Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LAMA1 Gene

protein-coding   GIFtS: 64
GCID: GC18M006941

Laminin, Alpha 1


(Previous symbol: LAMA)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Laminin, Alpha 11 2     S-Laminin Subunit Alpha2 3
LAMA1 2 3     S-LAM-alpha2
Laminin A Chain2 3     Laminin Subunit Alpha-12
Laminin-3 Subunit Alpha2 3     Laminin-1 Subunit Alpha3
S-LAM Alpha2 3     

External Ids:    HGNC: 64811   Entrez Gene: 2842172   Ensembl: ENSG000001016807   OMIM: 1503205   UniProtKB: P253913   

Export aliases for LAMA1 gene to outside databases

Previous GC identifers: GC18M006877 GC18M007006 GC18M006931 GC18M006905


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for LAMA1 Gene:
LAMA1 (laminin, alpha 1) is a protein-coding gene. GO annotations related to this gene include glycosphingolipid binding and receptor binding. An important paralog of this gene is LAMC1.

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components

Gene Wiki entry for LAMA1 (Laminin, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAMA1 gene promoter:
         Max1   AML1a   Sp1   E47   YY1   AREB6   MEF-2A   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAMA1 promoter sequence
   Search Chromatin IP Primers for LAMA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.23   HGNC cytogenetic band: 18p11.3

LAMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M006941:  view genomic region     (about GC identifiers)

Start:
6,941,743 bp from pter      End:
7,117,813 bp from pter
Size:
176,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See protein sequence)
Recommended Name: Laminin subunit alpha-1 precursor  
Size: 3075 amino acids; 337084 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3
(laminin-121 or S-laminin)

Explore the universe of human proteins at neXtProt for LAMA1: NX_P25391

Explore proteomics data for LAMA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn555, Asn665, Asn763, Asn926, Asn952, Asn1045, Asn1407, Asn1579, Asn1596,
                                 Asn1678, Asn1689, Asn1698, Asn1717, Asn1804, Asn1894, Asn1898, Asn1957, Asn1974, Asn1991 (see all 34)
  • Modification sites at PhosphoSitePlus

  • See LAMA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005550.2  
    ENSEMBL proteins: 
     ENSP00000374309  
    Reactome Protein details: P25391

    LAMA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LAMA1
    GenScript Custom Purified and Recombinant Proteins Services for LAMA1
    Novus Biologicals LAMA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LAMA1 

     
    antibodies-online proteins for LAMA1 (11 products) 

     
    antibodies-online peptides for LAMA1

    LAMA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
    R&D Systems Antibodies for LAMA1 (Laminin alpha 1)
    OriGene Antibodies for LAMA1
    OriGene Custom Antibody Services for LAMA1
    Novus Biologicals LAMA1 Antibodies
    Search for Antibodies for LAMA1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for LAMA1
    antibodies-online antibodies for LAMA1 (44 products) 

    LAMA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LAMA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LAMA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for LAMA1 
    antibodies-online kits for LAMA1 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    LAM: Laminins

    Selected InterPro protein domains (see all 9):
     IPR018031 Laminin_B_subgr
     IPR000034 Laminin_B_type_IV
     IPR008211 Laminin_N
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry P25391

    ProtoNet protein and cluster: P25391

    5 Blocks protein domains:
    IPB000034 Laminin B
    IPB001791 Laminin G
    IPB002049 Laminin-type EGF-like domain
    IPB009254 Laminin I
    IPB012679 Laminin G


    UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI, IV and G are globular
    Similarity: Contains 17 laminin EGF-like domains
    Similarity: Contains 5 laminin G-like domains
    Similarity: Contains 2 laminin IV type A domains
    Similarity: Contains 1 laminin N-terminal domain


    Find genes that share domains with LAMA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMA1_HUMAN, P25391
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMA1:
    laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005201extracellular matrix structural constituent ISS--
    GO:0005515protein binding IPI16677310
    GO:0043208glycosphingolipid binding IEA--
         
    Find genes that share ontologies with LAMA1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lama1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     mortality/aging  nervous system  normal  reproductive system  vision/eye 

    Find genes that share phenotypes with LAMA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LAMA1: Lama1tm1.1Olf Lama1tm1Ekb Lama1tm1.2Arhi Lama1tm1.1Ekb

       genOway: Develop your customized and physiologically relevant rodent model for LAMA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LAMA1:
    hsa-mir-124-3p (MIRT022954)

    Block miRNA regulation of human, mouse, rat LAMA1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LAMA1:
    hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidLAMA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAMA1
    Predesigned siRNA for gene silencing in human, mouse, rat LAMA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LAMA1

    Clone
    Products:
         
    OriGene clones in human, mouse for LAMA1 (see all 5)
    OriGene ORF clones in mouse, rat for LAMA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LAMA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LAMA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LAMA1_HUMAN, P25391: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005604basement membrane IDA10964500
    GO:0005606laminin-1 complex IPI10964500
    GO:0005608laminin-3 complex IPI10964500

    Find genes that share ontologies with LAMA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LAMA1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63


