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LAMA5 Gene

protein-coding GIFtS: 65

GC20M060317

laminin, alpha 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0533 ^³
KIAA1907 ^², ³

Descriptions
laminin alpha 5 ^²
laminin alpha-5 chain ^²
laminin, alpha 5 ^²

External Ids
HGNC: 6485¹
Entrez Gene: 3911²
UniProtKB: O15230³
Ensembl: ENSG00000130702⁷

Search outside databases for aliases for LAMA5 gene

Previous GC identifers: GC20M060647 GC20M061523 GC20M061569

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMA5:

Components of the extracellular matrix exert myriad effects on tissues throughout the body. In

particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue

development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It

is thought that laminins mediate the attachment, migration, and organization of cells into tissues

during embryonic development by interacting with other extracellular matrix components. Laminins

function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type

representing a different subfamily of proteins. The protein encoded by this gene belongs to the

alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript

variants encoding different isoforms have been found for this gene, but the full-length nature of

one of them has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMA5_HUMAN, O15230

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMA5 (Laminin%2C_alpha_5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMA5 gene

Entrez Gene cytogenetic band: 20q13.2-q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.2-q13.3

LAMA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M060317: (about GC identifiers)

Start:	60,317,516 bp from pter
End:	60,375,763 bp from pter
Size:	58,248 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMA5_HUMAN, O15230 (See protein sequence)

Recommended Name: Laminin subunit alpha-5 precursor

Size: 3695 amino acids; 399799 Da

Subunit: Laminin-15 complex is an heterotrimer composed of three chains (alpha-5/beta-2/gamma-3)

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long

and three short arms with globules at each end

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Note=Major component

Sequence caution: Sequence=CAC22310.1; Type=Erroneous gene model prediction;

Secondary accessions: Q8TDF8 Q8WZA7 Q9H1P1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005551.3

ENSEMBL proteins:

ENSP00000359725 ENSP00000252999 ENSP00000359711 ENSP00000359726

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Laminin alpha 5, Laminin 5)
	Human Recombinant Proteins from Abnova (LAMA5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005604	basement membrane	IEA	--
GO:0005606	laminin-1 complex	IEA	--

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Antibodies for LAMA5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LAMA5
	Sigma-Aldrich Antibodies for LAMA5
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Laminin alpha 5, Laminin 5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAMA5)
	Novus Biologicals Antibodies for LAMA5

Assays for LAMA5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15230

ProtoNet protein and cluster: O15230

5/6 Blocks protein families (see all 6 ):

IPB000034 Laminin B

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

IPB001638 Bacterial extracellular solute-binding protein

IPB001791 Laminin G

IPB002049 Laminin-type EGF-like domain

UniProtKB/Swiss-Prot: LAMA5_HUMAN, O15230

Domain: Domain G is globular and is part of the major cell-binding site located in the long arm of

the laminin heterotrimer

Similarity: Contains 22 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

Similarity: Contains 1 laminin IV type A domain

Similarity: Contains 1 laminin N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMA5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMA5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005560

Applied Biosystems Silencer® siRNAs for LAMA5

Sigma-Aldrich siRNA and siRNA Panels for LAMA5

Sigma-Aldrich shRNA Panels and shRNA for LAMA5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LAMA5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005560
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005560
untagged cDNA clones in CMV expression vector (see all 2): BC003355

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005560

UniProtKB/Swiss-Prot: LAMA5_HUMAN, O15230

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMA5:

laminin 5 (kalinin/nicein) alpha 5 polypeptide,component of basement membrane zone,expressed in

placenta,heart,lung,skeletal muscle,kidney,pancreas

15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lama5):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal	life span-post-weaning/aging
limbs/digits/tail	nervous system	renal/urinary system	respiratory system	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005198	structural molecule activity	NAS	9271224

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for LAMA5 (Your Favorite Gene powered by Ingenuity)

CDK5 Signaling

GeneDecks LAMA5 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for LAMA5

5/122 Interacting proteins for LAMA5 (ENSP00000252999³ O15230²) via UniProtKB, MINT, and/or STRING (see all 122 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²	MINT-61923
SMAD2	Q15796²	MINT-60924
BCAM	ENSP00000270233³	STRING (score=.988)
LAMC1	ENSP00000258341³	STRING (score=.968)
ITGA3	ENSP00000007722³	STRING (score=.967)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030155	regulation of cell adhesion	IEA	--
GO:0030334	regulation of cell migration	IEA	--
GO:0045995	regulation of embryonic development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMA5
1 Novoseek chemical compound relationship for LAMA5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	28.49	1	16288042 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMA5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMA5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005560

Sigma-Aldrich siRNA and siRNA Panels for LAMA5

Sigma-Aldrich shRNA Panels and shRNA for LAMA5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005560

REFSEQ mRNAs for LAMA5 gene:

NM_005560.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005560

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005560
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005560
                                 untagged cDNA clones in CMV expression vector (see all 2): BC003355

Additional cDNA sequence:

AB010099.1 AB011105.1 AB067494.1 AF443072.1 AK057740.1 AK074307.1 BC085017.1 Z95636.1

24/35 DOTS entries (see all 35 ):

