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LAMA2 Gene

protein-coding GIFtS: 69

GC06P129246

laminin, alpha 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LAMM)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LAMM ^², ³, ⁵
OTTHUMP00000017189 ^²

Descriptions
Laminin M chain ^³
Merosin heavy chain ^², ³
laminin M ^²
laminin alpha 2 subunit ^²
laminin, alpha 2 ^²

External Ids
HGNC: 6482¹
Entrez Gene: 3908²
UniProtKB: P24043³
Ensembl: ENSG00000196569⁷

Search outside databases for aliases for LAMA2 gene

Previous GC identifers: GC06P128863 GC06P129051 GC06P129184

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LAMA2:

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to

mediate the attachment, migration, and organization of cells into tissues during embryonic

development by interacting with other extracellular matrix components. It is composed of three

subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a

cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits

of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as

the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding

different proteins have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAMA2_HUMAN, P24043

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Gene Wiki entry for LAMA2 (Laminin%2C_alpha_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAMA2 gene

Entrez Gene cytogenetic band: 6q22-q23 Ensembl cytogenetic band: 6q22.33 HGNC cytogenetic band: 6q22-q23

LAMA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P129246: (about GC identifiers)

Start:	129,245,979 bp from pter
End:	129,879,404 bp from pter
Size:	633,426 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAMA2_HUMAN, P24043 (See protein sequence)

Recommended Name: Laminin subunit alpha-2 precursor

Size: 3122 amino acids; 343905 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains

(alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped

molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit

of laminin-2 (merosin) and laminin-4 (S-merosin)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Note=Major component

Sequence caution: Sequence=AAA63215.1; Type=Frameshift; Positions=3098; Sequence=AAB18388.1;

Type=Erroneous gene model prediction; Sequence=CAA81394.1; Type=Frameshift; Positions=3098;

Secondary accessions: Q14736 Q5VUM2 Q93022

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000417.2 NP_001073291.1

ENSEMBL proteins:

ENSP00000357133 ENSP00000350717 ENSP00000346769

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant LAMA2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Laminin, Laminin 2 alpha, Laminin 1+2)
	Human Recombinant Proteins from Abnova (LAMA2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005605	basal lamina	IEA	--
GO:0005606	laminin-1 complex	IEA	--
GO:0042383	sarcolemma	IEA	--

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Antibodies for LAMA2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LAMA2
	Sigma-Aldrich Antibody Arrays and Antibodies for LAMA2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Laminin, Laminin 2 alpha, Laminin 1+2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LAMA2)
	Novus Biologicals Antibody for LAMA2

Assays for LAMA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24043

ProtoNet protein and cluster: P24043

5 Blocks protein families:

IPB000034 Laminin B

IPB001791 Laminin G

IPB002049 Laminin-type EGF-like domain

IPB009254 Laminin I

IPB012679 Laminin G

UniProtKB/Swiss-Prot: LAMA2_HUMAN, P24043

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to

form a coiled coil structure

Domain: Domains VI, IV and G are globular

Similarity: Contains 17 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

Similarity: Contains 2 laminin IV type A domains

Similarity: Contains 1 laminin N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079823

Applied Biosystems Silencer® siRNAs for LAMA2

Sigma-Aldrich siRNA and siRNA Panels for LAMA2

Sigma-Aldrich shRNA Panels and shRNA for LAMA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000426
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000426
untagged cDNA clones in CMV expression vector (see all 2): NM_000426

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000426

UniProtKB/Swiss-Prot: LAMA2_HUMAN, P24043

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the

attachment, migration and organization of cells into tissues during embryonic development by

interacting with other extracellular matrix components

Genatlas biochemistry entry for LAMA2:

laminin,alpha 2 polypeptide,component of cutaneous basement membrane zone binding to alpha

dystroglycan,and coreceptor of mycobacterium leprae with alpha dystroglycan,heterotrimerizing

