Aliases for LAMA1 Gene
External Ids for LAMA1 Gene
Previous HGNC Symbols for LAMA1 Gene
Previous GeneCards Identifiers for LAMA1 Gene
This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
GeneCards Summary for LAMA1 Gene
LAMA1 (Laminin Subunit Alpha 1) is a Protein Coding gene. Diseases associated with LAMA1 include Poretti-Boltshauser Syndrome and Ataxia-Intellectual Disability-Oculomotor Apraxia-Cerebellar Cysts Syndrome. Among its related pathways are ERK Signaling and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. GO annotations related to this gene include receptor binding and glycosphingolipid binding. An important paralog of this gene is LAMC2.
UniProtKB/Swiss-Prot for LAMA1 Gene
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.