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Aliases for LAMA2 Gene

Aliases for LAMA2 Gene

  • Laminin, Alpha 2 2 3
  • LAMM 3 4 6
  • Laminin-12 Subunit Alpha 3 4
  • Laminin-2 Subunit Alpha 3 4
  • Laminin-4 Subunit Alpha 3 4
  • Merosin Heavy Chain 3 4
  • Laminin M Chain 3 4
  • Congenital Muscular Dystrophy 2
  • Laminin Subunit Alpha-2 3
  • Merosin 2

External Ids for LAMA2 Gene

Previous HGNC Symbols for LAMA2 Gene

  • LAMM

Previous GeneCards Identifiers for LAMA2 Gene

  • GC06P129051
  • GC06P129184
  • GC06P129246
  • GC06P126785

Summaries for LAMA2 Gene

Entrez Gene Summary for LAMA2 Gene

  • Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMA2 Gene

LAMA2 (Laminin, Alpha 2) is a Protein Coding gene. Diseases associated with LAMA2 include muscular dystrophy, congenital merosin-deficient and lama2-related muscular dystrophy. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include receptor binding and structural molecule activity. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for LAMA2 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Gene Wiki entry for LAMA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMA2 Gene

Genomics for LAMA2 Gene

Regulatory Elements for LAMA2 Gene

Genomic Location for LAMA2 Gene

128,883,141 bp from pter
129,516,569 bp from pter
633,429 bases
Plus strand

Genomic View for LAMA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMA2 Gene

Proteins for LAMA2 Gene

  • Protein details for LAMA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Laminin subunit alpha-2
    Protein Accession:
    Secondary Accessions:
    • Q14736
    • Q5VUM2
    • Q93022

    Protein attributes for LAMA2 Gene

    3122 amino acids
    Molecular mass:
    343905 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (laminin-211 or merosin), laminin-4 (laminin-221 or S-merosin) and laminin-12 (laminin-213). Interacts with FBLN1, FBLN2 and NID2
    • Sequence=AAA63215.1; Type=Frameshift; Positions=3098; Evidence={ECO:0000305}; Sequence=AAB18388.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA81394.1; Type=Frameshift; Positions=3098; Evidence={ECO:0000305};

neXtProt entry for LAMA2 Gene

Proteomics data for LAMA2 Gene at MOPED

Post-translational modifications for LAMA2 Gene

  • Glycosylation at Asn55, Asn89, Asn303, Asn363, Asn380, Asn470, Asn746, Asn1061, Asn1597, Asn1614, Asn1700, Asn1810, Asn1901, Asn1916, Asn1920, Asn2017, Asn2028, Asn2045, Asn2126, Asn2240, Asn2360, Asn2435, Asn2478, Asn2551, Asn2558, Asn2648, Asn2868, and Asn2893
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LAMA2 Gene

Domains for LAMA2 Gene

Gene Families for LAMA2 Gene

Suggested Antigen Peptide Sequences for LAMA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
  • Domains VI, IV and G are globular
  • Contains 17 laminin EGF-like domains.
  • Contains 5 laminin G-like domains.
  • Contains 2 laminin IV type A domains.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with LAMA2: view

Function for LAMA2 Gene

Molecular function for LAMA2 Gene

GENATLAS Biochemistry:
laminin,alpha 2 polypeptide,component of cutaneous basement membrane zone binding to alpha dystroglycan,and coreceptor of mycobacterium leprae with alpha dystroglycan,heterotrimerizing (laminin 12) with laminin beta 1 and gamma 3
UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Gene Ontology (GO) - Molecular Function for LAMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005198 structural molecule activity TAS 2185464
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LAMA2: view
genes like me logo Genes that share phenotypes with LAMA2: view

Animal Models for LAMA2 Gene

MGI Knock Outs for LAMA2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for LAMA2 Gene

Localization for LAMA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMA2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Subcellular locations from

Jensen Localization Image for LAMA2 Gene COMPARTMENTS Subcellular localization image for LAMA2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LAMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IDA 14557481
GO:0005605 basal lamina --
GO:0005606 laminin-1 complex IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with LAMA2: view

Pathways for LAMA2 Gene

genes like me logo Genes that share pathways with LAMA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LAMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance IEA --
GO:0007517 muscle organ development TAS 7550355
GO:0016192 vesicle-mediated transport --
GO:0022011 myelination in peripheral nervous system IEA --
genes like me logo Genes that share ontologies with LAMA2: view

Drugs for LAMA2 Gene

(4) Novoseek inferred chemical compound relationships for LAMA2 Gene

Compound -log(P) Hits PubMed IDs
creatinine 37.6 3
heparin 6.07 1
calcium 0 1
oligonucleotide 0 1
genes like me logo Genes that share compounds with LAMA2: view

Transcripts for LAMA2 Gene

Unigene Clusters for LAMA2 Gene

Laminin, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAMA2 Gene

No ASD Table

Relevant External Links for LAMA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAMA2 Gene

mRNA expression in normal human tissues for LAMA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LAMA2 Gene

This gene is overexpressed in Heart (26.9), Placenta (10.5), and Pancreas (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LAMA2 Gene

SOURCE GeneReport for Unigene cluster for LAMA2 Gene Hs.200841

mRNA Expression by UniProt/SwissProt for LAMA2 Gene

Tissue specificity: Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone
genes like me logo Genes that share expressions with LAMA2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for LAMA2 Gene

