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LAMA1 Gene

protein-coding GIFtS: 64
GCID: GC18M006941

Laminin, Alpha 1

(Previous symbol: LAMA)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Laminin, Alpha 1¹ ²		S-Laminin Subunit Alpha² ³
LAMA¹ ² ³		S-LAM-alpha²
Laminin A Chain² ³		Laminin Subunit Alpha-1²
Laminin-3 Subunit Alpha² ³		Laminin-1 Subunit Alpha³
S-LAM Alpha² ³

External Ids:	HGNC: 6481¹	Entrez Gene: 284217²	Ensembl: ENSG00000101680⁷	OMIM: 150320⁵	UniProtKB: P25391³

Export aliases for LAMA1 gene to outside databases

Previous GC identifers: GC18M006877 GC18M007006 GC18M006931 GC18M006905

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LAMA1 Gene:

LAMA1 (laminin, alpha 1) is a protein-coding gene. Diseases associated with LAMA1 include patau syndrome, and alport syndrome. GO annotations related to this gene include glycosphingolipid binding and receptor binding. An important paralog of this gene is LAMC1.

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration

and organization of cells into tissues during embryonic development by interacting with other extracellular

matrix components

Gene Wiki entry for LAMA1 (Laminin, alpha 1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000018.10 NC_018929.2 NT_010859.15

Regulatory elements:

Regulatory transcription factor binding sites in the LAMA1 gene promoter:
Max1 AML1a Sp1 E47 YY1 AREB6 MEF-2A aMEF-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAMA1 promoter sequence

Search Chromatin IP Primers for LAMA1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3 Ensembl cytogenetic band: 18p11.23 HGNC cytogenetic band: 18p11.3

LAMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M006941: view genomic region (about GC identifiers)

Start:	6,941,743 bp from pter	End:	7,117,813 bp from pter
Size:	176,071 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See protein sequence)

Recommended Name: Laminin subunit alpha-1 precursor

Size: 3075 amino acids; 337084 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short

arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3

(laminin-121 or S-laminin)

Explore the universe of human proteins at neXtProt for LAMA1: NX_P25391

Explore proteomics data for LAMA1 at MOPED

Post-translational modifications:

Glycosylation² at Asn38, Asn555, Asn665, Asn763, Asn926, Asn952, Asn1045, Asn1407, Asn1579, Asn1596,
Asn1678, Asn1689, Asn1698, Asn1717, Asn1804, Asn1894, Asn1898, Asn1957, Asn1974, Asn1991 (see all 34)

Modification sites at PhosphoSitePlus

See LAMA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005550.2

ENSEMBL proteins:

ENSP00000374309

Reactome Protein details: P25391

LAMA1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for LAMA1
	Novus Biologicals LAMA1 Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

LAMA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
	R&D Systems Antibodies for LAMA1 (Laminin alpha 1)
	OriGene Antibodies for LAMA1 OriGene Custom Antibody Services for LAMA1
	Novus Biologicals LAMA1 Antibodies
	Search for Antibodies for LAMA1 at Abcam
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for LAMA1
	LSBio Antibodies in human, mouse, rat for LAMA1

LAMA1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for LAMA1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAMA1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

LAM: Laminins

Selected InterPro protein domains (see all 9):

IPR018031 Laminin_B_subgr

IPR000034 Laminin_B_type_IV

IPR008211 Laminin_N

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

Graphical View of Domain Structure for InterPro Entry P25391

ProtoNet protein and cluster: P25391

5 Blocks protein domains:

IPB000034 Laminin B

IPB001791 Laminin G

IPB002049 Laminin-type EGF-like domain

IPB009254 Laminin I

IPB012679 Laminin G

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil

structure

Domain: Domains VI, IV and G are globular

Similarity: Contains 17 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

Similarity: Contains 2 laminin IV type A domains

Similarity: Contains 1 laminin N-terminal domain

LAMA1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: LAMA1_HUMAN, P25391

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration

and organization of cells into tissues during embryonic development by interacting with other extracellular

matrix components

Genatlas biochemistry entry for LAMA1:

laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005201	extracellular matrix structural constituent	ISS	--
GO:0005515	protein binding	IPI	16677310
GO:0043208	glycosphingolipid binding	IEA	--

LAMA1 for ontologies About GeneDecksing

Phenotypes:
10 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Lama1):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size/body
mortality/aging	nervous system	normal	reproductive system	vision/eye

