Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LAMB3 Gene

protein-coding   GIFtS: 68
GCID: GC01M209788

Laminin, Beta 3

(Previous names: laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600...)
(Previous symbol: LAMNB1)
  See LAMB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Laminin, Beta 31 2     Nicein Subunit Beta2 3
LAMNB11 2 3     BM600-125KDA2
Laminin, Beta 3 (Nicein (125kD), Kalinin (140kD), BM600 (125kD))1 2     LAM52
Epiligrin Subunit Bata2 3     kalinin-140kDa2
Kalinin B1 Chain2 3     Laminin S B3 Chain2
Kalinin Subunit Beta2 3     Laminin Subunit Beta-32
Laminin B1k Chain2 3     nicein-125kDa2
Laminin-5 Subunit Beta2 3     

External Ids:    HGNC: 64901   Entrez Gene: 39142   Ensembl: ENSG000001968787   OMIM: 1503105   UniProtKB: Q137513   

Export aliases for LAMB3 gene to outside databases

Previous GC identifers: GC01M208427 GC01M205494 GC01M206427 GC01M206867 GC01M206176 GC01M207854 GC01M180463


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LAMB3 Gene:
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein
is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this
gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa,
diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants
that encode the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LAMB3 Gene:
LAMB3 (laminin, beta 3) is a protein-coding gene. Diseases associated with LAMB3 include lamb3-related junctional epidermolysis bullosa, and maternal uniparental disomy of chromosome 1. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is NTN1.

UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components

Gene Wiki entry for LAMB3 (Laminin, beta 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAMB3 gene promoter:
         TBP   STAT3   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAMB3 promoter sequence
   Search Chromatin IP Primers for LAMB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

LAMB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMB3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M209788:  view genomic region     (about GC identifiers)

Start:
209,788,215 bp from pter      End:
209,825,820 bp from pter
Size:
37,606 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751 (See protein sequence)
Recommended Name: Laminin subunit beta-3 precursor  
Size: 1172 amino acids; 129572 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).
Interacts with ECM1
Secondary accessions: D3DT88 O14947 Q14733 Q9UJK4 Q9UJL1

Explore the universe of human proteins at neXtProt for LAMB3: NX_Q13751

Explore proteomics data for LAMB3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn220, Asn604, Ser712, Asn810
  • Modification sites at PhosphoSitePlus

  • See LAMB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000219.2  NP_001017402.1  NP_001121113.1  

    ENSEMBL proteins: 
     ENSP00000348384   ENSP00000355997   ENSP00000398683   ENSP00000388960   ENSP00000375778  
    Reactome Protein details: Q13751

    LAMB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LAMB3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LAMB3
    GenScript Custom Purified and Recombinant Proteins Services for LAMB3
    Novus Biologicals LAMB3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LAMB3 

    LAMB3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LAMB3
    OriGene Custom Antibody Services for LAMB3
    Novus Biologicals LAMB3 Antibodies
    Abcam antibodies for LAMB3 (Q13751, Q16787, Q13753)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for LAMB3
    LSBio Antibodies in human, mouse, rat for LAMB3

    LAMB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LAMB3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LAMB3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for LAMB3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    LAM: Laminins

    3 InterPro protein domains:
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry Q13751

    ProtoNet protein and cluster: Q13751

    1 Blocks protein domain: IPB002049 Laminin-type EGF-like domain

    UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domain VI is globular
    Similarity: Contains 6 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain


    Find genes that share domains with LAMB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMB3_HUMAN, Q13751
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMB3:
    laminin 5 (kalinin/nicein),beta 3 polypeptide,component of cutaneous basement membrane zone,expressed in
    stratifying squamous epithelium

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS7550320
    GO:0005515protein binding IPI19275936
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with LAMB3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LAMB3:
     Cell cycle / mitosis defect 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lamb3):
     craniofacial  digestive/alimentary  integument  mortality/aging  respiratory system 

    Find genes that share phenotypes with LAMB3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAMB3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAMB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAMB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAMB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAMB3:
    hsa-mir-124-3p (MIRT023092), hsa-mir-16-5p (MIRT031939), hsa-mir-218-5p (MIRT001062)

    Block miRNA regulation of human, mouse, rat LAMB3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LAMB3:
    hsa-miR-133a hsa-miR-133b hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidLAMB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAMB3
    Predesigned siRNA for gene silencing in human, mouse, rat LAMB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LAMB3

    Clone
    Products:
         
