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Aliases for LAMB4 Gene

Aliases for LAMB4 Gene

  • Laminin, Beta 4 2 3
  • Laminin Beta-1-Related Protein 4

External Ids for LAMB4 Gene

Previous GeneCards Identifiers for LAMB4 Gene

  • GC07M106148
  • GC07M107210
  • GC07M107224
  • GC07M107257
  • GC07M107451
  • GC07M107663
  • GC07M102026

Summaries for LAMB4 Gene

GeneCards Summary for LAMB4 Gene

LAMB4 (Laminin, Beta 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for LAMB4 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMB4 Gene

Genomics for LAMB4 Gene

Genomic Location for LAMB4 Gene

Start:
108,023,548 bp from pter
End:
108,130,356 bp from pter
Size:
106,809 bases
Orientation:
Minus strand

Genomic View for LAMB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMB4 Gene

Proteins for LAMB4 Gene

  • Protein details for LAMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D0S4-LAMB4_HUMAN
    Recommended name:
    Laminin subunit beta-4
    Protein Accession:
    A4D0S4
    Secondary Accessions:
    • A5PKU6
    • B2RTT3
    • B5MEB9
    • Q86TP7
    • Q86XN2
    • Q8NBX5

    Protein attributes for LAMB4 Gene

    Size:
    1761 amino acids
    Molecular mass:
    193540 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end

    Alternative splice isoforms for LAMB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMB4 Gene

Proteomics data for LAMB4 Gene at MOPED

Post-translational modifications for LAMB4 Gene

  • Glycosylation at Asn169, Asn229, Asn246, Asn1016, Asn1055, Asn1223, Asn1301, Asn1326, Asn1333, Asn1354, Asn1469, Asn1517, Asn1587, Asn1596, Asn1609, and Asn1725
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMB4 Gene

No data available for DME Specific Peptides for LAMB4 Gene

Domains for LAMB4 Gene

Gene Families for LAMB4 Gene

HGNC:
  • LAM :Laminins

Protein Domains for LAMB4 Gene

Suggested Antigen Peptide Sequences for LAMB4 Gene

Graphical View of Domain Structure for InterPro Entry

A4D0S4

UniProtKB/Swiss-Prot:

LAMB4_HUMAN :
  • A4D0S4
Domain:
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
  • Domains VI and IV are globular
  • Contains 13 laminin EGF-like domains.
  • Contains 1 laminin IV type B domain.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with LAMB4: view

Function for LAMB4 Gene

Molecular function for LAMB4 Gene

GENATLAS Biochemistry: laminin,beta 4,with two alternatively spliced
UniProtKB/Swiss-Prot Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LAMB4 Gene

Localization for LAMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMB4 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMB4 Gene COMPARTMENTS Subcellular localization image for LAMB4 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LAMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
genes like me logo Genes that share ontologies with LAMB4: view

Pathways for LAMB4 Gene

genes like me logo Genes that share pathways with LAMB4: view

Gene Ontology (GO) - Biological Process for LAMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with LAMB4: view

Transcripts for LAMB4 Gene

mRNA/cDNA for LAMB4 Gene

Unigene Clusters for LAMB4 Gene

Laminin, beta 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMB4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LAMB4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMB4 Gene

No ASD Table

Relevant External Links for LAMB4 Gene

GeneLoc Exon Structure for
LAMB4
ECgene alternative splicing isoforms for
LAMB4

Expression for LAMB4 Gene

mRNA expression in normal human tissues for LAMB4 Gene

mRNA differential expression in normal tissues according to GTEx for LAMB4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (24.1) and Skin - Sun Exposed (Lower leg) (22.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LAMB4 Gene

SOURCE GeneReport for Unigene cluster for LAMB4 Gene Hs.62022

genes like me logo Genes that share expressions with LAMB4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LAMB4 Gene

Orthologs for LAMB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMB4 35
  • 99.32 (n)
  • 98.81 (a)
LAMB4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAMB4 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMB4 35
  • 83.36 (n)
  • 77.68 (a)
LAMB4 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMB4 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMB4 35
  • 65.61 (n)
  • 59.31 (a)
LAMB4 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMB4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lamb4 35
  • 59.07 (n)
  • 50.78 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
lamb4 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta LanB1 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lam-1 36
  • 35 (a)
OneToMany
Species with no ortholog for LAMB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMB4 Gene

ENSEMBL:
Gene Tree for LAMB4 (if available)
TreeFam:
Gene Tree for LAMB4 (if available)

Paralogs for LAMB4 Gene

Paralogs for LAMB4 Gene

genes like me logo Genes that share paralogs with LAMB4: view

Variants for LAMB4 Gene

Sequence variations from dbSNP and Humsavar for LAMB4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs22783 -- 108,102,798(-) AGACG(A/C)CTTGA intron-variant
rs93619 -- 108,086,388(-) tgaca(A/G)caggg intron-variant
rs94604 -- 108,093,411(-) CAGGG(A/G)TTGTT intron-variant
rs366690 -- 108,109,435(+) ATAGG(G/T)TTCAC intron-variant
rs367538 -- 108,089,120(-) AGGAG(C/T)ACTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMB4 Gene

Variant ID Type Subtype PubMed ID
nsv831088 CNV Loss 17160897
esv2595279 CNV Deletion 19546169
esv2734998 CNV Deletion 23290073
esv2037177 CNV Deletion 18987734
esv3089 CNV Deletion 18987735
esv2734999 CNV Deletion 23290073
nsv365697 CNV Loss 16902084
esv2735000 CNV Deletion 23290073
nsv831089 CNV Loss 17160897

Relevant External Links for LAMB4 Gene

HapMap Linkage Disequilibrium report
LAMB4
Human Gene Mutation Database (HGMD)
LAMB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMB4 Gene

Disorders for LAMB4 Gene

Relevant External Links for LAMB4

Genetic Association Database (GAD)
LAMB4
Human Genome Epidemiology (HuGE) Navigator
LAMB4
genes like me logo Genes that share disorders with LAMB4: view

No data available for UniProtKB/Swiss-Prot for LAMB4 Gene

Publications for LAMB4 Gene

  1. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PMID: 21876539) Amin N. … van Duijn C.M. (Mol. Psychiatry 2012) 3 48
  2. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for LAMB4 Gene

Sources for LAMB4 Gene

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