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LAMA1 Gene

protein-coding   GIFtS: 64
GCID: GC18M006941

Laminin, Alpha 1


(Previous symbol: LAMA)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Laminin, Alpha 11 2     S-Laminin Subunit Alpha2 3
LAMA1 2 3     S-LAM-alpha2
Laminin A Chain2 3     Laminin Subunit Alpha-12
Laminin-3 Subunit Alpha2 3     Laminin-1 Subunit Alpha3
S-LAM Alpha2 3     

External Ids:    HGNC: 64811   Entrez Gene: 2842172   Ensembl: ENSG000001016807   OMIM: 1503205   UniProtKB: P253913   

Export aliases for LAMA1 gene to outside databases

Previous GC identifers: GC18M006877 GC18M007006 GC18M006931 GC18M006905


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LAMA1 Gene:
LAMA1 (laminin, alpha 1) is a protein-coding gene. GO annotations related to this gene include glycosphingolipid binding and receptor binding. An important paralog of this gene is LAMC1.

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
and organization of cells into tissues during embryonic development by interacting with other extracellular
matrix components

Gene Wiki entry for LAMA1 (Laminin, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAMA1 gene promoter:
         Max1   AML1a   Sp1   E47   YY1   AREB6   MEF-2A   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAMA1 promoter sequence
   Search Chromatin IP Primers for LAMA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAMA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.23   HGNC cytogenetic band: 18p11.3

LAMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M006941:  view genomic region     (about GC identifiers)

Start:
6,941,743 bp from pter      End:
7,117,813 bp from pter
Size:
176,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See protein sequence)
Recommended Name: Laminin subunit alpha-1 precursor  
Size: 3075 amino acids; 337084 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),
which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short
arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3
(laminin-121 or S-laminin)

Explore the universe of human proteins at neXtProt for LAMA1: NX_P25391

Explore proteomics data for LAMA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn555, Asn665, Asn763, Asn926, Asn952, Asn1045, Asn1407, Asn1579, Asn1596,
                                 Asn1678, Asn1689, Asn1698, Asn1717, Asn1804, Asn1894, Asn1898, Asn1957, Asn1974, Asn1991 (see all 34)
  • Modification sites at PhosphoSitePlus

  • See LAMA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005550.2  
    ENSEMBL proteins: 
     ENSP00000374309  
    Reactome Protein details: P25391

    LAMA1 Human Recombinant Protein Products:

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    Novus Biologicals LAMA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LAMA1 

     
    antibodies-online proteins for LAMA1 (11 products) 

     
    antibodies-online peptides for LAMA1

    LAMA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
    R&D Systems Antibodies for LAMA1 (Laminin alpha 1)
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    Novus Biologicals LAMA1 Antibodies
    Search for Antibodies for LAMA1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for LAMA1
    antibodies-online antibodies for LAMA1 (44 products) 

    LAMA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LAMA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for LAMA1 
    antibodies-online kits for LAMA1 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LAM: Laminins

    Selected InterPro protein domains (see all 9):
     IPR018031 Laminin_B_subgr
     IPR000034 Laminin_B_type_IV
     IPR008211 Laminin_N
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry P25391

    ProtoNet protein and cluster: P25391

    5 Blocks protein domains:
    IPB000034 Laminin B
    IPB001791 Laminin G
    IPB002049 Laminin-type EGF-like domain
    IPB009254 Laminin I
    IPB012679 Laminin G


    UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391
    Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil
    structure
    Domain: Domains VI, IV and G are globular
    Similarity: Contains 17 laminin EGF-like domains
    Similarity: Contains 5 laminin G-like domains
    Similarity: Contains 2 laminin IV type A domains
    Similarity: Contains 1 laminin N-terminal domain


    Find genes that share domains with LAMA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAMA1_HUMAN, P25391
    Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration
    and organization of cells into tissues during embryonic development by interacting with other extracellular
    matrix components

         Genatlas biochemistry entry for LAMA1:
    laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005201extracellular matrix structural constituent ISS--
    GO:0005515protein binding IPI16677310
    GO:0043208glycosphingolipid binding IEA--
         
    Find genes that share ontologies with LAMA1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lama1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     mortality/aging  nervous system  normal  reproductive system  vision/eye 

    Find genes that share phenotypes with LAMA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LAMA1: Lama1tm1.1Olf Lama1tm1Ekb Lama1tm1.2Arhi Lama1tm1.1Ekb

       genOway: Develop your customized and physiologically relevant rodent model for LAMA1

    miRNA
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    miRTarBase miRNAs that target LAMA1:
    hsa-mir-124-3p (MIRT022954)

