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Aliases for LAMA5 Gene

Aliases for LAMA5 Gene

  • Laminin Subunit Alpha 5 2 3 5
  • Laminin-10 Subunit Alpha 4
  • Laminin-11 Subunit Alpha 4
  • Laminin-15 Subunit Alpha 4
  • Laminin, Alpha 5 2
  • KIAA0533 4
  • KIAA1907 4

External Ids for LAMA5 Gene

Previous GeneCards Identifiers for LAMA5 Gene

  • GC20M060647
  • GC20M061523
  • GC20M061569
  • GC20M060317
  • GC20M060883
  • GC20M057659

Summaries for LAMA5 Gene

Entrez Gene Summary for LAMA5 Gene

  • This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

GeneCards Summary for LAMA5 Gene

LAMA5 (Laminin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with LAMA5 include galloway-mowat syndrome and alport syndrome. Among its related pathways are Degradation of the extracellular matrix and Metabolism. GO annotations related to this gene include receptor binding and integrin binding. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for LAMA5 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Gene Wiki entry for LAMA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMA5 Gene

Genomics for LAMA5 Gene

Regulatory Elements for LAMA5 Gene

Promoters for LAMA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAMA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAMA5 Gene

Chromosome:
20
Start:
62,307,955 bp from pter
End:
62,367,320 bp from pter
Size:
59,366 bases
Orientation:
Minus strand

Genomic View for LAMA5 Gene

Genes around LAMA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMA5 Gene

Proteins for LAMA5 Gene

  • Protein details for LAMA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15230-LAMA5_HUMAN
    Recommended name:
    Laminin subunit alpha-5
    Protein Accession:
    O15230
    Secondary Accessions:
    • Q5U4N9
    • Q8TDF8
    • Q8WZA7
    • Q9H1P1

    Protein attributes for LAMA5 Gene

    Size:
    3695 amino acids
    Molecular mass:
    399737 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).
    SequenceCaution:
    • Sequence=CAC22310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LAMA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMA5 Gene

Proteomics data for LAMA5 Gene at MOPED

Post-translational modifications for LAMA5 Gene

  • Ubiquitination at Lys 192
  • Glycosylation at Asn 95, Asn 143, Asn 243, Asn 452, Asn 479, Asn 900, Asn 921, Asn 959, Asn 1330, Asn 1529, Asn 1555, Asn 2019, Asn 2196, Asn 2209, Asn 2303, Asn 2423, Asn 2501, Asn 2568, Asn 2707, Asn 3107, Asn 3209, Asn 3257, Asn 3287, and Asn 3626
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LAMA5 Gene

Domains & Families for LAMA5 Gene

Gene Families for LAMA5 Gene

Suggested Antigen Peptide Sequences for LAMA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15230

UniProtKB/Swiss-Prot:

LAMA5_HUMAN :
  • Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
Domain:
  • Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
  • Contains 22 laminin EGF-like domains.
  • Contains 5 laminin G-like domains.
  • Contains 1 laminin IV type A domain.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with LAMA5: view

Function for LAMA5 Gene

Molecular function for LAMA5 Gene

GENATLAS Biochemistry:
laminin 5 (kalinin/nicein) alpha 5 polypeptide,component of basement membrane zone,expressed in placenta,heart,lung,skeletal muscle,kidney,pancreas
UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
genes like me logo Genes that share phenotypes with LAMA5: view

Animal Models for LAMA5 Gene

MGI Knock Outs for LAMA5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAMA5 Gene

Localization for LAMA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMA5 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMA5 Gene COMPARTMENTS Subcellular localization image for LAMA5 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LAMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA,IDA 14557481
GO:0043260 laminin-11 complex TAS 16236823
genes like me logo Genes that share ontologies with LAMA5: view

Pathways & Interactions for LAMA5 Gene

genes like me logo Genes that share pathways with LAMA5: view

SIGNOR curated interactions for LAMA5 Gene

Activates:

Gene Ontology (GO) - Biological Process for LAMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 11821406
GO:0001738 morphogenesis of a polarized epithelium IEA --
GO:0001755 neural crest cell migration IEA --
GO:0001942 hair follicle development IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with LAMA5: view

Drugs & Compounds for LAMA5 Gene

(1) Drugs for LAMA5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for LAMA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMA5: view

Transcripts for LAMA5 Gene

Unigene Clusters for LAMA5 Gene

Laminin, alpha 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59a · 59b ^ 60a · 60b ^ 61a · 61b · 61c ^ 62a · 62b ^ 63a · 63b ^ 64a · 64b ^ 65 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 66a · 66b ^ 67a · 67b ^ 68 ^ 69 ^ 70 ^ 71 ^ 72a · 72b · 72c ^ 73 ^ 74a · 74b ^ 75 ^ 76 ^ 77 ^ 78a · 78b ^ 79 ^ 80a · 80b · 80c ^ 81 ^ 82a · 82b ^
SP1: - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9: -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for LAMA5 Gene

GeneLoc Exon Structure for
LAMA5
ECgene alternative splicing isoforms for
LAMA5

Expression for LAMA5 Gene

mRNA expression in normal human tissues for LAMA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LAMA5 Gene

This gene is overexpressed in Gallbladder (21.0), Urinary Bladder (13.1), and Rectum (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMA5 Gene



SOURCE GeneReport for Unigene cluster for LAMA5 Gene Hs.473256

mRNA Expression by UniProt/SwissProt for LAMA5 Gene

O15230-LAMA5_HUMAN
Tissue specificity: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.
genes like me logo Genes that share expression patterns with LAMA5: view