LAMA1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for LAMA1: Lama1^tm1.1Olf Lama1^tm1Ekb Lama1^tm1.2Arhi Lama1^tm1.1Ekb

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAMA1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LAMA1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAMA1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAMA1

miRNA Products:		miRTarBase miRNAs that target LAMA1: hsa-mir-124-3p (MIRT022954)

		Block miRNA regulation of human, mouse, rat LAMA1 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate LAMA1:
		hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: LAMA1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for LAMA1
		Predesigned siRNA for gene silencing in human, mouse, rat LAMA1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LAMA1

Clone Products:		OriGene clones in human, mouse for LAMA1 (see all 5) OriGene ORF clones in mouse, rat for LAMA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LAMA1
		Browse ESI BIO Cell Lines and PureStem Progenitors for LAMA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

LAMA1_HUMAN, P25391: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
plasma membrane	2
lysosome	1
peroxisome	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	ISS	--
GO:0005604	basement membrane	IDA	10964500
GO:0005606	laminin-1 complex	IPI	10964500
GO:0005608	laminin-3 complex	IPI	10964500

LAMA1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for LAMA1 About (see all 23)

See pathways by source

SuperPath

Contained pathways About

Focal adhesion

	Focal adhesion	0.65			ECM-receptor interaction	0.31
	Focal Adhesion	0.65

Cell adhesion ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Cell adhesion ECM remodeling

0.31

Integrin Pathway

FAK1 Signaling	0.67	UPA-UPAR Pathway	0.56
Integrin Pathway	0.67	Inhibition of Angiogenesis by TSP1	0.50
GnRH Signaling	0.56	Transendothelial Migration of Leukocytes	0.38

ERK Signaling

Rho Family GTPases	0.61	Molecular Mechanisms of Cancer	0.51
ERK Signaling	0.61	ILK Signaling	0.49
MAPK Signaling	0.58

L1CAM interactions

	Axon guidance	0.63			L1CAM interactions	0.36
	Developmental Biology	0.63

Pathways by source See SuperPaths
Show some pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAMA1 (see first 5)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	CDK5 Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	ERK Signaling
	ILK Signaling
	Inhibition of Angiogenesis by TSP1
	Integrin Pathway
	GnRH Signaling
	FAK1 Signaling
	Phospholipase-C Pathway
	Rho Family GTPases

Selected GeneGo (Thomson Reuters) Pathways for LAMA1 (see first 5)

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion ECM remodeling
	Cell adhesion Plasmin signaling

5 BioSystems Pathways for LAMA1

	Focal Adhesion
	Alpha6-Beta4 Integrin Signaling Pathway
	Glypican 1 network
	Syndecan-2-mediated signaling events
	Syndecan-4-mediated signaling events

4 Reactome Pathways for LAMA1

	L1CAM interactions
	ECM proteoglycans
	Laminin interactions
	Non-integrin membrane-ECM interactions

Selected Kegg Pathways (Kegg details for LAMA1) (see first 5):

	PI3K-Akt signaling pathway
	Focal adhesion
	ECM-receptor interaction
	Toxoplasmosis
	Amoebiasis
	Pathways in cancer
	Small cell lung cancer

LAMA1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including LAMA1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Atherosclerosis in human mouse rat

Embryonic Stem Cells in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for LAMA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for LAMA1 (P25391^{1, 2, 3} ENSP00000374309⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGA1	P56199³, ENSP00000282588⁴	I2D: score=2 STRING: ENSP00000282588
ITGA2	P17301³, ENSP00000296585⁴	I2D: score=2 STRING: ENSP00000296585
NID1	P14543³, ENSP00000264187⁴	I2D: score=2 STRING: ENSP00000264187
PLAT	P00750³, ENSP00000220809⁴	I2D: score=2 STRING: ENSP00000220809
APP	P05067³, ENSP00000284981⁴	I2D: score=1 STRING: ENSP00000284981

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Gene Ontology (GO): Selected biological process terms (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002011	morphogenesis of an epithelial sheet	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007166	cell surface receptor signaling pathway	ISS	--
GO:0007411	axon guidance	TAS	--
GO:0009888	tissue development	--	--