    Find genes that share SuperPaths with LAMA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAMA1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    Selected GeneGo (Thomson Reuters) Pathways for LAMA1 (see all 6)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion ECM remodeling

    5 BioSystems Pathways for LAMA1
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Glypican 1 network
    Syndecan-2-mediated signaling events
    Syndecan-4-mediated signaling events

    4 Reactome Pathways for LAMA1
        L1CAM interactions
    ECM proteoglycans
    Laminin interactions
    Non-integrin membrane-ECM interactions


    Selected Kegg Pathways  (Kegg details for LAMA1) (see all 7) (see first 5):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Toxoplasmosis
    Amoebiasis
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAMA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LAMA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAMA1 (P253911, 2, 3 ENSP000003743094) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA1P561993, ENSP000002825884I2D: score=2 STRING: ENSP00000282588
    ITGA2P173013, ENSP000002965854I2D: score=2 STRING: ENSP00000296585
    NID1P145433, ENSP000002641874I2D: score=2 STRING: ENSP00000264187
    PLATP007503, ENSP000002208094I2D: score=2 STRING: ENSP00000220809
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway ISS--
    GO:0007411axon guidance TAS--
    GO:0009888tissue development ----

    Find genes that share ontologies with LAMA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAMA1

    1 HMDB Compound for LAMA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--

    4 Novoseek inferred chemical compound relationships for LAMA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 6.63 2 8068026 (1), 1532944 (1)
    lysine 0 2 8360181 (1)
    retinoic acid 0 2 9486851 (1)
    cysteine 0 2 2071595 (1), 2049067 (1)



    Find genes that share compounds with LAMA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LAMA1 gene: 
    NM_005559.3  

    Unigene Cluster for LAMA1:

    Laminin, alpha 1
    Hs.270364  [show with all ESTs]
    Unigene Representative Sequence: NM_005559
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389658(uc002knm.3) ENST00000492048(uc002knk.3) ENST00000488064(uc002knl.3)
    ENST00000579014(uc010wzj.2) ENST00000488089 ENST00000490190 ENST00000484335
    ENST00000585178
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LAMA1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LAMA1:
    hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidLAMA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LAMA1
    Predesigned siRNA for gene silencing in human, mouse, rat LAMA1
    Clone
    Products:
         
    OriGene clones in human, mouse for LAMA1 (see all 5)
    OriGene ORF clones in mouse, rat for LAMA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMA1
      QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
      QuantiFast Probe-based Assays in human, mouse, rat LAMA1

    Additional mRNA sequence: 

    AK091949.1 AK093376.1 BC016997.1 BC032758.1 BC039051.1 BC062318.1 BC107693.1 X58531.1 

    9 DOTS entries:

    DT.101982347  DT.99962344  DT.99994509  DT.209867  DT.40295787  DT.121103469  DT.91929959  DT.97785718 
    DT.101972320 

    2 AceView cDNA sequences:

    BC041471 BI837819 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
    SP1:                                      -                                                           -                                             
    SP2:                                                                    -                             -                                             
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for LAMA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LAMA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAACAAAT
    LAMA1 Expression
    About this image


    LAMA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Hypoblast Cells Hypoblast
             Extraembryonic endoderm-like cells
     
     Heart (Cardiovascular System)
             Subepicardial Cells Epicardium
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental Papilla Cells Dental Papilla
             Dentin
    LAMA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAMA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270364
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAMA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMA1
    QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
    QuantiFast Probe-based Assays in human, mouse, rat LAMA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LAMA1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lama11 , 5 laminin, alpha 11, 5 78.64(n)1
    76.5(a)1
      17 (38.80 cM)5
    167721  NM_008480.21  NP_032506.21 
     676972655 
    chicken
    (Gallus gallus)
    Aves LAMA11 laminin, alpha 1 68.98(n)
    66.08(a)
      374016  NM_001199806.1  NP_001186735.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMA16
    laminin, alpha 1
    63(a)
    1 ↔ 1
    GL343431.1(45011-174616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377110432   -- 78.98(n)    137711043 
    zebrafish
    (Danio rerio)
    Actinopterygii lama11 laminin, alpha 1 58.14(n)
    53.12(a)
      569971  NM_001034986.1  NP_001030158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wb6
    wing blister
    26(a)
    1 → many
    2L(14263027-14328262)
    worm
    (Caenorhabditis elegans)
    Secernentea lam-36
    Protein LAM-3 (lam-3) mRNA, complete cds
    29(a)
    1 → many
    I(10608466-10621428) WBGene00002248


    ENSEMBL Gene Tree for LAMA1 (if available)
    TreeFam Gene Tree for LAMA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LAMA1 gene
    LAMC12  LAMA52  LAMC22  LAMC32  LAMA42  LAMA32  LAMA22  USH2A2  
    LAMB42  LAMB22  LAMB12  
    7 SIMAP similar genes for LAMA1 using alignment to 5 protein entries:     LAMA1_HUMAN (see all proteins):
    LAMA2    LAMB4    LAMA3    LamA3    LAMC1    LAMC3
    NTN1

