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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAMA4 Gene

protein-coding GIFtS: 63
GCID: GC06M112475

laminin, alpha 4

Explore 19 diseases affiliated with
LAMA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Laminin, Alpha 4¹ ²		Laminin Subunit Alpha-4²
LAMA3¹ ² ⁵		Laminin-14 Subunit Alpha³
LAMA4*-1²		Laminin-8 Subunit Alpha³
Laminin Alpha 4 Chain²		Laminin-9 Subunit Alpha³

External Ids:	HGNC: 6484¹	Entrez Gene: 3910²	Ensembl: ENSG00000112769⁷	OMIM: 600133⁵	UniProtKB: Q16363³

Export aliases for LAMA4 gene to outside databases

Previous GC identifers: GC06M112265 GC06M112452 GC06M112536 GC06M110003

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAMA4:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement

membranes. They have been implicated in a wide variety of biological processes including cell adhesion,

differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical

chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure

consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin

chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described.

Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which

are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1.

The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have

been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This

gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3,

both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the

N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which

distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed

developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific

utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple

transcript variants encoding distinct isoforms. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Gene Wiki entry for LAMA4 (Laminin, alpha 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAMA4 gene promoter:
MEF-2A AML1a aMEF-2 Tal-1beta E47 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAMA4 promoter sequence

Search SABiosciences Chromatin IP Primers for LAMA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

LAMA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA4 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M112475: view genomic region (about GC identifiers)

Start:	112,429,134 bp from pter	End:	112,576,141 bp from pter
Size:	147,008 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363 (See protein sequence)

Recommended Name: Laminin subunit alpha-4 precursor

Size: 1823 amino acids; 202524 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms

with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14

(laminin-423)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component

Caution: Gene LAMA4 was formerly called LAMA3

Sequence caution: Sequence=BAE06109.1; Type=Erroneous initiation;

Secondary accessions: Q14731 Q14735 Q15335 Q4LE44 Q5SZG8 Q9BTB8 Q9UE18 Q9UJN9

Alternative splicing: 3 isoforms: Q16363-1 Q16363-2 Q16363-3

Explore the universe of human proteins at neXtProt for LAMA4: NX_Q16363

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16363

LAMA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001098676.2 NP_001098677.2 NP_001098678.1 NP_001098679.1 NP_002281.3

ENSEMBL proteins:

ENSP00000230538 ENSP00000429488 ENSP00000374114 ENSP00000416470 ENSP00000427837

ENSP00000427865 ENSP00000357629 ENSP00000430336 ENSP00000428583 ENSP00000412136

ENSP00000243219 ENSP00000430415 ENSP00000357627 ENSP00000398226 ENSP00000408604

Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for LAMA4 (Laminin alpha 4)
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	Novus Biologicals LAMA4 Protein Novus Biologicals LAMA4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005604	basement membrane	IDA	14557481
GO:0005605	basal lamina	TAS	7959779
GO:0005606	laminin-1 complex	IEA	--
GO:0031012	colocalizes with extracellular matrix	ISS	--
GO:0070062	extracellular vesicular exosome	IDA	--

LAMA4 for ontologies About GeneDecksing

LAMA4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA4
	R&D Systems Antibodies for LAMA4 (Laminin alpha 4)
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	GenScript Custom Superior Antibodies Services for LAMA4
	Novus Biologicals LAMA4 Antibodies
	Search for Antibodies for LAMA4 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for LAMA4

Assay Products for LAMA4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAMA4
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAMA4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

IPR009254 Laminin_I

IPR002049 EGF_laminin

IPR010307 Laminin_II

Graphical View of Domain Structure for InterPro Entry Q16363

ProtoNet protein and cluster: Q16363

2 Blocks protein families:

IPB001791 Laminin G

IPB009254 Laminin I

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil

structure

Domain: Domain G is globular

Similarity: Contains 4 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Genatlas biochemistry entry for LAMA4:

laminin,alpha 4 polypeptide,component of cutaneous basement membrane zone,forming heteromeric molecule with a beta and

a gamma chain

miRNA Products:		OriGene 3'-UTR Clone (see all 3): LAMA4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMA4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMA4 (see all 16):
		hsa-miR-1226 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-188-5p hsa-miR-539 hsa-miR-148b hsa-miR-197 hsa-miR-3133

		SwitchGear 3'UTR luciferase reporter plasmid: LAMA4 3' UTR sequence

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LAMA4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 5): LAMA4 (NM_001105207)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LAMA4
		Search LifeMap BioReagents cell lines for LAMA4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005201	extracellular matrix structural constituent	TAS	7959779

LAMA4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for LAMA4:

Decreased viability with pacli

Animal Models:
Mouse knock-out Lama4^tm1Ktry for LAMA4
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lama4):

behavior/neurological	cardiovascular system	growth/size	hematopoietic system	homeostasis/metabolism
integument	liver/biliary system	mortality/aging	muscle	nervous system
other