Orthologs for LAMA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LAMA2 35
  • 89.9 (n)
  • 91.95 (a)
LAMA2 36
  • 91 (a)
(Canis familiaris)
Mammalia LAMA2 35
  • 87.19 (n)
  • 89.58 (a)
LAMA2 36
  • 89 (a)
(Mus musculus)
Mammalia Lama2 35
  • 85.77 (n)
  • 88.64 (a)
Lama2 16
Lama2 36
  • 88 (a)
(Pan troglodytes)
Mammalia LAMA2 35
  • 99.47 (n)
  • 99.17 (a)
LAMA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lama2 35
  • 85.51 (n)
  • 88.54 (a)
(Monodelphis domestica)
Mammalia LAMA2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia LAMA2 36
  • 94 (a)
(Gallus gallus)
Aves LAMA2 35
  • 73.88 (n)
  • 74.03 (a)
LAMA2 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
-- 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lama2 35
  • 66.19 (n)
  • 64.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12786 35
(Danio rerio)
Actinopterygii Dr.20585 35
lama2 35
  • 61.47 (n)
  • 60.27 (a)
lama2 36
  • 66 (a)
LAMA2 (2 of 2) 36
  • 46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.577 35
fruit fly
(Drosophila melanogaster)
Insecta wb 37
  • 35 (a)
wb 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea lam-3 35
  • 47.09 (n)
  • 36.36 (a)
lam-3 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for LAMA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMA2 Gene

Gene Tree for LAMA2 (if available)
Gene Tree for LAMA2 (if available)

Paralogs for LAMA2 Gene

Paralogs for LAMA2 Gene

(6) SIMAP similar genes for LAMA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LAMA2: view

Variants for LAMA2 Gene

Sequence variations from dbSNP and Humsavar for LAMA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2381 -- 129,107,627(-) CATTT(A/G)TTATT intron-variant
rs2384 -- 129,107,583(-) TCTAC(C/T)TGGCC intron-variant
rs50667 -- 129,239,929(-) cttca(C/T)cttgt intron-variant
rs187851 -- 129,270,370(-) ATTAT(A/G)CAAAT intron-variant
rs190546 -- 129,255,354(-) atctc(A/G)gctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMA2 Gene

Variant ID Type Subtype PubMed ID
nsv830802 CNV Gain 17160897
nsv823840 CNV Loss 20364138
esv2672159 CNV Deletion 23128226
esv2732692 CNV Deletion 23290073
dgv2008e1 CNV Complex 17122850
esv2677740 CNV Deletion 23128226
nsv886655 CNV Loss 21882294
nsv5473 CNV Loss 18451855
nsv508429 CNV Loss 20534489
nsv436523 CNV Deletion 17901297
nsv499655 CNV Loss 21111241
esv2732693 CNV Deletion 23290073
nsv507359 CNV Insertion 20534489
nsv830803 CNV Gain 17160897
esv2129462 CNV Deletion 18987734
esv33261 CNV Loss 17666407
nsv517933 CNV Loss 19592680
esv1990859 CNV Deletion 18987734
nsv348464 CNV Loss 16902084
nsv348924 CNV Loss 16902084
esv259520 OTHER Complex 20981092
nsv348787 CNV Insertion 16902084
nsv350076 CNV Insertion 16902084
nsv350022 CNV Insertion 16902084
nsv528240 CNV Loss 19592680
nsv512894 CNV Insertion 21212237
esv1619204 CNV Insertion 17803354
esv33666 CNV Gain 17666407
esv33659 CNV Gain 17666407
esv32679 CNV Gain 17666407
esv269819 CNV Insertion 20981092
esv274524 CNV Insertion 20981092
esv2481557 CNV Deletion 19546169
esv2732696 CNV Deletion 23290073
esv2393123 CNV Deletion 18987734
esv4704 CNV Deletion 18987735
esv2678689 CNV Deletion 23128226
nsv348741 CNV Loss 16902084
esv2621974 CNV Deletion 19546169
esv1153219 CNV Deletion 17803354
esv7931 CNV Loss 19470904
esv33104 CNV Gain 17666407
esv33882 CNV Loss 17666407
esv2560686 CNV Insertion 19546169
esv272629 CNV Insertion 20981092
esv271598 CNV Insertion 20981092
nsv5474 CNV Insertion 18451855
nsv886656 CNV Loss 21882294
esv273133 CNV Insertion 20981092
esv271241 CNV Insertion 20981092

Relevant External Links for LAMA2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMA2 Gene

Disorders for LAMA2 Gene

(1) OMIM Diseases for LAMA2 Gene (156225)


  • Merosin-deficient congenital muscular dystrophy 1A (MDC1A) [MIM:607855]: Characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI. {ECO:0000269 PubMed:11591858, ECO:0000269 PubMed:12552556}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for LAMA2 Gene

(31) Novoseek inferred disease relationships for LAMA2 Gene

Disease -log(P) Hits PubMed IDs
mdc1a 97.6 23
muscular dystrophies 95.5 127
fukuyama congenital muscular dystrophy 92 7
walker-warburg syndrome 88.5 8
muscle-eye-brain disease 87.2 5

Relevant External Links for LAMA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LAMA2: view

No data available for Genatlas for LAMA2 Gene

Publications for LAMA2 Gene

  1. Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues. (PMID: 8294519) Vuolteenaho R. … Tryggvason K. (J. Cell Biol. 1994) 2 3 4 23
  2. Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency. (PMID: 12552556) Tezak Z. … Pegoraro E. (Hum. Mutat. 2003) 3 4 23
  3. Merosin, a tissue-specific basement membrane protein, is a laminin- like protein. (PMID: 2185464) Ehrig K. … Engvall E. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  4. Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study. (PMID: 11591858) He Y. … Guicheney P. (Neurology 2001) 3 4 23
  5. Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy. (PMID: 8910357) Zhang X. … Tryggvason K. (J. Biol. Chem. 1996) 3 4 23

Products for LAMA2 Gene

Sources for LAMA2 Gene

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