    Block miRNA regulation of human, mouse, rat LAMA1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LAMA1:
    hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidLAMA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LAMA1
    Predesigned siRNA for gene silencing in human, mouse, rat LAMA1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAMA1_HUMAN, P25391: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005604basement membrane IDA10964500
    GO:0005606laminin-1 complex IPI10964500
    GO:0005608laminin-3 complex IPI10964500

    Find genes that share ontologies with LAMA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LAMA1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63


    Find genes that share SuperPaths with LAMA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LAMA1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    CDK5 Pathway
    Transendothelial Migration of Leukocytes

    Selected GeneGo (Thomson Reuters) Pathways for LAMA1 (see all 6)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion ECM remodeling

    5 BioSystems Pathways for LAMA1
        Focal Adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Glypican 1 network
    Syndecan-2-mediated signaling events
    Syndecan-4-mediated signaling events

    4 Reactome Pathways for LAMA1
        L1CAM interactions
    ECM proteoglycans
    Laminin interactions
    Non-integrin membrane-ECM interactions


    Selected Kegg Pathways  (Kegg details for LAMA1) (see all 7):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Toxoplasmosis
    Amoebiasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAMA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LAMA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LAMA1 (P253911, 2, 3 ENSP000003743094) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA1P561993, ENSP000002825884I2D: score=2 STRING: ENSP00000282588
    ITGA2P173013, ENSP000002965854I2D: score=2 STRING: ENSP00000296585
    NID1P145433, ENSP000002641874I2D: score=2 STRING: ENSP00000264187
    PLATP007503, ENSP000002208094I2D: score=2 STRING: ENSP00000220809
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway ISS--
    GO:0007411axon guidance TAS--
    GO:0009888tissue development ----

    Find genes that share ontologies with LAMA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAMA1

    1 HMDB Compound for LAMA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--

    4 Novoseek inferred chemical compound relationships for LAMA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 6.63 2 8068026 (1), 1532944 (1)
    lysine 0 2 8360181 (1)
    retinoic acid 0 2 9486851 (1)
    cysteine 0 2 2071595 (1), 2049067 (1)



    Find genes that share compounds with LAMA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LAMA1 gene: 
    NM_005559.3  

    Unigene Cluster for LAMA1:

    Laminin, alpha 1
    Hs.270364  [show with all ESTs]
    Unigene Representative Sequence: NM_005559
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389658(uc002knm.3) ENST00000492048(uc002knk.3) ENST00000488064(uc002knl.3)
    ENST00000579014(uc010wzj.2) ENST00000488089 ENST00000490190 ENST00000484335
    ENST00000585178
    miRNA
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    hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidLAMA1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
      QuantiFast Probe-based Assays in human, mouse, rat LAMA1

    Additional mRNA sequence: 

    AK091949.1 AK093376.1 BC016997.1 BC032758.1 BC039051.1 BC062318.1 BC107693.1 X58531.1 

    9 DOTS entries:

    DT.101982347  DT.99962344  DT.99994509  DT.209867  DT.40295787  DT.121103469  DT.91929959  DT.97785718 
    DT.101972320 

    2 AceView cDNA sequences:

    BC041471 BI837819 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
    SP1:                                      -                                                           -                                             
    SP2:                                                                    -                             -                                             
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for LAMA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAMA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAACAAAT
    LAMA1 Expression
    About this image


    LAMA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Hypoblast Cells Hypoblast
             Extraembryonic endoderm-like cells
     
     Heart (Cardiovascular System)
             Subepicardial Cells Epicardium
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental Papilla Cells Dental Papilla
             Dentin
    LAMA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAMA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270364
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LAMA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LAMA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LAMA1
    QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
    QuantiFast Probe-based Assays in human, mouse, rat LAMA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LAMA1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lama11 , 5 laminin, alpha 11, 5 78.64(n)1
    76.5(a)1
      17 (38.80 cM)5
    167721  NM_008480.21  NP_032506.21 
     676972655 
    chicken
    (Gallus gallus)
    Aves LAMA11 laminin, alpha 1 68.98(n)
    66.08(a)
      374016  NM_001199806.1  NP_001186735.1 
    lizard
    (Anolis carolinensis)
    Reptilia LAMA16
    laminin, alpha 1
    63(a)
    1 ↔ 1
    GL343431.1(45011-174616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377110432   -- 78.98(n)    137711043 
    zebrafish
    (Danio rerio)
    Actinopterygii lama11 laminin, alpha 1 58.14(n)
    53.12(a)
      569971  NM_001034986.1  NP_001030158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wb6
    wing blister
    26(a)
    1 → many
    2L(14263027-14328262)
    worm
    (Caenorhabditis elegans)
    Secernentea lam-36
    Protein LAM-3 (lam-3) mRNA, complete cds
    29(a)
    1 → many
    I(10608466-10621428) WBGene00002248


