Aliases for LAMA5 Gene
External Ids for LAMA5 Gene
Previous GeneCards Identifiers for LAMA5 Gene
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
GeneCards Summary for LAMA5 Gene
LAMA5 (Laminin, Alpha 5) is a Protein Coding gene. Diseases associated with LAMA5 include galloway-mowat syndrome and pontocerebellar hypoplasia. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include structural molecule activity and integrin binding. An important paralog of this gene is LAMC2.
UniProtKB/Swiss-Prot for LAMA5 Gene
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components