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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAMA1 Gene

protein-coding GIFtS: 65
GCID: GC18M006941

Laminin, Alpha 1

(Previous symbol: LAMA)

Alzheimer's & Parkinson's Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Laminin, Alpha 1¹ ²		S-Laminin Subunit Alpha² ³
LAMA¹ ² ³		S-LAM-alpha²
Laminin A Chain² ³		Laminin Subunit Alpha-1²
Laminin-3 Subunit Alpha² ³		Laminin-1 Subunit Alpha³
S-LAM Alpha² ³

External Ids:	HGNC: 6481¹	Entrez Gene: 284217²	Ensembl: ENSG00000101680⁷	OMIM: 150320⁵	UniProtKB: P25391³

ORGUL members:
	NONCODE¹⁴:n339785

Export aliases for LAMA1 gene to outside databases

Previous GC identifers: GC18M006877 GC18M007006 GC18M006931 GC18M006905

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LAMA1 Gene:

LAMA1 (laminin, alpha 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with LAMA1 include patau syndrome, and alport syndrome, and among its related super-pathways are ECM-receptor interaction and Focal Adhesion. GO annotations related to this gene include glycosphingolipid binding and receptor binding. An important paralog of this gene is LAMA3.

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration

and organization of cells into tissues during embryonic development by interacting with other extracellular

matrix components

Gene Wiki entry for LAMA1 (Laminin, alpha 1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.2 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAMA1 gene promoter:
Max1 AML1a Sp1 E47 YY1 AREB6 MEF-2A aMEF-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAMA1 promoter sequence

Search SABiosciences Chromatin IP Primers for LAMA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3 Ensembl cytogenetic band: 18p11.23 HGNC cytogenetic band: 18p11.3

LAMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M006941: view genomic region (about GC identifiers)

Start:	6,941,743 bp from pter	End:	7,117,813 bp from pter
Size:	176,071 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See protein sequence)

Recommended Name: Laminin subunit alpha-1 precursor

Size: 3075 amino acids; 337084 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short

arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3

(laminin-121 or S-laminin)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component

Explore the universe of human proteins at neXtProt for LAMA1: NX_P25391

Explore proteomics data for LAMA1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P25391

LAMA1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_005550.2

ENSEMBL proteins:

ENSP00000374309

Reactome Protein details: P25391
Human Recombinant Protein Products for LAMA1:

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	GenScript Custom Purified and Recombinant Proteins Services for LAMA1
	Novus Biologicals LAMA1 Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	ISS	--
GO:0005604	basement membrane	IDA	10964500
GO:0005606	laminin-1 complex	IPI	10964500
GO:0005608	laminin-3 complex	IPI	10964500

LAMA1 for ontologies About GeneDecksing

LAMA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
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	Novus Biologicals LAMA1 Antibodies
	Abcam antibodies for LAMA1
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for LAMA1
	LSBio Antibodies in human, mouse, rat for LAMA1

Assay Products for LAMA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for LAMA1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAMA1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

LAM: Laminins

5/9 InterPro protein domains (see all 9):

IPR018031 Laminin_B_subgr

IPR000034 Laminin_B_type_IV

IPR008211 Laminin_N

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

Graphical View of Domain Structure for InterPro Entry P25391

ProtoNet protein and cluster: P25391

5 Blocks protein domains:

IPB000034 Laminin B

IPB001791 Laminin G

IPB002049 Laminin-type EGF-like domain

IPB009254 Laminin I

IPB012679 Laminin G

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil

structure

Domain: Domains VI, IV and G are globular

Similarity: Contains 17 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

Similarity: Contains 2 laminin IV type A domains

Similarity: Contains 1 laminin N-terminal domain

LAMA1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LAMA1_HUMAN, P25391

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration

and organization of cells into tissues during embryonic development by interacting with other extracellular

matrix components

Genatlas biochemistry entry for LAMA1:

laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005201	extracellular matrix structural constituent	ISS	--
GO:0005515	protein binding	IPI	17166913
GO:0043208	glycosphingolipid binding	IEA	--

