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LAMA4 Gene

protein-coding GIFtS: 69

GC06M112536

laminin, alpha 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686D23145 ^²
LAMA3 ^¹, ², ⁵
LAMA4*-1 ^²
OTTHUMP00000017039 ^²
OTTHUMP00000017043 ^²

Descriptions
laminin alpha 4 chain ^²
laminin, alpha 4 ^²

External Ids
HGNC: 6484¹
Entrez Gene: 3910²
UniProtKB: Q16363³
Ensembl: ENSG00000112769⁷

Search outside databases for aliases for LAMA4 gene

Previous GC identifers: GC06M112265 GC06M112452 GC06M112475

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMA4:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent

of basement membranes. They have been implicated in a wide variety of biological processes

including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.

Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1,

and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed

by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain

protein encoded by a distinct gene. Several isoforms of each chain have been described. Different

alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin

isoforms which are designated by Arabic numerals in the order of their discovery, i.e.

alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and

trimer molecules are largely unknown, but some of the chains have been shown to differ with

respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene

encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to

that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that

approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin,

alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and

gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of

expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific

utilization of alternative polyA-signal has been described in literature. Alternative splicing

results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMA4 (Laminin%2C_alpha_4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMA4 gene

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

LAMA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M112536: (about GC identifiers)

Start:	112,535,827 bp from pter
End:	112,682,542 bp from pter
Size:	146,716 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363 (See protein sequence)

Recommended Name: Laminin subunit alpha-4 precursor

Size: 1823 amino acids; 202528 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains

(alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped

molecule comprising one long and three short arms with globules at each end

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Note=Major component

Caution: Gene LAMA4 was formerly called LAMA3

Secondary accessions: Q14731 Q14735 Q15335 Q4LE44 Q5SZG8 Q9UE18 Q9UJN9

Alternative splicing: 2 isoforms: Q16363-1 Q16363-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001098676.1 NP_001098677.1 NP_001098678.1 NP_001098679.1 NP_002281.2

ENSEMBL proteins:

ENSP00000230538 ENSP00000374114 ENSP00000357629 ENSP00000357628 ENSP00000243219 ENSP00000357627

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LAMA4)
	Human Recombinant Proteins from Abnova (LAMA4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005605	basal lamina	TAS	7959779
GO:0005606	laminin-1 complex	IEA	--

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Antibodies for LAMA4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LAMA4
	R&D Systems Antibodies for LAMA4 (Laminin alpha 4)
	Antibodies from Abcam (LAMA4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAMA4)
	Novus Biologicals Antibodies for LAMA4

Assays for LAMA4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16363

ProtoNet protein and cluster: Q16363

2 Blocks protein families:

IPB001791 Laminin G

IPB009254 Laminin I

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to

form a coiled coil structure

Domain: Domain G is globular

Similarity: Contains 4 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMA4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_002290

Applied Biosystems Silencer® siRNAs for LAMA4

Sigma-Aldrich siRNA for LAMA4

Sigma-Aldrich shRNA Panels and shRNA for LAMA4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LAMA4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001105206
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001105206
untagged cDNA clones in CMV expression vector (see all 7): AK027151

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001105206

UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMA4:

laminin,alpha 4 polypeptide,component of cutaneous basement membrane zone,forming heteromeric

molecule with a beta and a gamma chain

13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lama4):

	behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle
nervous system	other	skin/coat/nails

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005201	extracellular matrix structural constituent	TAS	7959779

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/119 Interacting proteins for LAMA4 (ENSP00000230538³ Q16363²) via UniProtKB, MINT, and/or STRING (see all 119 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²	MINT-61925
FOXM1	ENSP00000342307³	STRING (score=.991)
DMD	ENSP00000354923³	STRING (score=.96)
RPSAP61	ENSP00000346067³	STRING (score=.954)
EGF	ENSP00000265171³	STRING (score=.953)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030155	regulation of cell adhesion	IEA	--
GO:0030334	regulation of cell migration	IEA	--
GO:0045995	regulation of embryonic development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMA4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMA4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_002290

Sigma-Aldrich siRNA for LAMA4

Sigma-Aldrich shRNA Panels and shRNA for LAMA4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001105206 NM_001105207 NM_001105208 NM_001105209 NM_002290

REFSEQ mRNAs for LAMA4 gene (5 alternative transcripts):

NM_001105206.1 NM_001105207.1 NM_001105208.1 NM_001105209.1 NM_002290.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001105206 NM_001105207 NM_001105208 NM_001105209 NM_002290

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001105206
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001105206
                                 untagged cDNA clones in CMV expression vector (see all 7): AK027151

Additional cDNA sequence:

AB210027.1 AK027151.1 AK304401.1 BC004241.1 BC026237.1 BC066552.1 BT006690.1 BX648467.1

CR407622.1 S78569.1 U77706.1 X70904.1 X76939.1 X91171.1

24/26 DOTS entries (see all 26 ):

