Aliases for LAMB3 Gene
External Ids for LAMB3 Gene
Previous Symbols for LAMB3 Gene
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LAMB3 Gene
LAMB3 (Laminin, Beta 3) is a Protein Coding gene. Diseases associated with LAMB3 include maternal uniparental disomy of chromosome 1 and epidermolysis bullosa, junctional, herlitz type. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is NTN3.
UniProtKB/Swiss-Prot for LAMB3 Gene
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components