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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAMA1 Gene

protein-coding   GIFtS: 65
GCID: GC18M006941

Laminin, Alpha 1


(Previous symbol: LAMA)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Laminin, Alpha 11 2     S-Laminin Subunit Alpha2 3
LAMA1 2 3     S-LAM-alpha2
Laminin A Chain2 3     Laminin Subunit Alpha-12
Laminin-3 Subunit Alpha2 3     Laminin-1 Subunit Alpha3
S-LAM Alpha2 3     

External Ids:    HGNC: 64811   Entrez Gene: 2842172   Ensembl: ENSG000001016807   OMIM: 1503205   UniProtKB: P253913   
ORGUL members:         
NONCODE14:n339785      

Export aliases for LAMA1 gene to outside databases

Previous GC identifers: GC18M006877 GC18M007006 GC18M006931 GC18M006905


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LAMA1 Gene: 
LAMA1 (laminin, alpha 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with LAMA1 include patau syndrome, and alport syndrome, and among its related super-pathways are ECM-receptor interaction and Focal Adhesion. GO annotations related to this gene include glycosphingolipid binding and receptor binding. An important paralog of this gene is LAMA3.

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components

Gene Wiki entry for LAMA1 (Laminin, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAMA1 gene promoter:
         Max1   AML1a   Sp1   E47   YY1   AREB6   MEF-2A   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAMA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAMA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.23   HGNC cytogenetic band: 18p11.3

LAMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M006941:  view genomic region     (about GC identifiers)

Start:
6,941,743 bp from pter      End:
7,117,813 bp from pter
Size:
176,071 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See protein sequence)
Recommended Name: Laminin subunit alpha-1 precursor  
Size: 3075 amino acids; 337084 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3
(laminin-121 or S-laminin)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component

Explore the universe of human proteins at neXtProt for LAMA1: NX_P25391

Explore proteomics data for LAMA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25391

  • LAMA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LAMA1 Protein Expression
    REFSEQ proteins: NP_005550.2  
    ENSEMBL proteins: 
     ENSP00000374309  
    Reactome Protein details: P25391
    Human Recombinant Protein Products for LAMA1: 
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    OriGene Custom Protein Services for LAMA1
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    Novus Biologicals LAMA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005604basement membrane IDA10964500
    GO:0005606laminin-1 complex IPI10964500
    GO:0005608laminin-3 complex IPI10964500

    LAMA1 for ontologies           About GeneDecksing



    LAMA1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for LAMA1 

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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LAM: Laminins

    5/9 InterPro protein domains (see all 9):
     IPR018031 Laminin_B_subgr
     IPR000034 Laminin_B_type_IV
     IPR008211 Laminin_N
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry P25391

    ProtoNet protein and cluster: P25391

    5 Blocks protein domains:
    IPB000034 Laminin B
    IPB001791 Laminin G
    IPB002049 Laminin-type EGF-like domain
    IPB009254 Laminin I
    IPB012679 Laminin G


    UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI, IV and G are globular
    Similarity: Contains 17 laminin EGF-like domains
    Similarity: Contains 5 laminin G-like domains
    Similarity: Contains 2 laminin IV type A domains
    Similarity: Contains 1 laminin N-terminal domain


    LAMA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMA1_HUMAN, P25391
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMA1:
    laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005201extracellular matrix structural constituent ISS--
    GO:0005515protein binding IPI17166913
    GO:0043208glycosphingolipid binding IEA--
         
    LAMA1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lama1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     mortality/aging  nervous system  normal  reproductive system  vision/eye 

    LAMA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LAMA1: Lama1tm1.1Olf Lama1tm1Ekb Lama1tm1.2Arhi Lama1tm1.1Ekb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LAMA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAMA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAMA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAMA1 

    miRNA
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    hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidLAMA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LAMA1 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM proteoglycans0.38
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    2Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    3Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    Metalloproteases in connective tissue degradation0.31
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for LAMA1 (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMA1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    6 GeneGo (Thomson Reuters) Pathways for LAMA1 (see first 5)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion ECM remodeling
    Cell adhesion Plasmin signaling