(laminin 12) with laminin beta 1 and gamma 3

15 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Lama2):

behavior/neurological	craniofacial	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	life span-post-weaning/aging
muscle	nervous system	other	reproductive system	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005198	structural molecule activity	TAS	2185464

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for LAMA2 (Your Favorite Gene powered by Ingenuity)

Agrin Interactions at Neuromuscular Junction

GeneDecks LAMA2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for LAMA2

5/129 Interacting proteins for LAMA2 (ENSP00000350717³ P24043²) via UniProtKB, MINT, and/or STRING (see all 129 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAG1	ENSP00000312435³	STRING (score=.998)
RPSAP61	ENSP00000346067³	STRING (score=.982)
ITGA7	ENSP00000257880³	STRING (score=.972)
UTRN	ENSP00000356515³	STRING (score=.957)
FKTN	ENSP00000223528³	STRING (score=.955)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007517	muscle development	TAS	7550355
GO:0030155	regulation of cell adhesion	IEA	--
GO:0030334	regulation of cell migration	IEA	--
GO:0032224	positive regulation of synaptic transmission, cholinergic	IEA	--
GO:0045995	regulation of embryonic development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAMA2
2 Novoseek chemical compound relationships for LAMA2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	0.00	1	8119705 (1)
calcium	0.00	1	10963991 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAMA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LAMA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079823

Sigma-Aldrich siRNA and siRNA Panels for LAMA2

Sigma-Aldrich shRNA Panels and shRNA for LAMA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000426 NM_001079823

REFSEQ mRNAs for LAMA2 gene (2 alternative transcripts):

NM_000426.3 NM_001079823.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000426 NM_001079823

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000426
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000426
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000426

Additional cDNA sequence:

AB208922.1 AK026829.1 AK125980.1 CR610868.1 M59832.1 Z26653.1

5 DOTS entries:

DT.446525 DT.91942849 DT.100782167 DT.75198315 DT.86842259

24/128 AceView cDNA sequences (see all 128 ):

BM684683 CR610868 BX495567 CA421469 C02228 BX107745 R97795 AA344840

AI954438 BI492593 AA401563 AA412661 AW950665 BQ632400 BX501430 AW207845

AA442826 BX423896 T05624 AI636560 CD608518 CD106260 Z26653 BI761480

highest scoring ESTs for LAMA2:

Z26653 AA028205 AA034939 AA035722 AA135644 AA135707 AA182666 AA344840 AA344841 AA400308

Unigene Cluster for LAMA2:

Laminin, alpha 2

Hs.200841 [show with all ESTs]

Unigene Representative Sequence: NM_000426

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000368151 ENST00000358023 ENST00000354729

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LAMA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAMA2

¹ / ² / ³

9 probe-sets matching LAMA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36917_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Z26653	1.00	1.00	1.00	1
216840_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK026829	0.80	1.00	0.91	1
213519_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI078169	0.80	1.00	0.91	1
205116_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000426	0.60	1.00	0.82	1
216839_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK026829	0.80	1.00	0.91	1
216840_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213519_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205116_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216839_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LAMA2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACATAGAAT

SOURCE GeneReport for Unigene cluster: Hs.200841
Expression variation in blood from EXPOLDB for LAMA2
UniProtKB/Swiss-Prot: LAMA2_HUMAN, P24043
Tissue specificity: Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung,
spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of
the brain; not in liver, thymus and bone

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAMA2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LAMA2¹	--	laminin, alpha 2	99.47(n) 99.17(a)	472122 XM_527501.2 XP_527501.2
rat (Rattus norvegicus)	Lama2¹	--	laminin, alpha 2	85.36(n) 88.39(a)	309368 XM_219866.4 XP_219866.4
mouse (Mus musculus)	Lama2^{1, 5}	10 (20.00 cM)⁵	laminin, alpha 2^{1, 5}	85.6(n)¹ 88.45(a)¹	16773¹ NM_008481.2¹ NP_032507.2¹ AK030879⁵ AK042011⁵ (see all 18)
chicken (Gallus gallus)	LAMA2¹	--	laminin, alpha 2 (merosin, congenital muscular dystrophy)	73.76(n) 73.88(a)	421709 XM_419746.2 XP_419746.2
zebrafish (Danio rerio)	Dr.20585²	--	Transcribed sequence with weak similarity to protein more	73.71(n)	57087370

