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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAMB1 Gene

protein-coding GIFtS: 65
GCID: GC07M107564

laminin, beta 1

(Previous name: cutis laxa with marfanoid phenotype )
(Previous symbol: CLM)

Explore 56 diseases affiliated with
LAMB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Laminin, Beta 1¹ ²		Laminin-10 Subunit Beta³
CLM¹ ²		Laminin-12 Subunit Beta³
Laminin B1 Chain² ³		Laminin-2 Subunit Beta³
Cutis Laxa With Marfanoid Phenotype¹		Laminin-6 Subunit Beta³
Laminin Subunit Beta-1²		Laminin-8 Subunit Beta³
Laminin-1 Subunit Beta³

External Ids:	HGNC: 6486¹	Entrez Gene: 3912²	Ensembl: ENSG00000091136⁷	OMIM: 150240⁵	UniProtKB: P07942³

Export aliases for LAMB1 gene to outside databases

Previous GC identifers: GC07M106048 GC07M107110 GC07M107124 GC07M107158 GC07M107351 GC07M101926

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAMB1:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement

membranes. They have been implicated in a wide variety of biological processes including cell adhesion,

differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical

chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure

consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin

chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described.

Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which

are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1.

The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have

been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This

gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it

shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by

domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation.

Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting

laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is

involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the

capacity to inhibit metastasis. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Gene Wiki entry for LAMB1 (Laminin, beta 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAMB1 gene promoter:
c-Fos AP-1 Pbx1a Brachyury FosB AP-2gamma AP-2beta c-Jun AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): LAMB1 promoter sequence

Search SABiosciences Chromatin IP Primers for LAMB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q22

LAMB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMB1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M107564: view genomic region (about GC identifiers)

Start:	107,564,244 bp from pter	End:	107,643,804 bp from pter
Size:	79,561 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 106,925,375-107,004,933

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942 (See protein sequence)

Recommended Name: Laminin subunit beta-1 precursor

Size: 1786 amino acids; 198038 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms

with globules at each end. Beta-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or

merosin), laminin-6 (laminin-311 or K-laminin), laminin-8 (laminin-411), laminin-10 (laminin-511) and laminin-12

(laminin-213)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component

Secondary accessions: Q14D91

Explore the universe of human proteins at neXtProt for LAMB1: NX_P07942

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07942

LAMB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002282.2

ENSEMBL proteins:

ENSP00000377191 ENSP00000222399 ENSP00000377190 ENSP00000412686 ENSP00000377189

Reactome Protein details: P07942
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005604	basement membrane	TAS	3493487
GO:0005605	basal lamina	--	--
GO:0005606	laminin-1 complex	TAS	14557481

LAMB1 for ontologies About GeneDecksing

LAMB1 Antibody Products:

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	Novus Biologicals LAMB1 Antibodies
	Abcam antibodies for LAMB1
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for LAMB1

Assay Products for LAMB1:

	EMD Millipore Kits and Assays for the Analysis of LAMB1
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAMB1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAMB1 for domains About GeneDecksing

4 InterPro domains/families:

IPR008211 Laminin_N

IPR002049 EGF_laminin

IPR009053 Prefoldin

IPR013015 Laminin_IV

Graphical View of Domain Structure for InterPro Entry P07942

ProtoNet protein and cluster: P07942

1 Blocks protein family: IPB002049 Laminin-type EGF-like domain

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil

structure

Domain: Domains VI and IV are globular

Similarity: Contains 13 laminin EGF-like domains

Similarity: Contains 1 laminin IV type B domain

Similarity: Contains 1 laminin N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Genatlas biochemistry entry for LAMB1:

laminin,beta 1 polypeptide,component of basement membrane zone,expressed during early development in

glomerular,perineural,arterial smooth muscle,paralog to LAMB2,heterotrimerizing (laminin 12) with laminin alpha 2 and

beta 1

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMB1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	IEA	--
GO:0005198	structural molecule activity	NAS	10842354
GO:0005201	extracellular matrix structural constituent	IDA	16289578
GO:0005515	protein binding	--	--
GO:0019899	enzyme binding	IEA	--