    5 BioSystems Pathways for LAMA1
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Glypican 1 network
    Syndecan-2-mediated signaling events
    Syndecan-4-mediated signaling events

    5/8        Reactome Pathways for LAMA1 (see all 8)
        ECM proteoglycans
    L1CAM interactions
    Developmental Biology
    Extracellular matrix organization
    Integrin cell surface interactions


    5/7         Kegg Pathways  (Kegg details for LAMA1) (see all 7):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Toxoplasmosis
    Amoebiasis


    LAMA1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LAMA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for LAMA1 (P253912, 3 ENSP000003743094) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA1P561993, ENSP000002825884I2D: score=2 STRING: ENSP00000282588
    ITGA2P173013, ENSP000002965854I2D: score=2 STRING: ENSP00000296585
    NID1P145433, ENSP000002641874I2D: score=2 STRING: ENSP00000264187
    PLATP007503, ENSP000002208094I2D: score=2 STRING: ENSP00000220809
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway ISS--
    GO:0007411axon guidance TAS--
    GO:0009888tissue development ----

    LAMA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LAMA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAMA1

    1 HMDB Compound for LAMA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--

    4 Novoseek inferred chemical compound relationships for LAMA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 6.63 2 8068026 (1), 1532944 (1)
    lysine 0 2 8360181 (1)
    retinoic acid 0 2 9486851 (1)
    cysteine 0 2 2071595 (1), 2049067 (1)

    Search CenterWatch for drugs/clinical trials and news about LAMA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAMA1 gene: 
    NM_005559.3  

    Unigene Cluster for LAMA1:

    Laminin, alpha 1
    Hs.270364  [show with all ESTs]
    Unigene Representative Sequence: NM_005559
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389658(uc002knm.3) ENST00000492048(uc002knk.3) ENST00000488064(uc002knl.3)
    ENST00000579014(uc010wzj.2) ENST00000488089 ENST00000490190 ENST00000484335
    ENST00000585178

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    Additional mRNA sequence: 

    AK091949.1 AK093376.1 BC016997.1 BC032758.1 BC039051.1 BC062318.1 BC107693.1 X58531.1 

    9 DOTS entries:

    DT.101982347  DT.99962344  DT.99994509  DT.209867  DT.40295787  DT.121103469  DT.91929959  DT.97785718 
    DT.101972320 

    2 AceView cDNA sequences:

    BC041471 BI837819 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
    SP1:                                      -                                                           -                                             
    SP2:                                                                    -                             -                                             
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for LAMA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAMA1 expression in normal human tissues (normalized intensities)      LAMA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAACAAAT
    LAMA1 Expression
    About this image


    LAMA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Inner Cell Mass Cells Inner Cell Mass
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Follicle
     
     Hypoblast (Extraembryonic Tissues)
             Hypoblast Cells Hypoblast

    See LAMA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAMA1

    SOURCE GeneReport for Unigene cluster: Hs.270364
        SABiosciences Expression via Pathway-Focused PCR Arrays including LAMA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LAMA1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lama11 , 5 laminin, alpha 11, 5 78.64(n)1
    76.48(a)1
      17 (38.80 cM)5
    167721  NM_008480.21  NP_032506.21 
     676972655 
    chicken
    (Gallus gallus)
    Aves LAMA11 laminin, alpha 1 68.91(n)
    65.92(a)
      374016  NM_001199806.1  NP_001186735.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMA16
    laminin, alpha 1
    63(a)
    1 ↔ 1
    GL343431.1(45011-174616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377110432   -- 78.98(n)    137711043 
    zebrafish
    (Danio rerio)
    Actinopterygii lama11 laminin, alpha 1 58.12(n)
    53.1(a)
      569971  NM_001034986.1  NP_001030158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LanA6
    Laminin A
    20(a)
    possible ortholog
    3L(6196931-6211122)
    worm
    (Caenorhabditis elegans)
    Secernentea lam-36
    epi-16
    Laminin-like protein epi-1
    29(a)
    20(a)
    1 ↔ many
    possible ortholog
    I(10608466-10621428)
    IV(10666827-10679441)