DT.452843 DT.92442493 DT.95299760 DT.95299749 DT.95299753 DT.100018633 DT.208870 DT.91681848

DT.120811692 DT.120811700 DT.120811631 DT.97772426 DT.120811708 DT.75100049 DT.92047817 DT.102838035

DT.95299751 DT.100804290 DT.100639822 DT.100877859 DT.91650621 DT.91678919 DT.92442495 DT.95290538

24/297 AceView cDNA sequences (see all 297 ):

AU125545 BM314422 AB011105 Z95636 AI935823 AA359774 BU784577 AA746169

BM976683 AW182720 BQ941656 AB067494 CA455127 BC003355 AI199493 AI434880

AI026737 BM741212 BQ940768 AI536942 BQ650028 BU152665 AI368603 AL844373

highest scoring ESTs for LAMA5:

AB011105 AF443072 AI401502 BG031255 BQ891602 BU860131 BU944182 AA344756 AA359598 AA359774

Unigene Cluster for LAMA5:

Laminin, alpha 5

Hs.473256 [show with all ESTs]

Unigene Representative Sequence: NM_005560

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA5 (see all 17 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24	^
SP1:															-
SP2:
SP3:
SP4:
SP5:

ExUns:	25	^	26	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43a	·	43b	^	44	^	45	^	46	^
SP1:													-																														-
SP2:
SP3:
SP4:
SP5:

ExUns:	47	^	48	^	49	^	50	^	51	^	52	^	53	^	54	^	55	^	56	^	57	^	58	^	59a	·	59b	^	60a	·	60b	^	61a	·	61b	·	61c	^	62a	·	62b	^	63a	·	63b	^	64a	·	64b	^	65	^
SP1:																									-								-																-
SP2:																																																	-
SP3:
SP4:
SP5:

ExUns:	66a	·	66b	^	67a	·	67b	^	68	^	69	^	70	^	71	^	72a	·	72b	·	72c	^	73	^	74a	·	74b	^	75	^	76	^	77	^	78a	·	78b	^	79	^	80a	·	80b	·	80c	^	81	^	82a	·	82b	^
SP1:																	-										-														-										-
SP2:					-		-										-										-												-		-										-
SP3:
SP4:
SP5:																	-

About this scheme

ECgene alternative splicing isoforms for LAMA5

4 Ensembl transcripts including schematic representations:

ENST00000370691 ENST00000252999 ENST00000370677 ENST00000370692

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LAMA5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMA5

¹ / ² / ³

4 probe-sets matching LAMA5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
83186_at²^{, 3}	U95-D	1	1.00	1.00	0.34	1.08	AI401502	0.80	1.00	0.91	1
41610_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.93	AB011105	0.80	1.00	0.91	1
210150_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003355	0.40	1.00	0.76	1
210150_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMA5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTCGCTCTG

SOURCE GeneReport for Unigene cluster: Hs.473256
Expression variation in blood from EXPOLDB for LAMA5
UniProtKB/Swiss-Prot: LAMA5_HUMAN, O15230
Tissue specificity: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and
placenta. Little or no expression in brain and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMA5 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMA5¹	--	laminin, alpha 5	82.13(n) 79.46(a)	442954 XM_850102.1 XP_855195.1
cow (Bos taurus)	LAMA5¹	--	laminin, alpha 5	83.75(n) 82.68(a)	506751 XM_583244.3 XP_583244.3
rat (Rattus norvegicus)	Lama5¹	--	laminin, alpha 5	80.25(n) 79.95(a)	140433 XM_215963.4 XP_215963.4
mouse (Mus musculus)	Lama5^{1, 5}	2 (106.00 cM)⁵	laminin, alpha 5^{1, 5}	80.09(n)¹ 79.83(a)¹	16776¹ NM_001081171.1¹ NP_001074640.1¹ AA408760⁵ AA408762⁵ (see all 22)
zebrafish (Danio rerio)	lama5¹	--	laminin, alpha 5	57.56(n) 50.65(a)	321243 NM_001039171.1 NP_001034260.1

About this table Species with no ortholog for LAMA5

ENSEMBL Gene Tree for LAMA5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMA5 gene