    OriGene clones in human, mouse for LAMB3 (see all 17)
    OriGene ORF clones in mouse, rat for LAMB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LAMB3 (NM_001127641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMB3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LAMB3
    ESI BIO PureStem Progenitor for LAMB3: 
    PureStem ES-209, Meso-prx/latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LAMB3_HUMAN, Q13751: Secreted, extracellular space, extracellular matrix, basement membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane ----
    GO:0005610laminin-5 complex IEA--

    Find genes that share ontologies with LAMB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LAMB3 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Alpha6-Beta4 Integrin Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway
    Type I hemidesmosome assembly0.00
    4Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with LAMB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAMB3 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for LAMB3
        Cell adhesion ECM remodeling

    2 BioSystems Pathways for LAMB3
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway

    Selected Reactome Pathways for LAMB3 (see all 6)
        Anchoring fibril formation
    Laminin interactions
    Type I hemidesmosome assembly
    Assembly of collagen fibrils and other multimeric structures
    Degradation of the extracellular matrix


    Selected Kegg Pathways  (Kegg details for LAMB3) (see all 7):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Toxoplasmosis
    Amoebiasis

        Pathway & Disease-focused RT2 Profiler PCR Array including LAMB3: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LAMB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAMB3 (Q137512, 3 ENSP000003483844) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301478 I2D: score=1 
    LAMA3Q167873, ENSP000003245324I2D: score=2 STRING: ENSP00000324532
    BMP1P134973, ENSP000003057144I2D: score=1 STRING: ENSP00000305714
    LAMC2Q137533, ENSP000002641444I2D: score=1 STRING: ENSP00000264144
    COL7A1Q023883, ENSP000003323714I2D: score=2 STRING: ENSP00000332371
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0008544epidermis development TAS7774918
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0031581hemidesmosome assembly TAS--

    Find genes that share ontologies with LAMB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAMB3

    1 Novoseek inferred chemical compound relationship for LAMB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 85.4 2 7833047 (1), 7635220 (1)



    Find genes that share compounds with LAMB3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LAMB3 gene (3 alternative transcripts): 
    NM_000228.2  NM_001017402.1  NM_001127641.1  

    Unigene Cluster for LAMB3:

    Laminin, beta 3
    Hs.497636  [show with all ESTs]
    Unigene Representative Sequence: NM_001017402
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356082(uc001hhh.3 uc010psl.1 uc009xcp.1) ENST00000367030
    ENST00000455193 ENST00000415782 ENST00000391911(uc001hhg.3 uc009xco.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LAMB3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LAMB3:
    hsa-miR-133a hsa-miR-133b hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidLAMB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LAMB3
    Predesigned siRNA for gene silencing in human, mouse, rat LAMB3
    Clone
    Products:
         
    OriGene clones in human, mouse for LAMB3 (see all 17)
    OriGene ORF clones in mouse, rat for LAMB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LAMB3 (NM_001127641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMB3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LAMB3
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMB3
      QuantiTect SYBR Green Assays in human, mouse, rat LAMB3
      QuantiFast Probe-based Assays in human, mouse, rat LAMB3

    Additional mRNA sequence: 

    AK296851.1 AK309524.1 AY035783.1 BC058922.1 BC075838.1 D37766.1 L25541.1 

    13 DOTS entries:

    DT.95186987  DT.86858908  DT.121417740  DT.121417732  DT.99927221  DT.100755268  DT.100014491  DT.100755266 
    DT.100755267  DT.121417754  DT.92409688  DT.95218181  DT.92443575 

    Selected AceView cDNA sequences (see all 248):

    BM043640 BM831008 CB853666 AI692263 BQ918264 AL555216 BQ687386 BU538660 
    BM047246 BQ951321 BQ951009 CA488672 BG681883 BQ083941 AI653969 BG680183 
    BM999909 BQ027535 AW087532 AW079615 BM819029 BM769454 BM831118 AL555685 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LAMB3 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^
    SP1:                    -                                   -                                                                                                   
    SP2:                                                        -                                                                                                   
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                    -                                   -     -     -                                                                                       

    ExUns: 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for LAMB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LAMB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATTGAAAC
    LAMB3 Expression
    About this image


    LAMB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Early Ameloblasts Dental Enamel
             Dental Enamel
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Keratinocytes-like cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Epithelial-like cells
    LAMB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAMB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497636

    UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751
    Tissue specificity: Found in the basement membranes (major component)

