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LAMB1 Gene

protein-coding GIFtS: 63

GC07M107351

laminin, beta 1
(Previous name: cutis laxa with marfanoid phenotype )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CLM)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CLM ^²
MGC142015 ^²

Descriptions
Laminin B1 chain ^³
cutis laxa with marfanoid phenotype ^¹, ²
laminin, beta 1 ^²

External Ids
HGNC: 6486¹
Entrez Gene: 3912²
UniProtKB: P07942³
Ensembl: ENSG00000091136⁷

Search outside databases for aliases for LAMB1 gene

Previous GC identifers: GC07M106048 GC07M107110 GC07M107124 GC07M107158

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMB1:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent

of basement membranes. They have been implicated in a wide variety of biological processes

including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.

Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1,

and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed

by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain

protein encoded by a distinct gene. Several isoforms of each chain have been described. Different

alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin

isoforms which are designated by Arabic numerals in the order of their discovery, i.e.

alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and

trimer molecules are largely unknown, but some of the chains have been shown to differ with

respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene

encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct

domains which it shares with other beta chain isomers. The C-terminal helical region containing

domains I and II are separated by domain alpha, domains III and V contain several EGF-like

repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most

tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the

first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that

is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and

shown to have the capacity to inhibit metastasis. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMB1 (Laminin%2C_beta_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMB1 gene

Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q22

LAMB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M107351: (about GC identifiers)

Start:	107,351,484 bp from pter
End:	107,431,040 bp from pter
Size:	79,557 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 106,925,392-107,004,933

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942 (See protein sequence)

Recommended Name: Laminin subunit beta-1 precursor

Size: 1786 amino acids; 198066 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains

(alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped

molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit

of laminin-1 (EHS laminin), laminin-2 (merosin), and laminin-6 (K-laminin)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Note=Major component

Secondary accessions: Q14D91

REFSEQ proteins: NP_002282.2

ENSEMBL proteins:

ENSP00000377190 ENSP00000377191 ENSP00000377189 ENSP00000222399

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant LAMB1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Laminin, Laminin beta 1, Laminin 1+2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005604	basement membrane	TAS	3493487
GO:0005606	laminin-1 complex	IDA	16289578
GO:0005607	laminin-2 complex	TAS	15894315
GO:0005737	cytoplasm	IDA	18029348

About this table

Antibodies for LAMB1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LAMB1
	Sigma-Aldrich Antibodies for LAMB1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Laminin, Laminin beta 1, Laminin 1+2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LAMB1

Assays for LAMB1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of LAMB1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07942

ProtoNet protein and cluster: P07942

1 Blocks protein family: IPB002049 Laminin-type EGF-like domain

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to

form a coiled coil structure

Domain: Domains VI and IV are globular

Similarity: Contains 13 laminin EGF-like domains

Similarity: Contains 1 laminin IV type B domain

Similarity: Contains 1 laminin N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMB1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002291

Applied Biosystems Silencer® siRNAs for LAMB1

Sigma-Aldrich siRNA and siRNA Panels for LAMB1

Sigma-Aldrich shRNA Panels and shRNA for LAMB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002291
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002291
untagged cDNA clone in CMV expression vector: NM_002291

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002291

UniProtKB/Swiss-Prot: LAMB1_HUMAN, P07942

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMB1:

laminin,beta 1 polypeptide,component of basement membrane zone,expressed during early development

in glomerular,perineural,arterial smooth muscle,paralog to LAMB2,heterotrimerizing (laminin 12)

with laminin alpha 2 and beta 1

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lamb1-1):

embryogenesis

lethality-prenatal/perinatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	IDA	16289578
GO:0005515	protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for LAMB1 (Your Favorite Gene powered by Ingenuity)

Agrin Interactions at Neuromuscular Junction
CDK5 Signaling

GeneDecks LAMB1 for the pathways selected above

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5/118 Interacting proteins for LAMB1 (ENSP00000222399³ P07942²) via UniProtKB, MINT, and/or STRING (see all 118 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN7L2	Q5T6C5²	MINT-2860416
PDIA3	P30101²	MINT-4301394
CD44	ENSP00000278385³	STRING (score=.97)
COL6A1	ENSP00000355180³	STRING (score=.954)
RPSAP61	ENSP00000346067³	STRING (score=.954)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	14557481
GO:0030335	positive regulation of cell migration	IDA	16289578
GO:0031175	neurite development	IDA	15894315
GO:0042476	odontogenesis	IDA	15894315
GO:0050679	positive regulation of epithelial cell proliferation	TAS	14557481

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMB1
3 Novoseek chemical compound relationships for LAMB1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ikvav	73.56	2	8688602 (1)
heparan sulfate	20.67	1	10772861 (1)
glucose	0.00	1	2015965 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMB1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002291

Sigma-Aldrich siRNA and siRNA Panels for LAMB1

Sigma-Aldrich shRNA Panels and shRNA for LAMB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002291

REFSEQ mRNAs for LAMB1 gene:

NM_002291.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002291

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002291
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002291
                                 untagged cDNA clone in CMV expression vector: NM_002291