    ENSEMBL Gene Tree for LAMA1 (if available)
    TreeFam Gene Tree for LAMA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LAMA1 gene
    LAMC12  LAMA52  LAMC22  LAMC32  LAMA42  LAMA32  LAMA22  USH2A2  
    LAMB42  LAMB22  LAMB12  
    7 SIMAP similar genes for LAMA1 using alignment to 5 protein entries:     LAMA1_HUMAN (see all proteins):
    LAMA2    LAMB4    LAMA3    LamA3    LAMC1    LAMC3
    NTN1

    Find genes that share paralogs with LAMA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAMA1 (see all 4818)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508151201,2
    C,Funtested16950940(+) GAGGCG/AAACGT 2 /F syn12Minor allele frequency- A:0.00NA EU 5851
    rs124546881,2
    C,F,H--6941244(+) ACGGAT/CAGCGG 1 -- ds50015Minor allele frequency- C:0.00NS EA NA 422
    rs1144235131,2
    F--6941322(+) AATCTG/CGGTCT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1467954701,2
    --6941389(+) TTTCAA/CATTAC 1 -- ds50010--------
    rs1175048751,2
    F--6941449(+) AGTGAT/CGAAAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1406093761,2
    --6941506(+) TTCTTC/TTTTTC 1 -- ds50010--------
    rs1146641321,2
    C,F--6941631(+) AAAGGT/GTATGT 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs38100461,2
    C,F,H--6941662(-) TAATTC/ACAGAT 1 -- ds500128Minor allele frequency- A:0.31NS EA NA CSA WA 2780
    rs1855026791,2
    --6941836(+) TGTGTA/GTAAAG 1 -- ut310--------
    rs1457338811,2
    C--6941962(+) CTCCCC/TAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LAMA1 (6941743 - 7117813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LAMA1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716745CNV Deletion23290073
    esv2716744CNV Deletion23290073
    esv2716743CNV Deletion23290073
    esv2671013CNV Deletion23128226
    esv1060234CNV Deletion17803354
    esv1093980CNV Deletion17803354
    nsv526300CNV Loss19592680
    esv1010298CNV Loss20482838
    dgv3381n71CNV Gain21882294
    dgv3380n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): LAMA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LAMA1
    DNA2.0 Custom Variant and Variant Library Synthesis for LAMA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 150320    OMIM disorders: --


    Find genes that share disorders with LAMA1           About GenesLikeMe

    4 Novoseek inferred disease relationships for LAMA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuromuscular diseases 31.5 2 7543975 (2)
    choriocarcinoma 25 1 2049067 (1)
    metastasis 0 1 1847824 (1)
    tumors 0 5 7875421 (1), 8780383 (1), 17695722 (1), 1544440 (1) (see all 5)

    Genetic Association Database (GAD): LAMA1
    Human Genome Epidemiology (HuGE) Navigator: LAMA1 (8 documents)