LAMA1 for ontologies About GeneDecksing

Phenotypes:
10 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Lama1):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
mortality/aging	nervous system	normal	reproductive system	vision/eye

LAMA1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for LAMA1: Lama1^tm1.1Olf Lama1^tm1Ekb Lama1^tm1.2Arhi Lama1^tm1.1Ekb

inGenious Targeting Laboratory - Custom generated mouse model solutions for LAMA1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAMA1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAMA1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAMA1

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMA1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMA1:
		hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: LAMA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for LAMA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMA1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LAMA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for LAMA1 (see all 5) OriGene ORF clones in mouse, rat for LAMA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LAMA1
		Search LifeMap BioReagents cell lines for LAMA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for LAMA1 About (see all 23)

See pathways by source

SuperPath

Contained pathways About

Non-integrin membrane-ECM interactions

	Non-integrin membrane-ECM interactions	0.44			ECM proteoglycans	0.38
	ECM-receptor interaction	0.42			Integrin cell surface interactions	0.32

Focal Adhesion

Focal Adhesion

0.64

Focal adhesion

0.64

Cell adhesion ECM remodeling

Cell adhesion ECM remodeling

0.31

Metalloproteases in connective tissue degradation

0.31

Integrin Pathway

Integrin Pathway	0.67	UPA-UPAR Pathway	0.56
FAK1 Signaling	0.67	Inhibition of Angiogenesis by TSP1	0.50
GnRH Signaling	0.56	Transendothelial Migration of Leukocytes	0.38

Rho Family GTPases

Rho Family GTPases	0.61	Molecular Mechanisms of Cancer	0.51
ERK Signaling	0.61	ILK Signaling	0.49
MAPK Signaling	0.58

Pathways by source See SuperPaths
Show some pathways

7/7 EMD Millipore Pathways for LAMA1 (see first 5)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation
	Cell adhesion Plasmin signaling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

14/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMA1 (see first 5)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	CDK5 Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	ERK Signaling
	ILK Signaling
	Inhibition of Angiogenesis by TSP1
	Integrin Pathway
	GnRH Signaling
	FAK1 Signaling
	Phospholipase-C Pathway
	Rho Family GTPases

6/6 GeneGo (Thomson Reuters) Pathways for LAMA1 (see first 5)

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion ECM remodeling
	Cell adhesion Plasmin signaling

5 BioSystems Pathways for LAMA1

	Focal Adhesion
	Alpha6-Beta4 Integrin Signaling Pathway
	Glypican 1 network
	Syndecan-2-mediated signaling events
	Syndecan-4-mediated signaling events

8/8 Reactome Pathways for LAMA1 (see first 5)

	ECM proteoglycans
	L1CAM interactions
	Developmental Biology
	Extracellular matrix organization
	Integrin cell surface interactions
	Signal Transduction
	Non-integrin membrane-ECM interactions
	Axon guidance

7/7 Kegg Pathways (Kegg details for LAMA1) (see first 5):

	PI3K-Akt signaling pathway
	Focal adhesion
	ECM-receptor interaction
	Toxoplasmosis
	Amoebiasis
	Pathways in cancer
	Small cell lung cancer

LAMA1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LAMA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/56 Interacting proteins for LAMA1 (P25391^{2, 3} ENSP00000374309⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGA1	P56199³, ENSP00000282588⁴	I2D: score=2 STRING: ENSP00000282588
ITGA2	P17301³, ENSP00000296585⁴	I2D: score=2 STRING: ENSP00000296585
NID1	P14543³, ENSP00000264187⁴	I2D: score=2 STRING: ENSP00000264187
PLAT	P00750³, ENSP00000220809⁴	I2D: score=2 STRING: ENSP00000220809
APP	P05067³, ENSP00000284981⁴	I2D: score=1 STRING: ENSP00000284981

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002011	morphogenesis of an epithelial sheet	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007166	cell surface receptor signaling pathway	ISS	--
GO:0007411	axon guidance	TAS	--
GO:0009888	tissue development	--	--

LAMA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LAMA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAMA1