    ENSEMBL Gene Tree for LAMA1 (if available)
    TreeFam Gene Tree for LAMA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAMA1 gene
    LAMA32  LAMA52  LAMA22  MEGF92  LAMA42  
    7 SIMAP similar genes for LAMA1 using alignment to 5 protein entries:     LAMA1_HUMAN (see all proteins):
    LAMA2    LAMB4    LAMA3    LamA3    LAMC1    LAMC3
    NTN1

    LAMA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4818 SNPs in LAMA1 are shown (see all 4818)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508151201,2
    C,Funtested16950940(+) GAGGCG/AAACGT 2 /F syn12Minor allele frequency- A:0.00NA EU 5851
    rs124546881,2
    C,F,H--6941244(+) ACGGAT/CAGCGG 1 -- ds50015Minor allele frequency- C:0.00NS EA NA 422
    rs1144235131,2
    F--6941322(+) AATCTG/CGGTCT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1467954701,2
    --6941389(+) TTTCAA/CATTAC 1 -- ds50010--------
    rs1175048751,2
    F--6941449(+) AGTGAT/CGAAAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1406093761,2
    --6941506(+) TTCTTC/TTTTTC 1 -- ds50010--------
    rs1146641321,2
    C,F--6941631(+) AAAGGT/GTATGT 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs38100461,2
    C,F,H--6941662(-) TAATTC/ACAGAT 1 -- ds500128Minor allele frequency- A:0.31NS EA NA CSA WA 2780
    rs1855026791,2
    --6941836(+) TGTGTA/GTAAAG 1 -- ut310--------
    rs1457338811,2
    C--6941962(+) CTCCCC/TAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LAMA1 (6941743 - 7117813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for LAMA1 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716745CNV Deletion23290073
    esv2716744CNV Deletion23290073
    esv2716743CNV Deletion23290073
    esv2671013CNV Deletion23128226
    esv1060234CNV Deletion17803354
    esv1093980CNV Deletion17803354
    nsv526300CNV Loss19592680
    esv1010298CNV Loss20482838
    dgv3381n71CNV Gain21882294
    dgv3380n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): LAMA1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150320    OMIM disorders: --

    20/33 diseases for LAMA1 (see all 33):    About MalaCards
    patau syndrome    alport syndrome    neuromuscular disease    familial colorectal cancer
    congenital muscular dystrophy    fainting    duchenne muscular dystrophy    bullous pemphigoid
    hirschsprung's disease    muscular dystrophy    toxoplasmosis    choriocarcinoma
    teratocarcinoma    myopia    nephritis    fibrosarcoma
    endometriosis    infertility    oral squamous cell carcinoma    colorectal cancer


    LAMA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for LAMA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuromuscular diseases 31.5 2 7543975 (2)
    choriocarcinoma 25 1 2049067 (1)
    metastasis 0 1 1847824 (1)
    tumors 0 5 7875421 (1), 8780383 (1), 17695722 (1), 1544440 (1) (see all 5)

    Genetic Association Database (GAD): LAMA1
    Human Genome Epidemiology (HuGE) Navigator: LAMA1 (8 documents)

    Export disorders for LAMA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAMA1 gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with LAMA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)1, 2, 9 Nissinen M....Tryggvason K. (1991)
    2. Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)1, 2, 9 Haaparanta T.... Engvall E. (1991)
    3. A genome-wide association study reveals susceptibilit y variants for non-small cell lung cancer in the Korean population. (PubMed id 20876614)1, 4 Yoon K.A....Lee J.S. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    7. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)1, 3 Nagayoshi T....Uitto J. (1989)
    8. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)1, 2 Olsen D.... Uitto J. (1989)
    9. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)1, 9 Moser T.L....Stack M.S. (1993)
    10. Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)1, 9 Taraboletti G....Roberts D.D. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284217 HGNC: 6481 AceView: LAMA1.1 Ensembl:ENSG00000101680 euGenes: HUgn284217
    ECgene: LAMA1 Kegg: 284217 H-InvDB: LAMA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAMA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LAMA1 gene:
    Search GeneIP for patents involving LAMA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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