        Pathway & Disease-focused RT2 Profiler PCR Array including LAMB3: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LAMB3
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMB3
    QuantiTect SYBR Green Assays in human, mouse, rat LAMB3
    QuantiFast Probe-based Assays in human, mouse, rat LAMB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for LAMB3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lamb31 , 5 laminin, beta 31, 5 82.28(n)1
    82.62(a)1
      1 (97.71 cM)5
    167801  NM_001277928.11  NP_001264857.11 
     1933019575 
    chicken
    (Gallus gallus)
    Aves LAMB31 laminin, beta 3 62.38(n)
    53.69(a)
      428268  XM_425827.3  XP_425827.3 
    lizard
    (Anolis carolinensis)
    Reptilia LAMB36
    laminin, beta 3
    52(a)
    1 ↔ 1
    4(125895133-125933194)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lamb31 laminin, beta 3 58.01(n)
    51.31(a)
      100125073  XM_002933504.2  XP_002933550.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LAMB36
    laminin, beta 3
    30(a)
    1 ↔ 1
    22(1050511-1065964) ENSDARG00000059369


    ENSEMBL Gene Tree for LAMB3 (if available)
    TreeFam Gene Tree for LAMB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LAMB3 gene
    NTN12  NTNG12  NTN32  NTN42  NTN52  NTNG22  
    4 SIMAP similar genes for LAMB3 using alignment to 2 protein entries:     LAMB3_HUMAN (see all proteins):
    LAMB4    LAMB1    LAMB2    NTN4

    Find genes that share paralogs with LAMB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LAMB3 (see all 1254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0373104
    Generalized atrophic benign epidermolysis bullosa (GABEB)4--see VAR_0373102 G A mis40--------
    VAR_0041704
    Generalized atrophic benign epidermolysis bullosa (GABEB)4--see VAR_0041702 E K mis40--------
    VAR_0041714
    Epidermolysis bullosa, junctional, Herlitz type (H-JEB)4--see VAR_0041712 P L mis40--------
    VAR_0358204
    A colorectal cancer sample4--see VAR_0358202 R C mis40--------
    VAR_0373114
    Generalized atrophic benign epidermolysis bullosa (GABEB)4--see VAR_0373112 K Q mis40--------
    rs803566821,2
    C,Fpathogenic1216604237(-) AGATCC/TGAGCA 6 R * stg11Minor allele frequency- T:0.00NA 4552
    rs803566801,2
    Cpathogenic1216628538(-) TTCTCC/TGAGCT 6 R * stg11Minor allele frequency- T:0.00EU 1323
    rs2003223801,2
    Cuntested1216601113(+) TCCATC/G/TTGGGA 6 Q syn11EU 963
    rs114468101,2
    C--180482193(+) ATTCA-/CAAAAA 3 -- int1 trp30--------
    rs1138742401,2
    C--180494342(+) AGGGG-/A/AA  
            
    AAAAA
    3 -- int11CSA 2

    HapMap Linkage Disequilibrium report for LAMB3 (209788215 - 209825820 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LAMB3: --
    Human Gene Mutation Database (HGMD): LAMB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAMB3
    DNA2.0 Custom Variant and Variant Library Synthesis for LAMB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 150310   
    OMIM disorders: 226700  226650  
    UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751
  • Epidermolysis bullosa, junctional, Herlitz type (H-JEB) [MIM:226700]: An infantile and lethal form of
    junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which
    occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months
    of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive
    denudation of skin and mucous membranes that may be hemorrhagic. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]: A non-lethal, adult form of
    junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and
    tooth abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for LAMB3 (see first 20):    
    About MalaCards
    lamb3-related junctional epidermolysis bullosa    maternal uniparental disomy of chromosome 1    junctional epidermolysis bullosa, herlitz type    amelogenesis imperfecta, type ib
    junctional epidermolysis bullosa, non-herlitz type    junctional epidermolysis bullosa    epidermolysis bullosa    mucous membrane pemphigoid

    1 disease from the University of Copenhagen DISEASES database for LAMB3:
    Epidermolysis bullosa