LAMB1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for LAMB1:

Increased gamma-H2AX phosphory

Wnt reporter upregulated

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamb1):

embryogenesis

mortality/aging

LAMB1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Integrin outside-in signaling	0.37
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
Cytoskeleton remodeling_Integrin outside-in signaling	0.37	Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

Cell adhesion_ECM remodeling

	Cell adhesion ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion_ECM remodeling	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for LAMB1 (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation

5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMB1 (see all 14)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	CDK5 Pathway
	Transendothelial Migration of Leukocytes

5/6 GeneGo (Thomson Reuters) Pathways for LAMB1 (see all 6)

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion ECM remodeling

3 BioSystems Pathways for LAMB1

	Focal Adhesion
	Alpha6-Beta4 Integrin Signaling Pathway
	Inflammatory Response Pathway

5 Reactome Pathways for LAMB1

	L1CAM interactions
	Developmental Biology
	Integrin cell surface interactions
	Signal Transduction
	Axon guidance

5/6 Kegg Pathways (Kegg details for LAMB1) (see all 6):

	Focal adhesion
	ECM-receptor interaction
	Toxoplasmosis
	Amoebiasis
	Pathways in cancer

LAMB1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LAMB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for LAMB1 (P07942^{2, 3} ENSP00000222399⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN7L2	Q5T6C5²^,³, ENSP00000358886⁴	MINT-2860416 I2D: score=3 STRING: ENSP00000358886
GFI1B	Q5VTD9²^,³, ENSP00000344782⁴	MINT-2860435 I2D: score=3 STRING: ENSP00000344782
PDIA3	P30101²^,³	MINT-4301394 I2D: score=1
LAMA5	O15230³, ENSP00000252999⁴	I2D: score=2 STRING: ENSP00000252999
COL6A1	P12109³, ENSP00000355180⁴	I2D: score=1 STRING: ENSP00000355180

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	14557481
GO:0007162	negative regulation of cell adhesion	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0007566	embryo implantation	IEA	--
GO:0016477	cell migration	IEA	--

LAMB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LAMB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAMB1
5 Novoseek chemical compound relationships for LAMB1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ikvav	72.3	2	8688602 (1)
yigsr	72.1	3	7534913 (1), 8069868 (1), 8688602 (1)
retinoic acid	46.7	23	9419418 (3), 2163993 (2), 1692330 (1), 1847931 (1) (see all 10)
heparan sulfate	19.8	1	10772861 (1)
glucose	0	1	2015965 (1)

Search CenterWatch for drugs/clinical trials and news about LAMB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAMB1 gene:

NM_002291.2

Unigene Cluster for LAMB1:

Laminin, beta 1

Hs.650585 [show with all ESTs]

Unigene Representative Sequence: NM_002291

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000472714 ENST00000393561(uc003vev.2) ENST00000222399(uc003vew.2 uc010ljn.1)

ENST00000474380 ENST00000468518 ENST00000491196 ENST00000470995 ENST00000468999

ENST00000476039 ENST00000479448 ENST00000393560(uc003vex.3) ENST00000439976

ENST00000393559

miRNA Products:		OriGene 3'-UTR Clone: LAMB1 Browse OriGene MicroRNA Expression Plasmids
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Additional cDNA sequence:

AK303501.1 AK307611.1 AK309921.1 BC026018.2 BC044633.1 BC052598.1 BC113455.1 BX648251.1

M20206.1 M61916.1

24/27 DOTS entries (see all 27):

DT.116492 DT.100826066 DT.100802139 DT.101977309 DT.434354 DT.121107815 DT.75100426 DT.40269438

DT.100826064 DT.65288674 DT.100826068 DT.95271406 DT.121107830 DT.121107880 DT.453345 DT.75192510

DT.92028197 DT.100714239 DT.95236215 DT.100045042 DT.102835860 DT.121107847 DT.306948 DT.75134510

24/401 AceView cDNA sequences (see all 401):

