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LAMB4 Gene

protein-coding   GIFtS: 50
GCID: GC07M107663

Laminin, Beta 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Laminin, Beta 41 2
Laminin Beta-1-Related Protein2 3
Laminin Subunit Beta-42

External Ids:    HGNC: 64911   Entrez Gene: 227982   Ensembl: ENSG000000911287   UniProtKB: A4D0S43   

Export aliases for LAMB4 gene to outside databases

Previous GC identifers: GC07M106148 GC07M107210 GC07M107224 GC07M107257 GC07M107451 GC07M102026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LAMB4 Gene:
LAMB4 (laminin, beta 4) is a protein-coding gene. An important paralog of this gene is LAMC1.

UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAMB4 gene promoter:
         HOXA9   Nkx3-1   Nkx3-1 v4   C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LAMB4 promoter sequence
   Search Chromatin IP Primers for LAMB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31

LAMB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M107663:  view genomic region     (about GC identifiers)

Start:
107,663,993 bp from pter      End:
107,770,801 bp from pter
Size:
106,809 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 107,025,127-107,131,988     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4 (See protein sequence)
Recommended Name: Laminin subunit beta-4 precursor  
Size: 1761 amino acids; 193540 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end
Secondary accessions: A5PKU6 B2RTT3 B5MEB9 Q86TP7 Q86XN2 Q8NBX5
Alternative splicing: 3 isoforms:  A4D0S4-1   A4D0S4-2   A4D0S4-3   

Explore the universe of human proteins at neXtProt for LAMB4: NX_A4D0S4

Explore proteomics data for LAMB4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn169, Asn229, Asn246, Asn1016, Asn1055, Asn1223, Asn1301, Asn1326, Asn1333, Asn1354,
                                 Asn1469, Asn1517, Asn1587, Asn1596, Asn1609, Asn1725
  • Modification sites at PhosphoSitePlus

  • See LAMB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031382.2  
    ENSEMBL proteins: 
     ENSP00000205386   ENSP00000416562   ENSP00000402353   ENSP00000373433   ENSP00000373432  
     ENSP00000402265  

    LAMB4 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LAMB4 

     
    Search antibodies-online for proteins for LAMB4 

     
    antibodies-online peptides for LAMB4

    LAMB4 Antibody Products:

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    Search antibodies-online for antibodies for LAMB4 

    LAMB4 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for LAMB4 
    antibodies-online kits for LAMB4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LAM: Laminins

    4 InterPro protein domains:
     IPR013015 Laminin_IV
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry A4D0S4

    ProtoNet protein and cluster: A4D0S4

    UniProtKB/Swiss-Prot: LAMB4_HUMAN, A4D0S4
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI and IV are globular
    Similarity: Contains 13 laminin EGF-like domains
    Similarity: Contains 1 laminin IV type B domain
    Similarity: Contains 1 laminin N-terminal domain


    Find genes that share domains with LAMB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMB4_HUMAN, A4D0S4
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMB4:
    laminin,beta 4,with two alternatively spliced

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LAMB4

    miRNA
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    Block miRNA regulation of human, mouse, rat LAMB4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LAMB4:
    hsa-miR-219-2-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidLAMB4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAMB4
    Predesigned siRNA for gene silencing in human, mouse, rat LAMB4

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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAMB4_HUMAN, A4D0S4: Secreted, extracellular space, extracellular matrix, basement membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--

    Find genes that share ontologies with LAMB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAMB4 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    4Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56
    5Beta-Adrenergic Signaling
    CDK5 Pathway0.36


    Find genes that share SuperPaths with LAMB4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAMB4 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes


    Selected Kegg Pathways  (Kegg details for LAMB4) (see all 7):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Toxoplasmosis
    Amoebiasis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LAMB4
    Interactions:

        Search GeneGlobe Interaction Network for LAMB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAMB4 (A4D0S43 ENSP000002053864) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCTD13Q8WZ193, ENSP000003112024I2D: score=2 STRING: ENSP00000311202
    PRKAG2Q9UGJ03I2D: score=1 
    CD44ENSP000002783854STRING: ENSP00000278385
    DAG1ENSP000003124354STRING: ENSP00000312435
    ITGA1ENSP000002825884STRING: ENSP00000282588
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with LAMB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAMB4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAMB4 gene: 
    NM_007356.2  

    Unigene Cluster for LAMB4:

    Laminin, beta 4
    Hs.62022  [show with all ESTs]
    Unigene Representative Sequence: AF028816
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000205386 ENST00000483484 ENST00000422975(uc010ljp.1) ENST00000475572
    ENST00000471677 ENST00000475469 ENST00000418464 ENST00000388781(uc010ljo.1 uc003vey.2)
    ENST00000388780 ENST00000414450
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LAMB4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LAMB4:
    hsa-miR-219-2-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidLAMB4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LAMB4
    Predesigned siRNA for gene silencing in human, mouse, rat LAMB4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMB4 (NM_007356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMB4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LAMB4
      QuantiTect SYBR Green Assays in human, mouse, rat LAMB4
      QuantiFast Probe-based Assays in human, mouse, rat LAMB4

    Additional mRNA sequence: 