    Find genes that share disorders with LAMB3           About GenesLikeMe

    10 Novoseek inferred disease relationships for LAMB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epidermolysis bullosa junctional 98.5 46 9457915 (4), 10469327 (3), 8618058 (3), 11023379 (3) (see all 30)
    gabeb 93.1 6 10951252 (3), 9690563 (2), 9767254 (1)
    lethal junctional epidermolysis bullosa 91 2 9579554 (1), 11296269 (1)
    epidermolysis bullosa 86.5 2 7774918 (1), 7550237 (1)
    skin diseases 60 6 8618058 (1), 9457915 (1), 9759651 (1), 8618020 (1) (see all 6)
    pemphigoid bullous 55.2 1 9487212 (1)
    necrosis 0 1 7635220 (1)
    cancer lung 0 2 10964684 (1)
    tumors 0 6 7635220 (1), 14973053 (1), 15846078 (1), 14695139 (1) (see all 5)
    cancer 0 3 18570662 (1), 14695139 (1)

    GeneTests: LAMB3
    GeneReviews: LAMB3
    Genetic Association Database (GAD): LAMB3
    Human Genome Epidemiology (HuGE) Navigator: LAMB3 (2 documents)

    Export disorders for LAMB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LAMB3 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with LAMB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa. (PubMed id 7774918)1, 2, 3, 9 Pulkkinen L.... Uitto J. (Genomics 1995)
    2. Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3). (PubMed id 7550237)1, 2, 9 Pulkkinen L.... Uitto J. (Hum. Mutat. 1995)
    3. Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3. (PubMed id 17476356)1, 2, 9 Pasmooij A.M.G.... Jonkman M.F. (J. Clin. Invest. 2007)
    4. E210K mutation in the gene encoding the beta3 chain of laminin-5 (LAMB3) is predictive of a phenotype of generalized atrophic benign epidermolysis bullosa. (PubMed id 9767254)1, 2, 9 Mellerio J.E.... McGrath J.A. (Br. J. Dermatol. 1998)
    5. The complete primary structure for a novel laminin chain, the laminin B1k chain. (PubMed id 7512558)1, 2, 9 Gerecke D.R.... Burgeson R.E. (J. Biol. Chem. 1994)
    6. Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. (PubMed id 20163849)1, 4, 9 Zhou X....Hu Z. (Gynecol. Oncol. 2010)
    7. In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa. (PubMed id 11296269)1, 2, 9 Robbins P.B.... Khavari P.A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    8. Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PubMed id 15370542)1, 4, 9 Hayashi M....Allikmets R. (Ophthalmic Genet. 2004)
    9. ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain. (PubMed id 19275936)1, 2 Sercu S.... Merregaert J. (Matrix Biol. 2009)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3914 HGNC: 6490 AceView: LAMB3 Ensembl:ENSG00000196878 euGenes: HUgn3914
    ECgene: LAMB3 Kegg: 3914 H-InvDB: LAMB3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LAMB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LAMB3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=LAMB3[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LAMB3 gene:
    Search GeneIP for patents involving LAMB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LAMB3   OriGene RNAi products in human, mouse, rat for LAMB3  
     OriGene qPCR primer pairs and template standards for LAMB3   OriGene Protein Over-expression Lysate for LAMB3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LAMB3  
     OriGene qSTAR qPCR primer pairs in human, mouse for LAMB3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LAMB3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LAMB3   OriGene Custom Protein Services for LAMB3  

     
     
     Block miRNA regulation of human, mouse, rat LAMB3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LAMB3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMB3 Predesigned siRNA for gene silencing in human, mouse, rat LAMB3
     QuantiFast Probe-based Assays in human, mouse, rat LAMB3 QuantiTect SYBR Green Assays in human, mouse, rat LAMB3
     PCR Arrays including human, mouse, rat LAMB3 Search Chromatin IP Primers for LAMB3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMB3  Search GeneGlobe Interaction Network for LAMB3
     Regulatory tfbs in LAMB3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LAMB3 GenScript cDNA clones with any tag delivered in your preferred vector for LAMB3
     GenScript Custom Assay Services for LAMB3 GenScript Custom overexpressing Cell Line Services for LAMB3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LAMB3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LAMB3 antibodies
     LAMB3 proteins
     Antibodies for LAMB3
     See all of Abcam's Antibodies, Kits and Proteins for LAMB3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     PureStem Progenitor for LAMB3: PureStem ES-209, Meso-prx/latp Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB3
     SwitchGear 3'UTR luciferase reporter plasmids for LAMB3
     SwitchGear Promoter luciferase reporter plasmids for LAMB3
     ThermoFisher Antibody for LAMB3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMB3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAMB3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAMB3
     LSBio Antibodies in human, mouse, rat for LAMB3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for LAMB3
      Search eBioscience for proteins for LAMB3
      Search eBioscience for elisas for LAMB3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LAMB3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4