CB410817 AI697343 CB120619 CA437281 H89256 AU119464 CA443283 BC044633

T28659 BC052598 BE464396 AU130889 AI632719 BQ225601 BX479270 BI060036

BM451937 BU074252 AU119378 AA366408 AA341427 BQ694312 BQ005994 AI423781

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for LAMB1 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^
SP1:									-		-
SP2:
SP3:																																	-		-		-
SP4:
SP5:											-

ExUns:	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20	^	21	^	22a	·	22b	·	22c	^	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b	^	28a	·	28b	·	28c	^	29a	·	29b	^	30a	·	30b	·	30c	^
SP1:																													-		-		-												-		-		-
SP2:																													-		-		-												-		-		-
SP3:
SP4:					-
SP5:

ExUns:	31	^	32	^	33a	·	33b	^	34	^	35a	·	35b	^	36
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LAMB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAMB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTAACAG

About this image

LAMB1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Ciliary Marginal Zone

Ciliary Marginal Zone Cells

Selective marker (cell-identifying gene)

Neural Ectoderm

Limb

Forelimb Dorsal Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Multinuclear Myocytes

Skeletal Muscle

Anterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Cervical Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Vertebrae Column Muscles

Multinuclear Myocytes

Skeletal Muscle

Pelvic Muscles

Multinuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Extraembryonic endoderm-like cells (Generation of extrae...)

See LAMB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMB1

SOURCE GeneReport for Unigene cluster: Hs.650585

SABiosciences Expression via Pathway-Focused PCR Arrays including LAMB1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LAMB1 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LAMB1¹	laminin, beta 1	75.95(n) 80.66(a)		396478 XM_415943.3 XP_415943.3
lizard (Anolis carolinensis)	Reptilia	LAMB1⁶ NTNG2⁶	--	79(a) 15(a)	1 ↔ 1 possible ortholog	5(97795495-97881961) GL343812.1(183328-201709)
African clawed frog (Xenopus laevis)	Amphibia	BX853547.1²	--	75.99(n)		BX853547.1
zebrafish (Danio rerio)	Actinopterygii	AF468049.1²	--	74.13(n)		286830 AF468049.1
fruit fly (Drosophila melanogaster)	Insecta	LanB1³	embryonic morphogenesis	40(a)		--
worm (Caenorhabditis elegans)	Secernentea	lam-1³	laminin	40(a)		IV(5173526-5183412) --

ENSEMBL Gene Tree for LAMB1 (if available)
TreeFam Gene Tree for LAMB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for LAMB1 gene

NTN4² LAMA1² NTN5² LAMA3² LAMA2² LAMB2² LAMC1² LAMC2²

LAMA5² NTN3² LAMB3² LAMC3² LAMA4² NTN1² NTNG1² USH2A²

LAMB4² NTNG2²

7 SIMAP similar genes for LAMB1 using alignment to 8 protein entries: LAMB1_HUMAN (see all proteins):

LAMB2 LAMB4 unknown LAMB3 NTN4 LAMA4

NTN1

LAMB1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for LAMB1
PGOHUM00000237622

