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LAMB2 Gene

protein-coding GIFtS: 66

GC03M049133

laminin, beta 2 (laminin S)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LAMS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LAMS ^², ³, ⁵
S-laminin ^³

Descriptions
Laminin B1s chain ^³
laminin S ^²
laminin, beta 2 ^²
laminin, beta 2 (laminin S) ^²

External Ids
HGNC: 6487¹
Entrez Gene: 3913²
UniProtKB: P55268³
Ensembl: ENSG00000172037⁷

Search outside databases for aliases for LAMB2 gene

Previous GC identifers: GC03P046915 GC03P048475 GC03M049012 GC03M049117

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMB2:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent

of basement membranes. They have been implicated in a wide variety of biological processes

including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.

Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1,

and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed

by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain

protein encoded by a distinct gene. Several isoforms of each chain have been described. Different

alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin

isoforms which are designated by Arabic numerals in the order of their discovery, i.e.

alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and

trimer molecules are largely unknown, but some of the chains have been shown to differ with

respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene

encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains

typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain,

beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of

muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic

mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in

the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative

splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has

been reported. It was suggested that inefficient splicing of this first intron, which does not

change the protein sequence, results in a greater abundance of the unspliced form of the

transcript than the spliced form. The full-length nature of the spliced transcript is not known.

[provided by RefSeq]

UniProtKB/Swiss-Prot: LAMB2_HUMAN, P55268

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMB2 (Laminin%2C_beta_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMB2 gene

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3-p21.2

LAMB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M049133: (about GC identifiers)

Start:	49,133,551 bp from pter
End:	49,145,603 bp from pter
Size:	12,053 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LAMB2_HUMAN, P55268 (See protein sequence)

Recommended Name: Laminin subunit beta-2 precursor

Size: 1798 amino acids; 195981 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains

(alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped

molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit

of laminin-3 (S-laminin), laminin-4 (S-merosin), and laminin-7 (KS-laminin)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Note=S-laminin is concentrated in the synaptic cleft of the neuromuscular junction

Secondary accessions: Q16321

REFSEQ proteins: NP_002283.3

ENSEMBL proteins:

ENSP00000378785 ENSP00000307156

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Laminin S, Laminin, Laminin 1+2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005605	basal lamina	TAS	7698745
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005783	endoplasmic reticulum	IDA	18029348

About this table

Antibodies for LAMB2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LAMB2
	Sigma-Aldrich Antibodies for LAMB2
	R&D Systems Antibodies for LAMB2 (Laminin S)
	Antibodies from Abcam (Laminin S, Laminin, Laminin 1+2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LAMB2

Assays for LAMB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P55268

ProtoNet protein and cluster: P55268

1 Blocks protein family: IPB002049 Laminin-type EGF-like domain

UniProtKB/Swiss-Prot: LAMB2_HUMAN, P55268

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to

form a coiled coil structure

Domain: Domains VI and IV are globular

Similarity: Contains 13 laminin EGF-like domains

Similarity: Contains 1 laminin IV type B domain

Similarity: Contains 1 laminin N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMB2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002292

Applied Biosystems Silencer® siRNAs for LAMB2

Sigma-Aldrich siRNA and siRNA Panels for LAMB2

Sigma-Aldrich shRNA Panels and shRNA for LAMB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002292
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002292
untagged cDNA clone in CMV expression vector: NM_002292

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002292

UniProtKB/Swiss-Prot: LAMB2_HUMAN, P55268

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMB2:

laminin,beta 2 polypeptide,component of basement membrane of skeletal muscle neuromuscular

junction,kidney glomerulus,nerve fascicle perineurium,vascular smooth muscle,paralog to LAMB1

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamb2):

behavior/neurological	growth/size	homeostasis/metabolism	immune system	lethality-postnatal
nervous system	renal/urinary system	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	7698745
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for LAMB2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Synaptic Long Term Depression
Inositol Metabolism
Phospholipid Degradation
Endothelin-1 Signaling
Eicosanoid Signaling

GeneDecks LAMB2 for the pathways selected above

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5/116 Interacting proteins for LAMB2 (ENSP00000307156³ P55268²) via UniProtKB, MINT, and/or STRING (see all 116 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZNF512B	Q96KM6²	MINT-60825
FN1	ENSP00000323534³	STRING (score=.964)
DMD	ENSP00000354923³	STRING (score=.96)
RPSAP61	ENSP00000346067³	STRING (score=.954)
EGF	ENSP00000265171³	STRING (score=.953)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0048677	axon extension involved in regeneration	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMB2
2 Novoseek chemical compound relationships for LAMB2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tripeptide	54.79	4	8568518 (1), 1683902 (1), 7875382 (1)
calcium	0.00	4	8568518 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMB2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002292

