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LAMB3 Gene

protein-coding GIFtS: 68

GC01M207854

laminin, beta 3
(Previous names: laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD)) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LAMNB1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BM600-125KDA ^²
BM600-125kDa ^¹
FLJ99565 ^²
LAM5 ^²
LAMNB1 ^², ³
OTTHUMP00000034555 ^²
OTTHUMP00000034640 ^²
kalinin-140kDa ^¹, ²
nicein-125kDa ^¹, ²

Descriptions
Kalinin B1 chain ^², ³
Laminin 5 beta 3 ^³
Laminin B1k chain ^², ³
laminin S B3 chain ^²
laminin, beta 3 ^²
laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD)) ^¹, ²

External Ids
HGNC: 6490¹
Entrez Gene: 3914²
UniProtKB: Q13751³
Ensembl: ENSG00000196878⁷

Search outside databases for aliases for LAMB3 gene

Previous GC identifers: GC01M208427 GC01M205494 GC01M206427 GC01M206867 GC01M206176

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMB3:

The product encoded by this gene is a laminin that belongs to a family of basement membrane

proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma

subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz

type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by

blistering of the skin. Multiple alternatively spliced transcript variants that encode the same

protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMB3 (Laminin%2C_beta_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMB3 gene

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32

LAMB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M207854: (about GC identifiers)

Start:	207,854,838 bp from pter
End:	207,892,443 bp from pter
Size:	37,606 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_021877.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751 (See protein sequence)

Recommended Name: Laminin subunit beta-3 precursor

Size: 1172 amino acids; 129572 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains

(alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped

molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit

of laminin-5 (epiligrin/kalinin/nicein)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane

Secondary accessions: O14947 Q14733 Q9UJK4 Q9UJL1

REFSEQ proteins (3 alternative transcripts):

NP_000219.2 NP_001017402.1 NP_001121113.1

ENSEMBL proteins:

ENSP00000348384 ENSP00000375778 ENSP00000355997

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kalinin)
	Human Recombinant Proteins from Abnova (LAMB3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005604	basement membrane	IEA	--

About this table

Antibodies for LAMB3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LAMB3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Kalinin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAMB3)
	Novus Biologicals Antibodies for LAMB3

Assays for LAMB3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13751

ProtoNet protein and cluster: Q13751

1 Blocks protein family: IPB002049 Laminin-type EGF-like domain

UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to

form a coiled coil structure

Domain: Domain VI is globular

Similarity: Contains 6 laminin EGF-like domains

Similarity: Contains 1 laminin N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMB3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000228

Applied Biosystems Silencer® siRNAs for LAMB3

Sigma-Aldrich siRNA and siRNA Panels for LAMB3

Sigma-Aldrich shRNA Panels and shRNA for LAMB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000228
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000228
untagged cDNA clones in CMV expression vector (see all 3): NM_000228

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000228

UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMB3:

laminin 5 (kalinin/nicein),beta 3 polypeptide,component of cutaneous basement membrane

zone,expressed in stratifying squamous epithelium

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamb3):

digestive/alimentary

lethality-prenatal/perinatal

respiratory system

skin/coat/nails

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	7550320
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/119 Interacting proteins for LAMB3 (ENSP00000348384³ Q13751²) via UniProtKB, MINT, and/or STRING (see all 119 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDIA3	P30101²	MINT-4301478
COL17A1	ENSP00000340937³	STRING (score=.993)
LAMC2	ENSP00000264144³	STRING (score=.976)
LAMA3	ENSP00000324532³	STRING (score=.972)
ITGB4	ENSP00000200181³	STRING (score=.942)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0008544	epidermis development	TAS	7774918

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMB3
1 Novoseek chemical compound relationship for LAMB3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
kalinin	85.73	2	7833047 (1), 7635220 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMB3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000228

Sigma-Aldrich siRNA and siRNA Panels for LAMB3

Sigma-Aldrich shRNA Panels and shRNA for LAMB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000228 NM_001017402 NM_001127641

REFSEQ mRNAs for LAMB3 gene (3 alternative transcripts):

NM_000228.2 NM_001017402.1 NM_001127641.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000228 NM_001017402 NM_001127641

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000228
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000228
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000228

Additional cDNA sequence:

AK296851.1 AK309524.1 AY035783.1 BC058922.1 BC075838.1 D37766.1 L25541.1

13 DOTS entries:

DT.95186987 DT.86858908 DT.121417740 DT.121417732 DT.99927221 DT.100755268 DT.100014491 DT.100755266

DT.100755267 DT.121417754 DT.92409688 DT.92443575 DT.95218181

24/248 AceView cDNA sequences (see all 248 ):

CA453966 AI696934 BQ918264 AW338452 BG681883 AI653969 BM769454 BQ951321

BM560717 AI692263 BM831118 BQ690508 CA488672 AI919062 BU538660 AY035783

BM047246 AL555685 AL555216 BM043640 AW079615 AI801158 AA659927 BM819029

highest scoring ESTs for LAMB3:

AA298962 AL555216 AL555685 BC058922 BI819478 BI820562 BM752299 BM753278 BM828925 D37766

Unigene Cluster for LAMB3:

Laminin, beta 3

Hs.497636 [show with all ESTs]

Unigene Representative Sequence: NM_001017402

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for LAMB3 (see all 17 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	^
SP1:							-												-
SP2:																			-
SP3:																			-
SP4:
SP5:							-												-		-		-

ExUns:	16a	·	16b	·	16c	·	16d	^	17	^	18a	·	18b	^	19a	·	19b	·	19c	^	20a	·	20b	·	20c	^	21	^	22	^	23a	·	23b	^	24	^	25
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LAMB3

3 Ensembl transcripts including schematic representations:

ENST00000356082 ENST00000391911 ENST00000367030

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LAMB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMB3

¹ / ² / ³

3 probe-sets matching LAMB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36929_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U17760	0.20	1.00	0.72	1
209270_at²^{, 3}	U133-A	2	1.00	0.95	--	--	L25541	0.60	1.00	0.82	1
209270_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks LAMB3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCATTGAAAC

SOURCE GeneReport for Unigene cluster: Hs.497636
Expression variation in blood from EXPOLDB for LAMB3
UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751
Tissue specificity: Found in the basement membranes (major component)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMB3 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMB3¹	--	laminin, beta 3	85.7(n) 85.1(a)	442953 XM_547393.2 XP_547393.2
cow (Bos taurus)	LAMB3¹	--	laminin, beta 3	85.21(n) 84.39(a)	529939 XM_608401.3 XP_608401.3
rat (Rattus norvegicus)	Lamb3¹	--	laminin, beta 3	82.15(n) 82.75(a)	305078 XM_223087.4 XP_223087.4
mouse (Mus musculus)	Lamb3^{1, 5}	1 (104.00 cM)⁵	laminin, beta 3^{1, 5}	82.42(n)¹ 82.71(a)¹	16780¹ NM_008484.2¹ NP_032510.2¹ AK078970⁵ AK155769⁵ (see all 14)
chicken (Gallus gallus)	LAMB3¹	--	laminin, beta 3	62.06(n) 53.24(a)	428268 XM_425827.2 XP_425827.2

About this table Species with no ortholog for LAMB3

ENSEMBL Gene Tree for LAMB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMB3 gene

NTN4² USH2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/291 NCBI SNPs in LAMB3 are shown (see all 291 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 167)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1534963^1,2	A,C,F,H,O	207894320(+)	`GTCCAG/CGAAGC`	1	--	ng3¹ tfbs³		16	EU EA WA NA	1474
	rs2229466^1,2	C,F,H,O	207863876(-)	`CTTCAA/GTGGTC`	3	N/S	mis¹ ese³		12	MN EU EA WA NA	1024
	rs3753522^1,2	A,C,F,H	207891522(-)	`TCTCCC/TTGTTG`	2	--	ng3¹ int¹		9	EA EU WA	2330
	rs1001929^1,2	A,C,F,O	207893540(-)	`GGAATA/CGTAGT`	1	--	ng3¹		9	NA EA	2055
	rs2566^1,2	A,C,F,H	207855137(-)	`TCATGC/TAGCCT`	3	--	ut3¹ ese³		16	MN EA NA EU WA	2856
	rs10863778^1,2	A,C,F,H	207892009(+)	`TCTTCC/TGACTT`	2	--	int¹ ng3¹		16	EA NA EU WA	1472
	rs2076349^1,2	A,C,F,H	207866853(+)	`GGCCAT/CGTCTC`	3	M/V	mis¹ ese³		11	EA MN EU WA NA	2114
	rs2076222^1,2	C,F,H,O	207858552(+)	`CAGTAG/TCTGAG`	3	A/D	mis¹ ese³		12	EA NA EU WA	2402
	rs926387^1,2	C,F,H,O	207854836(+)	`CAGACC/TGTTTT`	2	--	ng5¹		10	NA EA EU WA	1006
--	rs1001930^1,2	A,C,F	207893416(-)	`CTCTCC/G/TGACCC`	1	--	ng3¹		7	NA EA	608

About this table

HapMap Linkage Disequilibrium images for LAMB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 150310 disorders: 226700 226650

UniProtKB/Swiss-Prot: LAMB3_HUMAN, Q13751

Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB)

[MIM:226700]; also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a

group of blistering skin diseases characterized by tissue separation which occurs within the

dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs

usually within the first six months of life. Occasionally, children survive to teens. H-JEB is

marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may

be hemorrhagic

Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB)

[MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized

by life-long blistering of the skin, associated with hair and tooth abnormalities