Additional cDNA sequence:

AK303501.1 AK307611.1 AK309921.1 BC026018.2 BC044633.1 BC052598.1 BC113455.1 BX648251.1

CR601216.1 CR622254.1 M20206.1 M61916.1

24/27 DOTS entries (see all 27 ):

DT.116492 DT.100826066 DT.100802139 DT.101977309 DT.434354 DT.121107815 DT.100826068 DT.40269438

DT.75100426 DT.100826064 DT.65288674 DT.306948 DT.75192510 DT.95271406 DT.100714239 DT.121107830

DT.121107880 DT.453345 DT.92028197 DT.91733177 DT.95236215 DT.100045042 DT.102835860 DT.121107847

24/401 AceView cDNA sequences (see all 401 ):

CR622254 CA437281 BC052598 CA443283 BE464396 AI423781 AI632719 BG400644

T28659 BU165413 M61916 AU130889 CB143661 BI494528 AA358756 AA303886

BC026018 AA330574 AL699295 CA391954 BX491906 AA333061 AI948662 AI537398

highest scoring ESTs for LAMB1:

M61916 AL699295 AL701539 AL704496 AL710200 BX471292 BX473812 BX473829 BX473949 BX474256

Unigene Cluster for LAMB1:

Laminin, beta 1

Hs.650585 [show with all ESTs]

Unigene Representative Sequence: NM_002291

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for LAMB1 (see all 16 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^
SP1:									-		-
SP2:
SP3:																																	-		-		-
SP4:
SP5:											-

ExUns:	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20	^	21	^	22a	·	22b	·	22c	^	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b	^	28a	·	28b	·	28c	^	29a	·	29b	^	30a	·	30b	·	30c	^
SP1:																													-		-		-												-		-		-
SP2:																													-		-		-												-		-		-
SP3:
SP4:					-
SP5:

ExUns:	31	^	32	^	33a	·	33b	^	34	^	35a	·	35b	^	36
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LAMB1

4 Ensembl transcripts including schematic representations:

ENST00000393560 ENST00000393561 ENST00000393559 ENST00000222399

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LAMB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMB1

¹ / ² / ³

5 probe-sets matching LAMB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
581_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M61916	1.00	0.90	0.95	1
211651_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M20206	0.60	1.00	0.82	1
201505_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002291	0.60	1.00	0.82	1
211651_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201505_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMB1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTGTAACAG

SOURCE GeneReport for Unigene cluster: Hs.650585
Expression variation in blood from EXPOLDB for LAMB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMB1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMB1¹	--	laminin, beta 1	87.75(n) 92.42(a)	475882 XM_533089.2 XP_533089.2
chimpanzee (Pan troglodytes)	LAMB1¹	--	laminin, beta 1	99.51(n) 99.66(a)	463656 XM_001165667.1 XP_001165667.1
cow (Bos taurus)	LAMB1¹	--	laminin, beta 1	89.77(n) 93.35(a)	520030 XM_598260.3 XP_598260.3
rat (Rattus norvegicus)	Lamb1¹	--	laminin, beta 1	86.38(n) 92.66(a)	298941 XM_216679.4 XP_216679.4
mouse (Mus musculus)	Lamb1-1^{1, 5}	12 (20.00 cM)⁵	laminin B1 subunit 1^{1, 5}	86.66(n)¹ 92.83(a)¹	16777¹ NM_008482.2¹ NP_032508.2¹ AA073430⁵ AK013952⁵ (see all 25)

About this table Species with no ortholog for LAMB1

ENSEMBL Gene Tree for LAMB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMB1 gene

LAMB2² LAMB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/456 NCBI SNPs in LAMB1 are shown (see all 456 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 194)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2395813^1,2	A,C,F,H	107432369(+)	`CTTGCC/TCTGCT`	1	--	ng3¹		8	EU EA WA	836
	rs6965420^1,2	A,C,F,H	107431137(+)	`TGGGTT/GTTCAG`	1	--	ng3¹		4	EU EA WA	414
	rs2395814^1,2	A,C,F,H	107432729(+)	`CTGTTT/CAGAAG`	1	--	ng3¹		6	EU EA WA NA	600
	rs2070917^1,2	A,C,F,H	107431002(-)	`GCAGAT/CTCGGC`	1	--	ut5¹ ese³		10	EA NA EU WA	1830
	rs4320486^1,2	A,C,F,H	107431213(+)	`ATCACC/TAAACG`	1	--	ng3¹		12	EU EA WA NA	1040
	rs3814473^1,2	A,C,F,H	107431829(+)	`ACAGCC/AAGGAA`	1	--	ng3¹		11	EU EA WA NA	978
	rs7561^1,2	A,C,F	107351602(-)	`GGTGAC/ACAAGG`	1	--	ut3¹		5	MN NA	514
	rs3814474^1,2	C,F,H	107432044(+)	`CCACCC/TATTCT`	1	--	ng3¹		7	EU EA WA NA	558
	rs3829896^1,2	C,F,H	107433011(+)	`ACTCTG/ACATTG`	1	--	ng3¹		4	EU EA WA	420
	rs20555^1,2	C,F,H	107388987(-)	`GCCGGT/CGTGCT`	1	A/V	mis¹ ese³		12	MN EU EA WA NA	1022