About this table Species with no ortholog for LAMA2

ENSEMBL Gene Tree for LAMA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAMA2 gene

LAMA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/3518 NCBI SNPs in LAMA2 are shown (see all 3518 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1232)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2306942^1,2	A,C,F,H,O	129677493(-)	`ATTCAC/TCTGAG`	2	V/M	mis¹		18	EA NA EU WA	3028
	rs6939307^1,2	A,C,F,H	129879695(+)	`TCATTG/TTCCTG`	2	--	ng3¹		11	EU EA WA NA	964
	rs7773753^1,2	A,C,F,H	129879892(+)	`TGATAC/GTACAG`	2	--	ng3¹		16	NS NA EU EA WA	1088
	rs6569605^1,2	A,C,F,H	129849322(+)	`TTATGT/CAATAC`	2	A/V	mis¹		15	EA NA EU WA	1302
	rs3816665^1,2	A,C,F,H	129613023(-)	`GAACAC/TGTTCT`	2	R/H	mis¹		12	NA EU EA WA	1044
	rs2244008^1,2	C,F,H	129854746(+)	`TCTTTA/GCAGTT`	2	T/A	mis¹ ese³		17	EA NA EU WA	2954
	rs1049473^1,2	C,F,H	129879242(+)	`AAAACA/CAACAA`	2	--	ut3¹		8	MN NA EU EA WA	726
	rs1049476^1,2	C,F,H	129879303(+)	`AATTCT/CTTCTG`	2	--	ut3¹		13	NA PA MN EU EA WA	1144
	rs35412094^1,2	C,F,H	129245356(+)	`GAGATG/AAAATT`	2	--	ng5¹		8	EU EA WA	834
	rs34626728^1,2	C,F	129422626(-)	`GGGTGT/GCTCTC`	2	S/R	mis¹		5	NA EU EA WA	488

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HapMap Linkage Disequilibrium images for LAMA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 156225 disorders: 607855 607855

UniProtKB/Swiss-Prot: LAMA2_HUMAN, P24043

Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A

(MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness,

hyporeflexia, and white matter hypodensity on MRI

10/30 Novoseek disease relationships for LAMA2 gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mdc1a	97.20	22	18700894 (3), 19388593 (2), 17949279 (2), 17438294 (2) (see all 13)
muscular dystrophies	95.62	148	12609502 (5), 7477753 (4), 9444358 (3), 9541105 (3) (see all 88)
fukuyama congenital muscular dystrophy	92.53	7	9631397 (1), 16566880 (1), 10222457 (1), 10738921 (1) (see all 7)
walker-warburg syndrome	89.07	8	7477753 (3), 8542045 (1), 9492098 (1), 9660506 (1) (see all 6)
muscle-eye-brain disease	87.92	5	8542045 (1), 11592034 (1), 11053679 (1), 8879654 (1) (see all 5)
mdc1c	85.85	1	11741828 (1)
lgmd2i	84.12	2	18645206 (2)
muscular dystrophy limb-girdle	77.83	4	9829280 (1), 19258295 (1), 11584042 (1)
limb girdle	74.50	2	16566880 (1), 11077661 (1)
muscular dystrophy duchenne	68.53	3	17438294 (1), 9390664 (1), 16487936 (1)

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Human Gene Mutation Database: LAMA2
Genetic Association Database: LAMA2
Human Genome Epidemiology Navigator: LAMA2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/197 PubMed articles for LAMA2 gene (see all 197 ):

Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues. (PubMed id 8294519)^{1, 2, 3, 4} Vuolteenaho R....Tryggvason K. (1994)
Merosin, a tissue-specific basement membrane protein, is a laminin- like protein. (PubMed id 2185464)^{2, 3, 4} Ehrig K.... Engvall E. (1990)
Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency. (PubMed id 12552556)^{1, 3, 4} Tezak Z.... Pegoraro E. (2003)
Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study. (PubMed id 11591858)^{1, 3, 4} He Y....Guicheney P. (2001)
Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy. (PubMed id 8910357)^{1, 3, 4} Zhang X.... Tryggvason K. (1996)
Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression. (PubMed id 7535762)^{1, 3, 4} Hori H.... Nagai Y. (1994)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Association of a missense mutation of the laminin alpha2 gene with tuberculoid type of leprosy in Indonesian patients. (PubMed id 12100448)^{3, 6} Wibawa T....Matsuo M. (2002)
LAMA2 gene analysis in congenital muscular dystrophy: new mutations, prenatal diagnosis, and founder effect. (PubMed id 16216942)^{1, 3} Di Blasi C....Mora M. (2005)
The expanding phenotype of laminin alpha2 chain (merosin) abnormalities: case series and review. (PubMed id 11584042)^{1, 3} Jones K.J....North K.N. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3908	HGNC: 6482	AceView: LAMA2	Ensembl:ENSG00000196569	euGenes: HUgn3908
ECgene: LAMA2	H-InvDB: LAMA2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
LEIDEN Muscular Dystrophy page for LAMA2	Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
GeneReviews	http://www.genetests.org/query?gene=LAMA2

Licensable Technologies for LAMA2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LAMA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAMA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAMA2		Antibodies for LAMA2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAMA2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LAMA2)
	Antibodies (LAMA2)
	Chimera RNAi (LAMA2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Laminin, Laminin 2 alpha, Laminin 1+2)
	Antibodies (Laminin, Laminin 2 alpha, Laminin 1+2)

Search OriGene for LAMA2

Search Tocris compounds for LAMA2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LAMA2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LAMA2 Gene at Home site.
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LAMA2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for LAMA2

Summaries
for LAMA2

Genomic Location
for LAMA2

Proteins
for LAMA2

Protein Domains/
Families
for LAMA2

Gene Function
for LAMA2

Pathways & Interactions
for LAMA2

Drugs & Compounds
for LAMA2

Transcripts
for LAMA2

Expression
for LAMA2

Orthologs
for LAMA2

Paralogs
for LAMA2

SNPs/Variants
for LAMA2

Disorders & Mutations
for LAMA2

Medical News
for LAMA2

Publications
for LAMA2

Search for LAMA2

Genome Databases showing LAMA2

Other Databases showing LAMA2

Specialized Databases showing LAMA2

Licensable Technologies
for LAMA2

Services
for LAMA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAMA2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor LAMA2

Summariesfor LAMA2

Genomic Locationfor LAMA2

Proteinsfor LAMA2

Protein Domains/Familiesfor LAMA2

Gene Functionfor LAMA2

Pathways & Interactionsfor LAMA2

Drugs & Compoundsfor LAMA2

Transcriptsfor LAMA2

Expression for LAMA2

Orthologsfor LAMA2

Paralogsfor LAMA2

SNPs/Variantsfor LAMA2

Disorders & Mutationsfor LAMA2

Medical Newsfor LAMA2

Publicationsfor LAMA2

Search for LAMA2

Genome Databases showing LAMA2

Other Databases showing LAMA2

Specialized Databases showing LAMA2

Licensable Technologiesfor LAMA2

Servicesfor LAMA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAMA2

Summaries
for LAMA2

Genomic Location
for LAMA2

Proteins
for LAMA2

Protein Domains/
Families
for LAMA2

Gene Function
for LAMA2

Pathways & Interactions
for LAMA2

Drugs & Compounds
for LAMA2

Transcripts
for LAMA2

Expression
for LAMA2

Orthologs
for LAMA2

Paralogs
for LAMA2

SNPs/Variants
for LAMA2

Disorders & Mutations
for LAMA2

Medical News
for LAMA2

Publications
for LAMA2

Licensable Technologies
for LAMA2

Services
for LAMA2