    Export disorders for LAMA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAMA1 gene, integrated from 10 sources (see all 171) (see top 10):
    (articles sorted by number of sources associating them with LAMA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)1, 2, 9 Nissinen M....Tryggvason K. (Biochem. J. 1991)
    2. Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)1, 2, 9 Haaparanta T.... Engvall E. (Matrix 1991)
    3. A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. (PubMed id 20876614)1, 4 Yoon K.A....Lee J.S. (Hum. Mol. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    7. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)1, 3 Nagayoshi T....Uitto J. (Genomics 1989)
    8. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)1, 2 Olsen D.... Uitto J. (Lab. Invest. 1989)
    9. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)1, 9 Moser T.L....Stack M.S. (J. Biol. Chem. 1993)
    10. Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)1, 9 Taraboletti G....Roberts D.D. (J. Biol. Chem. 1990)
    11. Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits. (PubMed id 2099832)1, 9 Engvall E....Sanes J.R. (Cell Regul. 1990)
    12. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    13. The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells. (PubMed id 22919069)1 Kusuma S....Gerecht S. (FASEB J. 2012)
    14. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. (PubMed id 22693455)1 Perry J.R....Cauchi S. (PLoS Genet. 2012)
    15. Laminin-I+1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-I_B transcription factors but also has adverse effects. (PubMed id 22159078)1 Zhou Y.W....Jarrett H.W. (Am. J. Physiol., Cell Physiol. 2012)
    16. Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. (PubMed id 22760553)1 Adkins D.E....van den Oord E.J. (Transl Psychiatry 2012)
    17. Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA. (PubMed id 22840390)1 Nissan X....Peschanski M. (Cell Rep 2012)
    18. c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways. (PubMed id 21570970)1 Mruthyunjaya S....Padma S. (FEBS Lett. 2011)
    19. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    20. The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia. (PubMed id 21541277)1 Zhao Y.Y....Li Wang N. (Mol. Vis. 2011)
    21. Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin. (PubMed id 20237901)1 Siqueira A.S....Jaeger R.G. (Tumour Biol. 2010)
    22. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    23. Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy. (PubMed id 19416897)1 Rooney J.E....Burkin D.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    24. [Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome]. (PubMed id 20019771)1 Huang W....Liu G. (Beijing Da Xue Xue Bao 2009)
    25. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    26. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    27. A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study). (PubMed id 19672032)1 Akasaka H....Shimamoto K. (J. Atheroscler. Thromb. 2009)
    28. Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase. (PubMed id 19587235)1 Bao X....Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    29. Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression. (PubMed id 18162078)1 Vangipuram S.D....Lyman W.D. (Alcohol. Clin. Exp. Res. 2008)
    30. CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression. (PubMed id 18436868)1 Castaldo C....Montagnani S. (Stem Cells 2008)
    31. The relationship between expressions of the laminin gene and RET gene in Hirschsprung's disease. (PubMed id 18661771)1 Li A.W....Ruan Y. (World J Pediatr 2008)
    32. Vaccinia virus 4c (A26L) protein on intracellular mature virus binds to the extracellular cellular matrix laminin. (PubMed id 17166913)1 Chiu W.L....Chang W. (J. Virol. 2007)
    33. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    34. Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms. (PubMed id 17618648)1 von der Mark H....von der Mark K. (J. Mol. Biol. 2007)
    35. Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5. (PubMed id 17307732)1 Harrison D....Hohenester E. (J. Biol. Chem. 2007)
    36. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    37. Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11. (PubMed id 16709410)1 McDearmon E.L....Ervasti J.M. (FEBS Lett. 2006)
    38. Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin. (PubMed id 16677310)1 Kinhikar A.G....Laal S. (Mol. Microbiol. 2006)
    39. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    40. Selective down-regulation of the alpha6-integrin subunit in melanocytes by UVB light. (PubMed id 15885076)1 Krengel S....Tronnier M. (Exp. Dermatol. 2005)
    41. Large-scale analysis of the human ubiquitin-related proteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (Proteomics 2005)