1 HMDB Compound for LAMA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--

4 Novoseek inferred chemical compound relationships for LAMA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparin	6.63	2	8068026 (1), 1532944 (1)
lysine	0	2	8360181 (1)
retinoic acid	0	2	9486851 (1)
cysteine	0	2	2071595 (1), 2049067 (1)

Search CenterWatch for drugs/clinical trials and news about LAMA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAMA1 gene:

NM_005559.3

Unigene Cluster for LAMA1:

Laminin, alpha 1

Hs.270364 [show with all ESTs]

Unigene Representative Sequence: NM_005559

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389658(uc002knm.3) ENST00000492048(uc002knk.3) ENST00000488064(uc002knl.3)

ENST00000579014(uc010wzj.2) ENST00000488089 ENST00000490190 ENST00000484335

ENST00000585178

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMA1
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		hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: LAMA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA1

Additional mRNA sequence:

AK091949.1 AK093376.1 BC016997.1 BC032758.1 BC039051.1 BC062318.1 BC107693.1 X58531.1

9 DOTS entries:

DT.101982347 DT.99962344 DT.99994509 DT.209867 DT.40295787 DT.121103469 DT.91929959 DT.97785718

DT.101972320

2 AceView cDNA sequences:

BC041471 BI837819

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23	^	24	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	25a	·	25b	^	26	^	27	^	28a	·	28b	^	29a	·	29b	·	29c	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36a	·	36b	^	37	^	38	^	39	^	40	^	41	^	42
SP1:													-																				-
SP2:																							-										-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LAMA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAMA1 expression in normal human tissues (normalized intensities) LAMA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGCAACAAAT

About this image

LAMA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/13 selected tissues (see all 13) fully expand


Kidney (Urinary System) fully expand to see all 2 entries
Metanephros

Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Inner Cell Mass Cells Inner Cell Mass
Blimp1- mVenus and stella-ECFP genetically modified stem cells

Trophoblast (Extraembryonic Tissues) fully expand to see all 2 entries
Mural Trophectoderm Cells Mural Trophectoderm

Ovary (Reproductive System) fully expand to see all 2 entries
Secondary Follicle

Hypoblast (Extraembryonic Tissues)
Hypoblast Cells Hypoblast

See LAMA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMA1

SOURCE GeneReport for Unigene cluster: Hs.270364

SABiosciences Expression via Pathway-Focused PCR Arrays including LAMA1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Atherosclerosis in human mouse rat

Embryonic Stem Cells in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LAMA1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LAMA1 gene from 7/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lama1^{1 , 5}	laminin, alpha 1^{1, 5}	78.64(n)¹ 76.48(a)¹		17 (38.80 cM)⁵ 16772¹ NM_008480.2¹ NP_032506.2¹ 67697265⁵
chicken (Gallus gallus)	Aves	LAMA1¹	laminin, alpha 1	68.91(n) 65.92(a)		374016 NM_001199806.1 NP_001186735.1
lizard (Anolis carolinensis)	Reptilia	LAMA1⁶	laminin, alpha 1	63(a)	1 ↔ 1	GL343431.1(45011-174616)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137711043²	--	78.98(n)		137711043
zebrafish (Danio rerio)	Actinopterygii	lama1¹	laminin, alpha 1	58.12(n) 53.1(a)		569971 NM_001034986.1 NP_001030158.1
fruit fly (Drosophila melanogaster)	Insecta	LanA⁶	Laminin A	20(a)	possible ortholog	3L(6196931-6211122)
worm (Caenorhabditis elegans)	Secernentea	lam-3⁶ epi-1⁶	Laminin-like protein epi-1	29(a) 20(a)	1 ↔ many possible ortholog	I(10608466-10621428) IV(10666827-10679441)

ENSEMBL Gene Tree for LAMA1 (if available)
TreeFam Gene Tree for LAMA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for LAMA1 gene

