TreeFam:
Gene Tree for LAMB4 (if available)

Paralogs for LAMB4 Gene

Paralogs for LAMB4 Gene

genes like me logo Genes that share paralogs with LAMB4: view

Variants for LAMB4 Gene

Sequence variations from dbSNP and Humsavar for LAMB4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35644375 - 108,116,065(+) AAGCC(A/G)TAAGC nc-transcript-variant, reference, missense
rs2074749 - 108,105,987(+) GGTGT(A/G)GAGCT nc-transcript-variant, reference, missense
rs9690688 - 108,079,717(+) TGTAA(A/C)AGGGT nc-transcript-variant, reference, missense
rs2240445 - 108,066,450(+) ACCTA(C/T)TACAA nc-transcript-variant, reference, missense
rs10260756 - 108,049,399(+) TTGAG(G/T)TTAGT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LAMB4 Gene

Variant ID Type Subtype PubMed ID
nsv831088 CNV Loss 17160897
esv2595279 CNV Deletion 19546169
esv2734998 CNV Deletion 23290073
esv2037177 CNV Deletion 18987734
esv3089 CNV Deletion 18987735
esv2734999 CNV Deletion 23290073
nsv365697 CNV Loss 16902084
esv2735000 CNV Deletion 23290073
nsv831089 CNV Loss 17160897

Variation tolerance for LAMB4 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMB4 Gene

HapMap Linkage Disequilibrium report
LAMB4
Human Gene Mutation Database (HGMD)
LAMB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMB4 Gene

Disorders for LAMB4 Gene

Relevant External Links for LAMB4

Genetic Association Database (GAD)
LAMB4
Human Genome Epidemiology (HuGE) Navigator
LAMB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMB4

No disorders were found for LAMB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAMB4 Gene

Publications for LAMB4 Gene

  1. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PMID: 21876539) Amin N. … van Duijn C.M. (Mol. Psychiatry 2012) 3 48 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Laminin gene LAMB4 is somatically mutated and expressionally altered in gastric and colorectal cancers. (PMID: 25257191) Choi M.R. … Lee S.H. (APMIS 2015) 3
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for LAMB4 Gene

Sources for LAMB4 Gene

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