LAMA4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Cell adhesion_ECM remodeling

Cell adhesion ECM remodeling

1.00

Cell adhesion_ECM remodeling

1.00

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for LAMA4

	Cell adhesion ECM remodeling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMA4 (see all 14)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	CDK5 Pathway
	Transendothelial Migration of Leukocytes

2 GeneGo (Thomson Reuters) Pathways for LAMA4

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cell adhesion ECM remodeling

2 BioSystems Pathways for LAMA4

	Focal Adhesion
	FOXM1 transcription factor network

5/7 Kegg Pathways (Kegg details for LAMA4) (see all 7):

	Focal adhesion
	ECM-receptor interaction
	African trypanosomiasis
	Toxoplasmosis
	Amoebiasis

LAMA4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LAMA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for LAMA4 (Q16363^{2, 3} ENSP00000230538⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²^,³	MINT-61925 I2D: score=3
APC	P25054³, ENSP00000257430⁴	I2D: score=3 STRING: ENSP00000257430
LAMB1	P07942³, ENSP00000222399⁴	I2D: score=1 STRING: ENSP00000222399
LAMB2	P55268³, ENSP00000307156⁴	I2D: score=1 STRING: ENSP00000307156
LAMC3	Q9Y6N6³, ENSP00000354360⁴	I2D: score=1 STRING: ENSP00000354360

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0030155	regulation of cell adhesion	IEA	--
GO:0030334	regulation of cell migration	IEA	--
GO:0045995	regulation of embryonic development	IEA	--

LAMA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAMA4
Search CenterWatch for drugs/clinical trials and news about LAMA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAMA4 gene (5 alternative transcripts):

NM_001105206.2 NM_001105207.2 NM_001105208.2 NM_001105209.2 NM_002290.4

Unigene Clusters for LAMA4:

Laminin, alpha 4

Hs.654572 [show with all ESTs], Hs.744277 [show with all ESTs]

Unigene Representative Sequences: NM_001105206, W45534

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000230538(uc003pvv.2 uc003pvt.2 uc003pvu.2) ENST00000522006

ENST00000389463 ENST00000424408 ENST00000521693 ENST00000519245 ENST00000523765

ENST00000521187 ENST00000521732 ENST00000368640 ENST00000521398 ENST00000518842

ENST00000524032 ENST00000423735 ENST00000519932 ENST00000431543(uc003pvw.2)

ENST00000243219 ENST00000521690

miRNA Products:		OriGene 3'-UTR Clone (see all 3): LAMA4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMA4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMA4 (see all 16):
		hsa-miR-1226 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-188-5p hsa-miR-539 hsa-miR-148b hsa-miR-197 hsa-miR-3133

		SwitchGear 3'UTR luciferase reporter plasmid: LAMA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMA4 (see all 7) OriGene shRNA RFP: LAMA4 OriGene siRNA: LAMA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMA4

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		GenScript: all cDNA clones in your preferred vector (see all 5): LAMA4 (NM_001105207)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA4

Additional cDNA sequence: BT006690.1

24/25 DOTS entries (see all 25):

DT.100645740 DT.218682 DT.99975525 DT.100028306 DT.454764 DT.100794943 DT.95157565 DT.121339656

DT.100794945 DT.100032022 DT.97854111 DT.121339629 DT.109850 DT.87078943 DT.97810991 DT.121339625

DT.121339648 DT.100794942 DT.121339496 DT.75165221 DT.86837185 DT.92433798 DT.109849 DT.121339631

24/352 AceView cDNA sequences (see all 352):

AI990707 BM728803 CD614449 BE856387 CN484463 CA447086 AI050077 AI336272

AI140443 AI079488 BP372659 BM984575 BP377316 AI804271 AW665975 BU678262

AW873548 CA438708 BF592845 BX118389 AA628289 AL044151 BQ001390 AI207032

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA4 (see all 19) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·
SP1:
SP2:
SP3:																							-										-
SP4:
SP5:

ExUns:	11b	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	·	22c	·	22d	^	23a	·	23b	^	24	^	25a	·	25b	^	26	^	27	^
SP1:									-										-						-										-		-
SP2:
SP3:
SP4:
SP5:	-								-

ExUns:	28	^	29a	·	29b	^	30a	·	30b	^	31	^	32	^	33	^	34	^	35a	·	35b	^	36a	·	36b	·	36c	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44
SP1:									-										-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LAMA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAMA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGAGCACA

About this image

LAMA4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Kidney

Renal Vesicle

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

See LAMA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMA4

SOURCE GeneReport for Unigene clusters: Hs.654572 Hs.744277

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Tissue specificity: In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak

or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and

kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth

muscle and dermis

SABiosciences Custom PCR Arrays for LAMA4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMA4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LAMA4 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LAMA4¹	laminin, alpha 4	70.25(n) 66.12(a)		421749 XM_419780.3 XP_419780.3
lizard (Anolis carolinensis)	Reptilia	LAMA1⁶	--	59(a)	1 ↔ 1	1(188780041-188827314)
African clawed frog (Xenopus laevis)	Amphibia	BI347917.1²	--	89.15(n)		BI347917.1
zebrafish (Danio rerio)	Actinopterygii	lama4¹	laminin, alpha 4	55.06(n) 45.58(a)		566796 NM_001039065.2 NP_001034154.1

ENSEMBL Gene Tree for LAMA4 (if available)
TreeFam Gene Tree for LAMA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for LAMA4 gene

NTN4² LAMA1² NTN5² LAMA3² LAMA2² LAMB2² LAMC1² LAMC2²

LAMA5² NTN3² LAMB3² LAMC3² NTN1² NTNG1² USH2A² LAMB4²

LAMB1² NTNG2²

6 SIMAP similar genes for LAMA4 using alignment to 12 protein entries: LAMA4_HUMAN (see all proteins):

LAMA4*-1 LAMA3 HSPG2 LAMA5 LAMB1 LAMB4

LAMA4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74462824^1,2	F,	--	110003903(+)	`AGGCAG/ATCTTG`	3	--	ds500¹		1		WA	118
rs13219197^1,2	H	--	110004495(+)	`tgtttT/Gtgaga`	3	--	ut3¹		4		NS EA	420
rs75232337^1,2	F,	--	110004572(+)	`TTGAAC/TTCCTG`	3	--	ut3¹		1		NA	120
rs72948387^1,2	C,	--	110004701(+)	`TTTTAA/GTAAAA`	3	--	ut3¹		0	--	--	--	--
rs78797614^1,2	F,	--	110005947(+)	`TTCATG/TATCTA`	3	--	int¹		1		WA	118
rs75989462^1,2	F,	--	110006414(+)	`AAGCTT/GATTAT`	3	--	int¹		1		WA	118
rs73541478^1,2	C,F,	--	110006529(+)	`CAGCTG/TTAATA`	3	--	int¹		3		WA CSA	122
rs73541481^1,2	C,F,	--	110006602(+)	`AATAGC/TATTTT`	3	--	int¹		3		WA CSA	122
rs73541482^1,2	C,F,	--	110006641(+)	`TAGATT/CTGGAA`	3	--	int¹		3		WA CSA	122
rs117330027^1,2	C,F,	--	110006747(+)	`GTGAAC/TAGGAA`	3	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for LAMA4 (112429134 - 112576141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LAMA4
1 CNV: 69590
1 Indel: 69589
Human Gene Mutation Database (HGMD): LAMA4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAMA4

DNA2.0 Custom Variant and Variant Library Synthesis for LAMA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LAMA4 for disorders           About GeneDecksing

OMIM gene information: 600133    OMIM disorders: --

19 diseases for LAMA4:    About MalaCards

cleft lip/palate cleft lip myocardial infarction renal cell carcinoma

trypanosomiasis toxoplasmosis nephropathy kidney disease

lung adenocarcinoma hepatocellular carcinoma cardiomyopathy lung cancer

adenocarcinoma prostate cancer atherosclerosis carcinoma

hypoxia prostatitis melanoma

Human Genome Epidemiology (HuGE) Navigator: LAMA4 (4 documents)

Export disorders for LAMA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LAMA4 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with LAMA4)

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world of online information

Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain. (PubMed id 7959779)^{1, 2, 3} Richards A.J....Pope F.M. (1994)
The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains. (PubMed id 8706685)^{1, 2, 9} Richards A.J.... Pope F.M. (1996)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The structural organisation of LAMA4, the gene encoding laminin alpha4. (PubMed id 9310354)^{1, 2} Richards A.J.... Pope F.M. (1997)
Primary structure and expression of a novel human laminin alpha 4 chain. (PubMed id 7781776)^{1, 2} Iivanainen A.... Tryggvason K. (1995)
Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoi c membrane model. (PubMed id 19469865)^{1, 9} Lugassy C....Barnhill R.L. (2009)
Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo. (PubMed id 12454288)^{1, 9} Gonzalez A.M....Jones J.C. (2002)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)¹ Wang Y....Huang W. (2010)
Peptides derived from the human laminin alpha4 and al pha5 chains exhibit antimicrobial activity. (PubMed id 20433883)¹ SenyA1rek I....Schittek B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3910	HGNC: 6484	AceView: LAMA4	Ensembl:ENSG00000112769	euGenes: HUgn3910
ECgene: LAMA4	Kegg: 3910	H-InvDB: LAMA4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LAMA4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LAMA4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LAMA4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LAMA4 gene:
Search GeneIP for patents involving LAMA4

Licensable Technologies for LAMA4 gene:

Tufts University:

Laminins and their functions in nervous systems

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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laminin, alpha 4

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