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Aliases for LAMA5 Gene

Aliases for LAMA5 Gene

  • Laminin, Alpha 5 2 3
  • Laminin-10 Subunit Alpha 4
  • Laminin-11 Subunit Alpha 4
  • Laminin-15 Subunit Alpha 4
  • KIAA0533 4
  • KIAA1907 4

External Ids for LAMA5 Gene

Summaries for LAMA5 Gene

Entrez Gene Summary for LAMA5 Gene

  • This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

GeneCards Summary for LAMA5 Gene

LAMA5 (Laminin, Alpha 5) is a Protein Coding gene. Diseases associated with LAMA5 include pontocerebellar hypoplasia and galloway-mowat syndrome. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include structural molecule activity and integrin binding. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for LAMA5 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Gene Wiki entry for LAMA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMA5 Gene

Genomics for LAMA5 Gene

Genomic Location for LAMA5 Gene

Start:
62,307,955 bp from pter
End:
62,367,312 bp from pter
Size:
59,358 bases
Orientation:
Minus strand

Genomic View for LAMA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMA5 Gene

Regulatory Elements for LAMA5 Gene

Proteins for LAMA5 Gene

  • Protein details for LAMA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15230-LAMA5_HUMAN
    Recommended name:
    Laminin subunit alpha-5
    Protein Accession:
    O15230
    Secondary Accessions:
    • Q5U4N9
    • Q8TDF8
    • Q8WZA7
    • Q9H1P1

    Protein attributes for LAMA5 Gene

    Size:
    3695 amino acids
    Molecular mass:
    399737 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523)
    SequenceCaution:
    • Sequence=CAC22310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LAMA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMA5 Gene

Proteomics data for LAMA5 Gene at MOPED

Post-translational modifications for LAMA5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys192
  • Glycosylation at Asn95, Asn143, Asn243, Asn452, Asn479, Asn900, Asn921, Asn959, Asn1330, Asn1529, Asn1555, Asn2019, Asn2196, Asn2209, Asn2303, Asn2423, Asn2501, Asn2568, Asn2707, Asn3107, Asn3209, Asn3257, Asn3287, and Asn3626

Other Protein References for LAMA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LAMA5 Gene

Domains for LAMA5 Gene

Gene Families for LAMA5 Gene

HGNC:
  • LAM :Laminins

UniProtKB/Swiss-Prot:

LAMA5_HUMAN
Domain:
  • Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer:
    • O15230
  • Contains 22 laminin EGF-like domains.:
    • O15230
  • Contains 5 laminin G-like domains.:
    • O15230
  • Contains 1 laminin IV type A domain.:
    • O15230
  • Contains 1 laminin N-terminal domain.:
    • O15230
genes like me logo Genes that share domains with LAMA5: view

Function for LAMA5 Gene

Molecular function for LAMA5 Gene

GENATLAS Biochemistry: laminin 5 (kalinin/nicein) alpha 5 polypeptide,component of basement membrane zone,expressed in placenta,heart,lung,skeletal muscle,kidney,pancreas
UniProtKB/Swiss-Prot Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Gene Ontology (GO) - Molecular Function for LAMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005178 integrin binding IDA 11821406
GO:0005198 structural molecule activity IC 11821406
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LAMA5: view
genes like me logo Genes that share phenotypes with LAMA5: view

miRNA for LAMA5 Gene

miRTarBase miRNAs that target LAMA5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LAMA5 Gene

Localization for LAMA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMA5 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMA5 Gene COMPARTMENTS Subcellular localization image for LAMA5 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LAMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IDA 14557481
GO:0005605 basal lamina NAS 11821406
GO:0005606 laminin-1 complex IEA --
genes like me logo Genes that share ontologies with LAMA5: view

Pathways for LAMA5 Gene

genes like me logo Genes that share pathways with LAMA5: view

Gene Ontology (GO) - Biological Process for LAMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 11821406
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001738 morphogenesis of a polarized epithelium IEA --
GO:0001755 neural crest cell migration IEA --
GO:0001942 hair follicle development IEA --
genes like me logo Genes that share ontologies with LAMA5: view

Compounds for LAMA5 Gene

(4) Novoseek inferred chemical compound relationships for LAMA5 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 26.1 1
carbohydrates 8.92 1
heparin 7.44 3
vegf 0 2
genes like me logo Genes that share compounds with LAMA5: view

Transcripts for LAMA5 Gene

Unigene Clusters for LAMA5 Gene

Laminin, alpha 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
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SP5:
SP6:
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SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59a · 59b ^ 60a · 60b ^ 61a · 61b · 61c ^ 62a · 62b ^ 63a · 63b ^ 64a · 64b ^ 65 ^
SP1: - - -
SP2: -
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SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 66a · 66b ^ 67a · 67b ^ 68 ^ 69 ^ 70 ^ 71 ^ 72a · 72b · 72c ^ 73 ^ 74a · 74b ^ 75 ^ 76 ^ 77 ^ 78a · 78b ^ 79 ^ 80a · 80b · 80c ^ 81 ^ 82a · 82b ^
SP1: - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9: -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for LAMA5 Gene

GeneLoc Exon Structure for
LAMA5
ECgene alternative splicing isoforms for
LAMA5

Expression for LAMA5 Gene

mRNA expression in normal human tissues for LAMA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMA5 Gene