LAMA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for LAMA1

1 HMDB Compound for LAMA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--

4 Novoseek inferred chemical compound relationships for LAMA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparin	6.63	2	8068026 (1), 1532944 (1)
lysine	0	2	8360181 (1)
retinoic acid	0	2	9486851 (1)
cysteine	0	2	2071595 (1), 2049067 (1)

LAMA1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for LAMA1 gene:

NM_005559.3

Unigene Cluster for LAMA1:

Laminin, alpha 1

Hs.270364 [show with all ESTs]

Unigene Representative Sequence: NM_005559

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389658(uc002knm.3) ENST00000492048(uc002knk.3) ENST00000488064(uc002knl.3)

ENST00000579014(uc010wzj.2) ENST00000488089 ENST00000490190 ENST00000484335

ENST00000585178

miRNA Products:		Block miRNA regulation of human, mouse, rat LAMA1 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate LAMA1:
		hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: LAMA1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for LAMA1
		Predesigned siRNA for gene silencing in human, mouse, rat LAMA1

Clone Products:		OriGene clones in human, mouse for LAMA1 (see all 5) OriGene ORF clones in mouse, rat for LAMA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat LAMA1
		QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
		QuantiFast Probe-based Assays in human, mouse, rat LAMA1

Additional mRNA sequence:

AK091949.1 AK093376.1 BC016997.1 BC032758.1 BC039051.1 BC062318.1 BC107693.1 X58531.1

9 DOTS entries:

DT.101982347 DT.99962344 DT.99994509 DT.209867 DT.40295787 DT.121103469 DT.91929959 DT.97785718

DT.101972320

2 AceView cDNA sequences:

BC041471 BI837819

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23	^	24	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	25a	·	25b	^	26	^	27	^	28a	·	28b	^	29a	·	29b	·	29c	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36a	·	36b	^	37	^	38	^	39	^	40	^	41	^	42
SP1:													-																				-
SP2:																							-										-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LAMA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LAMA1 expression in normal human tissues (normalized intensities) LAMA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGCAACAAAT

About this image

LAMA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 11) fully expand


Trophoblast (Extraembryonic Tissues) fully expand to see all 2 entries
Mural Trophectoderm Cells Mural Trophectoderm

Hypoblast (Extraembryonic Tissues) fully expand to see all 2 entries
Hypoblast Cells Hypoblast
Extraembryonic endoderm-like cells

Heart (Cardiovascular System)
Subepicardial Cells Epicardium

Kidney (Urinary System) fully expand to see all 2 entries
Metanephros

Tooth (Integumentary System) fully expand to see all 2 entries
Dental Papilla Cells Dental Papilla
Dentin

LAMA1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

LAMA1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.270364

Pathway & Disease-focused RT² Profiler PCR Arrays including LAMA1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Atherosclerosis in human mouse rat

Embryonic Stem Cells in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat LAMA1
		QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
		QuantiFast Probe-based Assays in human, mouse, rat LAMA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LAMA1 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lama1^{1 , 5}	laminin, alpha 1^{1, 5}	78.64(n)¹ 76.5(a)¹		17 (38.80 cM)⁵ 16772¹ NM_008480.2¹ NP_032506.2¹ 67697265⁵
chicken (Gallus gallus)	Aves	LAMA1¹	laminin, alpha 1	68.98(n) 66.08(a)		374016 NM_001199806.1 NP_001186735.1
lizard (Anolis carolinensis)	Reptilia	LAMA1⁶	laminin, alpha 1	63(a)	1 ↔ 1	GL343431.1(45011-174616)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137711043²	--	78.98(n)		137711043
zebrafish (Danio rerio)	Actinopterygii	lama1¹	laminin, alpha 1	58.14(n) 53.12(a)		569971 NM_001034986.1 NP_001030158.1
fruit fly (Drosophila melanogaster)	Insecta	wb⁶	wing blister	26(a)	1 → many	2L(14263027-14328262)
worm (Caenorhabditis elegans)	Secernentea	lam-3⁶	Protein LAM-3 (lam-3) mRNA, complete cds	29(a)	1 → many	I(10608466-10621428) WBGene00002248

ENSEMBL Gene Tree for LAMA1 (if available)
TreeFam Gene Tree for LAMA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for LAMA1 gene