    Find genes that share paralogs with LAMA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LAMA1 (see all 4818)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508151201,2
    C,Funtested16950940(+) GAGGCG/AAACGT 2 /F syn12Minor allele frequency- A:0.00NA EU 5851
    rs124546881,2
    C,F,H--6941244(+) ACGGAT/CAGCGG 1 -- ds50015Minor allele frequency- C:0.00NS EA NA 422
    rs1144235131,2
    F--6941322(+) AATCTG/CGGTCT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1467954701,2
    --6941389(+) TTTCAA/CATTAC 1 -- ds50010--------
    rs1175048751,2
    F--6941449(+) AGTGAT/CGAAAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1406093761,2
    --6941506(+) TTCTTC/TTTTTC 1 -- ds50010--------
    rs1146641321,2
    C,F--6941631(+) AAAGGT/GTATGT 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs38100461,2
    C,F,H--6941662(-) TAATTC/ACAGAT 1 -- ds500128Minor allele frequency- A:0.31NS EA NA CSA WA 2780
    rs1855026791,2
    --6941836(+) TGTGTA/GTAAAG 1 -- ut310--------
    rs1457338811,2
    C--6941962(+) CTCCCC/TAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LAMA1 (6941743 - 7117813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LAMA1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716745CNV Deletion23290073
    esv2716744CNV Deletion23290073
    esv2716743CNV Deletion23290073
    esv2671013CNV Deletion23128226
    esv1060234CNV Deletion17803354
    esv1093980CNV Deletion17803354
    nsv526300CNV Loss19592680
    esv1010298CNV Loss20482838
    dgv3381n71CNV Gain21882294
    dgv3380n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): LAMA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAMA1
    DNA2.0 Custom Variant and Variant Library Synthesis for LAMA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 150320    OMIM disorders: --


    Find genes that share disorders with LAMA1           About GenesLikeMe

    4 Novoseek inferred disease relationships for LAMA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuromuscular diseases 31.5 2 7543975 (2)
    choriocarcinoma 25 1 2049067 (1)
    metastasis 0 1 1847824 (1)
    tumors 0 5 7875421 (1), 8780383 (1), 17695722 (1), 1544440 (1) (see all 5)

    Genetic Association Database (GAD): LAMA1
    Human Genome Epidemiology (HuGE) Navigator: LAMA1 (8 documents)

    Export disorders for LAMA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LAMA1 gene, integrated from 10 sources (see all 171):
    (articles sorted by number of sources associating them with LAMA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)1, 2, 9 Nissinen M....Tryggvason K. (Biochem. J. 1991)
    2. Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)1, 2, 9 Haaparanta T.... Engvall E. (Matrix 1991)
    3. A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. (PubMed id 20876614)1, 4 Yoon K.A....Lee J.S. (Hum. Mol. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    7. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)1, 3 Nagayoshi T....Uitto J. (Genomics 1989)
    8. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)1, 2 Olsen D.... Uitto J. (Lab. Invest. 1989)
    9. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)1, 9 Moser T.L....Stack M.S. (J. Biol. Chem. 1993)
    10. Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)1, 9 Taraboletti G....Roberts D.D. (J. Biol. Chem. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 284217 HGNC: 6481 AceView: LAMA1.1 Ensembl:ENSG00000101680 euGenes: HUgn284217
    ECgene: LAMA1 Kegg: 284217 H-InvDB: LAMA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LAMA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LAMA1 gene:
    Search GeneIP for patents involving LAMA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for LAMA1 (Laminin alpha 1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LAMA1   OriGene RNAi products in human, mouse, rat for LAMA1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LAMA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LAMA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LAMA1   OriGene Custom Protein Services for LAMA1  

     
     
     Block miRNA regulation of human, mouse, rat LAMA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LAMA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMA1 Predesigned siRNA for gene silencing in human, mouse, rat LAMA1
     QuantiFast Probe-based Assays in human, mouse, rat LAMA1 QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
     PCR Arrays including human, mouse, rat LAMA1 Search Chromatin IP Primers for LAMA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMA1  Search GeneGlobe Interaction Network for LAMA1
     Regulatory tfbs in LAMA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LAMA1 GenScript cDNA clones with any tag delivered in your preferred vector for LAMA1
     GenScript Custom Assay Services for LAMA1 GenScript Custom overexpressing Cell Line Services for LAMA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LAMA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LAMA1 antibodies
     LAMA1 proteins
     Search for Antibodies for LAMA1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LAMA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for LAMA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1
     SwitchGear 3'UTR luciferase reporter plasmids for LAMA1
     SwitchGear Promoter luciferase reporter plasmids for LAMA1
     ThermoFisher Antibody for LAMA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1
     Browse compounds at ApexBio
     Search Addgene for plasmids for LAMA1
      Search eBioscience for proteins for LAMA1
      Search eBioscience for elisas for LAMA1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for LAMA1
     antibodies-online antibodies for LAMA1 (44 products)
     antibodies-online kits for LAMA1 (7 products)
     antibodies-online peptides for LAMA1
     antibodies-online proteins for LAMA1 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LAMA1 gene at Home site.
    Version: 3.12.264 25 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4