Sigma-Aldrich siRNA and siRNA Panels for LAMB2

Sigma-Aldrich shRNA Panels and shRNA for LAMB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002292

REFSEQ mRNAs for LAMB2 gene:

NM_002292.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002292

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002292
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002292
                                 untagged cDNA clone in CMV expression vector: NM_002292

Additional cDNA sequence:

AK094050.1 S77512.1 X72760.1

19 DOTS entries:

DT.448403 DT.100825203 DT.97787761 DT.85104167 DT.100031014 DT.97821860 DT.100825205 DT.91876035

DT.95232335 DT.95229765 DT.97767595 DT.120921792 DT.95332409 DT.97792696 DT.120921772 DT.85104169

DT.91787263 DT.95087319 DT.91777805

24/443 AceView cDNA sequences (see all 443 ):

N80961 CD675282 CN482243 AW951881 CA396849 BE695052 BX106076 BM800431

CD673000 BQ950352 CA454715 BU157117 CA390148 BE008418 BQ923188 BQ029937

BU543641 AL548159 BM719839 BU845654 AL042497 CD672106 BU623752 AL520305

highest scoring ESTs for LAMB2:

S77512 X79683 AA025615 AA029360 AA076116 AA076218 AA093202 AA095122 AA156802 AA296977

Unigene Cluster for LAMB2:

Laminin, beta 2 (laminin S)

Hs.439726 [show with all ESTs]

Unigene Representative Sequence: NM_002292

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for LAMB2 (see all 21 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	17b	^	18a	·	18b	^	19a	·	19b	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^	24a	·	24b	^	25a	·	25b	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31a	·	31b	^	32	^	33	^	34	^
SP1:
SP2:
SP3:
SP4:																			-
SP5:																			-

ExUns:	35	^	36	^	37a	·	37b	·	37c	^	38	^	39	^	40a	·	40b	·	40c	^	41
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LAMB2

2 Ensembl transcripts including schematic representations:

ENST00000395387 ENST00000305544

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LAMB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMB2

¹ / ² / ³

3 probe-sets matching LAMB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38812_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X79683	0.80	1.00	0.91	1
216264_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X79683	0.80	1.00	0.91	1
216264_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMB2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTGCCTATG

SOURCE GeneReport for Unigene cluster: Hs.439726
Expression variation in blood from EXPOLDB for LAMB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMB2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMC1¹	--	laminin, gamma 1 (formerly LAMB2)	88.99(n) 91.05(a)	476626 XM_533831.2 XP_533831.2
rat (Rattus norvegicus)	Lamb2¹	--	laminin, beta 2	85.11(n) 88.1(a)	25473 NM_012974.1 NP_037106.1
mouse (Mus musculus)	Lamb2^{1, 5}	9 (60.00 cM)⁵	laminin, beta 2^{1, 5}	85.86(n)¹ 88.47(a)¹	16779¹ NM_008483.2¹ NP_032509.2¹ AK140351⁵ AK158444⁵ (see all 18)
chicken (Gallus gallus)	LAMC1¹	--	laminin, gamma 1 (formerly LAMB2)	66.65(n) 63.05(a)	373980 NM_204166.1 NP_989497.1
zebrafish (Danio rerio)	LOC561356¹	--	similar to LOC494988 protein	62.13(n) 60(a)	561356 XM_684764.3 XP_689856.3

About this table Species with no ortholog for LAMB2

ENSEMBL Gene Tree for LAMB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMB2 gene

LAMB1² LAMB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/50 NCBI SNPs in LAMB2 are shown (see all 50 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs34759087^1,2	C,F	49137288(+)	`GCACTC/TACACA`	1	E/K	mis¹		5		NA EU EA WA	478
	rs7426606^1,2	H	49144604(+)	`TCCAGC/GTGGAT`	1	Q/H	mis¹ ese³		4		EU EA WA	418
	rs7428401^1,2	H	49145433(+)	`GTCAGT/ATCCCA`	1	--	ut5¹		4		EU EA WA	404
	rs13082063^1,2	C,F,H	49136317(+)	`TCCTGC/TGCCCG`	1	A/A	syn¹ ese³		2		EU WA	218
	rs33942096^1,2	C,F	49141224(+)	`TCCCCG/AGGGGT`	1	P/P	syn¹		1		NA	76
	rs34967349^1,2	F	49136008(+)	`TCTTGC/AACATC`	1	V/V	syn¹		1		NA	78
	rs34290943^1,2	F	49136664(+)	`AGCTCT/CTGGCA`	1	Q/Q	syn¹		1		NA	74
	rs2071677^1,2	C,F,H	49143381(-)	`GTAAGG/AGGCTT`	1	--	int¹		4		EA EU	1040
	rs9865051^1,2	C	49141073(+)	`TCAGCC/TCCAGA`	1	--	int¹		0	--	--	--	--
	rs1131789^1,2	--	49141471(-)	`CTGAGA/GACACC`	1	D/N	mis¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for LAMB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 150325 disorders: 609049 609049