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140619520^1,2	C	other	106961257(+)	`CCTACG/ATTTGC`	2	/P /S	mis¹		1		NA	4550
rs78245660^1,2	C,F,	--	106925440(+)	`GGTGAT/CGTTTT`	1	--	ut3¹		1		WA	118
rs76734182^1,2		--	106926112(+)	`CAAACA/GGTGGA`	1	--	int¹		2		CSA WA	120
rs77636452^1,2	C,F,	--	106926154(+)	`ACATTT/GCAAAA`	1	--	int¹		1		WA	118
rs73410496^1,2	C,	--	106926572(+)	`TGTCAC/TTATGC`	1	--	int¹		1		WA	2
rs12533970^1,2	H	--	106926695(+)	`CATTGG/TTTTGT`	1	--	int¹		0	--	--	--	--
rs12533971^1,2	H	--	106926700(+)	`TTTTGG/TTCTCT`	1	--	int¹ trp³		0	--	--	--	--
rs111693975^1,2		--	106926954(+)	`GGAACT/CGTGCA`	1	--	int¹		2		CSA WA	120
rs56188789^1,2	C,F,	--	106927010(+)	`ATCTGA/CGCTGG`	1	--	int¹		4		WA CSA	124
rs79493403^1,2	F,	--	106927116(+)	`ATTCAA/GTGGTT`	1	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for LAMB1 (107564244 - 107643804 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LAMB1: --
Human Gene Mutation Database (HGMD): LAMB1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LAMB1 for disorders           About GeneDecksing

OMIM gene information: 150240    OMIM disorders: --

20/56 diseases for LAMB1 (see all 56):    About MalaCards

cutis laxa cutis laxa, marfanoid neonatal type limb-girdle muscular dystrophy junctional epidermolysis bullosa

epidermolysis bullosa supravalvular aortic stenosis muscular dystrophy diffuse mesangial sclerosis

mesangial sclerosis heart block bethlem myopathy duchenne muscular dystrophy

congenital heart block cocaine abuse autism spectrum disorder secretory meningioma

intractable epilepsy membranous glomerulonephritis congenital muscular dystrophy polycystic kidney disease

10/12 Novoseek disease relationships for LAMB1 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
teratocarcinoma	73.5	2	9419418 (1)
muscular dystrophies	56.4	2	9400354 (2)
carcinoma embryonal	55.8	1	2163993 (1)
leiomyoma	21.2	1	10730274 (1)
lung carcinoma	16	2	8494054 (2)
myopathy	11.4	1	9196901 (1)
carcinoma	11.1	3	8494054 (2), 7967523 (1)
lupus erythematosus systemic	0	1	9650095 (1)
glioma	0	1	9055641 (1)
adenocarcinoma	0	1	8494054 (1)

Human Genome Epidemiology (HuGE) Navigator: LAMB1 (4 documents)

Export disorders for LAMB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LAMB1 gene, integrated from 9 sources (see all 159):
(articles sorted by number of sources associating them with LAMB1)

Utopia: connect your pdf to the dynamic
world of online information

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype. (PubMed id 1864606)^{1, 3} Bonneau D....Larregue M. (1991)
Structure of the human laminin B1 chain gene. (PubMed id 1975589)^{1, 2} Vuolteenaho R.... Tryggvason K. (1990)
A Hpa I polymorphism in the human laminin B1 chain gene on 7q22. (PubMed id 2563160)^{1, 3} Ikonen J....Tryggvason K. (1989)
Aortic root dilatation associated with partial trisomy 7(q31.2----qter). (PubMed id 2704655)^{1, 3} Roche K.B....Wilson B.E. (1989)
Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7. (PubMed id 3611077)^{1, 2} Pikkarainen T.... Tryggvason K. (1987)
Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization. (PubMed id 3661559)^{1, 2} Jaye M....Drohan W.N. (1987)
Decreased expression of laminin beta 1 in chromosome 21-linked Bethlem myopathy. (PubMed id 10407855)^{1, 9} Merlini L....Maraldi N.M. (1999)
Early onset autosomal dominant myopathy with rigidity of the spine: a possible role for laminin beta 1? (PubMed id 9196901)^{1, 9} Taylor J....Sewry C. (1997)
Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. (PubMed id 15706419)^{1, 9} Saito E....Tanaka T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3912	HGNC: 6486	AceView: LAMB1	Ensembl:ENSG00000091136	euGenes: HUgn3912
ECgene: LAMB1	Kegg: 3912	H-InvDB: LAMB1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LAMB1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LAMB1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LAMB1 gene
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Patent Information for LAMB1 gene:
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LAMB1 Gene

laminin, beta 1

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laminin, beta 1

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