Protein tissue co-expression partners for LAMA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LAMA5 Gene

Orthologs for LAMA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMA5 35
  • 92.17 (n)
  • 90.15 (a)
cow
(Bos Taurus)
Mammalia LAMA5 35
  • 83.67 (n)
  • 82.54 (a)
LAMA5 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMA5 36
  • 56 (a)
OneToOne
LAMA5 35
  • 82.49 (n)
  • 80.28 (a)
mouse
(Mus musculus)
Mammalia Lama5 36
  • 79 (a)
OneToOne
Lama5 16
Lama5 35
  • 79.95 (n)
  • 79.68 (a)
oppossum
(Monodelphis domestica)
Mammalia LAMA5 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMA5 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lama5 35
  • 80.07 (n)
  • 79.71 (a)
chicken
(Gallus gallus)
Aves LAMA5 35
  • 66.01 (n)
  • 61.6 (a)
LAMA5 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lama5 35
  • 66.79 (n)
  • 64.57 (a)
zebrafish
(Danio rerio)
Actinopterygii lama5 36
  • 50 (a)
OneToOne
lama5 35
  • 57.7 (n)
  • 50.78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004993 35
  • 46.78 (n)
  • 34.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta LanA 35
  • 47.07 (n)
  • 35.34 (a)
LanA 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea epi-1 35
  • 42.51 (n)
  • 35.01 (a)
epi-1 37
  • 32 (a)
Species with no ortholog for LAMA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMA5 Gene

ENSEMBL:
Gene Tree for LAMA5 (if available)
TreeFam:
Gene Tree for LAMA5 (if available)

Paralogs for LAMA5 Gene

Paralogs for LAMA5 Gene

genes like me logo Genes that share paralogs with LAMA5: view

Variants for LAMA5 Gene

Sequence variations from dbSNP and Humsavar for LAMA5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_030847 -
rs477859 -- 62,362,541(+) ATGTC(A/G)CAGTA nc-transcript-variant, reference, synonymous-codon
rs944889 -- 62,329,448(-) CCTCA(C/T)GCCCC intron-variant
rs944890 -- 62,328,693(-) GGACT(C/T)CAGCT intron-variant
rs944891 -- 62,327,488(-) GGAGG(A/G/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMA5 Gene

Variant ID Type Subtype PubMed ID
dgv4599n71 CNV Loss 21882294
dgv4601n71 CNV Loss 21882294
nsv518296 CNV Loss 19592680
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
nsv834024 CNV Gain 17160897
nsv913048 CNV Loss 21882294
dgv4602n71 CNV Loss 21882294
nsv913052 CNV Gain 21882294
nsv913053 CNV Gain+Loss 21882294
dgv4603n71 CNV Loss 21882294
nsv913056 CNV Loss 21882294
nsv3441 CNV Insertion 18451855
dgv4604n71 CNV Loss 21882294
nsv913059 CNV Loss 21882294
nsv817907 CNV Loss 17921354
nsv817908 CNV Loss 17921354
nsv470557 CNV Gain 18288195
nsv520024 CNV Loss 19592680
esv2722792 CNV Deletion 23290073
dgv713e201 CNV Deletion 23290073
dgv714e201 CNV Deletion 23290073
nsv459059 CNV Loss 19166990
dgv518n27 CNV Loss 19166990
dgv4605n71 CNV Loss 21882294
esv2558907 CNV Loss 19546169
nsv913066 CNV Loss 21882294
nsv913067 CNV Loss 21882294
nsv459065 CNV Gain 19166990
esv1010421 CNV Insertion 20482838
nsv828771 CNV Gain 20364138
esv2722798 CNV Deletion 23290073
esv2669761 CNV Deletion 23128226
nsv828772 CNV Gain 20364138
nsv828773 CNV Loss 20364138
nsv179849 CNV Loss 16902084
nsv913071 CNV Gain 21882294
dgv4606n71 CNV Loss 21882294
esv1008423 CNV Insertion 20482838

Variation tolerance for LAMA5 Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.61; 99.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMA5 Gene

HapMap Linkage Disequilibrium report
LAMA5
Human Gene Mutation Database (HGMD)
LAMA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMA5 Gene

Disorders for LAMA5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LAMA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
galloway-mowat syndrome
  • galloway syndrome
alport syndrome
  • hereditary nephritis
spina bifida occulta
  • closed spina bifida
adams-oliver syndrome
  • adams oliver syndrome
- elite association - COSMIC cancer census association via MalaCards
Search LAMA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LAMA5

Genetic Association Database (GAD)
LAMA5
Human Genome Epidemiology (HuGE) Navigator
LAMA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMA5
genes like me logo Genes that share disorders with LAMA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMA5 Gene

Publications for LAMA5 Gene

  1. Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. (PMID: 9271224) Durkin M.E. … Wewer U.M. (FEBS Lett. 1997) 2 3 4 23 67
  2. [Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome]. (PMID: 20019771) Huang W. … Liu G. (Beijing Da Xue Xue Bao 2009) 3 23
  3. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells. (PMID: 18496706) Takkunen M. … Virtanen I. (Histochem. Cell Biol. 2008) 3 23
  4. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. (PMID: 18523231) Gorfu G. … Patarroyo M. (J. Leukoc. Biol. 2008) 3 23
  5. Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. (PMID: 18635166) Kikkawa Y. … Mitaka T. (Exp. Cell Res. 2008) 3 23

Products for LAMA5 Gene

Sources for LAMA5 Gene

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