    42. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    43. Laminin isoforms in fetal and adult human adrenal cortex. (PubMed id 14557481)1 Virtanen I....Konttinen Y.T. (J. Clin. Endocrinol. Metab. 2003)
    44. Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. (PubMed id 12524166)1 Johnson G. and Moore S.W. (Neurosci. Lett. 2003)
    45. Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. (PubMed id 12393739)1 Gu Y.C....Ekblom M. (Blood 2003)
    46. An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients. (PubMed id 12615822)1 Inagaki J....Matsuura E. (Hum. Reprod. 2003)
    47. Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. (PubMed id 11827968)1 Faisal Khan K.M....Falcone D.J. (J. Biol. Chem. 2002)
    48. Matrilin-2 interacts with itself and with other extracellular matrix proteins. (PubMed id 12180907)1 Piecha D....Paulsson M. (Biochem. J. 2002)
    49. Differential distribution of laminins in Alzheimer disease and normal human brain tissue. (PubMed id 12111806)1 Palu E. and Liesi P. (J. Neurosci. Res. 2002)
    50. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. (PubMed id 12149247)1 Velasco G.... Lopez-Otin C. (J. Biol. Chem. 2002)
    51. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    52. Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. (PubMed id 11311202)1 McArthur C.P....Gustafson S. (Arch. Oral Biol. 2001)
    53. Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro. (PubMed id 11798066)1 Durbeej M....Ekblom P. ( research in biological diversity 2001)
    54. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PubMed id 11022011)4 Ober C....Cox N.J. (Am. J. Hum. Genet. 2000)
    55. Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta. (PubMed id 10964500)1 Champliaud M.F....Gullberg D. (Exp. Cell Res. 2000)
    56. Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro. (PubMed id 10620696)1 KAPhler D....Sterchi E.E. (FEBS Lett. 2000)
    57. Laminin alpha1-chain shows a restricted distribution in epithelial basement membranes of fetal and adult human tissues. (PubMed id 10837144)1 Virtanen I....Ekblom P. (Exp. Cell Res. 2000)
    58. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. (PubMed id 10934193)1 Talts J.F....Timpl R. (J. Biol. Chem. 2000)
    59. Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry. (PubMed id 10470109)1 Ludwig H.C....Markakis E. (Anticancer Res. 1999)
    60. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. (PubMed id 9647658)1 O'Grady P....Saito H. (J. Cell Biol. 1998)
    61. The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan. (PubMed id 9688542)1 Ettner N....Timpl R. (FEBS Lett. 1998)
    62. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. (PubMed id 9169408)1 Chen M....Woodley D.T. (J. Biol. Chem. 1997)
    63. Characterization of the binding of serum amyloid P to laminin. (PubMed id 8999915)1 Zahedi K. (J. Biol. Chem. 1997)
    64. HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. (PubMed id 9597096)1 Mrowiec T....GA^rski A. (Arch. Immunol. Ther. Exp. (Warsz.) 1997)
    65. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. (PubMed id 9006922)1 Utani A....Yamada Y. (J. Biol. Chem. 1997)
    66. Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. (PubMed id 8995276)1 Ancsin J.B. and Kisilevsky R. (J. Biol. Chem. 1997)
    67. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. (PubMed id 9136074)1 CA!ceres J. and Brandan E. (J. Cell. Biochem. 1997)
    68. Laminin alpha1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. (PubMed id 9334356)1 Schuger L....He L. (J. Cell Biol. 1997)
    69. Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment. (PubMed id 8601594)1 Champliaud M.F....Burgeson R.E. (J. Cell Biol. 1996)
    70. Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. (PubMed id 7925941)1 Yamada H....Matsumura K. (FEBS Lett. 1994)
    71. Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. (PubMed id 7698745)1 Wewer U.M.... Albrechtsen R. (Genomics 1994)
    72. Recombinant laminin G domain mediates myoblast adhesion and heparin binding. (PubMed id 8463343)1 Yurchenco P.D....O'Rear J.J. (J. Biol. Chem. 1993)
    73. C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast. (PubMed id 3488995)1 Leivo I. and Engvall E. (J. Cell Biol. 1986)
    74. Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos. (PubMed id 9527881)9 Prokop A....Brown N.H. (Dev. Biol. 1998)
    75. Genetic analysis of Laminin A in Drosophila: extracellular matrix containing laminin A is required for ocellar axon pathfinding. (PubMed id 8787736)9 GarcA-a-Alonso L....Goodman C.S. (Development 1996)
    76. Increased laminin A expression in regenerating myofibers in neuromuscular disorders. (PubMed id 7543975)9 Mundegar R.R....Zierz S. (amp 1995)
    77. Characterization of alpha 1, beta 1, and gamma 1 laminin subunits during rabbit fetal lung development. (PubMed id 7496033)9 Durham P.L. and Snyder J.M. (Dev. Dyn. 1995)