DT.100645740 DT.218682 DT.99975525 DT.100028306 DT.454764 DT.100794943 DT.95157565 DT.121339656

DT.100794945 DT.100032022 DT.97854111 DT.121339629 DT.109850 DT.87078943 DT.97810991 DT.121339625

DT.121339648 DT.218686 DT.100794942 DT.121339496 DT.121339631 DT.75165221 DT.86837185 DT.92433798

24/352 AceView cDNA sequences (see all 352 ):

BF588563 AL712094 BF725882 BE503372 AI350769 BQ021115 AA628289 BX955199

AA304467 CA417364 CA427865 BU183738 CA418402 AW188262 BM929775 AA029443

AI633541 AI990707 CN484463 AI140443 AI336272 CA447086 AI079488 AA029508

highest scoring ESTs for LAMA4:

S78569 AA025650 AA062778 AA122294 AA302471 AA428919 AA490581 AA670089 AI742645 AJ711840

Unigene Cluster for LAMA4:

Laminin, alpha 4

Hs.654572 [show with all ESTs]

Unigene Representative Sequence: NM_001105206

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA4 (see all 19 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·
SP1:
SP2:
SP3:																							-										-
SP4:
SP5:

ExUns:	11b	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	·	22c	·	22d	^	23a	·	23b	^	24	^	25a	·	25b	^	26	^	27	^
SP1:									-										-						-										-		-
SP2:
SP3:
SP4:
SP5:	-								-

ExUns:	28	^	29a	·	29b	^	30a	·	30b	^	31	^	32	^	33	^	34	^	35a	·	35b	^	36a	·	36b	·	36c	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44
SP1:									-										-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LAMA4

6 Ensembl transcripts including schematic representations:

ENST00000230538 ENST00000389463 ENST00000368640 ENST00000368639 ENST00000243219 ENST00000368638

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LAMA4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMA4

¹ / ² / ³

12 probe-sets matching LAMA4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37671_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.96	S78569	1.00	0.90	0.95	1
71256_at²^{, 3}	U95-E	1	0.69	1.00	0.98	1.05	AI671092	0.60	1.00	0.82	1
210990_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U77706	0.60	1.00	0.82	1
210989_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U77706	0.60	1.00	0.82	1
202202_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002290	0.60	1.00	0.82	1
216081_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK027151	0.60	1.00	0.82	1
210089_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004241	0.80	1.00	0.91	1
210990_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210989_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202202_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216081_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210089_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMA4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACAGAGCACA

SOURCE GeneReport for Unigene cluster: Hs.654572
Expression variation in blood from EXPOLDB for LAMA4
UniProtKB/Swiss-Prot: LAMA4_HUMAN, Q16363
Tissue specificity: In adult, strong expression in heart, lung, ovary small and large intestines,
placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate,
brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is
observed in certain mesenchymal cells in tissues such as smooth muscle and dermis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMA4 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LAMA4¹	--	laminin, alpha 4	88.51(n) 91.13(a)	475034 XM_532269.2 XP_532269.2
chimpanzee (Pan troglodytes)	LAMA4¹	--	laminin, alpha 4	99.43(n) 99.23(a)	462946 XM_518696.2 XP_518696.2
cow (Bos taurus)	LAMA4¹	--	laminin, alpha 4	89.54(n) 91.46(a)	529670 XM_608123.3 XP_608123.3
rat (Rattus norvegicus)	Lama4¹	--	laminin, alpha 4	84.44(n) 87.87(a)	309816 XM_228209.4 XP_228209.4
mouse (Mus musculus)	Lama4^{1, 5}	10 (25.00 cM)⁵	laminin, alpha 4^{1, 5}	85.85(n)¹ 88.7(a)¹	16775¹ NM_010681.2¹ NP_034811.1¹ AK032825⁵ AK054014⁵ (see all 20)

About this table Species with no ortholog for LAMA4

ENSEMBL Gene Tree for LAMA4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMA4 gene

LAMA3² LAMA5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/959 NCBI SNPs in LAMA4 are shown (see all 959 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 391)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2032567^1,2	A,C,F,H,O	112564083(+)	`GCCACC/TGCTGA`	3	G/S	mis¹ ese³		14	MN EU EA WA NA	1292
	rs1050349^1,2	A,C,F,H,O	112564076(-)	`TGGCCC/GTGTGC`	3	P/R	mis¹ ese³		5	MN EA WA NA	542
	rs1050348^1,2	A,C,F,H	112600565(-)	`TTAACC/TATGTC`	3	Y/H	mis¹ ese³		16	MN EU EA WA NA	1494
	rs4571602^1,2	A,C,F,H	112683648(+)	`gatccA/Gggcct`	5	--	ng3¹ tfbs³		12	EU EA WA NA	1056
	rs7758910^1,2	A,C,F,H	112536605(+)	`CTCAAT/AGATTC`	3	--	ut3¹		4	EU EA WA	420
--	rs6568718^1,2	A,C,F	112536720(+)	`TTCCTG/TTGTTT`	3	--	ut3¹ ese³		3	NA	142
	rs11757455^1,2	C,F,H	112629545(+)	`GCACCG/AAACAG`	3	W/R	mis¹ ese³		9	EU EA WA NA	914
	rs6568717^1,2	A,C,F	112535405(+)	`TGGACG/AGGCAT`	3	--	ng5¹		3	NA	142
--	rs7758715^1,2	A,C,H	112536480(+)	`aaattT/Attttg`	3	--	ut3¹		4	EU EA WA	408
	rs12110554^1,2	C,F,H	112548198(+)	`CATCAT/CTGTAT`	3	S/N	mis¹		11	EU EA WA NA	974