    AF028816.1 AK300385.1 AK301777.1 BC045172.2 BC140804.1 BC142619.1 BC144591.1 

    6 DOTS entries:

    DT.40113979  DT.100698738  DT.100736500  DT.91700592  DT.100009859  DT.40114466 

    14 AceView cDNA sequences:

    AI803176 BC045172 AF028816 NM_007356 BX095174 BI459439 W69706 BI461103 
    BG480015 AF029325 BG216241 W69707 BV193712 AK075165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAMB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAAAAATA
    LAMB4 Expression
    About this image

    LAMB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAMB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62022
        Custom PCR Arrays for LAMB4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LAMB4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LAMB41 laminin, beta 4 83.36(n)
    77.68(a)
      483260  XM_540379.4  XP_540379.3 
    chicken
    (Gallus gallus)
    Aves LAMB41 laminin, beta 4 65.61(n)
    59.31(a)
      396076  NM_001199313.1  NP_001186242.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMB46
    laminin, beta 4
    56(a)
    1 ↔ 1
    5(97908253-97981067)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lamb41 laminin, beta 4 59.07(n)
    50.78(a)
      100485623  XM_002933116.2  XP_002933162.2 
    zebrafish
    (Danio rerio)
    Actinopterygii AF468050.12   -- 76.08(n)   286831  AF468050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LanB16
    LanB1
    35(a)
    1 → many
    2L(7811440-7820771)
    worm
    (Caenorhabditis elegans)
    Secernentea lam-16
    Protein LAM-1 (lam-1) mRNA, complete cds
    35(a)
    1 → many
    IV(5173280-5183708) WBGene00002247


    ENSEMBL Gene Tree for LAMB4 (if available)
    TreeFam Gene Tree for LAMB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LAMB4 gene
    LAMC12  LAMA52  LAMC22  LAMA12  LAMC32  LAMA42  LAMA32  LAMA22  
    USH2A2  LAMB22  LAMB12  
    Selected SIMAP similar genes for LAMB4 using alignment to 4 protein entries:     LAMB4_HUMAN (see all proteins) (see all similar genes):
    HMGA2    unknown    C4orf22    CHID1    FKBP3    RNF217
    ZNF737    AURA2    NF2    ZNF738    PTPLA    ZNF74
    CTSS    ZNF212    FP1523    SHANK2    QRICH2    ZNF564

    Find genes that share paralogs with LAMB4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAMB4 (see all 2422)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481599441,2
    --107663548(+) GTCACC/TATGCC 1 -- ds50010--------
    rs1852114691,2
    --107663563(+) TTTAAA/TTCTAT 1 -- ds50010--------
    rs1923706081,2
    --107663595(+) TGGAAA/TTGCTC 1 -- ds50010--------
    rs1820460911,2
    --107663639(+) ATGTAC/TATTAT 1 -- ds50010--------
    rs1871507381,2
    --107663690(+) ACTTTA/CTGAAG 1 -- ds50010--------
    rs17321511,2
    C,F,A,H--107663741(+) TCATAC/TGTGCA 1 -- ds500111Minor allele frequency- T:0.27NS EA NA WA CSA 664
    rs671670151,2
    C--107663751(+) AAAAA-/TAGT  
            
    TAGTA
    1 -- ds50011Minor allele frequency- TAGT:0.00CSA 2
    rs17321521,2
    C,F,A,H--107663947(+) AGAATT/CCCCTG 1 -- ds500112Minor allele frequency- C:0.27NS EA WA NA CSA 660
    rs1178511881,2
    C,F--107663975(+) AGGAAC/TGTAGG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1915312761,2
    --107664001(+) CATTTC/TGAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LAMB4 (107663993 - 107770801 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for LAMB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2037177CNV Deletion18987734
    esv2595279CNV Deletion19546169
    esv2734998CNV Deletion23290073
    esv2735000CNV Deletion23290073
    esv3089CNV Deletion18987735
    esv2734999CNV Deletion23290073
    nsv831089CNV Loss17160897
    nsv365697CNV Loss16902084
    nsv831088CNV Loss17160897

    Human Gene Mutation Database (HGMD): LAMB4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAMB4
    DNA2.0 Custom Variant and Variant Library Synthesis for LAMB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with LAMB4           About GenesLikeMe

    Genetic Association Database (GAD): LAMB4
    Human Genome Epidemiology (HuGE) Navigator: LAMB4 (2 documents)

    Export disorders for LAMB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAMB4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with LAMB4)
        Utopia: connect your pdf to the dynamic
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    1. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)1, 4 Amin N....van Duijn C.M. (Mol. Psychiatry 2012)
    2. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    3. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. A novel locus for autosomal-dominant dilated cardiomyopathy maps to chromosome 7q22.3-31.1. (PubMed id 16228230)1 SchAPnberger J....Zimmer M. (Hum. Genet. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. (PubMed id 11483367)1 Dry K.... Platzer M. (Gene 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22798 HGNC: 6491 AceView: LAMB4 Ensembl:ENSG00000091128 euGenes: HUgn22798
    ECgene: LAMB4 Kegg: 22798 H-InvDB: LAMB4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAMB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LAMB4 gene:
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