LAMC1² LAMA5² LAMC2² LAMC3² LAMA4² LAMA3² LAMA2² USH2A²

LAMB4² LAMB2² LAMB1²

7 SIMAP similar genes for LAMA1 using alignment to 5 protein entries: LAMA1_HUMAN (see all proteins):

LAMA2 LAMB4 LAMA3 LamA3 LAMC1 LAMC3

NTN1

LAMA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150815120^1,2	C,F	untested¹	6950940(+)	`GAGGCG/AAACGT`	2	/F	syn¹		2		NA EU	5851
rs12454688^1,2	C,F,H	--	6941244(+)	`ACGGAT/CAGCGG`	1	--	ds500¹		5		NS EA NA	422
rs114423513^1,2	F	--	6941322(+)	`AATCTG/CGGTCT`	1	--	ds500¹		1		WA	118
rs146795470^1,2		--	6941389(+)	`TTTCAA/CATTAC`	1	--	ds500¹		0	--	--	--	--
rs117504875^1,2	F	--	6941449(+)	`AGTGAT/CGAAAA`	1	--	ds500¹		1		EA	120
rs140609376^1,2		--	6941506(+)	`TTCTTC/TTTTTC`	1	--	ds500¹		0	--	--	--	--
rs114664132^1,2	C,F	--	6941631(+)	`AAAGGT/GTATGT`	1	--	ds500¹		1		WA	118
rs3810046^1,2	C,F,H	--	6941662(-)	`TAATTC/ACAGAT`	1	--	ds500¹		28		NS EA NA CSA WA	2780
rs185502679^1,2		--	6941836(+)	`TGTGTA/GTAAAG`	1	--	ut3¹		0	--	--	--	--
rs145733881^1,2	C	--	6941962(+)	`CTCCCC/TAGAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LAMA1 (6941743 - 7117813 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for LAMA1 (see all 16): About this table

Variant ID	Type	Subtype	PubMed ID
esv2716745	CNV	Deletion	23290073
esv2716744	CNV	Deletion	23290073
esv2716743	CNV	Deletion	23290073
esv2671013	CNV	Deletion	23128226
esv1060234	CNV	Deletion	17803354
esv1093980	CNV	Deletion	17803354
nsv526300	CNV	Loss	19592680
esv1010298	CNV	Loss	20482838
dgv3381n71	CNV	Gain	21882294
dgv3380n71	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): LAMA1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing LAMA1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 150320 OMIM disorders: --

Selected diseases for LAMA1 (see all 35): About MalaCards

patau syndrome alport syndrome neuromuscular disease congenital muscular dystrophy

familial colorectal cancer progeria fainting duchenne muscular dystrophy

bullous pemphigoid hirschsprung's disease muscular dystrophy toxoplasmosis

myopia teratocarcinoma choriocarcinoma fibrosarcoma

nephritis vaccinia pulmonary function endometriosis

LAMA1 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

4 Novoseek inferred disease relationships for LAMA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neuromuscular diseases	31.5	2	7543975 (2)
choriocarcinoma	25	1	2049067 (1)
metastasis	0	1	1847824 (1)
tumors	0	5	7875421 (1), 8780383 (1), 17695722 (1), 1544440 (1) (see all 5)

Genetic Association Database (GAD): LAMA1
Human Genome Epidemiology (HuGE) Navigator: LAMA1 (8 documents)

Export disorders for LAMA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LAMA1 gene, integrated from 10 sources (see all 171):
(articles sorted by number of sources associating them with LAMA1)

Utopia: connect your pdf to the dynamic
world of online information

Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)^{1, 2, 9} Nissinen M....Tryggvason K. (Biochem. J. 1991)
Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)^{1, 2, 9} Haaparanta T.... Engvall E. (Matrix 1991)
A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. (PubMed id 20876614)^{1, 4} Yoon K.A....Lee J.S. (Hum. Mol. Genet. 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)^{1, 4} Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)^{1, 3} Nagayoshi T....Uitto J. (Genomics 1989)
Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)^{1, 2} Olsen D.... Uitto J. (Lab. Invest. 1989)
The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)^{1, 9} Moser T.L....Stack M.S. (J. Biol. Chem. 1993)
Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)^{1, 9} Taraboletti G....Roberts D.D. (J. Biol. Chem. 1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284217	HGNC: 6481	AceView: LAMA1.1	Ensembl:ENSG00000101680	euGenes: HUgn284217
ECgene: LAMA1	Kegg: 284217	H-InvDB: LAMA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LAMA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LAMA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LAMA1 gene:
Search GeneIP for patents involving LAMA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Laminin, Alpha 1

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