About this table

HapMap Linkage Disequilibrium images for LAMA4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600133

Human Gene Mutation Database: LAMA4
Human Genome Epidemiology Navigator: LAMA4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/41 PubMed articles for LAMA4 gene (see all 41 ):

Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain. (PubMed id 7959779)^{2, 3, 4} Richards A.J....Pope F.M. (1994)
The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains. (PubMed id 8706685)^{1, 3, 4} Richards A.J.... Pope F.M. (1996)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
The structural organisation of LAMA4, the gene encoding laminin alpha4. (PubMed id 9310354)^{3, 4} Richards A.J.... Pope F.M. (1997)
Primary structure and expression of a novel human laminin alpha 4 chain. (PubMed id 7781776)^{3, 4} Iivanainen A.... Tryggvason K. (1995)
Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo. (PubMed id 12454288)^{1, 3} Gonzalez A.M....Jones J.C. (2002)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells. (PubMed id 18496706)³ Takkunen M....Virtanen I. (2008)
Senescence-induced alterations of laminin chain expression modulate tumorigenicity of prostate cancer cells. (PubMed id 19048114)³ Sprenger C.C....Plymate S.R. (2008)
LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. (PubMed id 18084776)³ Huang X....Yu L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3910	HGNC: 6484	AceView: LAMA4	Ensembl:ENSG00000112769	euGenes: HUgn3910
ECgene: LAMA4	H-InvDB: LAMA4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LAMA4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LAMA4
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for LAMA4 gene:

Tufts University:

Laminins and their functions in nervous systems

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LAMA4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMA4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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	Lentivirus-delivered shRNAs for LAMA4		Browse small molecules at Sigma-Aldrich
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	Recombinant Proteins (LAMA4)
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	Chimera RNAi (LAMA4)
	Custom Service for Mouse Mab
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Antibodies for LAMA4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LAMA4 Gene at Home site.
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LAMA4 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for LAMA4

Summaries
for LAMA4

Genomic Location
for LAMA4

Proteins
for LAMA4

Protein Domains/
Families
for LAMA4

Gene Function
for LAMA4

Pathways & Interactions
for LAMA4

Drugs & Compounds
for LAMA4

Transcripts
for LAMA4

Expression
for LAMA4

Orthologs
for LAMA4

Paralogs
for LAMA4

SNPs/Variants
for LAMA4

Disorders & Mutations
for LAMA4

Medical News
for LAMA4

Publications
for LAMA4

Search for LAMA4

Genome Databases showing LAMA4

Other Databases showing LAMA4

Specialized Databases showing LAMA4

Licensable Technologies
for LAMA4

Services
for LAMA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMA4 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor LAMA4

Summariesfor LAMA4

Genomic Locationfor LAMA4

Proteinsfor LAMA4

Protein Domains/Familiesfor LAMA4

Gene Functionfor LAMA4

Pathways & Interactionsfor LAMA4

Drugs & Compoundsfor LAMA4

Transcriptsfor LAMA4

Expression for LAMA4

Orthologsfor LAMA4

Paralogsfor LAMA4

SNPs/Variantsfor LAMA4

Disorders & Mutationsfor LAMA4

Medical Newsfor LAMA4

Publicationsfor LAMA4

Search for LAMA4

Genome Databases showing LAMA4

Other Databases showing LAMA4

Specialized Databases showing LAMA4

Licensable Technologiesfor LAMA4

Servicesfor LAMA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMA4

Summaries
for LAMA4

Genomic Location
for LAMA4

Proteins
for LAMA4

Protein Domains/
Families
for LAMA4

Gene Function
for LAMA4

Pathways & Interactions
for LAMA4

Drugs & Compounds
for LAMA4

Transcripts
for LAMA4

Expression
for LAMA4

Orthologs
for LAMA4

Paralogs
for LAMA4

SNPs/Variants
for LAMA4

Disorders & Mutations
for LAMA4

Medical News
for LAMA4

Publications
for LAMA4

Licensable Technologies
for LAMA4

Services
for LAMA4