    78. Genetic analysis of laminin A reveals diverse functions during morphogenesis in Drosophila. (PubMed id 8223265)9 Henchcliffe C....Goodman C.S. (Development 1993)
    79. Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. (PubMed id 20379222)9 Sorrosal G....MilA!n M. (EMBO Rep. 2010)
    80. A synthetic peptide deduced from the sequence in the cross-region of laminin A chain mediates neurite outgrowth, cell attachment and heparin binding. (PubMed id 8068026)9 Tashiro K....Anai M. (Biochem. J. 1994)
    81. The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development. (PubMed id 8330522)9 Fristrom D....Fristrom J. (Development 1993)
    82. Cellular localization of the human chorionic gonadotropin beta-subunit in transgenic mouse placenta. (PubMed id 10614666)9 Strauss B.L. and Boime I. (Endocrinology 2000)
    83. The role of cell adhesion molecules in Drosophila heart morphogenesis: faint sausage, shotgun/DE-cadherin, and laminin A are required for discrete stages in heart development. (PubMed id 10075841)9 Haag T.A....Hartenstein V. (Dev. Biol. 1999)
    84. Antibodies against domain E3 of laminin-1 and integrin alpha 6 subunit perturb branching epithelial morphogenesis of submandibular gland, but by different modes. (PubMed id 7536749)9 Kadoya Y....Ekblom P. (J. Cell Biol. 1995)
    85. Laminin is required for heart, somatic muscles, and gut development in the Drosophila embryo. (PubMed id 7781902)9 Yarnitzky T. and Volk T. (Dev. Biol. 1995)
    86. Reciprocal expression of laminin A-chain isoforms along the crypt-villus axis in the human small intestine. (PubMed id 8143989)9 Beaulieu J.F. and Vachon P.H. (Gastroenterology 1994)
    87. A family of laminin-related proteins controlling ectodermal differentiation in Drosophila. (PubMed id 1544440)9 Patthy L. (FEBS Lett. 1992)
    88. Basal lamina formation by epithelial cell lines correlates with laminin A chain synthesis and secretion. (PubMed id 1426050)9 Ecay T.W. and Valentich J.D. (Exp. Cell Res. 1992)
    89. A synthetic peptide derived from the carboxy terminus of the laminin A chain represents a binding site for the alpha 3 beta 1 integrin. (PubMed id 1560034)9 Gehlsen K.R....Skubitz A.P. (J. Cell Biol. 1992)
    90. Sex hormone-binding globulin, androgen-binding protein, and vitamin K-dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein. (PubMed id 1532944)9 Joseph D.R. and Baker M.E. (FASEB J. 1992)
    91. Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain. (PubMed id 1847824)9 Stack S....Pizzo S.V. (Biochemistry 1991)
    92. Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1. (PubMed id 2318314)9 Aumailley M....Timpl R. (FEBS Lett. 1990)
    93. Laminin alpha-1, alpha-3, and alpha-5 chain expression in human prepubertal [correction of prepubetal] benign prostate glands and adult benign and malignant prostate glands. (PubMed id 12640662)9 Brar P.K....Nagle R.B. (Prostate 2003)
    94. Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain. (PubMed id 11054814)9 Castillo G.M....Snow A.D. (J. Neurosci. Res. 2000)
    95. Immunolocalization of several laminin chains in the normal human central and peripheral nervous system. (PubMed id 9267051)9 Villanova M....Guazzi G.C. (J. Submicrosc. Cytol. Pathol. 1997)
    96. Congenital muscular dystrophy syndromes distinguished by alkaline and acid phosphatase, merosin, and dystrophin staining. (PubMed id 8618688)9 Connolly A.M....Choksi R. (Neurology 1996)
    97. Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation. (PubMed id 8609173)9 De Arcangelis A....Simon-Assmann P. (J. Cell Biol. 1996)
    98. Structural and functional analysis of the globular domain IVa of the laminin alpha 1 chain and its impact on an adjacent RGD site. (PubMed id 8615779)9 Schulze B....Timpl R. (Biochem. J. 1996)
    99. Activation of human lymphomononuclear cells by peptides derived from extracellular matrix proteins. (PubMed id 7696347)9 LA^pez-Moratalla N....Santiago E. (Biochim. Biophys. Acta 1995)
    100. Appearance and distribution of laminin A chain isoforms and integrin alpha 2, alpha 3, alpha 6, beta 1, and beta 4 subunits in the developing human small intestinal mucosa. (PubMed id 7545357)9 Perreault N....Beaulieu J.F. (Anat. Rec. 1995)
    101. Differential expression of laminin polypeptides in developing and adult human kidney. (PubMed id 7769233)9 Virtanen I....Korhonen M. (J. Histochem. Cytochem. 1995)
    102. [Expression of laminin is correlated to the differentiation of human colonic cancer cells]. (PubMed id 7875421)9 De Arcangelis A....Simon-Assmann P. (Gastroenterol. Clin. Biol. 1994)
    103. The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. (PubMed id 7943170)9 Pyke C....Tryggvason K. (Am. J. Pathol. 1994)