LAMA3² LAMA5² LAMA2² MEGF9² LAMA4²

7 SIMAP similar genes for LAMA1 using alignment to 5 protein entries: LAMA1_HUMAN (see all proteins):

LAMA2 LAMB4 LAMA3 LamA3 LAMC1 LAMC3

NTN1

LAMA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150815120^1,2	C,F	untested¹	6950940(+)	`GAGGCG/AAACGT`	2	/F	syn¹		2		NA EU	5851
rs12454688^1,2	C,F,H	--	6941244(+)	`ACGGAT/CAGCGG`	1	--	ds500¹		5		NS EA NA	422
rs114423513^1,2	F	--	6941322(+)	`AATCTG/CGGTCT`	1	--	ds500¹		1		WA	118
rs146795470^1,2		--	6941389(+)	`TTTCAA/CATTAC`	1	--	ds500¹		0	--	--	--	--
rs117504875^1,2	F	--	6941449(+)	`AGTGAT/CGAAAA`	1	--	ds500¹		1		EA	120
rs140609376^1,2		--	6941506(+)	`TTCTTC/TTTTTC`	1	--	ds500¹		0	--	--	--	--
rs114664132^1,2	C,F	--	6941631(+)	`AAAGGT/GTATGT`	1	--	ds500¹		1		WA	118
rs3810046^1,2	C,F,H	--	6941662(-)	`TAATTC/ACAGAT`	1	--	ds500¹		28		NS EA NA CSA WA	2780
rs185502679^1,2		--	6941836(+)	`TGTGTA/GTAAAG`	1	--	ut3¹		0	--	--	--	--
rs145733881^1,2	C	--	6941962(+)	`CTCCCC/TAGAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LAMA1 (6941743 - 7117813 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/16 variations for LAMA1 (see all 16): About this table

Variant ID	Type	Subtype	PubMed ID
esv2716745	CNV	Deletion	23290073
esv2716744	CNV	Deletion	23290073
esv2716743	CNV	Deletion	23290073
esv2671013	CNV	Deletion	23128226
esv1060234	CNV	Deletion	17803354
esv1093980	CNV	Deletion	17803354
nsv526300	CNV	Loss	19592680
esv1010298	CNV	Loss	20482838
dgv3381n71	CNV	Gain	21882294
dgv3380n71	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): LAMA1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 150320 OMIM disorders: --

20/33 diseases for LAMA1 (see all 33): About MalaCards

patau syndrome alport syndrome neuromuscular disease familial colorectal cancer

congenital muscular dystrophy fainting duchenne muscular dystrophy bullous pemphigoid

hirschsprung's disease muscular dystrophy toxoplasmosis choriocarcinoma

teratocarcinoma myopia nephritis fibrosarcoma

endometriosis infertility oral squamous cell carcinoma colorectal cancer

LAMA1 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

4 Novoseek inferred disease relationships for LAMA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neuromuscular diseases	31.5	2	7543975 (2)
choriocarcinoma	25	1	2049067 (1)
metastasis	0	1	1847824 (1)
tumors	0	5	7875421 (1), 8780383 (1), 17695722 (1), 1544440 (1) (see all 5)

Genetic Association Database (GAD): LAMA1
Human Genome Epidemiology (HuGE) Navigator: LAMA1 (8 documents)

Export disorders for LAMA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LAMA1 gene, integrated from 9 sources (see all 169):
(articles sorted by number of sources associating them with LAMA1)

Utopia: connect your pdf to the dynamic
world of online information

Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)^{1, 2, 9} Nissinen M....Tryggvason K. (1991)
Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)^{1, 2, 9} Haaparanta T.... Engvall E. (1991)
A genome-wide association study reveals susceptibilit y variants for non-small cell lung cancer in the Korean population. (PubMed id 20876614)^{1, 4} Yoon K.A....Lee J.S. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)^{1, 4} Uhl G.R....Lerman C. (2008)
Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)^{1, 3} Nagayoshi T....Uitto J. (1989)
Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)^{1, 2} Olsen D.... Uitto J. (1989)
The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)^{1, 9} Moser T.L....Stack M.S. (1993)
Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)^{1, 9} Taraboletti G....Roberts D.D. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284217	HGNC: 6481	AceView: LAMA1.1	Ensembl:ENSG00000101680	euGenes: HUgn284217
ECgene: LAMA1	Kegg: 284217	H-InvDB: LAMA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LAMA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LAMA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LAMA1 gene:
Search GeneIP for patents involving LAMA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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