SOURCE GeneReport for Unigene cluster for LAMA5 Gene Hs.473256

mRNA Expression by UniProt/SwissProt for LAMA5 Gene

O15230-LAMA5_HUMAN
Tissue specificity: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver
genes like me logo Genes that share expressions with LAMA5: view

Orthologs for LAMA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMA5 36
  • 92.17 (n)
  • 90.15 (a)
cow
(Bos Taurus)
Mammalia LAMA5 36
  • 83.67 (n)
  • 82.54 (a)
LAMA5 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMA5 36
  • 82.49 (n)
  • 80.28 (a)
LAMA5 37
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lama5 36
  • 79.95 (n)
  • 79.68 (a)
Lama5 16
Lama5 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMA5 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMA5 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lama5 36
  • 80.07 (n)
  • 79.71 (a)
chicken
(Gallus gallus)
Aves LAMA5 36
  • 66.01 (n)
  • 61.6 (a)
LAMA5 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lama5 36
  • 66.79 (n)
  • 64.57 (a)
zebrafish
(Danio rerio)
Actinopterygii lama5 36
  • 57.7 (n)
  • 50.78 (a)
lama5 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004993 36
  • 46.78 (n)
  • 34.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta LanA 36
  • 47.07 (n)
  • 35.34 (a)
LanA 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea epi-1 36
  • 42.51 (n)
  • 35.01 (a)
epi-1 38
  • 32 (a)
Species with no ortholog for LAMA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMA5 Gene

ENSEMBL:
Gene Tree for LAMA5 (if available)
TreeFam:
Gene Tree for LAMA5 (if available)

Paralogs for LAMA5 Gene

Paralogs for LAMA5 Gene

genes like me logo Genes that share paralogs with LAMA5: view

Variants for LAMA5 Gene

Sequence variations from dbSNP and Humsavar for LAMA5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs477859 -- 62,362,541(+) ATGTC(A/G)CAGTA synonymous-codon, reference
rs493809 -- 62,366,004(-) AGGGG(C/T)GAGTA intron-variant
rs508216 -- 62,361,595(-) GGCTC(C/T)GCCGC intron-variant
rs510634 -- 62,369,258(+) CAGGG(G/T)CTGGG upstream-variant-2KB
rs512452 -- 62,369,028(-) TAAAG(G/T)GCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LAMA5 Gene

Variant ID Type Subtype PubMed ID
dgv4599n71 CNV Loss 21882294
dgv4601n71 CNV Loss 21882294
nsv518296 CNV Loss 19592680
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
nsv834024 CNV Gain 17160897
nsv913048 CNV Loss 21882294
dgv4602n71 CNV Loss 21882294
nsv913052 CNV Gain 21882294
nsv913053 CNV Gain+Loss 21882294
dgv4603n71 CNV Loss 21882294
nsv913056 CNV Loss 21882294
nsv3441 CNV Insertion 18451855
dgv4604n71 CNV Loss 21882294
nsv913059 CNV Loss 21882294
nsv817907 CNV Loss 17921354
nsv817908 CNV Loss 17921354
nsv470557 CNV Gain 18288195
nsv520024 CNV Loss 19592680
esv2722792 CNV Deletion 23290073
dgv713e201 CNV Deletion 23290073
dgv714e201 CNV Deletion 23290073
nsv459059 CNV Loss 19166990
dgv518n27 CNV Loss 19166990
dgv4605n71 CNV Loss 21882294
esv2558907 CNV Loss 19546169
nsv913066 CNV Loss 21882294
nsv913067 CNV Loss 21882294
nsv459065 CNV Gain 19166990
esv1010421 CNV Insertion 20482838
nsv828771 CNV Gain 20364138
esv2722798 CNV Deletion 23290073
esv2669761 CNV Deletion 23128226
nsv828772 CNV Gain 20364138
nsv828773 CNV Loss 20364138
nsv179849 CNV Loss 16902084
nsv913071 CNV Gain 21882294
dgv4606n71 CNV Loss 21882294
esv1008423 CNV Insertion 20482838

Relevant External Links for LAMA5 Gene

HapMap Linkage Disequilibrium report
LAMA5
Human Gene Mutation Database (HGMD)
LAMA5

Disorders for LAMA5 Gene

(4) Novoseek inferred disease relationships for LAMA5 Gene

Disease -log(P) Hits PubMed IDs
muscular dystrophies 57.6 1
metastasis 0 1
tumors 0 2
carcinoma 0 3

Relevant External Links for LAMA5

Genetic Association Database (GAD)
LAMA5
Human Genome Epidemiology (HuGE) Navigator
LAMA5
genes like me logo Genes that share disorders with LAMA5: view

No data available for UniProtKB/Swiss-Prot for LAMA5 Gene

Publications for LAMA5 Gene

  1. Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. (PMID: 9271224) Durkin M.E. … Wewer U.M. (FEBS Lett. 1997) 2 3 4 23
  2. Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies. (PMID: 9353324) Tiger C.F. … Gullberg D. (J. Biol. Chem. 1997) 3 23
  3. Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta. (PMID: 10964500) Champliaud M.F. … Gullberg D. (Exp. Cell Res. 2000) 3 23
  4. Expression patterns of laminin alpha1 and alpha5 in human lung during development. (PMID: 11104726) Pierce R.A. … Senior R.M. (Am. J. Respir. Cell Mol. Biol. 2000) 3 23
  5. Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. (PMID: 11133776) Parsons S.F. … Chasis J.A. (Blood 2001) 3 23

Products for LAMA5 Gene

Sources for LAMA5 Gene

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