    104. Expression of laminin, type IV procollagen and 230 kDa bullous pemphigoid antigen genes by keratinocytes and fibroblasts in culture: application of the polymerase chain reaction for detection of small amounts of messenger RNA. (PubMed id 7818282)9 Nomura K....Uitto J. (Arch. Dermatol. Res. 1994)
    105. Laminin peptides stimulate human neutrophil motility. (PubMed id 8189064)9 Harvath L....Skubitz A.P. (J. Immunol. 1994)
    106. Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine. (PubMed id 7803849)9 Simon-Assmann P....Kedinger M. (Dev. Dyn. 1994)
    107. Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair. (PubMed id 8077230)9 Ryan M.C.... Carter W.G. (J. Biol. Chem. 1994)
    108. Laminin variants: why, where and when? (PubMed id 8433559)9 Engvall E. (Kidney Int. 1993)
    109. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. (PubMed id 1569102)9 Murdoch A.D.... Iozzo R.V. (J. Biol. Chem. 1992)
    110. Laminin A chain: expression during Drosophila development and genomic sequence. (PubMed id 1425586)9 Kusche-Gullberg M....Fessler J.H. (EMBO J. 1992)
    111. Laminin A-related domains in crb protein of Drosophila and their possible role in epithelial polarization. (PubMed id 1894012)9 Patthy L. (FEBS Lett. 1991)
    112. Merosin, a tissue-specific basement membrane protein, is a laminin- like protein. (PubMed id 2185464)9 Ehrig K.... Engvall E. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    113. Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. (PubMed id 2144001)9 Sorokin L....Ekblom P. (J. Cell Biol. 1990)
    114. [Biological active sites of laminin A chain]. (PubMed id 2402549)9 Tashiro K....Yamada Y. (Tanpakushitsu Kakusan Koso 1990)
    115. FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. (PubMed id 19458328)9 Skarie J.M. and Link B.A. (amp 2009)
    116. Biological effects of native and oxidized low-density lipoproteins in cultured human retinal pigment epithelial cells. (PubMed id 19071111)9 Yu A.L....Welge-Lussen U. (Exp. Eye Res. 2009)
    117. Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans. (PubMed id 18694491)9 De Luca M....FernA!ndez J.R. (BMC Genet. 2008)
    118. The AP-2alpha transcription factor regulates tumor cell migration and apoptosis. (PubMed id 17695722)9 Orso F....Taverna D. (Adv. Exp. Med. Biol. 2007)
    119. The Sp family of transcription factors regulates the human laminin alpha1 gene in JAR choriocarcinoma cells. (PubMed id 17141338)9 Niimi T....Kitagawa Y. (Biochim. Biophys. Acta 2006)
    120. laminin alpha 1 gene is essential for normal lens development in zebrafish. (PubMed id 16522196)9 Zinkevich N.S....Semina E.V. (BMC Dev. Biol. 2006)
    121. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. (PubMed id 16943280)9 Schneider M....Baumgartner S. (Development 2006)
    122. Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. (PubMed id 15944190)9 Medioni C. and Noselli S. (Development 2005)
    123. Distinct patterns of microvascular endothelial cell morphology are determined by extracellular matrix composition. (PubMed id 15370292)9 Dye J....Clark P. (Endothelium 2004)
    124. Extracellular matrix of the developing ovarian follicle. (PubMed id 14525524)9 Rodgers R.J....Russell D.L. (Reproduction 2003)
    125. A comparative histopathologic and immunohistopathologic evaluation of cremaster muscles from boys with various inguinoscrotal pathologies. (PubMed id 11371030)9 BingAPl-KoloA9lu M....HiAssAPnmez A. (Eur J Pediatr Surg 2001)
    126. The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing. (PubMed id 10520997)9 Rudenko G....Deisenhofer J. (Cell 1999)
    127. Growth factors in infant germinal matrix: relationship to extracellular matrix and cell adhesion molecules. (PubMed id 9737549)9 Nakamura Y....Hashimoto T. (J. Neuropathol. Exp. Neurol. 1998)
    128. Glomerular extracellular matrix components and integrins. (PubMed id 9686316)9 Sterk L.M....Sonnenberg A. (Cell Adhes. Commun. 1998)
    129. Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells. (PubMed id 9486851)9 Cho Y....Talmage D.A. (amp 1998)
    130. Changes in the distribution of integrins and their basement membrane ligands during development of human thyroid follicular epithelium. (PubMed id 9184849)9 Lohi J....Virtanen I. (Histochem. J. 1997)
    131. Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium. (PubMed id 9033287)9 Lotz M.M....Mercurio A.M. (Am. J. Pathol. 1997)
    132. Identification of integrin-dependent and -independent cell adhesion domains in COOH-terminal globular region of laminin-5 alpha 3 chain. (PubMed id 9300180)9 Mizushima H....Miyazaki K. (amp 1997)
    133. Immunohistochemical study of merosin-negative congenital muscular dystrophy: laminin alpha 2 deficiency in skin biopsy. (PubMed id 9255383)9 Marbini A....Gemignani F. (Acta Neuropathol. 1997)
    134. A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. (PubMed id 9409675)9 Stark K.A....Hynes R.O. (Development 1997)