10 Novoseek disease relationships for LAMB3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
epidermolysis bullosa junctional	98.49	46	9457915 (4), 10469327 (3), 8618058 (3), 11023379 (3) (see all 30)
gabeb	93.27	6	10951252 (3), 9690563 (2), 9767254 (1)
lethal junctional epidermolysis bullosa	91.32	2	9579554 (1), 11296269 (1)
epidermolysis bullosa	87.42	2	7774918 (1), 7550237 (1)
skin diseases	61.36	6	8618058 (1), 9457915 (1), 9759651 (1), 8618020 (1) (see all 6)
pemphigoid bullous	56.57	1	9487212 (1)
necrosis	0.00	1	7635220 (1)
cancer lung	0.00	2	10964684 (1)
cancer	0.00	3	18570662 (1), 14695139 (1)
tumors	0.00	6	7635220 (1), 14973053 (1), 15846078 (1), 14695139 (1) (see all 5)

About this table

GeneTests: LAMB3

Junctional Epidermolysis Bullosa

Human Gene Mutation Database: LAMB3
Genetic Association Database: LAMB3
Human Genome Epidemiology Navigator: LAMB3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/113 PubMed articles for LAMB3 gene (see all 113 ):

Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa. (PubMed id 7774918)^{1, 2, 3, 4} Pulkkinen L....Uitto J. (1995)
Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3). (PubMed id 7550237)^{1, 3, 4} Pulkkinen L.... Uitto J. (1995)
Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3. (PubMed id 17476356)^{1, 3, 4} Pasmooij A.M.G.... Jonkman M.F. (2007)
E210K mutation in the gene encoding the beta3 chain of laminin-5 (LAMB3) is predictive of a phenotype of generalized atrophic benign epidermolysis bullosa. (PubMed id 9767254)^{1, 3, 4} Mellerio J.E.... McGrath J.A. (1998)
The complete primary structure for a novel laminin chain, the laminin B1k chain. (PubMed id 7512558)^{1, 3, 4} Gerecke D.R.... Burgeson R.E. (1994)
In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa. (PubMed id 11296269)^{1, 3, 4} Robbins P.B.... Khavari P.A. (2001)
Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PubMed id 15370542)^{1, 3, 6} Hayashi M....Allikmets R. (2004)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization. (PubMed id 8530036)^{3, 4} Morishima Y....Inazawa J. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3914	HGNC: 6490	AceView: LAMB3	Ensembl:ENSG00000196878	euGenes: HUgn3914
ECgene: LAMB3	H-InvDB: LAMB3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LAMB3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=LAMB3

Licensable Technologies for LAMB3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAMB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAMB3		Antibodies for LAMB3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAMB3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LAMB3)
	Antibodies (LAMB3)
	Chimera RNAi (LAMB3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Kalinin)
	Antibodies (Kalinin)

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Search Tocris compounds for LAMB3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LAMB3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LAMB3 Gene at Home site.
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LAMB3 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for LAMB3

Summaries
for LAMB3

Genomic Location
for LAMB3

Proteins
for LAMB3

Protein Domains/
Families
for LAMB3

Gene Function
for LAMB3

Pathways & Interactions
for LAMB3

Drugs & Compounds
for LAMB3

Transcripts
for LAMB3

Expression
for LAMB3

Orthologs
for LAMB3

Paralogs
for LAMB3

SNPs/Variants
for LAMB3

Disorders & Mutations
for LAMB3

Medical News
for LAMB3

Publications
for LAMB3

Search for LAMB3

Genome Databases showing LAMB3

Other Databases showing LAMB3

Specialized Databases showing LAMB3

Licensable Technologies
for LAMB3

Services
for LAMB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMB3 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor LAMB3

Summariesfor LAMB3

Genomic Locationfor LAMB3

Proteinsfor LAMB3

Protein Domains/Familiesfor LAMB3

Gene Functionfor LAMB3

Pathways & Interactionsfor LAMB3

Drugs & Compoundsfor LAMB3

Transcriptsfor LAMB3

Expression for LAMB3

Orthologsfor LAMB3

Paralogsfor LAMB3

SNPs/Variantsfor LAMB3

Disorders & Mutationsfor LAMB3

Medical Newsfor LAMB3

Publicationsfor LAMB3

Search for LAMB3

Genome Databases showing LAMB3

Other Databases showing LAMB3

Specialized Databases showing LAMB3

Licensable Technologiesfor LAMB3

Servicesfor LAMB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMB3

Summaries
for LAMB3

Genomic Location
for LAMB3

Proteins
for LAMB3

Protein Domains/
Families
for LAMB3

Gene Function
for LAMB3

Pathways & Interactions
for LAMB3

Drugs & Compounds
for LAMB3

Transcripts
for LAMB3

Expression
for LAMB3

Orthologs
for LAMB3

Paralogs
for LAMB3

SNPs/Variants
for LAMB3

Disorders & Mutations
for LAMB3

Medical News
for LAMB3

Publications
for LAMB3

Licensable Technologies
for LAMB3

Services
for LAMB3