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HapMap Linkage Disequilibrium images for LAMB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 150240

10/12 Novoseek disease relationships for LAMB1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
teratocarcinoma	73.74	2	9419418 (1)
muscular dystrophies	57.21	2	9400354 (2)
carcinoma embryonal	56.32	1	2163993 (1)
leiomyoma	22.15	1	10730274 (1)
lung carcinoma	16.73	2	8494054 (2)
myopathy	12.43	1	9196901 (1)
carcinoma	11.82	3	8494054 (2), 7967523 (1)
glioma	0.00	1	9055641 (1)
tumors	0.00	3	7534913 (1), 8069868 (1), 8494054 (1)
adenocarcinoma	0.00	1	8494054 (1)

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Human Gene Mutation Database: LAMB1
Human Genome Epidemiology Navigator: LAMB1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/133 PubMed articles for LAMB1 gene (see all 133 ):

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype. (PubMed id 1864606)^{2, 3} Bonneau D....Larregue M. (1991)
Structure of the human laminin B1 chain gene. (PubMed id 1975589)^{3, 4} Vuolteenaho R.... Tryggvason K. (1990)
A Hpa I polymorphism in the human laminin B1 chain gene on 7q22. (PubMed id 2563160)^{2, 3} Ikonen J....Tryggvason K. (1989)
Aortic root dilatation associated with partial trisomy 7(q31.2----qter). (PubMed id 2704655)^{2, 3} Roche K.B....Wilson B.E. (1989)
Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7. (PubMed id 3611077)^{3, 4} Pikkarainen T.... Tryggvason K. (1987)
Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization. (PubMed id 3661559)^{3, 4} Jaye M....Drohan W.N. (1987)
Decreased expression of laminin beta 1 in chromosome 21-linked Bethlem myopathy. (PubMed id 10407855)^{1, 3} Merlini L....Maraldi N.M. (1999)
Early onset autosomal dominant myopathy with rigidity of the spine: a possible role for laminin beta 1? (PubMed id 9196901)^{1, 3} Taylor J....Sewry C. (1997)
Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. (PubMed id 15706419)^{1, 3} Saito E....Tanaka T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3912	HGNC: 6486	AceView: LAMB1	Ensembl:ENSG00000091136	euGenes: HUgn3912
ECgene: LAMB1	H-InvDB: LAMB1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LAMB1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LAMB1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAMB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAMB1		Antibodies for LAMB1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAMB1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Laminin, Laminin beta 1, Laminin 1+2)
	Antibodies (Laminin, Laminin beta 1, Laminin 1+2)

Search OriGene for LAMB1

Search Tocris compounds for LAMB1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LAMB1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LAMB1 Gene at Home site.
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LAMB1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for LAMB1

Summaries
for LAMB1

Genomic Location
for LAMB1

Proteins
for LAMB1

Protein Domains/
Families
for LAMB1

Gene Function
for LAMB1

Pathways & Interactions
for LAMB1

Drugs & Compounds
for LAMB1

Transcripts
for LAMB1

Expression
for LAMB1

Orthologs
for LAMB1

Paralogs
for LAMB1

SNPs/Variants
for LAMB1

Disorders & Mutations
for LAMB1

Medical News
for LAMB1

Publications
for LAMB1

Search for LAMB1

Genome Databases showing LAMB1

Other Databases showing LAMB1

Specialized Databases showing LAMB1

Licensable Technologies
for LAMB1

Services
for LAMB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMB1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor LAMB1

Summariesfor LAMB1

Genomic Locationfor LAMB1

Proteinsfor LAMB1

Protein Domains/Familiesfor LAMB1

Gene Functionfor LAMB1

Pathways & Interactionsfor LAMB1

Drugs & Compoundsfor LAMB1

Transcriptsfor LAMB1

Expression for LAMB1

Orthologsfor LAMB1

Paralogsfor LAMB1

SNPs/Variantsfor LAMB1

Disorders & Mutationsfor LAMB1

Medical Newsfor LAMB1

Publicationsfor LAMB1

Search for LAMB1

Genome Databases showing LAMB1

Other Databases showing LAMB1

Specialized Databases showing LAMB1

Licensable Technologiesfor LAMB1

Servicesfor LAMB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMB1

Summaries
for LAMB1

Genomic Location
for LAMB1

Proteins
for LAMB1

Protein Domains/
Families
for LAMB1

Gene Function
for LAMB1

Pathways & Interactions
for LAMB1

Drugs & Compounds
for LAMB1

Transcripts
for LAMB1

Expression
for LAMB1

Orthologs
for LAMB1

Paralogs
for LAMB1

SNPs/Variants
for LAMB1

Disorders & Mutations
for LAMB1

Medical News
for LAMB1

Publications
for LAMB1

Licensable Technologies
for LAMB1

Services
for LAMB1