    135. Differential expression of extracellular matrix components during the morphogenesis of human gastric mucosa. (PubMed id 8837725)9 Tremblay E. and MAcnard D. (Anat. Rec. 1996)
    136. Laminin chains in the basement membranes of human thymus. (PubMed id 8910035)9 Virtanen I....Lehto V.P. (Histochem. J. 1996)
    137. Laminins, tenascin and type VII collagen in colorectal mucosa. (PubMed id 8863048)9 Lohi J....Virtanen I. (Histochem. J. 1996)
    138. Alpha 6 beta 4 integrin and newly deposited laminin-1 and laminin-5 form the adhesion mechanism of gastric carcinoma. Continuous expression of laminins but not that of collagen VII is preserved in invasive parts of the carcinomas: implications for acquisition of the invading phenotype. (PubMed id 8780383)9 Tani T....Virtanen I. (Am. J. Pathol. 1996)
    139. Mild clinical phenotype in a 12-year-old boy with partial merosin deficiency and central and peripheral nervous system abnormalities. (PubMed id 8938702)9 Mora M....Morandi L. (Neuromuscul. Disord. 1996)
    140. Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors. (PubMed id 8618235)9 Ferrarini M....Zocchi R. (J. Natl. Cancer Inst. 1996)
    141. [Congenital muscular dystrophy with merosin deficiency: clinical, histopathological, immunocytochemical and genetic analysis]. (PubMed id 8729391)9 Fardeau M....Hillaire D. (Rev. Neurol. (Paris) 1996)
    142. Disruption of microfilaments alters laminin synthesis but not laminin trafficking in NHEK in vitro. (PubMed id 8792160)9 Cook J.R. and Van Buskirk R.G. (amp 1996)
    143. Identification of a cDNA encoding tubulointerstitial nephritis antigen. (PubMed id 7608193)9 Nelson T.R....Butkowski R.J. (J. Biol. Chem. 1995)
    144. Histopathological criteria for intestinal neuronal dysplasia of the submucosal plexus (type B) (PubMed id 7655734)9 Meier-Ruge W.A....Stoss F. (Virchows Arch. 1995)
    145. Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron. (PubMed id 8572172)9 Piepenhagen P.A. and Nelson W.J. (Am. J. Physiol. 1995)
    146. The extracellular matrix in hepatic regeneration. (PubMed id 7589981)9 Martinez-Hernandez A. and Amenta P.S. (FASEB J. 1995)
    147. Coculture modulates laminin synthesis and mRNA levels in epidermal keratinocytes and dermal fibroblasts. (PubMed id 8299713)9 Monical P.L. and Kefalides N.A. (Exp. Cell Res. 1994)
    148. Selective assembly of laminin variants by human carcinoma cells. (PubMed id 7967523)9 Wewer U.M.... Albrechtsen R. (Lab. Invest. 1994)
    149. The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen. (PubMed id 8117101)9 Stack M.S. and Pizzo S.V. (Arch. Biochem. Biophys. 1994)
    150. Binding of purified collagen receptors (alpha 1 beta 1, alpha 2 beta 1) and RGD-dependent integrins to laminins and laminin fragments. (PubMed id 7525287)9 Pfaff M....Timpl R. (Eur. J. Biochem. 1994)
    151. Co-expression of laminin and a 67 kDa laminin-binding protein in teratocarcinoma embryoid bodies. (PubMed id 8074991)9 Unda F.J....Arechaga J. (Int. J. Dev. Biol. 1994)
    152. Integrins and laminins in human renal carcinoma cells and tumors grown in nude mice. (PubMed id 8044804)9 Korhonen M....Virtanen I. (Cancer Res. 1994)
    153. Proteoglycans of basement membranes. (PubMed id 8298244)9 Timpl R. (EXS 1994)
    154. Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain. (PubMed id 7959779)9 Richards A.J....Pope F.M. (Genomics 1994)
    155. A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion. (PubMed id 7958432)9 Oda H....Takeichi M. (Dev. Biol. 1994)
    156. Expression of merosin in the thymus and its interaction with thymocytes. (PubMed id 8345183)9 Chang A.C....Coligan J.E. (J. Immunol. 1993)
    157. Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands. (PubMed id 8354280)9 Pan T.C....Chu M.L. (Eur. J. Biochem. 1993)
    158. Basement membranes during development of human nerve: Schwann cells and perineurial cells display marked changes in their expression profiles for laminin subunits and beta 1 and beta 4 integrins. (PubMed id 8478643)9 Jaakkola S....Peltonen J. (J. Neurocytol. 1993)
    159. Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit. (PubMed id 8081870)9 Hierck B.P....Sonnenberg A. (Cell Adhes. Commun. 1993)
    160. S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky. (PubMed id 8486374)9 Porter B.E....Sanes J.R. (Genomics 1993)
    161. Functions of agrin and agrin-related proteins. (PubMed id 7680504)9 Patthy L. and Nikolics K. (Trends Neurosci. 1993)
    162. Abnormal localization of laminin subunits in muscular dystrophies. (PubMed id 8246011)9 Hayashi Y.K....Arahata K. (J. Neurol. Sci. 1993)

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    Entrez Gene: 284217 HGNC: 6481 AceView: LAMA1.1 Ensembl:ENSG00000101680 euGenes: HUgn284217
    ECgene: LAMA1 Kegg: 284217 H-InvDB: LAMA1

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