LAMA3² LAMA4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/514 NCBI SNPs in LAMA5 are shown (see all 514 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 191)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4925229^1,2	A,C,F,H	60355038(+)	`GCCGGC/TGGTGT`	1	T/A	mis¹ ese³		4	EU EA WA	418
--	rs11698080^1,2	A,C,F,H	60332577(+)	`GGGGGC/TGCTGG`	1	A/T	mis¹ ese³		4	EU EA WA	376
	rs2427283^1,2	A,C,F,H	60332601(+)	`GCTCAT/CGAAGC`	1	M/V	mis¹ ese³		7	EU EA WA	710
	rs2297587^1,2	A,C,F,H	60329092(-)	`CCCCCG/ACCATG`	1	H/R	mis¹ ese³		4	EU EA WA	416
	rs944895^1,2	A,C,F,H	60320976(-)	`TGCGAT/CGGCTC`	1	W/R	mis¹ ese³		4	EU EA WA	420
	rs3737137^1,2	C,F,H	60331116(-)	`TGACCG/ACTGCC`	1	H/R	mis¹ ese³		5	EA EU WA	1798
	rs2427284^1,2	C,F,H	60333876(+)	`GCAGGG/AAGACA`	1	S/F	mis¹		4	EU EA WA	412
	rs3810548^1,2	C,F,H	60339273(+)	`GGGACG/ATGGCT`	1	T/M	mis¹ ese³		5	EA EU WA	1912
	rs2427286^1,2	C,F,H	60338248(+)	`GCCCTC/TGGGCA`	1	K/E	mis¹		8	EU EA WA	808
	rs944893^1,2	C,F,H	60335784(-)	`AGGGAC/TGGAGA`	1	T/M	mis¹ ese³		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for LAMA5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601033

4 Novoseek disease relationships for LAMA5 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
muscular dystrophies	59.59	1	9353324 (1)
carcinoma	0.00	4	17265066 (2), 12691260 (1)
tumors	0.00	2	9624186 (1), 18635166 (1)
metastasis	0.00	1	16288042 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/106 PubMed articles for LAMA5 gene (see all 106 ):

Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. (PubMed id 9271224)^{1, 2, 3, 4} Durkin M.E....Wewer U.M. (1997)
Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells. (PubMed id 11821406)^{3, 4} Doi M.... Tryggvason K. (2002)
Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{3, 4} Nagase T....Ohara O. (2001)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Laminin expression in adult and developing retinae: evidence of two novel CNS laminins. (PubMed id 10964957)^{3, 4} Libby R.T.... Brunken W.J. (2000)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{3, 4} Nagase T....Ohara O. (1998)
Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. (PubMed id 18635166)^{1, 3} Kikkawa Y....Mitaka T. (2008)
Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. (PubMed id 12682087)^{1, 3} Kikkawa Y....Miner J.H. (2003)
Expression patterns of laminin alpha1 and alpha5 in human lung during development. (PubMed id 11104726)^{1, 3} Pierce R.A....Senior R.M. (2000)
Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta. (PubMed id 10964500)^{1, 3} Champliaud M.F....Gullberg D. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3911	HGNC: 6485	AceView: LAMA5	Ensembl:ENSG00000130702	euGenes: HUgn3911
ECgene: LAMA5	H-InvDB: LAMA5

(According to HUGE)
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HUGE: KIAA1907 KIAA0533

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LAMA5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAMA5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMA5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAMA5		Antibodies for LAMA5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAMA5		Browse small molecules at Sigma-Aldrich
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (LAMA5)
	Antibodies (LAMA5)
	Chimera RNAi (LAMA5)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Laminin alpha 5, Laminin 5)
	Antibodies (Laminin alpha 5, Laminin 5)

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Antibodies for LAMA5

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LAMA5 Gene at Home site.
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LAMA5 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for LAMA5

Summaries
for LAMA5

Genomic Location
for LAMA5

Proteins
for LAMA5

Protein Domains/
Families
for LAMA5

Gene Function
for LAMA5

Pathways & Interactions
for LAMA5

Drugs & Compounds
for LAMA5

Transcripts
for LAMA5

Expression
for LAMA5

Orthologs
for LAMA5

Paralogs
for LAMA5

SNPs/Variants
for LAMA5

Disorders & Mutations
for LAMA5

Medical News
for LAMA5

Publications
for LAMA5

Search for LAMA5

Genome Databases showing LAMA5

Other Databases showing LAMA5

Specialized Databases showing LAMA5

Licensable Technologies
for LAMA5

Services
for LAMA5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMA5 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor LAMA5

Summariesfor LAMA5

Genomic Locationfor LAMA5

Proteinsfor LAMA5

Protein Domains/Familiesfor LAMA5

Gene Functionfor LAMA5

Pathways & Interactionsfor LAMA5

Drugs & Compoundsfor LAMA5

Transcriptsfor LAMA5

Expression for LAMA5

Orthologsfor LAMA5

Paralogsfor LAMA5

SNPs/Variantsfor LAMA5

Disorders & Mutationsfor LAMA5

Medical Newsfor LAMA5

Publicationsfor LAMA5

Search for LAMA5

Genome Databases showing LAMA5

Other Databases showing LAMA5

Specialized Databases showing LAMA5

Licensable Technologiesfor LAMA5

Servicesfor LAMA5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMA5

Summaries
for LAMA5

Genomic Location
for LAMA5

Proteins
for LAMA5

Protein Domains/
Families
for LAMA5

Gene Function
for LAMA5

Pathways & Interactions
for LAMA5

Drugs & Compounds
for LAMA5

Transcripts
for LAMA5

Expression
for LAMA5

Orthologs
for LAMA5

Paralogs
for LAMA5

SNPs/Variants
for LAMA5

Disorders & Mutations
for LAMA5

Medical News
for LAMA5

Publications
for LAMA5

Licensable Technologies
for LAMA5

Services
for LAMA5