UniProtKB/Swiss-Prot: LAMB2_HUMAN, P55268

Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as

microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome

with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the

leading clinical feature. Death usually occurs within the first weeks of life. Disease severity

depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes

ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome

Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital

nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption

of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be

associated with ocular abnormalities

6 Novoseek disease relationships for LAMB2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
walker-warburg syndrome	74.99	3	7501167 (2), 9327401 (1)
nephrosis	50.07	2	16912710 (1), 7670489 (1)
muscular dystrophies	48.91	2	9327401 (2)
nephrotic syndrome	33.69	5	16912710 (2), 16898484 (2), 7670489 (1)
tumors	0.00	1	8036181 (1)
metastasis	0.00	1	9687985 (1)

About this table

Human Gene Mutation Database: LAMB2
Human Genome Epidemiology Navigator: LAMB2 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/86 PubMed articles for LAMB2 gene (see all 86 ):

Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders. (PubMed id 16912710)^{1, 3, 4} Hasselbacher K.... Hildebrandt F. (2006)
The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene. (PubMed id 7795887)^{1, 3, 4} Iivanainen A.... Tryggvason K. (1995)
Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. (PubMed id 7698745)^{1, 3, 4} Wewer U.M.... Albrechtsen R. (1994)
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. (PubMed id 15367484)^{3, 4} Zenker M.... Reis A. (2004)
Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS). (PubMed id 10393422)^{2, 3} Durkin M.E....Wewer U.M. (1999)
A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction. (PubMed id 2922051)^{2, 3} Hunter D.D....Sanes J.R. (1989)
[LAMB2 gene mutation as a cause of congenital nephrotic syndrome with distinct eye abnormalities and hypotonia] (PubMed id 16898484)^{1, 3} Zurowska A....Zenker M. (2006)
Identification of a new autoantibody in patients with chronic hepatitis. (PubMed id 15603881)^{1, 3} Fukuda Y....Kato T. (2004)
Selective assembly of laminin variants by human carcinoma cells. (PubMed id 7967523)^{1, 3} Wewer U.M.... Albrechtsen R. (1994)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3913	HGNC: 6487	AceView: LAMB2	Ensembl:ENSG00000172037	euGenes: HUgn3913
ECgene: LAMB2	H-InvDB: LAMB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LAMB2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=LAMB2

Licensable Technologies for LAMB2
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for LAMB2 gene:

Tufts University:

Laminins and their functions in nervous systems

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAMB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
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GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

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LAMB2 Gene at Home site.
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LAMB2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for LAMB2

Summaries
for LAMB2

Genomic Location
for LAMB2

Proteins
for LAMB2

Protein Domains/
Families
for LAMB2

Gene Function
for LAMB2

Pathways & Interactions
for LAMB2

Drugs & Compounds
for LAMB2

Transcripts
for LAMB2

Expression
for LAMB2

Orthologs
for LAMB2

Paralogs
for LAMB2

SNPs/Variants
for LAMB2

Disorders & Mutations
for LAMB2

Medical News
for LAMB2

Publications
for LAMB2

Search for LAMB2

Genome Databases showing LAMB2

Other Databases showing LAMB2

Specialized Databases showing LAMB2

Licensable Technologies
for LAMB2

Services
for LAMB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMB2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor LAMB2

Summariesfor LAMB2

Genomic Locationfor LAMB2

Proteinsfor LAMB2

Protein Domains/Familiesfor LAMB2

Gene Functionfor LAMB2

Pathways & Interactionsfor LAMB2

Drugs & Compoundsfor LAMB2

Transcriptsfor LAMB2

Expression for LAMB2

Orthologsfor LAMB2

Paralogsfor LAMB2

SNPs/Variantsfor LAMB2

Disorders & Mutationsfor LAMB2

Medical Newsfor LAMB2

Publicationsfor LAMB2

Search for LAMB2

Genome Databases showing LAMB2

Other Databases showing LAMB2

Specialized Databases showing LAMB2

Licensable Technologiesfor LAMB2

Servicesfor LAMB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMB2

Summaries
for LAMB2

Genomic Location
for LAMB2

Proteins
for LAMB2

Protein Domains/
Families
for LAMB2

Gene Function
for LAMB2

Pathways & Interactions
for LAMB2

Drugs & Compounds
for LAMB2

Transcripts
for LAMB2

Expression
for LAMB2

Orthologs
for LAMB2

Paralogs
for LAMB2

SNPs/Variants
for LAMB2

Disorders & Mutations
for LAMB2

Medical News
for LAMB2

Publications
for LAMB2

Licensable Technologies
for LAMB2

Services
for LAMB2